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Trends of nanotechnology in type 2 diabetes mellitus treatment

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Asian Journal of Pharmaceutical Sciences 2021年第1期16卷 62-76页

作者： Yannis V.Simos Konstantinos Spyrou Michaela Patila Niki Karouta Haralambos Stamatis Dimitrios Gournis Evangelia Dounousi Dimitrios Peschos Department of Physiology Faculty of MedicineSchool of Health SciencesUniversity of IoanninaIoannina 45110Greece Department of Materials Science and Engineering University of IoanninaIoannina 45110Greece Biotechnology Laboratory Department of Biological Applications and TechnologiesUniversity of IoanninaIoannina 45110Greece Department of Nephrology Faculty of MedicineSchool of Health SciencesUniversity of IoanninaIoannina 45110Greece Nanomedicine and nanobiotechnology research Group University of IoanninaIoannina 45110Greece

There are several therapeutic approaches in type 2 diabetes mellitus(T2DM).When diet and exercise fail to control hyperglycemia,patients are forced to start therapy with antidiabetic ***,these drugs present several drawbacks that can affect the course of *** major disadvantages of current oral modalities for the treatment of T2DM are mainly depicted in the low bioavailability and the immediate release of the drug,generating the need for an increase in frequency of *** conjugation with the manifestation of adverse side effects,patient compliance to therapy is *** the past few years nanotechnology has found fertile ground in the development of novel delivery modalities that can potentially enhance anti-diabetic regimes *** efforts have been targeted towards two main vital steps:(a)to protect the drug by encapsulating it into a nano-carrier system and(b)efficiently release the drug in a gradual as well as controllable ***,only a limited number of studies published in the literature used in vivo techniques in order to support *** we discuss the current disadvantages of modern T2DMmarketed drugs,and the nanotechnology advances supported by in vivo in mouse/rat models of glucose *** generation of drug nanocarriers may increase bioavailability,prolong release and therefore reduce dosing and thus,improve patient *** novel approach might substantially improve quality of life for *** ofmetal nanoformulations as indirect hypoglycemic agents is also discussed.

关键词： Type 2 diabetes mellitus Nanotechnology Hyperglycemia Controlled release In vivo

Magnetic modification of diamagnetic agglomerate forming powder materials

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Particuology 2016年第6期14卷 169-171页

作者： Ivo Safarik Eva Baldikova Kristyna Pospiskova Mirka Safarikova Department of nanobiotechnology Biology Centre ISB CAS Na Sadkach 7 370 05 Ceske Budejovice Czech Republic Regional Centre of Advanced Technologies and Materials Palacky University Slechtitelu 27 783 71 Olomouc Czech Republic Global Change research Institute CAS Na Sadkach 7 370 05 Ceske Budejovice Czech Republic Department of Applied Chemistry Faculty of Agriculture University of South Bohemia Branisovska 1457 370 05 Ceske Budejovice Czech Republic

A simple method for the magnetic modification of various types of powdered agglomerate forming dia- magnetic materials was developed. Magnetic iron oxide particles were prepared from ferrous sulfate by microwave assisted synthesis. A suspension of the magnetic particles in water soluble organic solvent （methanol, ethanol, propanol, isopropyl alcohol, or acetone） was mixed with the material to be modified and then completely dried at elevated temperature. The magnetically modified materials were found to be stable in water suspension at least for 2 months.

关键词： Magnetic modification Magnetic separation Powdered material Magnetic iron oxide Microwave assisted synthesis

Silk-ELR co-recombinamer covered stents obtained by electrospinning

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Regenerative Biomaterials 2019年第1期6卷 21-28页

作者： M.Putzu F.Causa Manuel Parente Israel Gonza´lez de Torre J.C.Rodriguez-Cabello P.A.Netti Dipartimento di Ingegneria Chimica dei Materiali e della Produzione Industriale(DICMAPI)University“Federico II”Piazzale Tecchio 8080125 NaplesItaly Interdisciplinary research Centre on Biomaterials(CRIB) University of Naples Federico IIPiazzale Tecchio 8080125 NapoliItaly center for Advanced Biomaterials for Health Care@CRIB Istituto Italiano di TecnologiaLargo Barsanti e Matteucci 5380125 NapoliItaly Conic Vascular via Carlo Maderno 236901 LuganoSwitzerland Technical Proteins nanobiotechnology S.L. Edificio CTTAPaseo de Belen9A47011 ValladolidSpain Networking research center on Bioengineering Biomaterials and Nanomedicine(CIBER-BBN)ValladolidSpain Bioforge Lab University of ValladolidEdificio LUCIAPaseo de Belen1947011 ValladolidSpain

In the field of tissue engineering the choice of materials is of great importance given the possibility to use biocompatible polymers produced by means of biotechnology.A large number of synthetic and natural materials have been used to this purpose and processed into scaffolds using Electrospinning *** materials that could be used for the fabrication of scaffold and degradable membranes,natural polymers such as collagen,elastin or fibroin offer the possibility to design structures strictly similar to the extracellular matrix(ECM).Biotechnology and genetic engineering made possible the advent of a new class of biopolymers called protein-based *** example is represented by the silk-elastin-proteins that combine the elasticity and resilience of elastin with the high tensile strength of silk-fibroin and display engineered bioactive *** this work,we use electrospinning technique to produce a fibrous scaffold made of the corecombinamer *** fibres have been characterized from the morphological point of *** and morphology have been explored using Scanning Electron Microscopy.A thorough study regarding the influence of Voltage,flow rate and distance have been carried out to determine the appropriate parameters to obtain the fibrous mats without defects and with a good distribution of *** has also been in vitro *** the first time we use the co-recombinamer Silk-ELR for the fabrication of a 2.5 angioplasty balloon *** structure could be useful as a coated scaffold for the regeneration of intima layer of vessels.

关键词： electrospinning silk elastin-like-recombinamers tissue engineering

Amyloid beta peptides, tau protein acetylation and therapeutic strategies for treating Alzheimer’s disease: a review

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Life research 2021年第1期4卷 49-58页

作者： Sanjib Guha Rajalakshmi Subramaniyam University of Rochester Department of Anesthesiology&Perioperative MedicineNew York 14642USA AU-KBC research Centre Chemical Biology and Nanobiotechnology LaboratoryAnna UniversityChennai 600044India

Alzheimer’s disease(AD)is the most common progressive neurodegenerative *** is often lethal and currently lacks a satisfactory *** disease has a specific neuro-pathological profile:accumulation of proteinaceous deposits in the brain–amyloid plaques(containingβ-amyloid peptides)and neurofibrillary tangles which are accumulation of a profusion of long stringy tangles of proteins called *** the two highly recognized AD hypotheses,amyloid beta(Aβ)peptide aggregation and accumulation play a significant role and are considered as an important mechanism of AD pathology.Aβis a proteolytic product of amyloid precursor protein and genetic studies supported the relevance of Aβin AD pathogenesis.A large number of small molecules were studied for their ability to inhibit Aβ-aggregation in oligomer form or after ***,the protein-misfolding process has certain setbacks which are inevitable due to the different morphology of *** recent years,it has been demonstrated that tau also plays a central role in pathogenesis of this ***,abnormal post-translational modifications of tau,in particular,increases in acetylation at specific sites likely contribute to the toxicity of *** it is evident that tau with these aberrant post-translational modifications likely facilitates neurodegeneration,the precise cellular mechanisms by which tau compromises neuronal function remain *** addition,much remains to be learned about new interventions that might be developed to prevent or reduce the negative impact of tau posttranslational modifications-related *** review article addresses the key roles of amyloid beta and tau protein in AD as well as the possible therapeutic agents that can reduce the toxic levels of both the proteins,and thus providing beneficial effect for the AD patients.

关键词： Alzheimer’s disease Amyloid beta peptide Tau acetylation Therapeutic strategies Disease models

Gold Nanoparticle and Berberine Entrapped into Hydrogel Matrix as Drug Delivery System

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Journal of Biomaterials and nanobiotechnology 2015年第1期6卷 53-63页

作者： Camila Rufino Souza Henrique R. Oliveira Wagner M. Pinheiro Lubhandwa S. Biswaro Ricardo B. Azevedo Anderson J. Gomes Claure N. Lunardi Laboratory of nanobiotechnology Faculty of Ceilandia University of Brasilia Brasilia Brazil Institute of Biological Sciences University of Brasilia Brasilia Brazil

In this study the novel hydrogel loaded with gold nanoparticle (AuNP) enhanced the berberine (BS) release when compared with other formulations of hydrogel. Hydrogels are hydrophilic polymer networks having the capacity to absorb water, ranging from about twenty to thousand times their dry weight. BS is a natural product, a quaternary ammonium salt from the group of isoquinoline alkaloids found in medicinal plants as Berberis Vulgaris. BS has some activity against dysentery, hypertension, inflammation, and liver disease in China and Japan. In this work, BS was used as a model drug to study its association with different types of hydrogel composites of polyvinyl alcohol (BS-PVA 10%);gellan gum (BS-GG 2%), gellan gum-PVA crosslinked with cysteine (cys) (BSGG2%PVA2%cys) and gellan gum-PVA cosslinked with cysteine associated with gold nanoparticles (AuNP-BSGG2%PVA2%cys). Several parameters such as fraction of retained water (Wf), hydration percentage (%H), Swelling (DSw) and time course profile (t = 100%) (TC) were evaluated for all preparations. The results showed that the AuNP-BS-GG2%PVA2%cys was able to retain more water and swelling than the other preparations. The time course of release of the BS to the medium was greater for AuNP-BS-GG2%PVA2%cys making it a candidate to drug delivery studies in biological assays. Also Scanning Electron Microscopy (SEM) images of the surface of these hydrogel were performed. Furthermore, crosslink of the resulting hydrogels were investigated by Fourier Transform Infrared Spectroscopy (FTIR) and differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). Thus, briefly, the aim of this work was to study three composition of hydrogel loaded with BS and its composition in relation to addition to AuNP and evaluate its profile for further drug delivery application using the Surface Plasmonic Resonance (SPR) as a tool improving the drug release in the new hydrogel.

关键词： Hydrogel Berberine Drug Delivery AuNPs

Advanced metal-organic frameworks-polymer platforms for accelerated dermal wound healing

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Chinese Chemical Letters 2024年第11期35卷 57-65页

作者： Fereshte Hassanzadeh-Afruzi Mina Azizi Iman Zare Ehsan Nazarzadeh Zare Anwarul Hasan Siavash Iravani Pooyan Makvandi Yi Xu School of Chemistry Damghan UniversityDamghan 36716-45667Iran Department of nanobiotechnology/Biophysics Faculty of Biological ScienceTarbiat Modares UniversityTehran 14115-154Iran research and Development Department Sina Medical Biochemistry Technologies Co.Ltd.Shiraz ***Iran Department of Mechanical and Industrial Engineering Qatar UniversityDoha 2713Qatar Biomedical research center Qatar UniversityDoha 2713Qatar Independent researcher W Nazar STBoostan AveIsfahan 81756-33551Iran Centre of research Impact and Outcome Chitkara UniversityRajpuraPunjab 140401India Department of Biomaterials Saveetha Dental College and HospitalsSIMATSSaveetha UniversityChennai 600077India Department of Science&Technology Department of UrologyNanoBioMed GroupThe Quzhou Affiliated Hospital of Wenzhou Medical UniversityQuzhou People's HospitalQuzhou 324000China

Skin wound healing is an important aspect of regenerative ***-organic frameworks(MOFs)have attracted considerable attention as promising nanomaterials for skin wound healing due to their remarkable versatility,tunable pore size,surface area,targeted delivery of various therapeutic agents,and controlled release *** combination of these materials with biocompatible and synthetic polymers can help improve their performance in wound *** review examines the potential of MOF-polymer composites in skin wound *** and biological chemical properties and methods of making MOFs and their composites have been *** the final section of this review,challenges and future prospects for the development of MOF-polymer composites are stated.

关键词： Metal-organic frameworks Dermal wound healing Tissue engineering Nanocomposite Nanoparticles

Negative Feedback Regulation of Auxin Signaling by ATHB8/ACL5-BUD2 Transcription Module

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Molecular Plant 2014年第6期7卷 1006-1025页

作者： Simona Baima Valentina Forte Marco Possenti Andres Penalosa Guido Leoni Sergio Salvi Barbara Felici Ida Ruberti Giorgio Morelli Food and Nutrition research Centre Agricultural Research Council Via Ardeatina 546 00178 Rome Italy Present address: Department of Physics Sapienza University of Rome Rle A Moro 5 00185 Rome Italy Present address: Soil-Plant System Studies research Centre Agricultural Research Council Via della Navicella 2-4 00184 Rome Italy Institute of Biology Molecular Medicine and NanoBiotechnology National Research Council Rle A. Moro 5 00185 Rome Italy

The role of auxin as main regulator of vascular differentiation is well established, and a direct correlation between the rate of xylem differentiation and the amount of auxin reaching the （pro）cambial cells has been proposed. It has been suggested that thermospermine produced by ACAULIS5 （ACL5） and BUSHY AND DWARF2 （BUD2） is one of the factors downstream to auxin contributing to the regulation of this process in Arabidopsis. Here, we provide an in-depth characterization of the mechanism through which ACL5 modulates xylem differentiation. We show that an increased level of ACL5 slows down xylem differentiation by negatively affecting the expression of homeodomain-leucine zipper （HD- ZIP） III and key auxin signaling genes. This mechanism involves the positive regulation of thermospermine biosynthesis by the HD-ZIP III protein ARABIDOPSIS THALIANA HOMEOBOX8 tightly controlling the expression of ACL5 and BUD2. In addition, we show that the HD-ZIP III protein REVOLUTA contributes to the increased leaf vascularization and long hypocotyl phenotype of acl5 likely by a direct regulation of auxin signaling genes such as LIKE AUXIN RESISTANT2 （LAX2） and LAX3. We propose that proper formation and differentiation of xylem depend on a balance between positive and negative feedback loops operating through HD-ZIP III genes.

关键词： auxin procambium thermospermine autoregulation auxin influx transporters Arabidopsis.

Osteogenic composite nanocoating based on nanohydroxyapatite, strontium ranelate and polycaprolactone for titanium implants

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Transactions of Nonferrous Metals Society of China 2018年第9期28卷 1763-1773页

作者： Murat Taner VURAT Ayse Eser ELCIN Yasar Murat ELCIN Tissue Engineering Biomaterials and Nanobiotechnology LaboratoryFaculty of Science and Stem Cell InstituteAnkara UniversityAnkara 06100Turkey Biovalda Health Technologies Inc.Ankara 06830Turkey

Titanium and its alloys are commonly used as dental and bone implant *** coating of titanium surfaces could improve their osteoinductive *** this work,we have developed a novel osteogenic composite nanocoating for titanium surfaces,which provides a natural environment for facilitating adhesion,proliferation,and osteogenic differentiation of bone marrow mesenchymal stem cells(MSCs).Electrospinning was used to produce composite nanofiber coatings based on polycaprolactone(PCL),nano-hydroxyapatite(nHAp)and strontium ranelate(SrRan).Thus,four types of coatings,i.e.,PCL,PCL/nHAp,PCL/SrRan,and PCL/nHAp/SrRan,were applied on titanium *** assess chemical,morphological and biological properties of the developed coatings,EDS,FTIR,XRD,XRF,SEM,AFM,in-vitro cytotoxicity and in-vitro hemocompatibility analyses were *** findings have revealed that the composite nanocoatings were both cytocompatible and hemocompatible;thus PCL/HAp/SrRan composite nanofiber coating led to the highest cell *** culture of MSCs on the nanocoatings led to the osteogenic differentiation of stem cells,confirmed by alkaline phosphatase activity and mineralization *** findings support the notion that the proposed composite nanocoatings have the potential to promote new bone formation and enhance bone-implant integration.

关键词： osteogenic nanocoating composite nanofiber titanium implant nanohydroxyapatite strontium ranelate polycaprolactone electrospinning mesenchymal stem cells

Complete ablation of tumors using synchronous chemoradiation with bimetallic theranostic nanoparticles

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Bioactive Materials 2022年第1期7卷 74-84页

作者： Hamed Nosrati Elahe Attari Fatemeh Abhari Murat Barsbay Mohammadreza Ghaffarlou Navid Mousazadeh Rasoul Vaezi Taras Kavetskyy Hamed Rezaeejam Thomas J.Webster Behrooz Johari Hossein Danafar Zanjan Pharmaceutical Biotechnology research center Zanjan University of Medical SciencesZanjanIran Joint Ukraine-Azerbaijan International research and Education center of nanobiotechnology and Functional Nanosystems DrohobychUkraineBakuAzerbaijan Department of Radiology School of Paramedical SciencesZanjan University of Medical SciencesZanjan45139-56184Iran Hacettepe University Department of ChemistryBeytepeAnkara06800Turkey Department of Medical Biotechnology School of MedicineZanjan University of Medical SciencesZanjan45139-56184Iran Department of Pharmaceutical Nanotechnology School of PharmacyZanjan University of Medical SciencesZanjanIran Department of Surface Engineering The John Paul II Catholic University of Lublin20-950LublinPoland Drohobych Ivan Franko State Pedagogical University 82100DrohobychUkraine Department of Chemical Engineering Northeastern University360 Huntington AvenueBostonMA02115United States

Synchronous chemotherapy and radiotherapy,termed chemoradiation therapy,is now an important standard regime for synergistic cancer *** such treatment,nanoparticles can serve as improved carriers of chemotherapeutics into tumors and as better radiosensitizers for localized ***,we designed a Schottky-type theranostic heterostructure,Bi_(2)S_(3)-Au,with deep level defects(DLDs)in Bi_(2)S_(3) as a nano-radiosensitizer and CT imaging contrast agent which can generate reactive free radicals to initiate DNA damage within tumor cells under X-ray ***(MTX)was conjugated onto the Bi_(2)S_(3)-Au nanoparticles as a chemotherapeutic agent showing enzymatic stimuli-responsive release *** designed hybrid system also contained curcumin(CUR),which cannot only serve as a nutritional supplement for chemotherapy,but also can play an important role in the radioprotection of normal ***,this combined one-dose chemoradiation therapeutic injection of co-drug loaded bimetallic multifunctional theranostic nanoparticles with a one-time clinical X-ray irradiation,completely eradicated tumors in mice after approximately 20 days after irradiation showing extremely effective anticancer efficacy which should be further studied for numerous anti-cancer applications.

关键词： Combination therapy Radiosensitizer Semiconductor Heterojunction Radioprotector