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Chinese Journal of Chemistry 2012年第3期30卷 709-714页

作者： Mirhosseini Moghaddam, Mojtaba Bazgir, Ayoob Mohammad Mehdi, Akhondi Ghahremanzadeh, Ramin nanobiotechnology research center Avicenna Research Institute ACECR Tehran Iran Department of Chemistry Shahid Beheshti University Tehran Iran Reproductive research center Avicenna Research Institute ACECR Tehran Iran

The combination of isatin, barbituric acid, and cyclohexane-1,3-dione derivatives in the presence of alum （KAI（SO4）2· 12H2O） as a catalyst for 15 min was found to be a suitable and efficient method for the synthe... 详细信息

关键词： isatin spirooxindoles dimedone barbituric acid ionic liquids

An Efficient Four-component Synthesis of Spiro[indolinepyrazolo[4＇,3＇：5,6] pyrido[2,3-d] pyrimidine]triones

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Chinese Journal of Chemistry 2012年第2期30卷 321-326页

作者： Ghahremanzadeh,Ramin Moghaddam,Mojtaba Mirhosseini Bazgir,Ayoob Akhondi,Mohammad Mehdi nanobiotechnology research center Avicenna Research InstituteACECRTehranIran Department of Chemistry Shahid Beheshti UniversityG.C.P.O.Box 19396-4716TehranIran Reproductive research center Avicenna Research InstituteACECRTehranIran

A four-component reaction in the presence of Alum [KAl（SO4）2·12H2O] as an inexpensive and reusable catalyst using the ionic liquid as an effective green reaction media is reported.

关键词： catalysis condensation cyclization green chemistry ionic liquids multicomponent reaction spiro compounds

In situ formation of bimetallic FeNi nanoparticles on sand through green technology:Application for tetracycline removal

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Frontiers of Environmental Science & Engineering 2020年第1期14卷 185-197页

作者： Ravikumar KVG Debayan Ghosh M rudula Pulimi Chandrasekaran Natarajan Amitava Mukherjee Centre for nanobiotechnology VITVelloreTamil NaduIndia

In this study,FeNi nanoparticles were green synthesized using Punica granatum(pomegranate)peel extract,and these nanoparticles were also formed in situ over quartz sand(GS-FeNi)for removal of tetracycline(TC).Under the optimized operating conditions,(GS-FeNi concentration:1.5%w/v;concentration of TC:20 mg/L;interaction period:180 min),99±0.2%TC removal was achieved in the batch reactor The removaT capacity was 181±1 mg/g.A detailed characterization of the sorbent and the solution before and after the interaction revealed that the removal mechanism(s)involved both the sorption and degradation of *** reusability of reactant was assessed for four cycles of operation,and 77±4%of TC removal was obtained in the *** judge the environmental sustainability of the process,residual toxicity assay of the interacted TC solution was performed with indicator bacteria(Bacillus and Pseudomonas)and algae(Chlorella sp.),which confirmed a substantial decrease in the *** continuous column studies were undertaken in the packed bed reactors using *** the optimized conditions,quite high removal efficiency(978±5 mg/g)was obtained in the *** application of GS-FeNi for antibiotic removal was further evaluated in lake water,tap water,and ground water spiked with TC,and the removal capacity achieved was found to be 781±5,712±5,and 687±3 mg/g,*** work can pave the way for treatment of antibiotics and other pollutants in the reactors using novel green composites prepared from fruit wastes.

关键词： GS-FeNi nanoparticles Tetracycline removal Re-usability Residual toxicity Column studies

Synthesis of photocatalytic La_(1–x)A_xTiO_(3.5–δ)(A=Ba, Sr, Ca) nano perovskites and their application for photocatalytic oxidation of congo red dye in aqueous solution

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Journal of Rare Earths 2015年第2期33卷 160-167页

作者： M.Bradha T.Vijayaraghavan S.P.Suriyaraj R.Selvakumar Anuradha M.Ashok Nanotech research Facility PSG Institute of Advanced StudiesCoimbatore-641 004 India nanobiotechnology Laboratory PSG Institute of Advanced StudiesCoimbatore-641 004 India

A-site substituted La0.8A0.2TiO3.5–δ（A=Ba, Sr, Ca） nano perovskites were prepared by sol-gel method and characterized using thermogravimetry/differential thermal analysis（TGA/DTA）, X-ray diffraction（XRD）, ultraviolet-visible（UV-Vis） spectroscopy and transmission electron microscopy（TEM）. XRD analysis showed that the La0.8A0.2TiO3.5–δ（A=Ba, Sr, Ca） nano perovskites derived after calcination at 800 oC were in single phase with orthorhombic structure. The particle size of all nano perovskites was found to be ~20 nm. The synthesized nano perovskites were tested for the photocatalytic decomposition of an azo dye, Congo red. The sequential behavior of La0.8A0.2TiO3.5–δ（A=Ba, Sr, Ca） nanoperovskites for photocatalytic decomposition of congo red in aqueous solution by visible light at room temperature was studied at various time intervals and the efficiency of degradation of the nanoperovskites was compared. Among all the A-site substituted La0.8A0.2TiO3.5–δ（A=Ba, Sr, Ca） nano perovskites, Ba substituted compound showed the highest dye degradation.

关键词： nano perovskite oxidation photocatalyst congo red dye degradation rare earths

Cytogenetic studies of chromium(Ⅲ) oxide nanoparticles on Allium cepa root tip cells

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Journal of Environmental Sciences 2015年第12期27卷 150-157页

作者： Deepak Kumar A.Rajeshwari Pradeep Singh Jadon Gouri Chaudhuri Anita Mukherjee Natarajan Chandrasekaran Amitava Mukherjee Centre for nanobiotechnology VIT University Centre of Advanced Study Department of BotanyUniversity of Calcutta

The current study evaluates the cytogenetic effects of chromium（Ⅲ） oxide nanoparticles on the root cells of Allium *** root tip cells of *** were treated with the aqueous dispersions of Cr2O3 nanoparticles（NPs） at five different concentrations（0.01,0.1,1,10,and 100 μg/m L） for 4 *** colloidal stability of the nanoparticle suspensions during the exposure period were ascertained by particle size *** 4 hr exposure to Cr2O3 NPs,a significant decrease in mitotic index（MI） from 35.56%（Control） to 35.26%（0.01 μg/m L）,34.64%（0.1 μg/m L）,32.73%（1 μg/m L）,29.6%（10 μg/m L） and 20.92%（100 μg/m L） was *** optical,fluorescence and confocal laser scanning microscopic analyses demonstrated specific chromosomal aberrations such as-chromosome stickiness,chromosome breaks,laggard chromosome,clumped chromosome,multipolar phases,nuclear notch,and nuclear bud at different exposure *** concentration-dependent internalization/bio-uptake of Cr2O3 NPs may have contributed to the enhanced production of anti oxidant enzyme,superoxide dismutase to counteract the oxidative stress,which in turn resulted in observed chromosomal aberrations and cytogenetic *** results suggest that *** root tip assay can be successfully applied for evaluating environmental risk of Cr2O3 NPs over a wide range of concentrations.

关键词： A.cepa Bio-uptake Chromosomal aberration C2O3 nanoparticles Mitotic index SOD

Innovative application of the Echinacea purpurea (L.) extract-phospholipid phytosomes embedded within Alyssum homolocarpum seed gum film for enhancing the shelf life of chicken meat

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Food Bioscience 2022年第6期50卷 465-473页

作者： Mohammad Molaveisi Ramezan Ali Taheri Danial Dehnad Department of Food Chemistry Research Institute of Food Science and Technology (RIFST)MashhadIran nanobiotechnology research center Baqiyatallah University of Medical SciencesTehranIran Young researchers and Elite Club Gorgan BranchIslamic Azad UniversityGorganIran

To the best of our knowledge, “phytosomal” encapsulation of extracts in edible films has not been applied for enhancing the shelf life of food products by now;as a result, phytosomal encapsulation was used in this research to bring about a sustainable release of the extract from the edible film and prompt a significant shelf life enhancement. For this purpose, first, the Alyssum homolocarpum seed gum (AHSG) film was enriched with various levels (1–20% w/w) of Echinacea purpurea (L.) extract-phospholipid phytosome (EEPP) and, then, the structural (FTIR and SEM), thermal, physicochemical, mechanical and radical scavenging properties of the films as well as release kinetics of the extracts from the films were evaluated. Then, the chicken meat was packaged with the developed film and its different parameters including microbial population, chemical indices (TBARS and pH) as well as sensory properties of the meat were compared with those of the control film. Based on the results, as the EEPP percentage increased, water solubility, moisture content, water vapor permeability of AHSG films decreased favorably, and their tensile strength enhanced successfully. Besides, incorporation of EEPP improved the radical scavenging properties and melting point of the base film considerably. Structural surveys revealed that some chemical interactions (hydrogen bonds) occurred between EEPP and AHSG matrix. A two-fold increase in the shelf life of meat was recognized as the microbial and chemical indices of the developed film after 14 days were even better than those indices of the control film after 7 days.

关键词： Sustainable film Phytosome Active film Meat spoilage Green packaging

Assessing combined toxic effects of tetracycline and P25 titanium dioxide nanoparticles using Allium cepa bioassay

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Frontiers of Environmental Science & Engineering 2021年第1期15卷 101-112页

作者： Barsha Roy Khushboo Kadam Suresh Palamadai Krishnan Chandrasekaran Natarajan Amitava Mukherjee School of Biosciences and Technology VITVellore 632014India Centre for nanobiotechnology VITVellore 632014India

Usage of titanium dioxide nanoparticles(TiO_(2) NPs)and tetracycline(TC)has increased significantly in the present *** leads to their release and accumulation in the *** the compounds,individually,can have adverse toxic effects on the *** binary mixtures can increase this degree of *** present study aimed to evaluate the toxicity of both the contaminants in individual and binary mixtures in Allium ***,the toxicity of TiO_(2) NPs upon UVA pre-irradiation was also *** showed that UVA pre-irradiated NPs(UVA-TiO_(2) NPs)had a significant decrease in cell viability than their non-irradiated counterparts(NI-TiO_(2)),denoting an increase in photocatalytic activity upon UVA *** low concentrations of TC(EC10=0.016µmol/L)mixed with TiO2 NPs significantly increased the toxicity for both UVA-TiO_(2) and NI-TiO_(2) *** ROS generation was significantly high for UVA-TiO_(2) ***,TC did not have any effects on ROS *** the compounds exhibited genotoxic potential in *** chromosomal abnormalities like anaphase bridges,telophase bridges,laggard chromosomes,binucleate cells,*** *** binary mixture of UVA-TiO_(2) NPs and TC showed the highest chromosomal aberrations(64.0%±1.26%)than the mixture with NI-TiO_(2) or the individual *** decreased significantly after recovery(46.8%±1.92%),denoting the self-repair *** study proved that UVA-TiO2 NPs were more toxic and could be enhanced further when mixed with a sub-lethal concentration of *** work will help to assess the risk of both compounds in the environment.

关键词： Binary toxicity Cell viability Mitotic index Chromosomal aberration Reactive oxygen species Nanoparticles internalization

Optical tweezer and TIRF microscopy for single molecule manipulation of RNA/DNA nanostructures including their rubbery property and single molecule counting

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Biophysics Reports 2021年第6期7卷 449-474页

作者： Chiran Ghimire Peixuan Guo center for RNA nanobiotechnology and Nanomedicine College of Pharmacy 3. Dorothy M. Davis Heart and Lung research Institute 4. College of Medicine 5. James Compréhensive Cancer center The Ohio State University

Life science is often focused on the microscopic level. Single-molecule technology has been used to observe components at the micro-or nanoscale. Single-molecule imaging provides unprecedented information about the behavior of individual molecules in contrast to the information from ensemble methods that average the information of many molecules in various states. A typical feature of living systems is motion. The lack of synchronicity of motion biomachines in living systems makes it challenging to image the motion process with high resolution. Thus, single-molecule technology is especially useful for real-time study on motion mechanism of biomachines, such as viral DNA packaging motor, or other ATPases. The most common optical instrumentations in single-molecule studies are optical tweezers and single molecule total internal refection fluorescence microscopy(sm TIRF). Optical tweezers are the force-based technique. The analysis of RNA using optical tweezer has led to the discovery of the rubbery or amoeba property of RNA nanoparticles for compelling vessel extravasation to enhance tumor targeting and fast renal excretion. The rubbery property of RNA lends mechanistic evidence for RNAs use as an ideal reagent in cancer treatment with undetectable toxicity. Single molecule photobleaching allows for the direct counting of biomolecules. This technique was invented for single molecule counting of RNA in the phi29 DNA packaging motor to resolve the debate between five and six copies of RNA in the motor. The technology has subsequently extended to counting components in biological machines composed of protein, DNA, and other macromolecules. In combination with statistical analysis, it reveals biomolecular mechanisms in detail and leads to the development of ultra-sensitive sensors in diagnosis and forensics. This review focuses on the applications of optical tweezers and fluorescence-based techniques as single-molecule technologies to resolve mechanistic questions related

关键词： Stoichiometry Passive targeting Photobleaching Renal excretion Cancer imaging pRNA Bacteriophage Phi29 DNA packaging motor Portal vertex Organ accumulation Single layer patterned arrays

Translation of the long-term fundamental studies on viral DNA packaging motors into nanotechnology and nanomedicine

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Science China(Life Sciences) 2020年第8期63卷 1103-1129页

作者： Chenxi Liang Tao Weitao Lixia Zhou Peixuan Guo center for RNA nanobiotechnology and Nanomedicine College of PharmacyCollege of MedicineDorothy M.Davis Heart and Lung Research Instituteand Comprehensive Cancer Center.The Ohio State UniversityColumbusOhio 43210USA Biology Department College of Science and MathematicsSouthwest Baptist UniversityBolivarMissouri 65613USA

Many years of fundamental studies on viral genome packaging motors have led to fruitful *** double-stranded DNA(dsDNA)viruses package their genomes into preformed protein shells via nanomotors including several elegant and meticulous coaxial *** motor is geared by the hexameric RNA *** open washer displayed as hexametric string of phi29 motor ATPase has been *** open washer linked into a filament as a queue with left-handed chirality along the dsDNA *** was found that a free 5′-and 3′-dsDNA end is not required for one gp16 dimer and four monomers to assemble into the hexametric washer on *** above studies have inspired several applications in nanotechnology and *** applications include:(i)studies on the precision motor channels have led to their application in the single pore sensing;(ii)investigations into the hand-in-hand integration of the hexametric pRNA ring have resulted in the emergence of the new field of RNA nanotechnology;and(iii)the studies on the motor stoichiometry of homologous multi-subunits that subsequently have inspired the discovery of new methods in highly potent drug *** review focuses on the structure and function of the viral DNA packaging motors and describes how fundamental studies inspired various *** these advantages,more nanotechnological and biomedical applications using bacteriophage motor components are expected.

关键词： nanopores packaging motor phi29 pRNA single pore sensing chemical detection peptide differentiation and sensing nanotechnology nanobiotechnology

Preparation of monodisperse, superparamagnetic, luminescent, and multifunctional PGMA microspheres with amino-groups

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Chinese Science Bulletin 2008年第8期53卷 1165-1170页

作者： WANG WeiCai ZHANG Qi ZHANG BingBo LI DeNa DONG XiaoQing ZHANG Lei CHANG Jin Institute of nanobiotechnology School of Materials Science & Engineering Tianjin University Tianjin 300072 China

Micron-sized, monodisperse, superparamagnetic, luminescent composite poly(glycidyl methacrylate) (PGMA) microspheres with functional amino-groups were successfully synthesized in this study. The process of preparation was as follows: preparation of monodisperse poly(glycidyl methacrylate) mi- crospheres by dispersion polymerization method; modification of poly(glycidyl methacrylate) micro- spheres with ethylene diamine to form amino-groups; impregnation of iron ions (Fe2+ and Fe3+) inside the microspheres and subsequently precipitating them with ammonium hydroxide to form magnetite (Fe3O4) nanoparticles within the polymer microspheres; infusion of CdSe/CdS core-shell quantum dots (QDs) into magnetic polymer microspheres. Scanning electron microscopy (SEM) was used to char- acterize surface morphology and size distribution of composite microspheres. The average size of mi- crospheres was 1.42 μm with a size variation of 3.8%. The composite microspheres were bright enough and easily observed using a conventional fluorescence microscope. The composite microspheres were easily separated from solution by magnetic decantation using a permanent magnet. The new multi- functional composite microspheres are promising to be used in a variety of bioanalytical assays in- volving luminescence detection and magnetic separation.

关键词：发光性磁性缩水甘油基异丁烯酸盐量子点