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New insights into disruption of iron homeostasis by environmental pollutants

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Journal of Environmental Sciences 2015年第8期27卷 256-258页

作者： Xiang Wang Tian Xia Department of Medicine Division of Nano Medicine University of California California nano Systems Institute University of California

Among the numerous health conditions environmental pollutants can cause, chronic exposure to pollutants including persistent organic pollutants（POPs） and heavy metals has been shown to disturb a specific biological homeostatic process, the iron metabolism in human body. Disorders of iron metabolism are among the common diseases of humans and encompass a broad spectrum of diseases with different clinical manifestations, ranging from anemia to iron overload, and possibly to neurodegenerative diseases and ***–ferroportin（FPN） signaling is one of the key mechanisms responsible for iron supply, utilization, recycling, and storage, and recent studies demonstrated that exposure to environmental pollutants including POPs and heavy metals could lead to disruption of the hepcidin–FPN axis along with disordered systemic iron homeostasis and diseases. This article introduces and highlights the accompanying review article by Drs. Xu and Liu in this journal, which elaborates in detail the adverse effects of environmental pollutants on iron metabolism, and the mechanisms responsible for these toxicological outcomes. It also points out the knowledge gaps still existing in this subject matter. Research that will fill these gaps will improve our understanding of the issue and provide useful information to prevent or treat diseases induced by environmental pollutants.

关键词： Environmental pollution Persistent organic pollutants Heavy metals Iron homeostasis Hepcidin Ferroportin

Single molecule electro-catalysis of non-fluorescent molecule

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Chinese Chemical Letters 2015年第12期26卷 1514-1517页

作者： Fei-Fei Li Jun-Nan Gu Xiao-Chun Zhou division of Advanced nanomaterials Suzhou Institute of Nano-tech and Nano-bionics Chinese Academy of Sciences

Single molecule catalysis is very powerful in revealing catalytic mechanism at the single molecule *** fluorescent molecule is always necessary to take part into the catalysis directly in previous *** order to study the single molecule electro-catalysis of non-fluorescent molecule（SMECNFM） on nanocatalyst, we couple the SMECNFM with a single molecule fluorescence reaction. A certain number of fluorescent molecules will be generated and detected when the SMECNFM happens. Through this method, we can detect the electro-oxidation reaction of one HCOONa molecule. The stability of Pt nanocatalyst supported on active carbon is studied at the single molecule level by this method. This paper also provides a general way to make ultra-sensitive sensor, and to study the SMECNFM for the molecules,such as formic acid, hydrogen, oxygen, etc., on single nanoparticle.

关键词： catalysis powerful reactant silica stoichiometric detecting camera slide redox revealing

Fabrication and characterization of 3D scaffold using 3D plotting system

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Chinese Science Bulletin 2010年第1期55卷 94-98页

作者： LEE Jun-Hee PARK Su-A PARK KoEun KIM Jae-Hyun KIM Kyung-Shik LEE Jihye Kim WanDoo Bio-Mechatronics Team Division of Nano-Machinery Korea Institute of Machinery and Materials (KIMM) nano-Mechanics Team Division of Nano-Machinery Korea Institute of Machinery and Materials (KIMM) nano-Mechatronics Team Division of Nano-Machinery Korea Institute of Machinery and Materials (KIMM)

In this paper, we design and fabricate a 3D scaffold using rapid prototyping (RP) technology for tissue engineering. The scaffold should have a three-dimensional interconnected pore network. We fabricate a polycaprolactone (PCL) scaffold with interconnecting pores and uniform porosity for cell ingrowth using a 3D plotting system. In order to keep the three dimensional shape under mechanical loading while implanted, we design an oscillating nozzle system to increase elastic modulus and yield strength of PCL strand. We characterize the influence of pore geometry, compressive modulus of the scaffold, elastic modulus and yield strength of the strand using SEM, dynamical mechanical analysis (DMA) and nano-UTM. Finally the cell responses on scaffolds are observed.

关键词：三维形状绘图系统表征支架制作动态机械分析弹性模量细胞反应

1.82 wt.% Pt/N, P co-doped carbon overwhelms 20 wt.% Pt/C as a high-efficiency electrocatalyst for hydrogen evolution reaction

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nano Research 2017年第1期10卷 238-246页

作者： Changhong Wang Feng Hu Hongchao Yang Yejun Zhang Huan Lu Qiangbin Wang Key Laboratory of nano-Bio Interface Division of Nanobiomedicine and i-Lab Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Suzhou 215123 China School of nano-Tech and nano-Bionics University of Science and Technology of China Suzhou 215123 China

Cost-effective electrocatalysts for the hydrogen evolution reaction （HER） play a key role in the field of renewable energy. Although tremendous efforts have been devoted to the search of alternative materials, Pt/C is still the most efficient electrocatalyst for the HER. Nevertheless, decreasing the loading of Pt in the designed eletrocatalysts is of significance. However, with low Pt loading, it is challenging to maintain excellent catalytic performance. Herein, a new catalyst （Pt/NPC） was prepared by dispersing Pt nanoparticles （PtNPs） with an average diameter of 1.8 nm over a three-dimensional （3D） carbon network co-doped with N and P. Because of the high electronegativity of the N and P dopants, PtNPs were uniformly dispersed on the carbon network via high electronic affinity between Pt and carbon, affording a Pt/NPC catalyst; Pt/NPC exhibited superior HER activity, attributed to the down-shift of the Pt d-band caused by the donation of charge from N and P to Pt. The results show that Pt/NPC with an ultralow Pt loading of 1.82 wt.% exhibits excellent HER performance, which corresponds to a HER mass activity 20.6-fold greater than that observed for commercial 20% Pt/C at an overpotential of 20 mV vs. RHE.

关键词： electrocatalysis Pt N and P co-doped carbon hydrogen evolution reaction

Influence of tool deflection on micro channel pattern of 6:4 brass with rectangular tool

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中国有色金属学会会刊：英文版 2009年第B9期19卷 164-170页

作者： Tae-Jin JE Kang-Won LEE Sang-Cheon PARK Jae-Gu KIM Doo-Sun CHOI Kyoung-Taik PARK Kyung-Hyun WHANG nano Mechanical Systems Research division Korea Institute of Machinery & Materials (KIMM)

Machining experiment of micro channel structure with 6:4 brass was carried out by shaping process using a single crystal diamond tool. FEM simulation using solid cantilever beam model was analyzed. In result of experiment, tool deflection is observed as machining characteristics through result of experiments such as surface roughness, cutting force and burr formations. And the influence of tool deflection is experimentally proved.

关键词：金刚石工具挠度通道模式黄铜矩形实验证明加工特性有限元模拟

An intelligent DNA nanodevice for precision thrombus therapy

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Science China Chemistry 2024年第10期67卷 3195-3197页

作者： Yihao Zhou Qiangbin Wang CAS Key Laboratory of nano-Bio Interface Division of Nanobiomedicine and i-LabSuzhou Instiute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China

Obstruction of blood vessels(thrombosis)due to blood clots is one of the main causes of death worldwide and is associated with many cardiovascular diseases,such as myocardial infarction,ischemic stroke,and pulmonary embolism[1].Thrombolytic therapy is currently the preferred treatment for acute thrombosis and is administered intravenously with thrombolytic drugs,such as tissue plasminogen activator(tPA)[2].

关键词： drugs cardiovascular acute

Phase transferring atomically precise gold nanoclusters to aqueous solution via single stranded DNA

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Science China Chemistry 2022年第6期65卷 1003-1004页

作者： Qiangbin Wang CAS Key Laboratory of nano-Bio Interface Division of Nanobiomedicine and i-LabSuzhou Institute of Nano-Tech and Nano-BionicsSuzhou215123China

Atomically precise gold nanoclusters (Au NCs) are an emerging class of quantum-sized nanomaterials. The intrinsic discrete electronic energy levels endowed them with fascinating electronic and optical properties [1]. However,the prepared Au NCs are often protected with hydrophobic ligands and are not dispersible in aqueous solutions, which restricts their biological applications. To overcome this limitation, some phase transfer agents have been devoted to transferring hydrophobic Au NCs into the aqueous solution[2]. However, the resulting Au NCs are generally heterogeneous and aggregated, which makes their subsequent biofunctionalization difficult to control.

关键词： materials precise clusters

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Real-time in vivo visualization of tumor therapy by a near-infrared-II Ag2S quantum dot-based theranostic nanoplatform

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nano Research 2015年第5期8卷 1637-1647页

作者： Feng Hu Chunyan Li Yejun Zhang Mao Wang Dongming Wu Qiangbin Wang Key Laboratory of nano-Bio Interface Division of Nanobiomedicine and i-Lab Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Suzhou 215123 China

Real-time and objective feedback of therapeutic efficacies would be of great value for tumor treatment. Here, we report a smart Ag2S QD-based theranostic nanoplatform （DOX@PEG-Ag2S） obtained by loading the anti-cancer drug doxorubicin （DOX） into polyethylene glycol-coated silver sulfide quantum dots （PEG-Ag2S QDs） through hydrophobic-hydrophobic interactions, which exhibited high drug loading capability （93 wt.% of DOX to Ag2S QDs）, long circulation in blood （t1/2 = 10.3 h）, and high passive tumor-targeting efficiency （8.9% ID/gram） in living mice where % ID/gram reflects the probe concentration in terms of the percentage of the injected dose （ID） per gram of tissue. After targeting the tumor tissue, DOX from PEG-AgRS cargoes was selectively and rapidly released into cancer cells, giving rise to a significant tumor inhibition. Owing to the deep tissue penetration and high spatio-temporal resolution of Ag2S QDs fluorescence in the second near-infrared window （NIR-II）, the DOX@PEG-Ag2S enabled real-time in vivo reading of the drug targeting process and therapeutic efficacy. We expect that such a novel theranostic nanoplatform, DOX@PEG-Ag2S, with integrated drug delivery, therapy and assessment functionalities, will be highly useful for personalized treatments of tumors.

关键词： in vivo imaging Ag2S quantum dots second near-infraredwindow fluorescence drug delivery tumor therapy

Histogram method for reliable thickness measurements of graphene films using atomic force microscopy(AFM)

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Journal of Materials Science & Technology 2017年第8期33卷 815-820页

作者： Yaxuan Yao Lingling Ren Sitian Gao Shi Li division of nano-Metrology and Materials Measurement National Institute of MetrologyBeijing 100029China

Atomic force microscopy（AFM） is a commonly used technique for graphene thickness ***, due to surface roughness caused by graphene itself and variation introduced in AFM measurement, graphene thickness is difficult to be accurately determined by AFM. In this paper, a histogram method was used for reliable measurements of graphene thickness using AFM. The influences of various measurement parameters in AFM analysis were investigated. The experimental results indicate that significant deviation can be introduced using various order of flatten and improperly selected measurement parameters including amplitude setpoint and drive amplitude. At amplitude setpoint of 100 mV and drive amplitude of 100 m V, thickness of 1 layer（1L）, 2 layers（2L） and 4 layers（4L） graphene were *** height differences for 1L, 2L and 4L were 1.51 ± 0.16 nm, 1.92 ± 0.13 nm and 2.73 ± 0.10 nm, respectively. By comparing these values, thickness of single layer graphene can be accurately determined to be0.41 ± 0.09 nm.

关键词： Graphene Thickness measurement Atomic force microscopy Histogram method