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Journal of Environmental Sciences 2024年第8期142卷 269-278页

作者： Ying Lu Se Wang Yifan Shen School of Environmental Science and Engineering Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologyJiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution ControlNanjing University of Information Science and TechnologyNanjing 210044China

The frequent detection of pharmaceutical compounds in the environment has led to a growing awareness,which may pose a major threat to the aquatic environment.In this study,photodegradation(direct and indirect photolysis)of two different dissociation states of fluoxetine(FLU)was investigated in water,mainly including the determination of photolytic transition states and products,and the mechanisms of indirect photodegradation with·OH,CO_(3)^(*-)and NO_(3)^(*).The main direct photolysis pathways are defluorination and C–C bond cleavage.In addition,the indirect photodegradation of FLU in water is mainly through the reactions with·OH and NO_(3)^(*),and the photodegradation reaction with CO_(3)^(*-)is relatively difficult to occur in the water environment.Our results provide a theoretical basis for understanding the phototransformation process of FLU in the water environment and assessing its potential risk.

关键词： Fluoxetine Photochemical mechanism Direct photolysis Free radical reaction DFT

Improving the electrical performances of InSe transistors by interface engineering

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Chinese Physics B 2024年第4期33卷 153-158页

作者：曹天俊郝松吴晨晨潘晨戴玉頔程斌梁世军缪峰 Institute of Brain-Inspired Intelligence National Laboratory of Solid State MicrostructuresSchool of PhysicsCollaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China Institute of Interdisciplinary Physical Sciences School of PhysicsNanjing University of Science and TechnologyNanjing 210014China

InSe has emerged as a promising candidate for next-generation electronics due to its predicted ultrahigh electrical performance.However,the efficacy of the InSe transistor in meeting application requirements is hindered due to its sensitivity to interfaces.In this study,we have achieved notable enhancement in the electrical performance of InSe transistors through interface engineering.We engineered an InSe/h-BN heterostructure,effectively suppressing dielectric layer-induced scattering.Additionally,we successfully established excellent metal-semiconductor contacts using graphene ribbons as a buffer layer.Through a methodical approach to interface engineering,our graphene/InSe/h-BN transistor demonstrates impressive on-state current,field-effect mobility,and on/off ratio at room temperature,reaching values as high as 1.1 mA/μm,904 cm^(2)·V^(-1)·s^(-1),and>10~6,respectively.Theoretical computations corroborate that the graphene/InSe heterostructure shows significant interlayer charge transfer and weak interlayer interaction,contributing to the enhanced performance of InSe transistors.This research offers a comprehensive strategy to elevate the electrical performance of InSe transistors,paving the way for their utilization in future electronic applications.

关键词： two-dimensional materials InSe van der Waals heterostructure electrical performances charge density difference

circPVT1 promotes silica-induced epithelial-mesenchymal transition by modulating the miR-497-5p/TCF3 axis

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Journal of Biomedical Research 2024年第2期38卷 163-174,I0011-I0015页

作者： Siyun Zhou Yan Li Wenqing Sun Dongyu Ma Yi Liu Demin Cheng Guanru Li Chunhui Ni Department of Occupational Medical and Environmental Health Key Laboratory of Modern Toxicology of Ministry of EducationCenter for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Biomedical Publications center Nanjing Medical UniversityNanjingJiangsu 211166China Gusu School Nanjing Medical UniversityNanjingJiangsu 211166China

Epithelial-mesenchymal transition(EMT)is a vital pathological feature of silica-induced pulmonary fibrosis.However,whether circRNA is involved in the process remains unclear.The present study aimed to investigate the role of circPVT1 in the silica-induced EMT and the underlying mechanisms.We found that an elevated expression of circPVT1 promoted EMT and enhanced the migratory capacity of silica-treated epithelial cells.The isolation of cytoplasmic and nuclear separation assay showed that circPVT1 was predominantly expressed in the cytoplasm.RNA immunoprecipitation assay and RNA pull-down experiment indicated that cytoplasmic-localized circPVT1 was capable of binding to miR-497-5p.Furthermore,we found that miR-497-5p attenuated the silica-induced EMT process by targeting transcription factor 3(TCF3),an E-cadherin transcriptional repressor,in the silica-treated epithelial cells.Collectively,these results reveal a novel role of the circPVT1/miR-497-5p/TCF3 axis in the silica-induced EMT process in lung epithelial cells.Once validated,this finding may provide a potential theoretical basis for the development of interventions and treatments for pulmonary fibrosis.

关键词： silicosis epithelial-mesenchymal transition circPVT1 miR-497-5p TCF3

Electrochemical Analysis of Single Glucose Oxidase with a Nanopipette

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Chemical Research in Chinese Universities 2024年第2期40卷 272-278页

作者： WANG Yongyong MA Hui LONG Yi-Tao YING Yi-Lun School of Chemistry and Chemical Engineering Molecular Sensing and Imaging Center(MSIC)Nanjing UniversityNanjing210023P.R.China

Nanopore-based electrochemical technique is a promising tool for detecting single proteins.However,detecting single proteins using a nanopipette in their native state without labeling is challenging due to the rapid translocation,which results in an inefficient signal identification.In our study,we finely tuned the driving force equilibrium between electrophoretic force(EPF)and electroosmotic flow(EOF)inside the nanopipette for efficient sensing of single glucose oxidase(GOD)molecules.The duration time of GOD within the nanopipette is extended to about 4 ms.This strategy provided clear ionic current signals with a signal-to-noise ratio of 3.3.As EPF increased in the direction opposite to the motion of GOD,we observed a nonlinear growth in GOD’s duration time.This extended the duration to about 4.4 times longer at−1000 mV compared to at−800 mV.Hence,nanopore-based electrochemical sensing could be used for single GOD molecule analysis as an ultrasensitive method.

关键词： Nanopore Single-molecule analysis Glucose oxidase Electrophoretic force Electroosmotic flow

Gypenosides ameliorate morphine-induced immunosuppression with an increased proportion of thymic T lymphocyte subsets and are involved in the regulation of the cAMP-CREM/CREB-IL-2 pathway

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Genes & Diseases 2024年第3期11卷 120-123页

作者： Hui Wang Zhonghao Li Qisheng Wang Weixin Lin Ziting Zhou Xinru Mu Yongwei Jiang Shengfeng Lu Shaodong Chen Zhigang Lu Jiangsu Collaborative Innovation center of Traditional Chinese Medicine in Prevention and Treatment of Tumor Nanjing University of Chinese MedicineNanjingJiangsu 210023China Key Laboratory of Acupuncture and Medicine Research of Ministry of Education Nanjing University of Chinese MedicineNanjingJiangsu 210023China College of Pharmacy Nanjing University of Chinese MedicineNanjingJiangsu 210023China School of Medicine Xiamen UniversityXiamenFujian 361102China

Opioid abuse can suppress the lymphatic system function,and produce severe immunosuppression that poses a significant risk of opportunistic infections such as methicillinresistant Staphylococcus aureus(MRSA)pneumonia.^(1,2)Gypenosides(Gps)are the most important immunomodulator components in the Chinese herbal medicine Gynostemma pentaphyllum.

关键词： herbal Gypenosides immunosuppression

ANALYSIS OF THE IMPLICIT-EXPLICIT ULTRA-WEAK DISCONTINUOUS GALERKIN METHOD FOR CONVECTION-DIFFUSION PROBLEMS

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Journal of Computational Mathematics 2024年第1期42卷 1-23页

作者： Haijin Wang Anping Xu Qi Tao School of Science Nanjing University of Posts and TelecommunicationsNanjing 210023China Beijing Computational Science Research center Beijing 100193China

In this paper,we first present the optimal error estimates of the semi-discrete ultra-weak discontinuous Galerkin method for solving one-dimensional linear convection-diffusion equations.Then,coupling with a kind of Runge-Kutta type implicit-explicit time discretization which treats the convection term explicitly and the diffusion term implicitly,we analyze the stability and error estimates of the corresponding fully discrete schemes.The fully discrete schemes are proved to be stable if the time-stepτ≤τ0,whereτ0 is a constant independent of the mesh-size h.Furthermore,by the aid of a special projection and a careful estimate for the convection term,the optimal error estimate is also obtained for the third order fully discrete scheme.Numerical experiments are displayed to verify the theoretical results.

关键词： The ultra-weak discontinuous Galerkin method Convection-diffusion Implicitexplicit time discretization Stability Error estimate

Improved decoy-state quantum key distribution with uncharacterized heralded single-photon sources

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Chinese Physics B 2024年第2期33卷 204-208页

作者：徐乐辰张春辉周星宇王琴 Institute of Quantum Information and Technology Nanjing 210003China Broadband Wireless Communication and Sensor Network Technology Key Laboratory of Ministry of EducationNanjing University of Posts and TelecommunicationsNanjing 210003China Telecommunication and Networks National Engineering Research center Nanjing University of Posts and TelecommunicationsNanjing 210003China

Encoding system plays a significant role in quantum key distribution(QKD).However,the security and performance of QKD systems can be compromised by encoding misalignment due to the inevitable defects in realistic devices.To alleviate the influence of misalignments,a method exploiting statistics from mismatched basis is proposed to enable uncharacterized sources to generate secure keys in QKD.In this work,we propose a scheme on four-intensity decoy-state quantum key distribution with uncharacterized heralded single-photon sources.It only requires the source states are prepared in a two-dimensional Hilbert space,and can thus reduce the complexity of practical realizations.Moreover,we carry out corresponding numerical simulations and demonstrate that our present four-intensity decoy-state scheme can achieve a much higher key rate compared than a three-intensity decoy-state method,and meantime it can obtain a longer transmission distance compared than the one using weak coherent sources.

关键词： quantum key distribution heralded single-photon source decoy-state method

Using Machine Learning to Identify and Optimize Sensitive Parameters in Urban Flood Model Considering Subsurface Characteristics

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International Journal of Disaster Risk Science 2024年第1期15卷 116-133页

作者： Hengxu Jin Yu Zhao Pengcheng Lu Shuliang Zhang Yiwen Chen Shanghua Zheng Zhizhou Zhu Key Laboratory of VGE of Ministry of Education Nanjing Normal UniversityNanjing 210023China Jiangsu center for Collaborative Innovation in Geographical Information Resource Development and Application Nanjing 210023China

This study presents a novel method for optimizing parameters in urban flood models,aiming to address the tedious and complex issues associated with parameter optimization.First,a coupled one-dimensional pipe network runoff model and a two-dimensional surface runoff model were integrated to construct an interpretable urban flood model.Next,a principle for dividing urban hydrological response units was introduced,incorporating surface attribute features.The K-means algorithm was used to explore the clustering patterns of the uncertain parameters in the model,and an artificial neural network(ANN)was employed to identify the sensitive parameters.Finally,a genetic algorithm(GA) was used to calibrate the parameter thresholds of the sub-catchment units in different urban land-use zones within the flood model.The results demonstrate that the parameter optimization method based on K-means-ANN-GA achieved an average Nash-Sutcliffe efficiency coefficient(NSE) of 0.81.Compared to the ANN-GA and K-means-deep neural networks(DNN) methods,the proposed method better characterizes the runoff generation and flow processes.This study demonstrates the significant potential of combining machine learning techniques with physical knowledge in parameter optimization research for flood models.

关键词： Artifcial neural network Coupled urban fooding model Genetic algorithm K-means algorithm Subcatchment delineation Uncertain parameters

Stereoselective synthesis of substituted 1,3-dienes from propargylic esters: electrophilic-metal or redox catalysis?

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Science China Chemistry 2024年第5期67卷 1384-1396页

作者： Mengfu Dai Liangliang Song Liang-An Chen Jiangsu Collaborative Innovation center of Biomedical Functional Materials Jiangsu Key Laboratory of New Power BatteriesSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023China Jiangsu Co-Innovation center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and MaterialsCollege of Chemical EngineeringNanjing Forestry UniversityNanjing 210037China

1,3-Diene architectures are not only widely present in natural products, pharmaceuticals, and functional organic materials but also serve as versatile building blocks to furnish important functionalized molecules in synthetic chemistry due to conjugated repeating C=C units. Accordingly, various strategies to access substituted 1,3-dienes in a stereoselective manner have been developed. However, chemo-, regio-and stereoselective synthesis of highly substituted 1,3-dienes still remains elusive and challenging. Readily available propargylic esters have emerged as an appealing class of synthetic intermediates for accessing functionalized 1,3-dienes, especially challenging tri-or tetrasubstituted variants, via transition-metal catalysis, including electrophilic metal and redox neutral catalysis. This review, for the first time, systematically highlights recent advances in transitionmetal catalyzed synthesis of substituted 1,3-dienes from propargylic esters, discusses the mechanisms and synthetic utilities, and gives the remaining challenges and potential opportunities in this field.

关键词： 1 3-diene propargylic ester Lewis acid redox catalysis transition metal

Logic-gated tumor-microenvironment nanoamplifier enables targeted delivery of CRISPR/Cas9 for multimodal cancer therapy

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Acta Pharmaceutica Sinica B 2024年第2期14卷 795-807页

作者： Yongchun Pan Xiaowei Luan Fei Zeng Xuyuan Wang Shurong Qin Qianglan Lu Guanzhong He Yanfeng Gao Xiaolian Sun Xin Han Bangshun He Yujun Song Department of Laboratory Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006China College of Engineering and Applied Sciences State Key Laboratory of Analytical Chemistry for Life ScienceNanjing UniversityNanjing 210023China State Key Laboratory of Natural Medicines Key Laboratory of Drug Quality Control and PharmacovigilanceDepartment of Pharmaceutical AnalysisChina Pharmaceutical UniversityNanjing 211198China School of Medicine&Holistic Integrative Medicine Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources IndustrializationNanjing University of Chinese MedicineNanjing 210023China

Recent innovations in nanomaterials inspire abundant novel tumor-targeting CRISPR-based gene therapies.However,the therapeutic efficiency of traditional targeted nanotherapeutic strategies is limited by that the biomarkers vary in a spatiotemporal-dependent manner with tumor progression.Here,we propose a self-amplifying logic-gated gene editing strategy for gene/H_(2)O_(2)-mediated/starvation multimodal cancer therapy.In this approach,a hypoxia-degradable covalent-organic framework(COF) is synthesized to coat a-ZIF-8 in which glucose oxidase(GOx) and CRISPR system are packaged.To intensify intracellular redox dyshomeostasis,DNAzymes which can cleave catalase mRNA are loaded as well.When the nano system gets into the tumor,the weakly acidic and hypoxic microenvironment degrades the ZIF-8@COF to activate GOx,which amplifies intracellular H^(+)and hypoxia,accelerating the nanocarrier degradation to guarantee available CRISPR plasmid and GOx release in target cells.These tandem reactions deplete glucose and oxygen,leading to logic-gated-triggered gene editing as well as synergistic gene/H_(2)O_(2)-mediated/starvation therapy.Overall,this approach highlights the biocomputing-based CRISPR delivery and underscores the great potential of precise cancer therapy.

关键词： CRISPRdelivery Enzymeencapsulation Logic gate Hybridmaterial Hypoxia Gene editing Precise nanomedicine Multimodal therapy