检索结果-南通市图书馆

Insights into Triclosan-Induced Endocrine Disruption:Evidence from the National Health and Nutrition Examination Survey and Zebrafish Models

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Environment & Health 2024年第7期2卷 424-440页

作者： Zhiming Li Hongyi Xian Xiaohu Ren Rongyi Ye Yizhou Zhong Yuji Huang Boxuan Liang Yanhong Deng Mingzhu Dai Jie Guo Shuqin Tang Jialiang Pan Yu Feng Ruobing Bai Xueping Chen Sahoko Ichihara Gaku Ichihara Da Chen Xingfen Yang Zhenlie Huang nmpa key laboratory for Safety evaluation of cosmetics Guangdong Provincial Key Laboratory of Tropical Disease ResearchDepartment of ToxicologySchool of Public HealthSouthern Medical UniversityGuangzhou 510515China Shenzhen key laboratory of Modern Toxicology Shenzhen Medical Key Discipline of Health ToxicologyShenzhen Center for Disease Control and PreventionShenzhen 518055China Hunter Biotechnology Inc.Hangzhou 310051China College of Environment and Climate Guangdong Provincial Key Laboratory of Environmental Pollution and HealthJinan UniversityGuangzhou 510632China Vitargent(International)Biotechnology Limited Shatin 999077Hong Kong SARChina Department of Environmental and Preventive Medicine School of MedicineJichi Medical UniversityTochigi 329-0498Japan Department of Occupational and Environmental Health Faculty of Pharmaceutical SciencesTokyo University of ScienceNoda 278-8510Japan

Triclosan(TCS)has garnered significant attention due to its widespread use and associated endocrine-disrupting ***,its impact on the neuroendocrine system and underlying mechanisms remain poorly ***,we established correlations between TCS exposure and serum sex hormone levels in participants of the National Health and Nutrition Examination Survey(NHANES).Additionally,we investigated TCS’s influence on the neuroendocrine system using adult zebrafish exposed to environmentally relevant concentrations of TCS(0.361–48.2μg/L)for 21 *** of reproductive and neurotoxicity included histopathological examination and behavioral ***,proteomics analyses,and biochemical detection were employed to elucidate mechanisms underlying TCS-induced neuroendocrine *** correlations were found between TCS exposure and estradiol,testosterone,and sex hormone-binding globulin levels in NHANES *** addition,TCS exposure inhibited ovary development and spermatogenesis in *** and proteomics analysis revealed gender-specific key signaling and metabolism-related pathways implicated in TCS-induced reproductive ***,TCS exposure induced nervous system impairment,as evidenced by histological changes and altered motor behavior,possibly associated with oxidative *** analysis further highlighted the potential connection between endocrine system disruption and nervous system impairment following TCS ***,this study provided evidence supporting TCS-induced endocrine disruption and offered insights into its underlying mechanisms.

关键词： Emerging Contaminants Ecotoxicity Public Health Endocrine-Disrupting Chemicals Endocrine-Disrupting Effects

Propolis inspired sunscreens for efficient UV-protection and skin barrier maintenance

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2022年第9期15卷 8237-8246页

作者： Yu Fu Ruoyu Wan Lei Yang Lidan Xiong Junfei Hu Jie Tang Hailun He Zhipeng Gu Li Li Yiwen Li College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China cosmetics Safety and Efficacy evaluation Center Department of DermatologyWest China HospitalSichuan UniversityChengdu 610041China nmpa key laboratory for Human evaluation and Big Data of cosmetics Chengdu 610041China

The direct use of naturally occurring,small molecular ingredients in bioinspired sunscreens has raised several concerns due to the instability,photocytotoxicity,and potential blood toxicity of those *** this work,we have employed natural ultraviolet(UV)-blocking molecule caffeic acid phenethyl ester(CAPE)from propolis to prepare poly(CAPE)nanoparticles(NPs)as the main bioactive ingredient to fabricate propolis-inspired hydrogel *** with small molecular CAPE,poly(CAPE)NPs exhibited better dispersion and stability in water,as well as lower physiological toxicity and skin *** the resulting composite hydrogels demonstrated promising properties including water-resistant whereas can be easily erased by warm water as well as safety when interacting with *** importantly,the hydrogel sunscreens showed excellent UV protection properties both in vitro and in vivo,and the positive effects in maintaining skin barrier *** work provides new strategies towards the facile construction of nature-inspired robust sunscreens in the future.

关键词： bioinspired sunscreen composite hydrogel ultraviolet protection

Status and developmental trends in recombinant collagen preparation technology

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Regenerative Biomaterials 2024年第2期3卷 17-36页

作者： Xiaolei Guo Yuan Ma Hang Wang Hongping Yin Xinli Shi Yiqin Chen Guobiao Gao Lei Sun Jiadao Wang Yunbing Wang Daidi Fan Center for Medical Device evaluation National Medical Products AdministrationBeijing 100081China State key laboratory of Tribology Tsinghua UniversityBeijing 100084China school of Life Science and Technology China Pharmaceutical UniversityNanjing 210009China National Engineering Research Center for Biomaterials&College of Biomedical Engineering Sichuan UniversityChengdu 610064China Biotech.&Biomed.Research Institute Northwest UniversityXi'an 710127China

Recombinant collagen is a pivotal topic in foundational biological research and epitomizes the application of critical bioengineer-ing *** technological advancements have pro-found implications across diverse areas such as regenerative medicine,organ replacement,tissue engineering,cosmetics and ***,recombinant collagen and its preparation methodologies rooted in genetically engineered celis mark pivotal milestones in medical product *** article pro-vides a comprehensive overview of the current genetic engi-neering technologies and methods used in the production of recombinant collagen,as well as the conventional production process and gquality control detection methods for this ***,the discussion extends to foresee the strides in physical transfection and magnetic control sorting studies,envisioning an enhanced preparation of recombinant collagen-seeded cells to further fuel recombinant collagen production.

关键词： recombinant collagen preparation genetic engineering collagen characterization physical transfection seed cell sorting

A Ten-year Retrospective Study of Invasive Candidiasis in a Tertiary Hospital in Beijing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2021年第10期34卷 773-788页

作者： YANG Zhi Hui SONG Ying Gai LI Ruo Yu Department of Dermatology and Venerology Beijing Key Laboratory of Molecular Diagnosis of DermatosesNational Clinical Research Center for Skin and Immune DiseasesNMPA Key Laboratory for Quality Control and Evaluation of CosmeticsPeking University First HospitalBeijing 100034China

Objective This study aimed to evaluate the epidemiological,clinical and mycological characteristics of invasive candidiasis(IC)in *** A ten-year retrospective study including 183 IC episodes was conducted in a tertiary hospital in Beijing,*** The overall incidence of IC from 2010–2019 was 0.261 episodes per 1,000 ***(71.0%)was the major infective pattern;70.3%of the patients tested positive for Candida *** before IC and the median time to develop an invasive infection after colonization was13.5 days(interquartile range:4.5–37.0 days).Candida albicans(45.8%)was the most prevalent species,followed by Candida parapsilosis(19.5%),Candida glabrata(14.2%)and Candida tropicalis(13.7%).***-albicans IC was more common in patients with severe anemia(P=0.018),long-term hospitalization(P=0.015),hematologic malignancies(P=0.002),continuous administration of broad-spectrum antibiotics(P<0.001)and mechanical ventilation(P=0.012).In vitro resistance testing showed that11.0%of the Candida isolates were resistant/non-wild type(non-WT)to fluconazole,followed by voriconazole(9.6%),micafungin(3.8%),and caspofungin(2.9%).Fluconazole was the most commonly used drug to initiate antifungal therapy both before and after the proven diagnosis(52.6%and 54.6%,respectively).The 30-day and 90-day all-cause mortality rates were 24.5%and 32.7%,*** The incidence of IC has declined in the recent five ***-albicans contributed to more than half of the IC *** can be used as first-line therapy if resistant strains are not ***,multi-center surveillance of the clinical and mycological characteristics of IC is required.

关键词： Invasive candidiasis Epidemiology Risk factors Antifungal resistance Treatment Mortality

Anti-oxidant anti-inflammatory and antibacterial tannin-crosslinked citrate-based mussel-inspired bioadhesives facilitate scarless wound healing

在线全文

学校读者我要写书评

暂无评论

Bioactive Materials 2023年第2期20卷 93-110页

作者： Keke Wu Meimei Fu Yitao Zhao Ethan Gerhard Yue Li Jian Yang Jinshan Guo Department of Histology and Embryology NMPA Key Laboratory for Safety Evaluation of CosmeticsSchool of Basic Medical SciencesGuangdong Provincial Key Laboratory of Bone and Joint Degeneration DiseasesThe Third Affiliated Hospital of Southern Medical UniversitySouthern Medical UniversityGuangzhouChina Department of Biomedical Engineering Pennsylvania State UniversityUniversity ParkPA16802USA

The revolutionary role of tissue adhesives in wound closure,tissue sealing,and bleeding control necessitates the development of multifunctional materials capable of effective and scarless *** contrast to the use of traditionally utilized toxic oxidative crosslinking initiators(exemplified by sodium periodate and silver nitrate),herein,the natural polyphenolic compound tannic acid(TA)was used to achieve near instantaneous(90%bacterial death upon near-infrared(NIR)irradiation).In vivo evaluation in both an infected full-thickness skin wound model and a rat skin incision model demonstrated that 3A-TCMBAs+NIR treatment could promote wound closure and collagen deposition and improve the collagen Ⅰ/Ⅲ ratio on wound sites while simultaneously inhibiting the expression of pro-inflammatory ***,phased angiogenesis was observed via promotion in the early wound closure phases followed by inhibition and triggering of degradation&remodeling of the extracellular matrix(ECM)in the late stage(supported by phased CD31(platelet endothelial cell adhesion molecule-1)PDGF(platelet-derived growth factor)and VEGF(vascular endothelial growth factor)expression as well as elevated matrix metalloprotein-9(MMP-9)expression on day 21),resulting in scarless wound *** significant convergence of material and bioactive properties elucidated above warrant further exploration of 3A-TCMBAs as a signific

关键词： Anti-oxidant Hydrogen bond crosslinking Phased angiogenesis Scarless wound healing Tannic acid

Structural landscape investigations on bendable plastic crystals of isonicotinamide polymorphs

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2022年第8期33卷 4069-4073页

作者： Jianting Li Jiaquan Li Hongji Liu Li Zhang Yang Lu Zhengzheng Zhou nmpa key laboratory for Safety evaluation of cosmetics Guangdong Provincial Key Laboratory of Tropical Disease ResearchDepartment of Hygiene Inspection&Quarantine ScienceSchool of Public HealthSouthern Medical UniversityGuangzhou 510515China Beijing City key laboratory of Polymorphic Drugs Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Three polymorphs(forms I,II and V)of isonicotinamide(INA)were mechanically flexible and exhibited one-dimensional(1 D)*** intermolecular interactions contribute to the plasticity of single crystals:weak dispersive interactions between slip planes such as 1 D columns in forms I and II or 2 D layers in form V were stabilized by strong hydrogen bonds,allowing the layer or column's surface to glide smoothly without *** disparity of intermolecular interactions on plastic properties of INA polymorphic crystals was confirmed by energy framework analysis,nanoindentation tests and micro-Raman *** crystal which exhibits plastic property provides a promising application in pharmaceuticals and material sciences.

关键词： Isonicotinamide Polymorph Plasticity Slip plane Bending crystal

Application of in Vitro Alternative Tests Based on AOP in Skin Sensitization evaluation of cosmetics

在线全文

学校读者我要写书评

暂无评论

China Detergent & cosmetics 2023年第2期8卷 31-37页

作者： Ying Mengchao Xiao Ping Hong Xinyu Sun Jingqiu Huo Qian Li Chen Chen Tian Tao Gonghua Shanghai Municipal Center For Disease Control&Prevention China nmpa key laboratory for monitoring and evaluation of cosmetics State Environmental Protection Key Laboratory of the Assessment of Effects of Emerging Pollutants on Environmental and Human HealthChina

To evaluate and discuss two novels in vitro alternative tests which based on the 2nd and 4th event of the AOP in skin sensitization and their application in skin sensitization evaluation of cosmetics in *** DSens(DSens method)and Jurkat(TCPA method)were used as the test models and 9 of reference chemicals and 12 kinds of cosmetic products were used to confirm and assess the application capability in skin *** results showed that the DSens method was more sensitive to the reference chemicals compare to the TCPA *** the results of cosmetic products showed a high consistency between these two assays and h-CLAT or in vivo *** the new screening method for skin sensitization evaluation of cosmetics,the in vitro alternative tests based on AOP have certain *** reasonable combination strategy can bring a bright future for the development and application of animal alternative test in China.

关键词： skin sensitization in vitro alternative methods T cell activation cosmetic safety assessment

Structural landscape on a series of rhein:Berberine cocrystal salt solvates:The formation,dissolution elucidation from experimental and theoretical investigations

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2022年第6期33卷 3207-3211页

作者： Dezhi Yang Hongjuan Wang Qiwen Liu Penghui Yuan Ting Chen Li Zhang Shiying Yang Zhengzheng Zhou Yang Lu Guanhua Du Beijing City key laboratory of Polymorphic Drugs Center of Pharmaceutical PolymorphsInstitute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Department of Hygiene Inspection and Quarantine Science School of Public HealthSouthern Medical University(Guangdong Provincial Key Laboratory of Tropical Disease ResearchNMPA Key Laboratory for Safety Evaluation of Cosmetics)Guangzhou 510515China Beijing City key laboratory of Drug Target and Screening Research National Center for Pharmaceutical ScreeningInstitute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

The specific crystalline form of a compound remarkably affects its physicochemical ***,a detailed analysis of the structural features and intermolecular interactions of a multi-component crystal is feasible to understand the relationships among the structure,physicochemical properties and the formation *** the present study,three novel cocrystal salt solvates of rhein and berberine were reported for the first *** solid characterizations and theoretical computations based on density functional theory(DFT)were carried out to demonstrate the intermolecular *** theoretical computation shows that the strongest interaction existed between berberine cation and rhein anion,and the electrostatic interaction play a dominant ***,no salt bond was observed between *** intrinsic dissolution rate analysis in water shows that the monohydrate exhibits 17 times enhancement in comparison with *** rhein and berberine combined in ionic state in cocrystal salt is the main reason for the solubility *** paper suggests that the interactions between the different components can be visualized and qualitatively and quantitatively analyzed by theoretical computation,which is helpful to understand the relationship between stereochemical structure and physicochemical properties of multi-component complex.

关键词： Cocrystal Rhein Berberine Theoretical computation Energy decomposition analysis Solubility

A colorimetric assay for cholesterol based on the encapsulation of multienzyme in leaf-shape crossed ZIF-L

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2023年第2期34卷 382-387页

作者： Jiaqi He Tingling Zhuo Yintong Teng Guoqin Chen Peng Zhao Caiwen Ou Department of Cardiology Guangzhou Panyu Central HospitalGuangzhou University of Chinese MedicineGuangzhou 510006China Department of Cardiology and laboratory of Heart Center Zhujiang HospitalSouthern Medical UniversityGuangzhou 510280China nmpa key laboratory for Research and evaluation of Drug Metabolism Guangdong Provincial Key Laboratory of New Drug ScreeningSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China Affiliated Dongguan Hospital Southern Medical UniversityDongguan 523059China Guangdong Provincial key laboratory of Shock and Microcirculation Southern Medical UniversityGuangzhou 510515China

The serum cholesterol level is an important indicator of healthy and there is a great necessity for frequent cholesterol monitoring to some cardiovascular-related diseases, which puts forward higher requirements for point-of-care testing(POCT) of cholesterol. In this work, a cascade catalytic system of cholesterol is developed by encapsulation of cholesterol oxidase(Ch Ox) and Pd Cu Au nanoparticles into zeolitic imidazolate framework-L(Ch Ox/PCA@ZIF-L). Results indicate that ZIF-L carrier can significantly increase the catalytic activity of single or multiple enzymes, due to its high loading capacity and efficient molecular transport. Under the optimal conditions, the absorbance of reaction system performs linear relationships with the concentration of cholesterol in two intervals from 0.0005 mmol/L to 1.0000 mmol/L, with a limit of detection of 0.2176 μmol/L. The proposed colorimetric strategy based on Ch Ox/PCA@ZIF-L performs a good agreement with the results provided by chemiluminescence method for the serum cholesterol detection. Interestingly, a simple paper-based sensing system is constructed through a pre-reaction-transfer operation, which gets rid of the complex pre-processing requirements of traditional operations on filter paper. The presented strategy allows for the sensitive, convenient, costless assay of serum cholesterol,and paves a new way to design the POCT device for daily monitoring of healthy.

关键词： Cholesterol Zeolitic imidazolate framework-L Artificial enzyme Colorimetric Point-of-care testing