检索结果-南通市图书馆

Cervical cancer:a tale from HPV infection to PARP inhibitors

Genes & Diseases 2023年第4期10卷 1445-1456页

作者： Minakshi Mann Vikram Pratap Singh Lalit Kumar Department of Medical Oncology Dr.B.R.A.Institute Rotary Cancer HospitalAll India Institute of Medical SciencesNew Delhi 110029India Department of Oncoanaesthesia and Palliative Medicine Dr.B.R.A.Institute Rotary Cancer HospitalAll India Institute of Medical SciencesNew Delhi 110029India Epigenetics Section Mouse Cancer Genetics ProgramCenter for Cancer ResearchNational Cancer InstituteFrederickMD 21702USA

Globally,cervical cancer(CxCa)ranks 4th common cancer among females and led to 569,847 incidences and 311,365 deaths in 2018.80%of CxCa cases occur due to persistent infection with a high-risk subtype of human papillomavirus(HPV-16 and 18).Smoking,high par-ity,and co-infection with type 2 herpes simplex or HIV are other known risk factors for *** histological subtypes are squamous(70%)and adenocarcinoma(25%).Presently,concur-rent radiation plus cisplatin(CDDP)-based chemotherapy is the standard treatment for CxCa ***,CDDP resistance and toxic side effects limit its efficacy,leading to a poorer response rate and an expected overall survival ranging from 10 to 17.5 *** drug uptake,increased DNA damage repair,increased CDDP inactivation,and overexpressed Bcl-2 or caspase inhibition,are primarily accountable mechanisms for CDDP resistance and improving CDDP’s efficacy remains the major ***(ADP-ribosyl)polymerase-1,an effective mediator of nucleotide excision repair pathway,is involved in DNA repair as well as maintaining genomic stability and is significantly expressed in malignant lymphomas,hepa-tocellular-,cervical-and colorectal carcinoma,which has been approved effective in mainte-nance therapy and may serve as an effective target to enhance CDDP sensitivity in ***,we summarize the etiology and epidemiology of and treatment for CxCa,the mechanism responsible for chemotherapy resistance,PARP inhibitor as a possible therapy for CxCa,and other possible chemotherapeutic options for CxCa treatment.

关键词： Cervical cancer Chemotherapy Cisplatin Disease etiology and histology PARP inhibitors Resistance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Deoxyribonucleic acid methylation driven aberrations in pancreatic cancer-related pathways

引用

World Journal of Gastrointestinal Oncology 2023年第9期15卷 1505-1519页

作者： Akash Bararia Amlan Das Sangeeta Mitra Sudeep Banerjee Aniruddha Chatterjee Nilabja Sikdar Human genetics Unit Indian Statistical InstituteKolkata 700108India Department of Biochemistry Royal Global UniversityAssam 781035India Department of Biochemistry and Biophysics University of KalyaniWest Bengal 741235India Department of Gastrointestinal Surgery Tata Medical CenterKolkata 700160India Department of Pathology Dunedin School of MedicineUniversity of OtagoDunedin 9054New Zealand School of Health Sciences and Technology University of Petroleum and Energy StudiesDehradun 248007India

Pancreatic cancer(PanCa)presents a catastrophic disease with poor overall survival at advanced stages,with immediate requirement of new and effective treatment *** genetic mutations,epigenetic dysregulation of signaling pathway-associated enriched genes are considered as novel therapeutic *** beneath the deoxyribonucleic acid methylation and its utility in developing of epi-drugs in PanCa are under *** of epigenetic medicines with conventional cytotoxic treatments or targeted therapy are promising options to improving the dismal response and survival rate of PanCa *** studies have identified potentially valid pathways that support the prediction that future PanCa clinical trials will include vigorous testing of epigenomic *** thus promises to generate a significant amount of new knowledge of biological and medical *** review could identify various components of epigenetic mechanisms known to be involved in the initiation and development of pancreatic ductal adenocarcinoma and related precancerous lesions,and novel pharmacological strategies that target these components could potentially lead to *** aim to highlight the possibilities that exist and the potential therapeutic interventions.

关键词： Methylation driven pathways Pancreatic cancer methylation markers Signaling pathway targeted therapy PanCa enriched methylated pathway Pre-cancer methylated pathways

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Growth response of Pterocarpus santalinus seedlings to native microbial symbionts(arbuscular mycorrhizal fungi and Rhizobium aegyptiacum)under nursery conditions

引用

Journal of Forestry Research 2021年第1期32卷 225-231页

作者： Arumugam Karthikeyan Thangavel Arunprasad Institute of Forest genetics and Tree Breeding Coimbatore 641002India

The objective of this research was to improve the growth and biomass of Pterocarpus santalinus L.f.(an endangered leguminous tree)using native microbial symbionts such as arbuscular mycorrhizal fungi and Rhizobium associated with native populations of *** native arbuscular mycorrhizal fungi isolated from *** soils were identifi ed as(1)Glomus fasciculatum;(2)Glomus geosporum;and Glomus aggregatum.A nitrogenfi xing microbial symbiont was isolated from the root nodules of *** and identifi ed as Rhizobium aegyptiacum by 16s rRNA gene *** microbial symbionts were inoculated individually and in combination into *** seedling *** 90 days,growth and biomass had improved compared with uninoculated *** and root lengths,number of leaves,stem circumference,number of root nodules,biomass,nutrient uptake and seedling quality index were signifi cantly increased by a combined inoculation of arbuscular mycorrhizal fungi+Rhizobium *** was concluded that native microbial symbionts positively infl uenced *** seedling growth which will be helpful for successful fi eld establishment.

关键词： Arbuscular mycorrhizal fungi Microbial symbionts Pterocarpus santalinus Red sanders Rhizobium aegyptiacum

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Responses of Bruguiera sexangula propagules to beneficial microbes in the nursery

引用

Journal of Forestry Research 2018年第4期29卷 1082-1087页

作者： Arumugam Karthikeyan Natchimuthu Balasubramaniam Sivapriya Institute of Forest genetics and Tree Breeding Coimbatore 641002 India

Bruguiera sexangula （Lout） Poir., a threatened mangrove tree, was inoculated with beneficial microbes in a nursery to assess any improvements in growth and bio- mass. From soil samples from the rhizosphere of B. sexangula in a mangrove forest in Panangadu of Kerala india, nitrogen-fixing bacteria Azotobacter chroococcum and Azospirillum brasilense were isolated. The phosphatesolubilising bacterium Bacillus megaterium and potassiummobilizing bacteria Frateruria aurantia were also isolated and cultured on suitable media. Later, ripe propagules of B. sexangula were collected from matured trees and raised in sterilized soil bags （13 × 25 cm） containing sterilized soil and sand （2：1 ratio）. The cultured beneficial microbes were propagated and used to inoculate the ripe propagules of B. sexangula and maintained in the nursery for 6 months. After 6 months, growth and biomass of the inoculated propagules were greater than for the uninoculated control propagules. Shoot length, number of leaves, stem girth and root length were also significantly greater than in the controls. This study showed that the mangrove-specific beneficial microbes influenced the growth of B. sexangula

关键词： Mangroves Bruguiera sexangula Beneficial microbes Nursery Propagules

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Emerging role of non-invasive and liquid biopsy biomarkers in pancreatic cancer

引用

World Journal of Gastroenterology 2023年第15期29卷 2241-2260页

作者： Akash Bararia Prosenjeet Chakraborty Paromita Roy Bitan Kumar Chattopadhay Amlan Das Aniruddha Chatterjee Nilabja Sikdar Human genetics Unit Indian Statistical InstituteKolkata 700108India Department of Molecular Biosciences SVYASA School of Yoga and NaturopathyBangalore 560105India Department of Pathology Tata Medical CenterKolkata 700160India Department of General Surgery IPGMER&SSKM HospitalKolkata 700020India Department of Biochemistry Royal Global UniversityAssam 781035India Department of Pathology Dunedin School of MedicineUniversity of OtagoDunedin 9061New Zealand School of Health Sciences and Technology University of Petroleum and Energy StudiesDehradun 248007India

A global increase in the incidence of pancreatic cancer(PanCa)presents a major concern and health *** traditional tissue-based diagnostic techniques provided a major way forward for molecular diagnostics;however,they face limitations based on diagnosis-associated difficulties and concerns surrounding tissue availability in the clinical *** disease development with asymptomatic behavior is a drawback in the case of existing diagnostic *** capability of cell free markers in discriminating PanCa from autoimmune pancreatitis and chronic pancreatitis along with other precancerous lesions can be a boon to ***-stage diagnosis of PanCa can be achieved only if these biomarkers specifically discriminate the non-carcinogenic disease stage from malignancy with respect to tumor *** this review,we comprehensively described the non-invasive disease detection approaches and why these approaches are gaining popularity for their early-stage diagnostic capability and associated clinical feasibility.

关键词： Non-invasive biomarkers Cell free biomarkers Proteomic biomarkers Liquid biopsy-based diagnostics Pancreatic cancer biomarkers

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Novel insights on acetylcholinesterase inhibition by Convolvulus pluricaulis,scopolamine and their combination in zebrafish

引用

Natural Products and Bioprospecting 2022年第1期12卷 56-70页

作者： Kalyani Bindu Karunakaran Anand Thiyagaraj Kirankumar Santhakumar Supercomputer Education and Research Centre Indian Institute of Sci-enceBengaluruIndia Department of Genetic Engineering SRM Institute of Science and TechnologyKattankulathur 603203India Zebrafish genetics Laboratory Department of Genetic EngineeringSRM Institute of Science and TechnologyKattankulathur 603203India

Acetylcholinesterase(AChE)inhibitors increase the retention of acetylcholine(ACh)in *** they allevi-ate cognitive deficits in Alzheimer’s disease,their limited benefits warrant investigations of plant extracts with similar *** studied the anti-AChE activity of Convolvulus pluricaulis(CP)in a zebrafish model of cognitive impair-ment induced by scopolamine(SCOP).CP is a perennial herb with anti-amnesiac and anxiolytic *** contains alkaloid,anthocyanin,coumarin,flavonoid,phytosterol and triterpenoid ***(ISOX)was used as a positive control for AChE ***-treated 168 hpf larvae showed a similar pattern of AChE inhibition(in the myelencephalon and somites)as that of ISOX-treated *** was superior to ISOX as evidenced by the retention of avoidance response behavior in adult *** docking studies indicated that ISOX binds Ser203 of the catalytic triad on the human *** active components of CP-scopoletin and kaempferol-were bound by His447 of the catalytic triad,the anionic subsite of the catalytic center,and the peripheral anionic *** suggested the ability of CP to mediate both competitive and non-competitive modes of ***,SCOP showed AChE inhibition in larvae,possibly mediated via the choline-binding ***+SCOP induced a concentration-dependent increase in AChE inhibition and ACh *** motor responses were observed with ISOX,CP,ISOX+SCOP,and CP+SCOP,indicative of undesirable effects on the peripheral cholinergic *** study proposes the examination of CP,SCOP,and CP+SCOP as potential AChE inhibitors for their ability to modulate cognitive deficits.

关键词： Alzheimer’s disease Acetylcholinesterase Zebrafish Convolvulus pluricaulis Scopolamine Isoxazole

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ocular manifestations of central insulin resistance

引用

Neural Regeneration Research 2023年第5期18卷 1139-1146页

作者： Muneeb A.Faiq Trina Sengupta Madhu Nath Thirumurthy Velpandian Daman Saluja Rima Dada Tanuj Dada Kevin C.Chan Dr.Rajendra Prasad Centre for Ophthalmic Sciences All India Institute of Medical SciencesNew DelhiIndia Neuroimaging and Visual Science Laboratory Department of OphthalmologyNYU Grossman School of MedicineNYU Langone HealthNew York UniversityNew YorkNYUSA Medical Biotechnology Laboratory Dr.B.R.Ambedkar Center for Biomedical ResearchUniversity of DelhiDelhiIndia Dr.Baldev Singh Sleep Laboratory Department of PhysiologyAll India Institute of Medical SciencesNew DelhiIndia Department of Ocular Pharmacology Dr.Rajendra Prasad Center for Ophthalmic SciencesAll India Institute of Medical SciencesNew DelhiIndia Laboratory for Molecular Reproduction and genetics Department of AnatomyAll India Institute of Medical SciencesNew DelhiIndia

Central insulin resistance, the diminished cellular sensitivity to insulin in the brain, has been implicated in diabetes mellitus, Alzheimer’s disease and other neurological disorders. However, whether and how central insulin resistance plays a role in the eye remains unclear. Here, we performed intracerebroventricular injection of S961, a potent and specific blocker of insulin receptor in adult Wistar rats to test if central insulin resistance leads to pathological changes in ocular structures. 80 mg of S961 was stereotaxically injected into the lateral ventricle of the experimental group twice at 7 days apart, whereas buffer solution was injected to the sham control group. Blood samples, intraocular pressure, trabecular meshwork morphology, ciliary body markers, retinal and optic nerve integrity, and whole genome expression patterns were then evaluated. While neither blood glucose nor serum insulin level was significantly altered in the experimental or control group, we found that injection of S961 but not buffer solution significantly increased intraocular pressure at 14 and 24 days after first injection, along with reduced porosity and aquaporin 4 expression in the trabecular meshwork, and increased tumor necrosis factor α and aquaporin 4 expression in the ciliary body. In the retina, cell density and insulin receptor expression decreased in the retinal ganglion cell layer upon S961 injection. Fundus photography revealed peripapillary atrophy with vascular dysregulation in the experimental group. These retinal changes were accompanied by upregulation of pro-inflammatory and pro-apoptotic genes, downregulation of anti-inflammatory, anti-apoptotic, and neurotrophic genes, as well as dysregulation of genes involved in insulin signaling. Optic nerve histology indicated microglial activation and changes in the expression of glial fibrillary acidic protein, tumor necrosis factor α, and aquaporin 4. Molecular pathway architecture of the retina revealed the three most s

关键词： brain ciliary bodies gene expression inflammation insulin receptor insulin resistance intraocular pressure neurodegeneration optic nerve retina retinal ganglion cells trabecular meshwork

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Absence of sperm meiotic segregation error of chromosomes 1, 9,12,13,16,18, 21, X and Y in a case of 100 %necrozoospermia

引用

Asian Journal of Andrology 2003年第2期5卷 163-166页

作者： Ashutosh Halder Vandana Chaddha Savita Agarwal Ashish Fauzdar Department of Medical genetics Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow IndiaDepartment of Medical Genetics Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow IndiaDepartment of Medical Genetics Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow IndiaDepartment of Medical Genetics Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow India

Varying degrees of necrozoospermia are common findings in cases of male sub-fertility; however, it is rare to find persistent and 100 % necrozoospermia. A case of persistent 100 % necrozoospermia is presented in this paper, where aneuploidy analysis was carried out on sperm. No known associations like thyrotoxicosis, genital infection, spinal injury and diabetes were found. Sperm fluorescent in situ hybridization (FISH) was carried out to evaluate sperm aneuploidy for chromosome 1, 9, 12, 13, 16, 18, 21, X and Y and did not show any excess of aneuploidy over controls. To the best of our knowledge, this is the first attempt on meiotic segregation analysis on 100 % necrozoospermic patient.

关键词： oligospermia necrozoospermia fluorescent in situ hybridization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Differential miRNA expression profiling of highly pathogenic avian influenza virus H5N1 infected chicken lungs reveals critical microRNAs,biological pathways and genes involved in the molecular pathogenesis

引用

Virologica Sinica 2022年第3期37卷 465-468页

作者： Anamika Mishra Muhasin Asaf Amod Kumar Diwakar Dattatreya Kulkarni Richa Sood Sandeep Bhatia Bharat Bhushan Ashwin Ashok Raut Pathogenomics Laboratory ICAR-National Institute of High Security Animal DiseasesOIE referral laboratory for Avian InfluenzaBhopal 462021India ICAR-National Institute of High Security Animal Diseases OIE referral lab for Avian InfluenzaBhopal 462021India Division of Animal genetics ICAR-Indian Veterinary Research InstituteBareilly 243122India

Dear Editor,Avian influenza is a highly contagious viral infection affecting the respiratory ***(miRNAs)are small,regulatory,endogenous,non-coding RNAs of~22 nt that regulate the gene expression of the target mRNAs by cleavage or translational *** are connected with the host response during avian influenza virus(AIV)infection(Wang et al.,2009,2012).In this study.

关键词： influenza endogenous pathogenesis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

genetics of diabetes

引用

World Journal of Diabetes 2023年第6期14卷 656-679页

作者： Shiwali Goyal Jyoti Rani Mohd Akbar Bhat Vanita Vanita Department of Ophthalmic genetics and Visual Function Branch National Eye InstituteRockvilleMD 20852United States Department of Human genetics Guru Nanak Dev UniversityAmritsar 143005PunjabIndia Department of Ophthalmology Georgetown University Medical CenterWashington DCDC 20057United States

Diabetes mellitus is a complicated disease characterized by a complex interplay of genetic,epigenetic,and environmental *** is one of the world's fastestgrowing diseases,with 783 million adults expected to be affected by *** macrovascular consequences(cerebrovascular disease,cardiovascular disease,and peripheral vascular disease)and microvascular complications(like retinopathy,nephropathy,and neuropathy)increase mortality,blindness,kidney failure,and overall quality of life in individuals with *** risk factors and glycemic management alone cannot predict the development of vascular problems;multiple genetic investigations have revealed a clear hereditary component to both diabetes and its related *** the twenty-first century,technological advancements(genome-wide association studies,nextgeneration sequencing,and exome-sequencing)have led to the identification of genetic variants associated with diabetes,however,these variants can only explain a small proportion of the total heritability of the *** this review,we address some of the likely explanations for this"missing heritability",for diabetes such as the significance of uncommon variants,gene-environment interactions,and *** discoveries clinical value,management of diabetes,and future research directions are also discussed.

关键词： Type 1 diabetes Type 2 diabetes Gestational diabetes mellitus Maturityonset diabetes of young Genome-wide association studies Common variants Rare variants

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：