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China CDC weekly 2024年第24期6卷 563-567,I0001页

作者： Dan Huang Xiaomin Xu Bing Lyu Jingguang Li Yunfeng Zhao Yongning Wu School of Population Medicine and Public Health Chinese Academy of Medical Sciences Peking Union Medical CollegeBeijingChina nhc key lab of food safety risk assessment Research Unit of Food SafetyChina National Center for Food Safety Risk AssessmentBeijingChina Zhejiang Provincial Center for Disease Control and Prevention Hangzhou CityZhejiang ProvinceChina

What is already known about this topic?Chloropropanols,along with their fatty acid esters and glycidyl fatty acid esters(GEs),are prevalent contaminants in a variety of processed foods,posing potential health risks to *** is added by this report?In the Sixth China Total Diet Study(TDS),3-monochloropropane-1,2-diol esters(3-MCPD esters)and GEs were identified as the predominant chloropropanols and their esters in composite food ***(47.0%)and cereals(15.4%)were the major contributors to exposure among the 12 food categories *** are the implications for public health practice?The Sixth China TDS highlighted concerns regarding potential health risks associated with dietary exposure to *** study underscores the need for further attention in devising practical strategies to mitigate dietary exposure to GEs.

关键词： esters predominant 1,2

Potential Provoking Effects of Environmental Pollutants on food Allergy:An Issue That Is Gaining Increasing Attention

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China CDC weekly 2024年第24期6卷 585-588页

作者： Yiyun Zhang Lei Zhang Di Wu Yongning Wu School of Population Medicine and Public Health Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina Department of Nutrition and food safety Peking Union Medical CollegeResearch Unit of Food SafetyChinese Academy of Medical SciencesBeijingChina nhc key lab of food safety risk assessment China National Center for Food Safety Risk AssessmentBeijingChina Institute for Global food Security School of Biological SciencesQueen’s University Belfast19 Chlorine GardensBelfastUnited Kingdom

Allergic diseases are widespread globally,affecting over 40%of the *** allergy(FA),characterized by an abnormal immune response to harmless proteins in foods,is one of these prevalent *** estimates suggest that approximately 220 million people worldwide suffer from FA(1).In children,over one-third of parents report their children experiencing hypersensitive reactions to food,with FA affecting around 8%of this demographic.

关键词： diseases Allergy globally

New food sources and production systems:a comparison of international regulations and China’s advancements in novel foods with synthetic biology

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food Science and Human Wellness 2024年第5期13卷 2519-2542页

作者： Xin Liu Di Wu Yi Shao Yongning Wu key laboratory for Deep Processing of Major Grain and Oil(The Chinese Ministry of Education) College of Food Science and EngineeringWuhan Polytechnic UniversityWuhan 430023China Institute for Global food Security School of Biological SciencesBelfast B795DLUnited Kingdom nhc key laboratory of food safety risk assessment China National Center for Food Safety Risk AssessmentBeijing 100021China Department of Nutrition and food safety Peking Union Medical CollegeResearch Unit of Food SafetyChinese Academy of Medical SciencesBeijing 100021China

The global shift towards sustainable food systems has sparked innovations in food sources and production systems,including cell-based meat,plant-based food products,precision fermentation,and 3D food *** advancements pose regulatory challenges and opportunities,with China emerging as a critical player in adopting and regulating new food *** review explores the international landscape of new food sources and production systems(NFPS),focusing on China’s role and regulatory approaches compared to global *** this comparative analysis,we aim to contribute to the ongoing dialogue on food safety regulation,offering insights and recommendations for policymakers,industry stakeholders,and researchers engaged in the global food system’s *** comprehensive overview underscores the dynamic nature of regulatory frameworks governing NFPS,highlighting the international efforts to ensure food safety,consumer protection,and the sustainable evolution of the food industry.

关键词： New food sources food production system food safety International regulation Synthetic biology China

Benchmark Dose for Dioxin Based on Gestational Diabetes Mellitus Using Coexposure Statistical Methods and an Optimized Physiologically Based Toxicokinetic Model

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Environment & Health 2024年第9期2卷 661-671页

作者： Tao Ying Xin Liu Lei Zhang Wencheng Cao Sheng Wen Yongning Wu Gengsheng He Jingguang Li School of Public Health Key Laboratory of Public Health Safety of the Ministry of EducationFudan UniversityShanghai 200032China nhc key laboratory of food safety risk assessment Chinese Academy of Medical Science Research Unit(No.2019RU014)China National Center for Food Safety Risk AssessmentBeijing 100021China key laboratory for Deep Processing of Major Grain and Oil(The Chinese Ministry of Education) College of Food Science and EngineeringWuhan Polytechnic UniversityWuhan 430023China China Hubei Provincial Center for Disease Control and Prevention Hubei Provincial Academy of Preventive MedicineHubei 430023China

Dioxins are ubiquitous endocrine-disrupting substances,but determining the effects and benchmark doses in situations of coexposure is highly *** objective of this study was to assess the relationship between dioxin andgestational diabetes mellitus(GDM),calculate the benchmark dose(BMD)of dioxin in coexposure scenarios,and derive a daily exposure threshold using an optimized physiologically based toxicokinetic(PBTK)*** on a nested casecontrol study including 77 cases with GDM and 154 controls,serum levels of 29 dioxin-like compounds(DLCs)along with 10 perfluoroalkyl acids(PFAAs),seven polybrominated diphenyl ethers(PBDEs),and five non-dioxin-like polychlorinated biphenyls(ndl-PCBs)were measured at 9−16 weeks of *** machine kernel regression(BKMR)was employed to identify significant chemicals,and probit and logistic models were used to calculate BMD adjusted for significant chemicals.A physiologically based toxicokinetic(PBTK)model was optimized using polyfluorinated dibenzo-p-dioxins and dibenzofurans(PFDD/Fs)data by the Bayesian−Monte Carlo Markov chain method and was used to determine the daily dietary exposure *** median serum level of total dioxin toxic equivalent(TEQ)was 7.72 pg TEQ/g *** regression analysis revealed that individuals in the fifth quantile of total TEQ level had significantly higher odds of developing GDM compared to those in the first quantile(OR,8.87;95%CI 3.19,27.58).The BKMR analysis identified dioxin TEQ and BDE-153 as the compounds with the greatest *** binary logistic and probit models showed that the BMD10(benchmark dose corresponding to a 10%extra risk)and BMDL_(10)(lower bound on the BMD_(10))were 3.71 and 3.46 pg TEQ/g fat,respectively,when accounting for coexposure to BDE-153 up to the 80%*** the optimized PBTK model and modifying factor,it was estimated that daily exposure should be below 4.34 pg TEQ kg^(−1)bw week^(−1)in order to not reach a harmful serum concen

关键词： dioxin gestational diabetes mellitus coexposure benchmark dose physiologically based toxicokinetic model

Innovative 3D Microfluidic Intestinal Organoid Model for Assessing Cadmium Bioavailability in food: Implications for Enhanced Exposure risk assessment

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food Science and Human Wellness 2024年

作者： Yan Li Wen Sun Qiao Wang Wan Shi Yu Chen Zhiyong Gong Xiao Guo Xin Liu Yongning Wu key laboratory of Animal Biological Products & Genetic Engineering， Ministry of Agriculture and Rural， Sinopharm Animal Health Corporation Ltd. State key laboratory of Novel Vaccines for Emerging Infectious Diseases， China National Biotec Group Company Limited key laboratory for Deep Processing of Major Grain and Oil (The Chinese Ministry of Education)， College of food Science and Engineering， Wuhan Polytechnic University Department of Oncology， Xiangya Hospital， Central South University nhc key laboratory of food safety risk assessment， China National Center for food safety risk assessment

Given the severe toxicity and widespread presence of cadmium (Cd) in staple foods such as rice， accurate dietary exposure assessments are imperative for public health. In vitro bioavailability is commonly used to adjust dietary exposure levels of risk factors; however， traditional planar Transwell models have limitations， such as cell dedifferentiation and lack of key intestinal components， necessitating a more physiologically relevant in vitro platform. This study introduces an innovative three-dimensional (3D) intestinal organoid model using a microfluidic chip to evaluate Cd bioavailability in food. Caco-2 cells were cultured on the chip to mimic small intestinal villi's 3D structure， mucus production， and absorption functions. The model's physiological relevance was thoroughly characterized， demonstrating the formation of a confluent epithelial monolayer with well-developed tight junctions (ZO-1)， high microvilli density (F-actin)， and significant mucus secretion (Alcian blue staining)， closely resembling the physiological intestinal epithelium. Fluorescent particle tracking confirmed its ability to simulate intestinal transport and diffusion. The Cd bioavailability in rice measured by the 3D intestinal organoid model (9.07% ± 0.21%) was comparable to the mouse model (12.82% ± 3.42%) but significantly lower than the Caco-2 monolayer model (26.97% ± 1.11%). This 3D intestinal organoid model provides a novel and reliable strategy for in vitro assessment of heavy metal bioavailability in food， with important implications for food safety and risk assessment.

关键词：

Community Incidence Estimates of Five Pathogens Based on foodborne Diseases Active Surveillance—China,2023

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China CDC weekly 2024年第24期6卷 574-579,I0002页

作者： Penghui Fan Haihong Han Jikai Liu Xiaochen Ma Ronghua Zhang Hong Liu Yijing Zhou Zunhua Chu Jian Wen Li Lin Weiwei Li Yunchang Guo nhc key laboratory of food safety risk assessment China National Center for Food Safety Risk AssessmentBeijingChina Beijing Center for Disease Prevention and Control BeijingChina Zhejiang Provincial Center for Disease Control and Prevention Hangzhou CityZhejiang ProvinceChina Shanghai Center for Disease Control and Prevention ShanghaiChina Jiangsu Provincial Center for Disease Control and Prevention Nanjing CityJiangsu ProvinceChina Shandong Province Center for Disease Control and Prevention Jinan CityShandong ProvinceChina Guangdong Province Center for Disease Control and Prevention Guangzhou CityGuangdong ProvinceChina Sichuan Province Center for Disease Control and Prevention Chengdu CitySichuan ProvinceChina

What is already known about this topic?foodborne diseases,representing significant food safety and public health challenges globally,are not welldocumented in terms of incidence,particularly for cases characterized by acute gastroenteritis(AGI)in *** is added by this report?This study developed a pyramid model to estimate the incidence of five pathogens,stratified by gender and *** estimated incidences per 100,000 people with 95%uncertainty intervals(UI)are as follows:Norovirus,3,188.28(95%UI:2,518.03,7,296.96);Salmonella spp.,1,295.59(95%UI:1,002.62,1,573.11);diarrheagenic ***(DEC),782.62(95%UI:651.19,932.05);Vibrio parahaemolyticus,404.06(95%UI:342.19,468.93);and Shigella spp.,26.73(95%UI:21.05,33.46).What are the implications for public health practice?This study elucidates the incidence rates across various gender and age groups,thereby identifying priority populations for targeted preventive interventions aimed at reducing disease *** insights are crucial for the development of public health policies and management of food safety risks.

关键词： acute diseases stratified

Geographical origin identification of winter jujube(Ziziphus jujuba Dongzao')by using multi-element fingerprinting with chemometrics

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Journal of Integrative Agriculture 2024年第5期23卷 1749-1762页

作者： Xiabing Kong Qiusheng Chen Min Xu Yihui Liu Xiaoming Li Lingxi Han Qiang Zhang Haoliang Wan Lu Liu Xubo Zhao Jiyun Nie College of Horticulture Qingdao Agricultural University/Laboratory of Quality&Safety Risk Assessment for Fruit(Qingdao)Ministry of Agriculture and Rural Affairs/National Technology Centre for Whole Process Quality Control of FSEN Horticultural Products(Qingdao)/Qingdao Key Lab of Modern Agriculture Quality and Safety EngineeringQingdao 266109China Institute of Agricultural Product Quality Safety and NutritionTianjin Academy of Agricultural SciencesTianjin 300381China College of food Science and Engineering Northwest A&F UniversityYangling 712100China

Winter jujube(Ziziphus jujuba'Dongzao')is greatly appreciated by consumers for its excellent quality,but brand infringement frequently occurs in the ***,we first determined a total of 38 elements in 167 winter jujube samples from the main winter jujube producing areas of China by inductively coupled plasma mass spectrometer(ICP-MS).As a result,16 elements(Mg,K,Mn,Cu,Zn,Mo,Ba,Be,As,Se,Cd,Sb,Ce,Er,Tl,and Pb)exhibited significant differences in samples from different producing *** linear discriminant analysis(LDA)and orthogonal projection to latent structures discriminant analysis(OPLS-DA)showed better performance in identifying the origin of samples than unsupervised principal component analysis(PCA).LDA and OPLS-DA had a mean identification accuracy of 87.84 and 94.64%in the testing set,*** using the multilayer perceptron(MLP)and C5.0,the prediction accuracy of the models could reach 96.36 and 91.06%,*** on the above four chemometric methods,Cd,Tl,Mo and Se were selected as the main variables and principal markers for the origin identification of winter ***,this study demonstrates that it is practical and precise to identify the origin of winter jujube through multi-element fingerprint analysis with chemometrics,and may also provide reference for establishing the origin traceability system of other fruits.

关键词： winter jujube multi-element fingerprint analysis chemometrics origin traceability

Higher ambient temperatures may worsen obstructive sleep apnea:A nationwide smartwatch-based analysis of 6.2 million person-days

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Science Bulletin 2024年第13期69卷 2114-2121页

作者： Anni Li Qingli Zhang Yuan Yao Xinlei Zhu Cong Liu Yutao Guo Haidong Kan Renjie Chen School of Public Health Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology AssessmentFudan UniversityShanghai 200032China Ministry of Education-Shanghai key laboratory of Children’s Environmental Health Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Pulmonary Vessel and Thrombotic Disease Sixth Medical CenterChinese PLA General HospitalBeijing 100048China Institute for Hospital Management Research Chinese PLA General HospitalBeijing 100048China Children’s Hospital of Fudan University National Children’s Medical CenterShanghai 201102China School of Public Health Hengyang Medical SchoolUniversity of South ChinaHengyang 421001China

Obstructive sleep apnea(OSA)is a serious type of sleep disorder that can lead to cardiometabolic and neurocognitive *** utilized smart device-based photoplethysmography technology to collect sleep data from the Chinese population from 2019 to *** lag nonlinear models combined with a generalized nonlinear model or a linear mixed effects model were used to investigate the shortterm associations between daily temperature and indicators of OSA *** included a total of 6,232,056 d of sleep monitoring data from 51,842 participants with moderate to severe risk of OSA from 313 Chinese *** relationships between ambient temperature and OSA exacerbation,apneahypopnea index(AHI),and minimum oxygen saturation(MinSpO_(2))were almost linear and present only on the same *** temperatures were associated with a greater risk of OSA exacerbation,with an 8.4%(95%confidence interval(CI):7.6%–9.3%)increase per 10℃increase in temperature.A 10℃increase in daily temperature corresponded to an AHI increase of 0.70 events/h(95%CI:0.65–0.76)and a MinSpO_(2)decrease of 0.18%(95%CI:0.16%–0.19%).Exposure to elevated temperatures during the night can also lead to adverse *** effects of higher temperatures on OSA severity were stronger among men,participants with a body mass index24 kg/m2,those aged 45 years and older,individuals with a history of hypertension and diabetes,and during the cold *** large-scale,nationwide,longitudinal study provides robust evidence suggesting that higher ambient temperatures may immediately worsen OSA.

关键词： Obstructive sleep apnea Temperature Apnea-hypopnea index Oxygen saturation Smart device

Surveillance of SARS-CoV-2 Contamination in Frozen food-Related Samples--China,July 2020-July 2021

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China CDC weekly 2022年第22期4卷 465-470页

作者： Fengqin Li Jiahui Wang Zhaoping Liu Ning Li nhc key laboratory of food safety risk assessment China National Center for Food Safety Risk AssessmentBeijingChina

Introduction:Current evidence shows that coronavirus disease 2019(COVID-19)is neither a food safety issue nor a foodborne ***,the outbreaks of this disease in workers of meat-or poultry-processing plants and food markets have been reported in many *** reports on severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)contamination in food-related samples worldwide are lacking so *** study aimed to survey and monitor SARS-CoV-2 contamination in samples of foods or their packaging,storage environment,and employees,as well as explore the possible potential for virus transmission via frozen ***:Swabs of frozen food-related samples were collected between July 2020 and July 2021 in 31 provincial-level administrative divisions(PLADs)and Xinjiang Construction Corps in *** SARSCoV-2 RNAs were extracted and analyzed by real-time quantitative polymerase chain reaction using the commercially available SARS-CoV-2 nucleic acid test ***:More than 55.83 million samples were analyzed,and 1,455(0.26 per 10,000)were found to be positive for SARS-CoV-2 nucleic *** the virus-positive samples,96.41%(1,398/1,450)and 3.59%(52/1,450)were food/food packaging materials and environment,*** for 1,398 SARS-CoV-2-positive food and food packaging materials,99.50%,(1,391/1,398)were imported and 7 were *** outer packaging of food was frequently contaminated by the virus 78.75%(1,101/1,398).Conclusions:Our study supported speculation that cold-chain foods might act as the SARS-CoV-2 carrier,and food handlers/operators were at high risk of exposure to the *** is necessary to carry out a comprehensive mass testing for SARS-CoV-2 nuclei acid,along with contact tracing and symptom screening in cold-chain food handlers and processors so as to identify high proportions of asymptomatic or presymptomatic ***,research and development of effective self-protection equipment available at a temperature b

关键词： handle packaging carry

COVID-19 Outbreaks Linked to Imported Frozen food in China:Status and Challege

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China CDC weekly 2022年第22期4卷 483-487页

作者： Jiahui Wang Fengqin Li Zhaoping Liu Ning Li nhc key laboratory of food safety risk assessment China National Center for Food Safety Risk AssessmentBeijingChina

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)RNA contamination was reported on China’s imported frozen foods and packaging ***,there was no evidence of this disease initiated by environment-to-human transmission until the outbreak of coronavirus disease 2019(COVID-19)in Beijing in June *** article aimed to analyze and summarize COVID-19 outbreaks related to cold-chain foods to provide a scientific basis for tracing the epidemiological trajectory of the pandemic,providing risk assessments,and mitigation ***,37 COVID-19 outbreaks and 5,741 infected cases were reported within the study *** was found that 7 outbreaks and 689 cases were linked to imported frozen *** first index case among the 7 outbreaks was exposed to SARS-CoV-2-contaminated outer packaging of frozen food,triggering the subsequent community *** study supported the speculation that cold-chain foods act as a pathway for SARS-CoV-2 and might present a risk for virus transmission between countries and *** and processors exposed to the imported frozen foods should be effectively self-protected,daily monitored for clinical manifestations of COVID-19,and tested for SARS-CoV-2 nucleic acid at regular intervals.

关键词： frozen protected imported