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Influence of Interrupted childhood Biographies on Health development: Evaluation of the Scientific Literature on the Example of Being Taken into Care*

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Journal of Biosciences and Medicines 2024年第7期12卷 108-119页

作者： Manuela Loderer Ursula Gresser Dental Office for Orthodontics Dingolfing Germany Outpatient clinic for Internal Medicine and Medical Expert Reports Munich Germany

Background: An interrupted family history, as is the case after taking someone into care, can complicate collecting family anamnesis data. In addition, the interrupted family history itself could be considered part of a person’s risk profile. Aim and methods: Literature analysis was conducted to examine whether there are scientific studies on health development after placement in out-of-home-care in order to recognise any existing medical characteristics that may be relevant for internal medical care. Results: There are few scientific publications on the health development of people after being placed in out-of-home-care. Direct reactions to the stress of being taken into custody include nausea and fever. However, effects that go beyond the acute situation and last into adulthood have also been described, such as AD(H)D, asthma, diabetes, cancer, hypertension and cardiovascular diseases (myocardial infarction, stroke), epilepsy and increased overall mortality in adulthood. Studies show that not only previous experience but also the stress of being taken into care is triggers for this. Conclusion: Information about a previous institutionalisation can hence be important for internal medical practice. The available scientific literature shows heterogeneous study methodology and no group of people with experience of out-of-home-placement has yet been scientifically accompanied for a long time period. Further studies on this could help to better weigh up the consequences of omitting and conducting an intervention for child/youth protection as well as to improve the medical care for this group of people.

关键词： Taking into Care Out-of-Home-Care Interrupted Family History Physical Outcomes Internal Medicine

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Pseudotyped lentiviral vectors:Ready for translation into targeted cancer gene therapy?

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Genes & Diseases 2023年第5期10卷 1937-1955页

作者： Longfei Deng Ping Liang Hongjuan Cui Cancer Center Medical Research InstituteSouthwest UniversityChongqing 400716China Department of Neurosurgery Children's Hospital of Chongqing Medical UniversityNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChongqing 400014China Chongqing Key Laboratory of Pediatrics Chongqing 400014China State Key Laboratory of Silkworm Genome Biology Southwest UniversityChongqing 400716China

Gene therapy holds great promise for curing cancer by editing the deleterious genes of tumor cells,but the lack of vector systems for efficient delivery of genetic material into specific tumor sites in vivo has limited its full therapeutic potential in cancer gene *** the past two decades,increasing studies have shown that lentiviral vectors(LVs)modified with different glycoproteins from a donating virus,a process referred to as pseudotyping,have altered tropism and display cell-type specificity in transduction,leading to selective tumor cell *** feature of LVs together with their ability to enable high efficient gene delivery in dividing and non-dividing mammalian cells in vivo make them to be attractive tools in future cancer gene *** review is intended to summarize the status quo of some typical pseudotypings of LVs and their applications in basic anti-cancer studies across many *** opportunities of translating pseudotyped LVs into clinic use in cancer therapy have also been discussed.

关键词： Cancer therapy clinical translation Gene delivery Lentiviral vector Pseudotype

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Association between innate immunity gene polymorphisms and neonatal sepsis development:a systematic review and meta-analysis

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World Journal of Pediatrics 2022年第10期18卷 654-670页

作者： Tamara Sljivancanin Jakovljevic Jelena Martic Jelena Jacimovic Nadja Nikolic Jelena Milasin Tanja Lazić Mitrović Department of Neonatology The Obstetrics and Gynecology Clinic“Narodni Front”BelgradeSerbia School of Medicine University of BelgradeBelgradeSerbia Department of Neonatology Mother and Child Health Care Institute of Serbia“Dr Vukan Cupic”BelgradeSerbia Central Library School of Dental MedicineUniversity of BelgradeBelgradeSerbia Department of Human Genetics School of Dental MedicineUniversity of BelgradeBelgradeSerbia

Background The aim of this meta-analysis was to analyze all available data from studies investigating associations between polymorphisms in genes responsible for innate immunity and neonatal sepsis *** A comprehensive literature search,reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses-S guidelines,was performed with no language *** derived using the PICO(population,intervention,comparison and outcomes)strategy,with data on the genotype distribution for innate immunity gene polymorphisms in newborns with and without *** were analyzed using Review *** Cochran–Mantel–Haenszel test was used to calculate odds ratios with 95%confidence *** was tested using the I2 *** From a total of 9428 possibly relevant articles,33 qualified for inclusion in this systematic *** to the STrengthening the REporting of Genetic Association Studies,23 studies were found to be of moderate quality,while 10 were of low *** results showed an association of the mannose-binding lectin(MBL)exon 1 genetic polymorphism with the risk of culture-proven ***-like receptor(TLR)4 rs4986791 genotype distribution suggests its association with the increased risk of culture-proven *** certainty of evidence per GRADE(Grading of Recommendations,Assessment,development,and Evaluation)varied from very low to *** bias was not *** Out of the 11 investigated single-nucleotide polymorphisms,this meta-analysis found a possible association between the risk for culture-proven sepsis and MBL exon 1 and TLR4 rs4986791 *** is an evident need for larger well-designed,multicentric observational studies investigating inflammatory gene polymorphisms in neonatal sepsis.

关键词： Genetic Immunity Innate Neonatal sepsis Polymorphism

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Analysis of the characteristics and management of critical values in a newborn tertiary center in China

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World Journal of Pediatrics 2017年第1期13卷 49-56页

作者： Zheng-Li Wang Li-Zhong Du Yi-Yu Chen Lu-Quan Li Qi Lu Ying Liu Lu-Ying Cao Yu He Jia-Lin Yu Department of Neonatology Children's Hospital of Chongqing Medical UniversityMinistry of Education Key Laboratory of Child Development and DisordersKey Laboratory of Pediatrics in Chongqing and Chongqing International Science and Technology Cooperation Center for Child Development and DisordersChongqingChina Department of Neonatology Children's HospitalZhejiang University School of Medicine

Background."Critical value reporting has been widely adopted by hospitals throughout the world,but there were few reports about neonatal critical *** study aimed to analyze characteristics of the neonatal critical values considered at our center and to provide information on improving neonatal intensive ***:A retrospective study of critical values at a newborn tertiary center in China was conducted to assess neonatal critical values according to test,distribution,reporting time,patient outcome and the impact to the therapy.

关键词： critical care critical value management strategies newborn

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Attention-Deficit/Hyperactivity Disorder in Adults with High-Functioning Pervasive developmental Disorders in Japan

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Open Journal of Psychiatry 2014年第4期4卷 372-380页

作者： Yasuko Takanashi Hirobumi Mashiko Hirohide Yokokawa Yoko Kawasaki Shuntaro Itagaki Hiromichi Ishikawa Norihiro Miyashita Yasuaki Hayashi Asako Kudo Kentaro Oga Rieko Matsuura Shin-Ichi Niwa Department of Neuropsychiatry Fukushima Medical University School of Medicine Fukushima Japan Fukushima General Health and Welfare Center Fukushima Japan Department of Public Health Fukushima Medical University School of Medicine Fukushima Japan Department of General Medicine Juntendo University School of Medicine Tokyo Japan musasino child development clinic Tokyo Japan Hanawakousei Hospital Fukushima Japan Landic Nihonbashi clinic Tokyo Japan Hoshigaoka Hospital Fukushima Japan Surugadai Nihon University Hospital Tokyo Japan Shiba clinic Tokyo Japan

Aims: This study was designed to verify the proportion of Japanese adults with pervasive developmental disorder (PDD) who met the diagnostic criteria (other than E) for attention-deficit/hyperactivity disorder (ADHD) in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR). Furthermore, we examined to what extent adults with PDD think that they exhibit ADHD symptoms. Methods: We developed an original Japanese self-report questionnaire to determine the presence or absence of 18 symptoms from the diagnostic criteria for ADHD in the DSM-IV-TR. We administered the questionnaire to 64 adults with high-functioning PDD (45 men and 19 women) and 21 adults with ADHD (10 men and 11 women), aged 18 to 59 years, with a full-scale intelligence quotient ≥75. Target patients were evaluated for ADHD by their psychiatrists. Results: Twenty-nine (45.3%) adults with PDD also had ADHD. The percentage of these adults who had over six perceived inattention symptoms from the DSM-IV-TR was 96.6%. The percentage of these adults who had over six perceived hyperactivity-impulsivity symptoms was 65.5%. Thirty-five (55.6%) adults with PDD responded that they were aware of having ADHD symptoms at the level of the relevant diagnostic criteria. Conclusions: The present study is the first to examine the frequency of objective and perceived ADHD symptoms in adults with PDD in Japan. Our results show that both objective and perceived ADHD symptoms frequently appear in a large number of adults with PDD. This suggests that it is necessary to attend to concomitant ADHD symptoms in the medical care of adults with PDD.

关键词： Adults Attention-Deficit/Hyperactivity Disorder (ADHD) High-Functioning Pervasive developmental Disorders (PDD) Self-Report

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Endothelial impairment evaluation by peripheral arterial tonometry in pediatric endocrinopathies:A narrative review

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World Journal of Diabetes 2021年第6期12卷 810-826页

作者： Alberto La Valle Marco Crocco Decimo Silvio Chiarenza Mohamad Maghnie Giuseppe d'Annunzio Pediatric clinic and Endocrinology IRCCS Istituto Giannina GasliniGenoa16147Italy Pediatric clinic and Endocrinology IRCCS Giannina Gaslini InstituteDepartment of NeuroscienceRehabilitationOphthalmologyGeneticsMaternal and Child Health University of GenoaGenoa16147Italy

Endothelial dysfunction(ED)is characterized by an imbalance between vasodilator and vasoconstriction *** pathological conditions clinically diagnosed in childhood and adolescence are characterized by ED and increased risk for early development of microangiopathic and macroangiopathic impairment,in particular type 1 diabetes mellitus(T1DM),T2DM,obesity,metabolic syndromeand pituitary dysfunction associated to various *** recently insulin resistance following chemotherapy or radiotherapy for tumors,bone marrow transplantation for hematological malignancies(i.e.,cancer survivors),or immunosuppressive treatment for solid organ transplantation has been *** of ED by means of non-invasive techniques is the gold standard for early ED detection before clinical *** is aimed to recognize patients at risk and to avoid the development and progression of more serious *** hyperemia-peripheral artery tonometry is a noninvasive technique to assess peripheral endothelial function by measuring modifications in digital pulse volume during reactive hyperemia,and represents a non-invasive,reproducible and operator-independent tool able to detect precocious *** narrative review aimed to provide an overview of the most important papers regarding ED detection by EndoPat 2000 in children and adolescents with different endocrine diseases.A comprehensive search of English language articles was performed in the MEDLINE database without using other search filters except the publication interval between 2005 and 2020.

关键词： Pediatric diabetes mellitus Pediatric endocrinopathies Metabolic syndrome Cancer survivors Endothelial dysfunction Peripheral artery tonometry

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Expert consensus on pediatric orthodontic therapies of malocclusions in children

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International Journal of Oral Science 2024年第2期16卷 186-196页

作者： Chenchen Zhou Peipei Duan Hong He Jinlin Song Min Hu Yuehua Liu Yan Liu Jie Guo Fang Jin Yang Cao Lingyong Jiang Qingsong Ye Min Zhu Beizhan Jiang Wenhua Ruan Xiao Yuan Huang Li Rui Zou Yulou Tian Li Gao Rui Shu Jianwei Chen Renkai Liu Shujuan Zou Xiaobing Li State Key Laboratory of Oral Diseases&National Center for Stomatology&National clinical Research Center for Oral Diseases&Department of Pediatric Dentistry West China Hospital of StomatologySichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National clinical Research Center for Oral Diseases&Department of Orthodontics West China Hospital of StomatologySichuan UniversityChengduChina State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration&Key Laboratory of Oral Biomedicine Ministry of Education&Hubei Key Laboratory of Stomatology&Department of Orthodontics&Center for Dentofacial development and Sleep Medicine School and Hospital of StomatologyWuhan UniversityWuhanChina Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences&Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education Stomatological Hospital of Chongqing Medical UniversityChongqing Medical University&College of StomatologyChongqing Medical UniversityChongqingChina Department of Orthodontics Hospital of StomatologyJilin UniversityChangchunChina Department of Orthodontic&Oral Biomedical Engineering Laboratory Shanghai Stomatological HospitalFudan UniversityShanghaiChina Department of Orthodontics Central LaboratoryPeking University School and Hospital for Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical Devices&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental Materials&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijingChina Department of Orthodontics School and Hospital of StomatologyCollege of MedicineShandong University&Shandong Key Laboratory of Oral Tissue Regeneration&Shandong Engineering Laboratory for Dental Materials and Oral Tissue

Malocclusion,identified by the World Health Organization(WHO)as one of three major oral diseases,profoundly impacts the dental-maxillofacial functions,facial esthetics,and long-term development of~260 million children in *** its physical manifestations,malocclusion also significantly influences the psycho-social well-being of these *** intervention in malocclusion can foster an environment conducive to dental-maxillofacial development and substantially decrease the incidence of malocclusion or reduce the severity and complexity of malocclusion in the permanent dentition,by mitigating the negative impact of abnormal environmental influences on the *** orthodontic treatment encompasses accurate identification and treatment of dental and maxillofacial morphological and functional abnormalities during various stages of dental-maxillofacial development,ranging from fetal stages to the early permanent dentition *** an economic and societal standpoint,the urgency for effective early orthodontic treatments for malocclusions in childhood cannot be overstated,underlining its profound practical and social *** consensus paper discusses the characteristics and the detrimental effects of malocclusion in children,emphasizing critical need for early *** elaborates on corresponding core principles and fundamental approaches in early orthodontics,proposing comprehensive guidance for preventive and interceptive orthodontic treatment,serving as a reference for clinicians engaged in early orthodontic treatment.

关键词： permanent stated children

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Artificial intelligence promotes shared decision-making through recommending tests to febrile pediatric outpatients

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World Journal of Emergency Medicine 2023年第2期14卷 106-111页

作者： Wei-hua Li Bin Dong Han-song Wang Jia-jun Yuan Han Qian Ling-ling Zheng Xu-lin Lin Zhao Wang Shi-jian Liu Bo-tao Ning Dan Tian Lie-bin Zhao Pediatric AI clinical Application and Research Center Shanghai Children’s Medical CenterShanghai 200127China Shanghai Engineering Research Center of Intelligence Pediatrics(SERCIP) Shanghai 200127China child Health Advocacy Institute China Hospital Development Institute of Shanghai Jiao Tong UniversityShanghai 200127China Pediatric Intensive Care Unit Shanghai Children’s Medical CenterShanghai Jiao Tong University School of MedicineShanghai 200127China Hangzhou YITU Healthcare Technology Co.Ltd. Hangzhou 310000China

BACKGROUND:To promote the shared decision-making(SDM)between patients and doctors in pediatric outpatient departments,this study was designed to validate artificial intelligence(AI)-initiated medical tests for children with ***:We designed an AI model,named Xiaoyi,to suggest necessary tests for a febrile child before visiting a pediatric outpatient *** calculated the sensitivity,specificity,and F1 score to evaluate the efficacy of Xiaoyi’s *** patients were divided into the rejection and acceptance *** we analyzed the rejected examination items in order to obtain the corresponding ***:We recruited a total of 11,867 children with fever who had used Xiaoyi in outpatient *** recommended examinations given by Xiaoyi for 10,636(89.6%)patients were *** average F1 score reached 0.94.A total of 58.4%of the patients accepted Xiaoyi’s suggestions(acceptance group),and 41.6%refused(rejection group).Imaging examinations were rejected by most patients(46.7%).The tests being time-consuming were rejected by 2,133 patients(43.2%),including rejecting pathogen studies in 1,347 patients(68.5%)and image studies in 732 patients(31.8%).The difficulty of sampling was the main reason for rejecting routine tests(41.9%).CONCLUSION:Our model has high accuracy and acceptability in recommending medical tests to febrile pediatric patients,and is worth promoting in facilitating SDM.

关键词： Artificial intelligence Pediatric outpatient Medical examinations Shared decision-making

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Are multidisciplinary consultation meetings for prenatal diagnosis achievable in a low-income country? A descriptive cross-sectional survey in Benin

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World Journal of Pediatric Surgery 2023年第4期6卷 270-275页

作者： Monsoia Gildas Yassegoungbe Beaudelaire Romulus Assan Amoussou Sedjro Clotaire Romeo Houegban Codjo Serge Metchihoungbe Jean-Francois Lecompte Christine Tschabu Aguemon Sidoine Bitho Gbetey Jean Breaud Antoine Seraphin Gbenou Pediatric Surgery Department Mother and Child Teaching Hospital LaguneUniversity of Abomey-CalaviCotonouBenin Pediatric Surgery Department National Teaching Hospital Hubert Koutoukou MagaUniversity of Abomey-CalaviCotonouBenin Pediatric Surgery Department CHU-LENVAL Paediatric Hospitals of NiceNiceFrance University clinic of Gynecological Obstetrics National Teaching Hospital Hubert Koutoukou MagaUniversity of Abomey-CalaviCotonouBenin Intellectual Production Department Center of Expertise in Applied Social SciencesCotonouBenin

Objective The multidisciplinary antenatal diagnosis staff bring together practitioners who are involved in the management of the antenatal period at *** project was designed following the French experience to institute multidisciplinary consultation meetings for prenatal diagnosis(MCMPD)in *** This is a descriptive cross-sectional study examining the knowledge,attitudes,and practices of Beninese practitioners in the field of MCMPD to develop the pilot phase of the *** We collected 108 participants from different *** and pediatric surgeons were in the majority at 23.9% and 16.5%,***-seven percent of participants were from the public sector(n=75).One practitioner felt that it was not a good idea to implement these *** all staff(96.2%)agreed that this meeting would have a positive impact on reducing neonatal ***(58.5%),spina bifida aperta(43.6%),and gastroschisis(34%)were the most commonly diagnosed antenatal conditions in *** neonatal pathology required medical termination of the pregnancy according to 35.6% of the *** The objective of reducing infant mortality due to medical and surgical pathologies is a noble one and deserves to be *** innovative project,developed through this study,the first of its kind in the subregion,will contribute inexorably to the achievement of the third Goal Sustainable development.

关键词： diagnosis sectional income

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Vegetarian Diets in children—Some Thoughts on Restricted Diets and Allergy

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International Journal of clinical Medicine 2021年第2期12卷 43-60页

作者： Hermann Kalhoff Mathilde Kersting Lennart Lücke Thomas Lücke Pediatric clinic Dortmund Germany Research Department of child Nutrition (FKE) Pediatric University Clinic Ruhr-University Bochum Bochum Germany Pediatric University clinic Ruhr-University Bochum Bochum Germany

Vegetarianism is a common diet worldwide. For a large proportion of people, meat or fish is not available at all or not regularly as a meal. But also in the industrialised countries, vegetarian nutrition is becoming more and more popular for various reasons. Many vegetarian parents also want a suitable diet for their children. But are restrictive diets beneficial or potentially harmful in certain situations, such as a predisposition to severe atopy? Are vegetarian diets equally suitable for pregnant women, nursing mothers, infants, children, and adolescents? What critical nutrients should parents, children, pediatricians, and nutritionists pay particular attention to? This article is focused on questions like these and discusses scientifically based concepts of nutrition. Main findings are that exposure to a variety of food antigens during early life may play a role in the development of healthy eating habits and that restrictive diets have not been found in studies to prevent allergic disease.

关键词： Infants-children-Adolescents Nutrition Vegetarian Critical Nutrients Dietary Supplementation Food Allergy

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