Endothelial impairment evaluation by peripheral arterial tonometry in pediatric endocrinopathies:A narrative review
作者机构：Pediatric Clinic and EndocrinologyIRCCS Istituto Giannina GasliniGenoa16147Italy Pediatric Clinic and EndocrinologyIRCCS Giannina Gaslini InstituteDepartment of NeuroscienceRehabilitationOphthalmologyGeneticsMaternal and Child Health University of GenoaGenoa16147Italy
出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)
年 卷 期：2021年第12卷第6期
页 面：810-826页
核心收录：
学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学]
主 题：Pediatric diabetes mellitus Pediatric endocrinopathies Metabolic syndrome Cancer survivors Endothelial dysfunction Peripheral artery tonometry
摘 要：Endothelial dysfunction(ED)is characterized by an imbalance between vasodilator and vasoconstriction *** pathological conditions clinically diagnosed in childhood and adolescence are characterized by ED and increased risk for early development of microangiopathic and macroangiopathic impairment,in particular type 1 diabetes mellitus(T1DM),T2DM,obesity,metabolic syndromeand pituitary dysfunction associated to various *** recently insulin resistance following chemotherapy or radiotherapy for tumors,bone marrow transplantation for hematological malignancies(i.e.,cancer survivors),or immunosuppressive treatment for solid organ transplantation has been *** of ED by means of non-invasive techniques is the gold standard for early ED detection before clinical *** is aimed to recognize patients at risk and to avoid the development and progression of more serious *** hyperemia-peripheral artery tonometry is a noninvasive technique to assess peripheral endothelial function by measuring modifications in digital pulse volume during reactive hyperemia,and represents a non-invasive,reproducible and operator-independent tool able to detect precocious *** narrative review aimed to provide an overview of the most important papers regarding ED detection by EndoPat 2000 in children and adolescents with different endocrine diseases.A comprehensive search of English language articles was performed in the MEDLINE database without using other search filters except the publication interval between 2005 and 2020.
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