检索结果-南通市图书馆

Age-dependent impact of the SYNTAX-score on longer-term mortality after percutaneous coronary intervention in an all-comer population

引用

Journal of Geriatric Cardiology 2018年第9期15卷 559-566页

作者： Madeleine Eickhoff Stefanie Schupke Alexander Khandoga Julia Fabian Moritz Baquet David Jochheim David Grundmann Manuela Thienel Axel Bauer Hans Theiss Stefan Brunner Jorg Hausleiter Steffen Massberg Julinda Mehilli Department of Cardiology Munich University Clinic Ludwig-Maximilians University Munich Germany German Centre for Cardiovascular Research (DZHK) Partner Site Munich Heart Alliance Germany Deutsches Herzzentrum Miinchen Klinik fiir Herz- und Kreislauferkrankungen ISAResearch Center Munich Germany

Background The Synergy between Percutaneous Coronary Intervention with TAXUS and Cardiac Surgery （SYNTAX）-score is a validated tool for risk stratification and revascularization strategy selection in patients with complex coronary artery disease. The aim of this study was to analyse its age-related prognostic value. Methods SYNTAX-score was calculated in 1331 all-comer patients undergoing percutaneous coronary intervention （PCI）： 463 patients ≥ 75 years and 868 patients 〈 75 years. Outcomes of interest were all-cause mortality at one and two years. Results A significant interaction of age and SYNTAX-score for mortality was observed at two-year （Pinteraction= 0.019） but not at one-year follow-up （Pinteraction= 0.594）. In multivariable analysis, SYNTAX-score independently predicted 1-year mortality in both age groups （〈 75 years, hazard ratio （HR）： 1.43, 95% confidence intervals （CI）： 1.03-2.00, P = 0.034; and 〉 75 years, HR： 1.37, 95% CI： 1.01-1.85, P = 0.042）, but only two-year mortality among younger patients （〈 75 years, HR： 1.33, 95% CI： 1.01-1.76, P = 0.041; and ≥ 75 years, HR： 1.11, 95% CI： 0.87-1.41, P = 0.394）. SYNTAX-score tertiles were useful to stratify 1-year mortality in both, patients 〈 75 years （SYNTAX-score 〈 9, 3.8%; 9-20, 5.3%; 〉 20, 10.3%; P = 0.004） and 〉 75 years （SYNTAX-score 〈 11, 5.7%; 11-22.5, 16.1%; 〉 22.5, 18.7%; P = 0.003）, but two-year mortality only among patients 〈 75 years （SYNTAX-score 〈 9, 6.5%; 9-20, 7.6%; ≥ 20, 15%; P 〈 0.001） and not among ≥ 75 years old patients （SYNTAX-score 〈 11, 19.4%; 11-22.5, 26.3%; _〉 22.5, 27.9%; P = 0.138）. Conclusions Age modi- fies the impact of the SYNTAX-score on longer-term mortality after PCI. Among patients 〈 75 years, the SYNTAX-score independently predicts the risk of death at one and two years after PCI, while among patients 〉 75 years its predictive role is limited to the first year after PCI. Further studies are needed to evaluate the value of SYNTAX-score for selecting the most appropriate re

关键词： Age Mortality Percutaneous coronary intervention Syntax-score The elderly

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tracing the failing heart: dual genetic fate mapping for target identification

引用

Signal Transduction and Targeted Therapy 2023年第9期8卷 3880-3882页

作者： Yaw Asare Christian Stoppe Jürgen Bernhagen Institute for Stroke and Dementia Research(ISD) Klinikum der Universität München(KUM)Ludwig-Maximilian-University(LMU)81377 MunichGermany Department of Anesthesiology Intensive CareEmergency and Pain MedicineUniversity Hospital Würzburg97080 WürzburgGermany Department of Cardiac Anesthesiology and Intensive Care Medicine German Heart Center CharitéBerlin13353 BerlinGermany munich Cluster for Systems Neurology 81377 MunichGermany munich heart alliance 80802 MunichGermany

In a recent study published in Nature Genetics,1 Han and colleagues employed a dual genetic lineage tracing approach in combination with a model of heart failure(HF)to identify a key sub-population of endocardium-derived fibroblasts,which gives rise to excessive myofibroblast formation in a Wnt pathway-mediated manner and contributes to cardiac fibrosis.1 The identified fibroblast sub-population and Wnt signaling pathway could be novel targets for the therapy of *** in risk management and cardiovascular inter-vention have significantly reduced age-specific cardiovascular disease-related *** contrast,the rate of HF-related hospitalisations has increased over the past decades and HF is a disease with highest social and economic cost in industrialized *** is defined as impairment of the heart’s blood pumping function and its severity is assessed based on ejection *** often occurs after myocardial infarction(MI),with infarct size and quality of ventricular remodeling after MI influencing ventricular *** of HF also include hypertension,atrial fibrillation,and cardiomyopathies(Fig.1).Especially elderly patients with recurrent MI and comorbidities are increasingly presenting with signs of HF.

关键词： cardiovascular ventricular mortality

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Developing a comprehensive response for treatment of children under 6 years of age with schistosomiasis:research and development of a pediatric formulation of praziquantel

引用

Infectious Diseases of Poverty 2017年第1期6卷 1079-1082页

作者： Jutta Reinhard-Rupp Katharina Klohe Merck Coinsins CoinsinsSwitzerland Global Schistosomiasis alliance Westenriederstrasse 1080331 MunichGermany

Schistosomiasis is a parasitic disease caused by blood *** disease is caused by an inflammatory reaction to parasite eggs retained in the liver,bladder and reproductive *** to 2017 World Health Organization(WHO)estimates 220 million people are potentially infected,from which probably 10%are children under 6 years of *** regular treatment approach of a single,oral dose of 40 mg/kg body weight with praziquantel however,is difficult for children under the age of 6,leaving them without a treatment *** order to address this important gap in treatment target populations,an international public-private partnership that works on a not-for-profit basis in the field of drug research and development for schistosomiasis was established in *** is called the Pediatric Praziquantel *** mission was and continues to be to develop,register and provide access to a suitable pediatric praziquantel formulation for treating schistosomiasis in preschool-age children(3-6 months up to 6 years).The Target Product Profile for the pediatric formulation of praziquantel that would be suitable to treat children as young as 3-6 months was then defined by a group of experts,including members from the Pediatric Praziquantel Consortium partner organizations as well as experts from WHO(as observer)and schistosomiasis endemic *** development of the drug is ongoing and the Pediatric Praziquantel Consortium aims to submit the regulatory dossier for marketing approval in endemic countries and WHO prequalification in 2018/19 with approval and product launch for schistosomiasis pediatric case management in key endemic countries in ***,the goal is for the product to be considered for a large-scale mass distribution program by 2022.

关键词： Schistosomiasis Pediatric formulation Children Praziquantel

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Animal models of pulmonary hypertension due to left heart disease

引用

Animal Models and Experimental Medicine 2022年第3期5卷 197-206页

作者： Shao-Fei Liu Yi Yan Charité-Universitätsmedizin Berlin Corporate Member of Freie Universität BerlinHumboldt-Universität zu Berlinand Berlin Institute of HealthBerlinGermany DZHK(German Centre for Cardiovascular Research) Partner Site BerlinBerlinGermany Institute for Cardiovascular Prevention(IPEK) Ludwig-Maximilians-University MunichMunichGermany DZHK(German Centre for Cardiovascular Research) Partner Site Munich Heart AllianceMunichGermany

Pulmonary hypertension due to left heart disease(PH-LHD) is regarded as the most prevalent form of pulmonary hypertension(PH). Indeed, PH is an independent risk factor and predicts adverse prognosis for patients with left heart disease(LHD). Clinically, there are no drugs or treatments that directly address PH-LHD, and treatment of LHD alone will not also ameliorate PH. To target the underlying physiopathological alterations of PH-LHD and to develop novel therapeutic approaches for this population, animal models that simulate the pathophysiology of PH-LHD are required. There are several available models for PH-LHD that have been successfully employed in rodents or large animals by artificially provoking an elevated pressure load on the left heart, which by transduction elicits an escalated pressure in pulmonary artery. In addition, metabolic derangement combined with aortic banding or vascular endothelial growth factor receptor antagonist is also currently applied to reproduce the phenotype of PH-LHD. As of today, none of the animal models exactly recapitulates the condition of patients with PH-LHD. Nevertheless, the selection of an appropriate animal model is essential in basic and translational studies of PH-LHD. Therefore, this review will summarize the characteristics of each PH-LHD animal model and discuss the advantages and limitations of the different models.

关键词： animal model l eft ventricular failure metabolic syndrome pulmonary hypertension due to left heart disease pulmonary vascular remodeling

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fire up the pyre:inosine thermogenic signaling for obesity therapy

引用

Signal Transduction and Targeted Therapy 2022年第12期7卷 4255-4256页

作者： Nienke Willemsen Stefan Kotschi Alexander Bartelt Institute for Cardiovascular Prevention(IPEK) Ludwig-Maximilians-UniversityMunichGermany Institute for Diabetes and Cancer(IDC) Helmholtz Center MunichGerman Research Center for Environmental HealthNeuherbergGermany German Center for Cardiovascular Research Partner Site Munich Heart AllianceLMU HospitalMunichGermany Department of Molecular Metabolism&SabriÜlker Center for Metabolic Research Harvard T.H.Chan School of Public HealthBostonMAUSA

In a recent study published in Nature,Niemann et *** have discovered a metabolite signaling pathway that could pave the way to new weight loss drugs1(Fig.1).Obesity and its comorbidities are a major threat to public h... 详细信息

关键词： sine weight drugs

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Therapeutic ACPA inhibits NET formation: a potential therapy for neutrophil-mediated inflammatory diseases

引用

Cellular & Molecular Immunology 2021年第6期18卷 1528-1544页

作者： Renato G.S.Chirivi Jos W.Gvan Rosmalen Maarten van der Linden Maximilien Euler Gonny Schmets Galina Bogatkevich Konstantinos Kambas Jonas Hahn Quinte Braster Oliver Soehnlein Markus H.Hoffmann Helmuth H.Gvan Es Jos M.H.Raats ModiQuest B.V. OssThe Netherlands Citryll B.V. OssThe Netherlands Department of Internal Medicine 3-Rheumatology and Immunology University Hospital ErlangenFriedrich-Alexander-Universität Erlangen-Nürnberg and University Hospital ErlangenErlangenGermany Department of Medicine Division of Rheumatology and ImmunologyMedical University of South CarolinaCharlestonSCUSA Laboratory of Molecular Hematology Democritus University of ThraceAlexandroupoliGreece Institute for Cardiovascular Prevention(IPEK) Ludwig-Maximilians-University MunichMunichGermany German Center for Cardiovascular Research(DZHK) Partner Site Munich Heart AllianceMunichGermany Department of Physiology and Pharmacology Karolinska InstitutetStockholmSweden

Excessive release of neutrophil extracellular traps(NETs)is associated with disease severity and contributes to tissue injury,followed by severe organ *** or genetic inhibition of NET release reduces pathology in multiple inflammatory disease models,indicating that NETs are potential therapeutic ***,we demonstrate using a preclinical basket approach that our therapeutic anti-citrullinated protein antibody(tACPA)has broad therapeutic *** with tACPA prevents disease symptoms in various mouse models with plausible NET-mediated pathology,including inflammatory arthritis(IA),pulmonary fibrosis,inflammatory bowel disease and *** show that citrulline residues in the N-termini of histones 2A and 4 are specific targets for therapeutic intervention,whereas antibodies against other N-terminal post-translational histone modifications have no therapeutic *** citrullinated histones are generated during NET release,we investigated the ability of tACPA to inhibit NET *** suppressed NET release from human neutrophils triggered with physiologically relevant human disease-related ***,tACPA diminished NET release and potentially initiated NET uptake by macrophages in vivo,which was associated with reduced tissue damage in the joints of a chronic arthritis mouse model of *** our knowledge,we are the first to describe an antibody with NET-inhibiting properties and thereby propose tACPA as a drug candidate for NET-mediated inflammatory diseases,as it eliminates the noxious triggers that lead to continued inflammation and tissue damage in a multidimensional manner.

关键词： Neutrophil Extracellular Traps Autoimmunity Citrullination Therapeutic Antibody NET inhibition

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Opening a window to skin biomarkers for diabetes stage with optoacoustic mesoscopy

引用

Light(Science & Applications) 2023年第11期12卷 2335-2349页

作者： Hailong He Nikolina-Alexia Fasoula Angelos Karlas Murad Omar Juan Aguirre Jessica Lutz Michael Kallmayer Martin Fuchtenbusch Hans-Henning Eckstein Annette Ziegler Vasilis Ntziachristos Institute of Biological and Medical Imaging Helmholtz Zentrum MunchenNeuherbergGermany Chair of Biological Imaging at the Central Institute for Translational Cancer Research(TranslaTUM) School of MedicineTechnical University of MunichMunichGermany Department for Vascular and Endovascular Surgery Klinikum rechts der IsarTechnical University of Munich(TUM)MunichGermany DZHK(German Centre for Cardiovascular Research) partner site Munich Heart AllianceMunichGermany Diabetes Center at Marienplatz MunichGermany Forschergruppe Diabetes e.V. Helmholtz Zentrum MunchenNeuherbergGermany Institute of Diabetes Research Helmholtz Zentrum MunchenNeuherbergGermany

Being the largest and most accessible organ of the human body,the skin could offer a window to diabetes-related complications on the ***,skin microvasculature is typically assessed by histological analysis,which is not suited for applications to large populations or longitudinal *** introduce ultra-wideband rasterscan optoacoustic mesoscopy(RSOM)for precise,non-invasive assessment of diabetes-related changes in the dermal microvasculature and skin micro-anatomy,resolved with unprecedented sensitivity and detail without the need for contrast *** unique imaging contrast,we explored a possible role for RSOM as an investigational tool in diabetes healthcare and offer the first comprehensive study investigating the relationship between different diabetes complications and microvascular features in *** applied RSOM to scan the pretibial area of 95 participants with diabetes mellitus and 48 age-matched volunteers without diabetes,grouped according to disease complications,and extracted six label-free optoacoustic biomarkers of human skin,including dermal microvasculature density and epidermal parameters,based on a novel image-processing *** then correlated these biomarkers to disease severity and found statistically significant effects on microvasculature parameters as a function of diabetes *** discuss how label-free RSOM biomarkers can lead to a quantitative assessment of the systemic effects of diabetes and its complications,complementing the qualitative assessment allowed by current clinical metrics,possibly leading to a precise scoring system that captures the gradual evolution of the disease.

关键词： diabetes anatomy precise

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Implication of proliferation gene biomarkers in pulmonary hypertension

引用

Animal Models and Experimental Medicine 2021年第4期4卷 369-380页

作者： Yi Yan Rong Jiang Ping Yuan Li Wen Xiao-Bin Pang Zhi-Cheng Jing Yang-Yang He Zhi-Yan Han Institute for Cardiovascular Prevention(IPEK) Ludwig-Maximilians-University MunichMunichGermany DZHK(German Centre for Cardiovascular Research) partner site Munich Heart AllianceMunichGermany Department of Cardio-Pulmonary Circulation Shanghai Pulmonary HospitalTongji University School of MedicineShanghaiChina Department of Cardiology The First Affiliated HospitalChongqing Medical UniversityChongqingChina School of Pharmacy Henan UniversityHenanChina State Key Laboratory of Complex Severeand Rare Diseasesand Department of CardiologyPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina State Key Laboratory of Cardiovascular Disease and FuWai Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Objective/Background:Proliferation is a widely recognized trigger for pulmonary hypertension(PH),a life-threatening,progressive disorder of pulmonary blood *** study was aimed to identify some proliferation associated genes/targets for better comprehension of PH ***:Human pulmonary arterial smooth muscle cells(hPASMCs)were cultured in the presence or absence of human recombinant platelet derived growth factor(rhPDGF)-*** were collected for metabolomics or transcriptomics *** profiling of lungs of PH rats after hypoxia exposure or of PH patients were retrieved from GEO ***:90 metabolites(VIP score>1,fold change>2 or2 or<0.5 and p<.05).152 differentially expressed MAGs were then determined,out of which 9 hub genes(IL6,CXCL8,CCL2,CXCR4,CCND1,PLAUR,PLAU,HBEGF and F3)were defined as core proliferation associated hub genes in protein proten interaction *** addition,the hub gene-based LASSO model can predict the occurrence of PH(AUC=0.88).The expression of CXCR4,as one of the hub genes,was positively correlated to immune cell ***:Our findings revealed some key proliferation associated genes in PH,which provide the crucial information concerning complex metabolic reprogramming and inflammatory modulation in response to proliferation signals and might offer therapeutic gains for PH.

关键词： metabolism associated genes metabolomics proliferation pulmonary hypertension transcriptomics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Arterial thrombosis in the context of HCV-associated vascular disease can be prevented by protein C

引用

Cellular & Molecular Immunology 2017年第12期14卷 986-996页

作者： Philipp Blüm Joachim Pircher Monika Merkle Thomas Czermak Andrea Ribeiro Hanna Mannell Florian Krötz Alexander Hennrich Michael Spannagl Simone Köppel Erik Gaitzsch Markus Wörnle Medizinische Klinik und Poliklinik IV InnenstadtKlinikum der Universität München80336 MünchenGermany Walter Brendel Centre of Experimental Medicine and munich heart alliance Ludwig Maximilians University München80336 MünchenGermany Medizinische Klinik und Poliklinik I Klinikum der Universität München80336 MünchenGermany Abteilung für Transfusionsmedizin Zelltherapeutika und HämostaseologieKlinikum der Universität München80336 MünchenGermany

Hepatitis C virus(HCV)infection is a major problem *** is not limited to liver disease but is frequently complicated by immune-mediated extrahepatic manifestations such as glomerulonephritis or vasculitis.A fatal complication of HCV-associated vascular disease is ***:polyribocytidylic acid(poly(I:C)),a synthetic analog of viral RNA,induces a Toll-like receptor 3(TLR3)-dependent arteriolar thrombosis without significant thrombus formation in venules in *** procoagulant effects are caused by increased endothelial synthesis of tissue factor and PAI-1 without platelet *** addition to human umbilical endothelial cells(HUVEC),human mesangial cells(HMC)produce procoagulatory factors,cytokines and adhesion molecules after stimulation with poly(I:C)or HCV-containing cryoprecipitates from a patient with a HCV infection as *** protein C(APC)is able to prevent the induction of procoagulatory factors in HUVEC and HMC in vitro and blocks the effects of poly(I:C)and HCV-RNA on the expression of cytokines and adhesion molecules in HMC but not in *** vivo,protein C inhibits poly(I:C)-induced arteriolar ***,endothelial cells are de facto able to actively participate in immune-mediated vascular thrombosis caused by viral ***,we provide evidence for the ability of protein C to inhibit TLR3-mediated arteriolar thrombosis caused by HCV infection.

关键词： hepatitis C thrombosis toll-like receptor 3

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Unmodified autologous stem cells at point of care for chronic myocardial infarction

引用

World Journal of Stem Cells 2019年第10期11卷 831-858页

作者： Alexander Haenel Mohamad Ghosn Tahereh Karimi Jody Vykoukal Dipan Shah Miguel Valderrabano Daryl G Schulz Albert Raizner Christoph Schmitz Eckhard U Alt heart and Vascular Institute Department of MedicineTulane University Health Science CenterNew OrleansLA 70112United States The Methodist Hospital Research Institute HoustonTX 77030United States Department of Radiology and Nuclear Medicine University Hospital Schleswig-HolsteinLübeck D-23562Germany Houston Methodist DeBakey heart and Vascular Center HoustonTX 77030United States Department of Translational Molecular Pathology MD Anderson Cancer CenterThe University of TexasHoustonTX 77030United States Institute of Anatomy Faculty of MedicineLMU MunichMunich D-80336Germany Isar Klinikum munich Munich D-80331Germany

BACKGROUND Numerous studies investigated cell-based therapies for myocardial infarction(MI).The conflicting results of these studies have established the need for developing innovative approaches for applying cell-based therapy for *** studies on animal models demonstrated the potential of fresh,uncultured,unmodified,autologous adipose-derived regenerative cells(UAADRCs)for treating acute *** contrast,studies on the treatment of chronic MI(CMI;>4 wk post-MI)with UA-ADRCs have not been published so *** several methods for delivering cells to the myocardium,retrograde delivery into a temporarily blocked coronary vein has recently been demonstrated as an effective *** To test the hypothesis that in experimentally-induced chronic myocardial infarction(CMI;>4 wk post-MI)in pigs,retrograde delivery of fresh,uncultured,unmodified,autologous adipose-derived regenerative cells(UA-ADRCs)into a temporarily blocked coronary vein improves cardiac function and *** The left anterior descending(LAD)coronary artery of pigs was blocked for 180 min at time point ***,either 18×106 UA-ADRCs prepared at“point of care”or saline as control were retrogradely delivered via an over-the-wire balloon catheter placed in the temporarily blocked LAD vein 4 wk after T0(T1).Effects of cells or saline were assessed by cardiac magnetic resonance(CMR)imaging,late gadolinium enhancement CMR imaging,and post mortem histologic analysis 10 wk after T0(T2).RESULTS Unlike the delivery of saline,delivery of UA-ADRCs demonstrated statistically significant improvements in cardiac function and structure at T2 compared to T1(all values given as mean±SE):Increased mean LVEF(UA-ADRCs group:34.3%±2.9%at T1 vs 40.4±2.6%at T2,P=0.037;saline group:37.8%±2.6%at T1 vs 36.2%±2.4%at T2,P>0.999),increased mean cardiac output(UA-ADRCs group:2.7±0.2 L/min at T1 vs 3.8±0.2 L/min at T2,P=0.002;saline group:3.4±0.3 L/min at T1 vs 3.6±0.3 L/min at T2,P=0.798),increased mean mass of the

关键词： Adipose tissue-derived regenerative cells Chronic myocardial infarction heart failure Stem cells Translational medicine Point of care cell therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：