Tracing the failing heart: dual genetic fate mapping for target identification

作     者：Yaw Asare Christian Stoppe Jürgen Bernhagen Yaw Asare;Christian Stoppe;Jürgen Bernhagen

作者机构：Institute for Stroke and Dementia Research(ISD)Klinikum der Universität München(KUM)Ludwig-Maximilian-University(LMU)81377 MunichGermany Department of AnesthesiologyIntensive CareEmergency and Pain MedicineUniversity Hospital Würzburg97080 WürzburgGermany Department of Cardiac Anesthesiology and Intensive Care MedicineGerman Heart Center CharitéBerlin13353 BerlinGermany Munich Cluster for Systems Neurology81377 MunichGermany Munich Heart Alliance80802 MunichGermany 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2023年第8卷第9期

页      面：3880-3882页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：J.B.received funding from Deutsche Forschungsgemeinschaft(DFG)grants DFG-SFB1123-A3,BE 1977/14-1 the Munich Cluster for Systems Neurology(DFG,EXC 2145 SyNergy-ID 390857198) well as from the German Center for Cardiovascular Diseases(DZHK) partner site Munich Heart Alliance(grant DZHK B 20-004 Extern-81×2600258) Y.A.acknowledges support from DFG grant SFB1123-B3 and AS 575/1-1 and C.S.received funding from DFG grant STO 1099/8-1 

主　　题：cardiovascular ventricular mortality 

摘      要：In a recent study published in Nature Genetics,1 Han and colleagues employed a dual genetic lineage tracing approach in combination with a model of heart failure(HF)to identify a key sub-population of endocardium-derived fibroblasts,which gives rise to excessive myofibroblast formation in a Wnt pathway-mediated manner and contributes to cardiac fibrosis.1 The identified fibroblast sub-population and Wnt signaling pathway could be novel targets for the therapy of *** in risk management and cardiovascular inter-vention have significantly reduced age-specific cardiovascular disease-related *** contrast,the rate of HF-related hospitalisations has increased over the past decades and HF is a disease with highest social and economic cost in industrialized *** is defined as impairment of the heart’s blood pumping function and its severity is assessed based on ejection *** often occurs after myocardial infarction(MI),with infarct size and quality of ventricular remodeling after MI influencing ventricular *** of HF also include hypertension,atrial fibrillation,and cardiomyopathies(Fig.1).Especially elderly patients with recurrent MI and comorbidities are increasingly presenting with signs of HF.