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A new horizon for neuroscience:terahertz biotechnology in brain research

Neural Regeneration Research 2025年第2期20卷 309-325页

作者： Zhengping Pu Yu Wu Zhongjie Zhu Hongwei Zhao Donghong Cui Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry Kangci Hospital of JiaxingTongxiangZhejiang ProvinceChina Shanghai Synchrotron Radiation facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied PhysicsChinese Academy of ScienceShanghaiChina National facility for Protein Science in Shanghai Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina

Terahertz biotechnology has been increasingly applied in various biomedical fields and has especially shown great potential for application in brain *** this article,we review the development of terahertz biotechnology and its applications in the field of *** evidence indicates promising prospects for the use of terahertz spectroscopy and terahertz imaging techniques in the diagnosis of amyloid disease,cerebrovascular disease,glioma,psychiatric disease,traumatic brain injury,and myelin *** vitro and animal experiments have also demonstrated the potential therapeutic value of terahertz technology in some neuropsychiatric *** the precise underlying mechanism of the interactions between terahertz electromagnetic waves and the biosystem is not yet fully understood,the research progress in this field shows great potential for biomedical noninvasive diagnostic and therapeutic ***,the biosafety of terahertz radiation requires further exploration regarding its two-sided efficacy in practical *** review demonstrates that terahertz biotechnology has the potential to be a promising method in the field of neuropsychiatry based on its unique advantages.

关键词： biological effect brain neuron neuropsychiatry neuroscience non-thermal effect terahertz imaging terahertz radiation terahertz spectroscopy terahertz technology

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Organic fluorescent probes for live-cell super-resolution imaging

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Frontiers of Optoelectronics 2023年第4期16卷 25-36页

作者： Xinxin Duan Meng Zhang Yu‑Hui Zhang Britton Chance Center for biomedical Photonics MoE Key Laboratory for Biomedical PhotonicsAdvanced Biomedical Imaging Facility-Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhan 430074China

The development of super-resolution technology has made it possible to investigate the ultrastructure of intracellular organelles by fuorescence microscopy,which has greatly facilitated the development of life sciences and *** realize super-resolution imaging of living cells,both advanced imaging systems and excellent fuorescent probes are *** fuorescent probes have good availability,but that is not the case for probes for live-cell super-resolution *** this review,we frst introduce the principles of various super-resolution technologies and their probe requirements,then summarize the existing designs and delivery strategies of super-resolution probes for live-cell imaging,and fnally provide a brief conclusion and overview of the future.

关键词： Super-resolution imaging Organic fluorescent dyes-Live-cell imaging Cell-impermeable organic probes

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Tissue optical clearing for neural regeneration research

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Neural Regeneration Research 2023年第9期18卷 1940-1941页

作者： Tingting Yu Jianyi Xu Dan Zhu Britton Chance Center for biomedical Photonics-MoE Key Laboratory for biomedical Photonics Wuhan National Laboratory for Optoelectronics-Advanced biomedical imaging facility Huazhong University of Science and TechnologyWuhanHubei ProvinceChina Optics Valley Laboratory WuhanHubei ProvinceChina

Nerve injury,whether traumatic or degenerative,disrupts the transmission of information in the nervous syste m,leading to *** is widely known that neural regeneration is vital to the restoration of function after nerve ***,outcomes are often limited by the misguidance of axonal regeneration and complex pathological changes in neurons and glia,as well as the longterm denervation of target organs.

关键词： organs neural traumatic

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Photostimulation of lymphatic clearance ofβ‑amyloid from mouse brain:a new strategy for the therapy of Alzheimer’s disease

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Frontiers of Optoelectronics 2023年第4期16卷 179-190页

作者： Dongyu Li Hao Lin Silin Sun Shaojun Liu Zhang Liu Yuening He Jingtan Zhu Jianyi Xu Oxana Semyachkina‑Glushkovskaya Tingting Yu Dan Zhu Britton Chance Center for biomedical Photonics-MoE Key Laboratory for biomedical Photonics Wuhan National Laboratory for Optoelectronics-Advanced Biomedical Imaging FacilityHuazhong University of Science and TechnologyWuhan 430074China School of Optical Electronic Information Huazhong University of Science and TechnologyWuhan 430074China Department of Biology Saratov State UniversitySaratov 410012Russia

Alzheimer’s disease(AD)is an age-related neurodegenerative disorder that poses a signifcant burden on socio-economic and healthcare systems ***,the currently available therapy of AD is limited,and new strategies are needed to enhance the clearance ofβ-amyloid(Aβ)protein and improve cognitive ***(PBM)is a noninvasive and efective therapeutic method that has shown promise in treating various brain ***,we demonstrate that 1267-nm PBM signifcantly alleviates cognitive decline in the 5xFAD mouse model of AD and is safe as it does not induce a signifcant increase in cortical ***,with the combination of 3D tissue optical clearing imaging and automatic brain region segmentation,we show that PBM-mediated reductions of Aβplaques in diferent subregions of prefrontal cortex and the hippocampus are *** PBM-induced lymphatic clearance of Aβfrom the brain is associated with improvement of memory and cognitive functions in 5xFAD *** results suggest that the modulation of meningeal lymphatic vessels(MLVs)should play an important role in promoting Aβ***,this pilot study demonstrates that PBM can safely accelerate lymphatic clearance of Aβfrom the brain of 5xFAD mice,promoting improvement of neurocognitive status of AD animals suggesting that PBM can be an efective and bedside therapy for AD.

关键词： Photostimulation-Meningeal lymphatic vessels Amyloid-βclearance Alzheimer's disease

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Tissue optical clearing imaging for structural changes of neuromuscular junctions after mice ischemic stroke[Invited]

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Chinese Optics Letters 2023年第12期21卷 54-60页

作者：徐健壹戴奕宣昂姚应涛刘少军俞婷婷朱䒟 Britton Chance Center for biomedical Photonics MoE Key Laboratory for Biomedical PhotonicsWuhan National Laboratory for OptoelectronicsAdvanced Biomedical Imaging FacilityHuazhong University of Science and TechnologyWuhan 430074China

Ischemic stroke causes long-term disability and results in motor *** impairments are associated with structural changes in the neuromuscular junction(NMJ),including detailed morphology and three-dimensional(3D)***,previous studies only explored morphological changes of individual NMJs after stroke,which limits the understanding of their role in post-stroke motor ***,we examine 3D distributions and detailed morphology of NMJs in entire mouse muscles after unilateral and bilateral strokes induced by *** results show that 3D distributions and numbers of NMJs do not change after stroke,and severe unilateral stroke causes similar levels of NMJ fragmentation and area enlargement to bilateral *** research provides structural data,deepening the understanding of neuromuscular pathophysiology after stroke.

关键词： tissue optical clearing optical imaging stroke neuromuscular junction

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Tuning the fields focused by a high NA lens using spirally polarized beams(Invited Paper)

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Chinese Optics Letters 2017年第3期15卷 51-54页

作者： F.Wackenhut B.Zobiak A.J.Meixner A.V.Failla Eberhard Karls University Tübingen Institute of Physical and Theoretical Chemistry University Medical Center Hamburg-Eppendorf UKE Microscopy Imaging Facility

We show the power of spirally polarized doughnut beams as a tool for tuning the field distribution in the focus of a high numerical aperture （NA） lens. Different and relevant states of polarization as well as field distributions can be created by the simple turning of a λ/2 retardation wave plate placed in the excitation path of a micro- scope. The realization of such a versatile excitation source can provide an essential tool for nanotechnology investigations and biomedical experiments.

关键词： Tuning the fields focused by a high NA lens using spirally polarized beams high

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Contractile apparatus dysfunction early in the pathophysiology of diabetic cardiomyopathy

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World Journal of Diabetes 2015年第7期6卷 943-960页

作者： Mark T Waddingham Amanda J Edgley Hirotsugu Tsuchimochi Darren J Kelly Mikiyasu Shirai James T Pearson Department of Medicine St Vincent’s HospitalUniversity of Melbourne Department of Physiology Monash University Department of Cardiac Physiology National Cerebral and Cardiovascular Center Research Institute monash biomedical imaging facility Monash University Australian Synchrotron

Diabetes mellitus significantly increases the risk of cardiovascular disease and heart failure in *** of hypertension and coronary artery disease,diabetes is associated with a specific cardiomyopathy,known as diabetic cardiomyopathy(DCM).Four decades of research in experimental animal models and advances in clinical imaging techniques suggest that DCM is a progressive disease,beginning early after the onset of type 1 and type 2 diabetes,ahead of left ventricular remodeling and overt diastolic *** the molecular pathogenesis of early DCM still remains largely unclear,activation of protein kinase C appears to be central in driving the oxidative stress dependent and independent pathways in the development of contractile *** subcellular alterations to the cardiomyocyte are now being highlighted as critical events in the early changes to the rate of force development,relaxation and stability under pathophysiological *** changes include perturbed calcium handling,suppressed activity of aerobic energy producing enzymes,altered transcriptional and posttranslational modification of membrane and sarcomeric cytoskeletal proteins,reduced actin-myosin cross-bridge cycling and dynamics,and changed myofilament calcium *** this review,we will present and discuss novel aspects of the molecular pathogenesis of early DCM,with a special focus on the sarcomeric contractile apparatus.

关键词： Diabetes Prediabetes Insulin resistance Myocardium Sarcomere Protein kinase C Rho kinase

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Light sheet fluorescence microscopy: Advancing biological discovery with more dimensions, higher speed, and lower phototoxicity

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The Innovation 2024年第5期5卷 29-30页

作者： Yao Zhou Shiqi Mao Peng Fei School of Optical and Electronic Information-Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China Advanced biomedical imaging facility Huazhong University of Science and TechnologyWuhan 430074China

TO SEE THE WORLD IN A GRAIN OF *** microscopy has proved to be essential for seeing life in a grain of a *** epifluorescence microscopes,such as wide-field microscopes and laser scanning confocal microscopes,have been widely used for biology research over the past few *** goal of fluorescence microscopy is to observe the structure and function of cellular events across time and threedimensional(3D)space with spatiotemporal resolution as high as ***,conventional epifluorescence microscopes illuminate the entire 3D volume of the sample while detecting signals only from the 2D focal plane,thereby leading to low photon utilization and high phototoxicity issues that notably prevent high-resolution imaging of live biological specimens(Figure 1A).It becomes increasingly noteworthy that the massively emerging biomedical applications are posing significant challenges to current fluorescence microscopy techniques.

关键词： fluorescence dimensions Figure

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X-ray phase-sensitive microscope imaging with a grating interferometer:Theory and simulation

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Chinese Physics B 2022年第9期31卷 652-657页

作者： Jiecheng Yang Peiping Zhu Dong Liang Hairong Zheng Yongshuai Ge Research Center for Medical Artificial Intelligence Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Platform of Advanced Photon Source Technology R&D Laboratory of X-ray Optics and TechnologyBeijing Synchrotron Radiation FacilityInstitute of High Energy PhysicsChinese Academy of SciencesBeijing100049China Beijing Advanced Innovation Center for imaging Theory and Technology Capital Normal UniversityBeijing 100048China Paul C Lauterbur Research Center for biomedical imaging Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China4.Paul C Lauterbur Research Center for Biomedical ImagingShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

A general theoretical framework is presented to explain the formation of the phase signal in an x-ray microscope integrated with a grating interferometer,which simultaneously enables the high spatial resolution imaging and the improved image *** using this theory,several key parameters of phase contrast imaging can be predicted,for instance,the fringe visibility and period,and the conversion condition from the differential phase imaging(DPI)to the phase difference imaging(PDI).Additionally,numerical simulations are performed with certain x-ray optical components and imaging *** with the available experimental measurement[***.113063105(2018)]demonstrates the accuracy of this developed quantitative analysis method of x-ray phase-sensitive microscope imaging.

关键词： x-ray phase contrast imaging x-ray microscope grating interferometer

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Preface–Introduction to the Special Issue for Chinese-Russian Workshop on Biophotonics and biomedical Optics

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Journal of Innovative Optical Health Sciences 2024年第5期17卷 1-3页

作者： Tingting Yu Dan Zhu Valery V.Tuchin Britton Chance Center for biomedical Photonics-MoE Key Laboratory for biomedical Photonics Advanced Biomedical Imaging FacilityWuhan National Laboratory for Optoelectronics–Advanced Biomedical Imaging FacilityHuazhong University of Science and TechnologyWuhan 430074China Department of Optics and Biophotonics Science Medical CenterSaratov State UniversitySaratov 410012Russia Laboratory of Laser Diagnostics of Technical and Living Systems Institute of Precision Mechanics and ControlFRC“Saratov Scientic Centre of the Russian Academy of Sciences”Saratov 410028Russia Laboratory of Laser Molecular imaging and Machine Learning Tomsk State UniversityTomsk 634050Russia

The Chinese-Russian Workshop on Biophotonics and biomedical Optics 2023 was held online twice on 18–21 September and 25–26 September *** bilateral workshop brought together both Russian and Chinese scientists,engineers,and clinical researchers from a variety of disciplines engaged in applying optical science,photonics,and imaging technologies to problems in biology and *** the workshops,two plenary lectures and twenty invited presentations were *** special issue selects some papers from both Russian and Chinese sides,consisting of one review and seven original research articles.

关键词： Russian photonics biomedical

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