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Medical micro-and nanomotors in the body

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Acta Pharmaceutica Sinica B 2023年第2期13卷 517-541页

作者： Huaan Li Fei Peng Xiaohui Yan Chun Mao Xing Ma Daniela A.Wilson Qiang He Yingfeng Tu Department of Pharmacy Zhujiang HospitalSouthern Medical UniversityGuangzhou 510280China School of Pharmaceutical Science Guangdong Provincial Key Laboratory of New Drug ScreeningSouthern Medical UniversityGuangzhou 510515China School of Materials Science and Engineering Sun Yat-Sen UniversityGuangzhou 510275China State Key Laboratory of molecular Vaccinology and molecular Diagnostics&Centre for molecular Imaging and Translational Medicine School of Public HealthXiamen UniversityXiamen 361005China National and Local Joint Engineering research center of Biomedical Functional Materials School of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023China Sauvage Laboratory for Smart Materials School of Materials Science and EngineeringHarbin Institute of Technology(Shenzhen)Shenzhen 518055China Institute for Molecules and Materials Radboud UniversityNijmegen6525 AJthe Netherlands Key Laboratory of Microsystems and Microstructures Manufacturing(Ministry of Education) School of Medicine and HealthHarbin Institute of TechnologyHarbin 150080China

Attributed to the miniaturized body size and active mobility,micro-and nanomotors(MNMs)have demonstrated tremendous potential for medical ***,from bench to bedside,massive efforts are needed to address critical issues,such as cost-effective fabrication,on-demand integration of multiple functions,biocompatibility,biodegradability,controlled propulsion and in vivo ***,we summarize the advances of biomedical MNMs reported in the past two decades,with particular emphasis on the design,fabrication,propulsion,navigation,and the abilities of biological barriers penetration,biosensing,diagnosis,minimally invasive surgery and targeted cargo *** perspectives and challenges are discussed as *** review can lay the foundation for the future direction of medical MNMs,pushing one step forward on the road to achieving practical theranostics using MNMs.

关键词： Micro-and nanomotors Function integration Controlled propulsion In vivo navigation Biomedical applications Minimally invasive microsurgery Biosensing Biological barrier penetration

COVID-19康复者持续恢复趋势下的部分异常:一项2年随访研究

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Science Bulletin 2022年第15期67卷 1556-1561,M0004页

作者：林浩刘雪媛孙合张杰董少波刘茂顺李蕾田金珉郭雅欣甘金籼陈章馥王鑫林颖张丹妮刘亚宁张小山刘培培徐柯周翔天梁浩高福刘军武桂珍 National Health Commission Key Laboratory of Biosafety Research Unit of Adaptive Evolution and Control of Emerging VirusesChinese Academy of Medical SciencesNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Department of Epidemiology School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012China Department of Laboratory Medicine The Second Medical Center&National Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalBeijing 100853China Macheng center for Disease Control and Prevention Huanggang 438300China College of Laboratory Medicine and Life Sciences Wenzhou Medical UniversityWenzhou 325035China School of Ophthalmology and Optometry Wenzhou Medical UniversityWenzhou 325027China Collaborative Innovation center of Regenerative Medicine and Medical Biological Resources Development and Application Guangxi Medical UniversityNanning 530021China CAS Key Laboratory of Pathogen microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China center for Biosafety Mega-Science Chinese Academy of SciencesWuhan 430071China

对COVID-19康复患者健康水平和康复后生活质量的评估是值得关注的重要问题.本研究建立了COVID-19康复者的随访队列,进行问卷调查和血液样本检测,血液指标共55项.参与者为2020年初大流行早期阶段湖北省麻城市的COVID-19患者(n=136),同时... 详细信息

对COVID-19康复患者健康水平和康复后生活质量的评估是值得关注的重要问题.本研究建立了COVID-19康复者的随访队列,进行问卷调查和血液样本检测,血液指标共55项.参与者为2020年初大流行早期阶段湖北省麻城市的COVID-19患者(n=136),同时纳入对照人群(n=125).康复1年后,60.5%报告至少存在一种不适症状,2年后该比例下降至47.5%.在急性期异常的白细胞、血小板、胆红素等指标,1年后基本恢复正常并在2年随访时保持.部分康复者血红蛋白、肌酐等在1年后异常,但多在2年后恢复.少数康复者肌红蛋白、碱性磷酸酶等指标在康复2年仍未完全恢复正常.本研究结果提示,对于新冠康复者需要合理的健康干预措施和较长的后续行动以促进康复.

关键词：康复者随访研究康复患者健康干预后续行动肌红蛋白碱性磷酸酶血液指标

Global view of transcriptome in the brains of aged NR2B transgenic mice

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Neural Regeneration research 2013年第29期8卷 2734-2743页

作者： Chunxia Li Men Su Huimin Wang Yinghe Hu Key Lab of Brain Functional Genomics MOE&STCSMInstitute of Cognitive NeuroscienceEast China Normal University Shanghai Engineering research center for molecular Therapeutics and New Drug Development East China Normal University

NR2B subunits are involved in regulating aging, in particular, age-related learning and memory deficits. We examined 19-month-old NR2B transgenic mice and their littermate controls. First, we detected expression of the NR2B subunit gene, Grin2b, in the neocortex of transgenic mice using real-time PCR. Next, we used microarrays to examine differences in neocortical gene expression. Pathway and signal-net analyses identified multiple pathways altered in the transgenic mice, in-cluding the P53, Jak-STAT, Wnt, and Notch pathways, as well as regulation of the actin cytoskeleton and neuroactive ligand-receptor interactions. Further signal-net analysis highlighted the P53 and insulin-like growth factor pathways as key regulatory pathways. Our results provide new insight into understanding the molecular mechanisms of NR2B regulated age-related memory storage, normal organismal aging and age-related disease.

关键词： neural regeneration memorygrowth factor grants-supportedNR2B transgenic mice aging gene expression P53 insulin-likepaper neuroregeneration

Engineering G-quadruplex aptamer to modulate its binding specificity

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National Science Review 2021年第4期8卷 107-113页

作者： Long Li Shujuan Xu Xueyu Peng Yuzhuo Ji He Yan Cheng Cui Xiaowei Li Xiaoshu Pan Lu Yang Liping Qiu Jianhui Jiang Weihong Tan Department of Chemistry and Department of Physiology and Functional Genomics Center for Research at the Bio/Nano Interface Health Cancer Center UF Genetics InstituteMcKnight Brain Institute University of Florida molecular Science and Biomedicine Laboratory State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical Engineering College of Biology Aptamer Engineering Center of Hunan ProvinceHunan University molecular Science and Biomedicine Laboratory(MBL) State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical Engineering College of Biology Aptamer Engineering Center of Hunan ProvinceHunan University Institute of molecular Medicine(IMM) Renji HospitalShanghai Jiao Tong University School of Medicine and College of Chemistry and Chemical EngineeringShanghai Jiao Tong University

The use of aptamers in bioanalytical and biomedical applications exploits their ability to recognize cell surface protein receptors. Targeted therapeutics and theranostics come to mind in this regard. However,protein receptors occur on both cancer and normal cells; as such, aptamers are now taxed with identifying high vs. low levels of protein expression. Inspired by the flexible template mechanism and elegant control of natural nucleic acid-based structures, we report an allosteric regulation strategy for constructing a structure-switching aptamer for enhanced target cell recognition by engineering aptamers with DNA intercalated motifs(i-motifs) responsive to the microenvironment, such as p H. Structure-switching sensitivity can be readily tuned by manipulating i-motif sequences. However, structure-switching sensitivity is difficult to estimate, making it equally difficult to effectively screen modified aptamers with the desired sensitivity. To address this problem, we selected a fluorescent probe capable of detecting G-quadruplex in complicated biological media.

关键词： G-quadruplex aptamer i-motif binding specificity cell microenvironment

Mechanochemistry in cancer cell metastasis

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Chinese Chemical Letters 2019年第1期30卷 7-14页

作者： Di Zhang Feng Feng Ruping Liu Wenjia Zhu Li Yao State Key Laboratory for Structural Chemistry of Unstable and Stable Species CAS Research/Education Center for Excellence in Molecular Sciences Institute of Chemistry Chinese Academy of Science University of Chinese Academy of Sciences Beijing Institute of Graphic Communication

Metastasis is the leading cause of death in people with cancer. In the series of steps comprising metastasis process, mechanochemistry plays crucial roles. In this review, we introduced the mechanical factors in cancer cell metastasis, intracellular mechanical sensors and methods for measuring the mechanical forces of tumor cells. The recent researches on the contribution of mechanochemistry to metastasis and future perspectives were summarized.

关键词： Mechanochemistry Mechanical force Adhesion Migration Tumor metastasis

OBSERVATION OF DNA PARTIAL DENATURATION BY ATOMIC FORCE MICROSCOPY

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Chinese Journal of Polymer Science 2004年第2期22卷 117-122页

作者：徐坚 State Key Laboratory of Polymer Physics and Chemistry The Center for Molecular Science Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China

Atomic force microscopy was used to investigate the DNA-cetyltrimethylammonium bromide (CTAB) complexes adsorbed on highly ordered pyrolytic graphite (HOPG). These complexes, at low concentrations, can automatically spread out on the surface of HOPG. The DNA-CTAB complexes display a typically extended structure rather than a globular structure. Partially denaturated DNA produced by binding CTAB to DNA is directly observed by AFM with high resolution. The three-dimensional resolution of partially denaturated DNA obtained by AFM is not available by any other technique at present.

关键词： DNA Denaturation Extended-structure AFM

Emerging role of the orphan nuclear receptor estrogen-related receptor gamma in liver metabolic diseases

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Liver research 2019年第2期3卷 99-105页

作者： Don-Kyu Kim Hueng-Sik Choi Department of molecular Biotechnology Chonnam National UniversityGwangjuRepublic of Korea National Creative research Initiatives center for Nuclear Receptor Signals Hormone Research CenterSchool of Biological Sciences and TechnologyChonnam National UniversityGwangjuRepublic of Korea

Estrogen-related receptor gamma(ERRg)is one of three members of the ERR family and remains an orphan,as there are no known natural *** is an inducible transcription factor,and its ligandindependent transcriptional activity is regulated by co-regulator interactions and post-transcriptional *** findings from animal models show that ERRg,as a downstream mediator of multiple extracellular signals,plays a key role in coordinating endocrine and metabolic signals,resulting in changes in glucose,alcohol,lipid,and iron metabolism in the ***,dysregulation of this receptor contributes to the pathogenesis of metabolic diseases such as hyperglycemia,insulin resistance,and alcoholic liver ***,ERRg is also involved in responses to bacterial *** findings establish the importance of ERRg in the endocrine and metabolic control of liver metabolism,and suggest that ERRg may be a promising therapeutic target for metabolic diseases of the liver.

关键词： Orphan nuclear receptor Estrogen-related receptor gamma(ERRg) Gene regulation Cell signaling Liver metabolism

Synthesis and Interfacial Properties of Bio-Based Zwitterionic Surfactants Derived from Different Fatty Acids in Non-Edible Vegetable Oils

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Journal of Renewable Materials 2020年第4期8卷 417-429页

作者： Hongze Gang Qiqi Zhang Wei Wang Bangxin Cai Jinfeng Liu Shizhong Yang Bozhong Mu State Key Laboratory of Bioreactor Engineering School of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai200237China Engineering research center MEOR-MOE Shanghai Collaborative Innovation Center for Biomanufacturing TechnologyEast China University of Science and TechnologyShanghai200237China

Waste cooking oils and non-edible vegetable oils are abundant and renewable resources for bio-based materials which have showed great potential applications in many *** this study,five fatty acids commonly found in non-edible vegetable oils,including palmitic acid,stearic acid,linoleic acid,linolenic acid,ricinoleic acid,and their mixtures,were used to produce bio-based zwitterionic surfactants through a facile and high-yield chemical *** surfactants demonstrated excellent surface/interfacial properties with the minimum surface tensions ranging from 28.4 mN/m to 32.8 mN/m in aqueous *** interfacial tensions between crude oil and surfactant solutions were remarkably reduced to lower values ranging from 0.0028 mN/m to 0.1983 mN/m without the aid of extra alkali,which particularly implied a great potential application in enhanced oil ***,these bio-based surfactants also showed good wetting properties(contact angles of~51°comparing with that of double distilled water,92.04°)and appropriate predicted biodegradability(degradation order of“weeks”for bio-based surfactants synthesized from saturated fatty acids,and“months”for those synthesized from unsaturated fatty acids).Bio-based surfactants synthesized from unsaturated fatty acids showed better interfacial properties in reducing interfacial tension between crude oil and formation *** bio-based surfactants presented in this study are alternative substitutes for traditional petroleum-based surfactants in various surfactant application fields.

关键词： Bio-based surfactants zwitterionic surfactants fatty acid non-edible oil interfacial properties

Interpretation of breast cancer screening guideline for Chinese women

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Cancer Biology & Medicine 2019年第4期16卷 825-835页

作者： Yubei Huang Zhongsheng Tong Kexin Chen Ying Wang Peifang Liu Lin Gu Juntian Liu Jinpu Yu Fengju Song Wenhua Zhao Yehui Shi Hui Li Huaiyuan Xiao Xishan Hao Department of Epidemiology and Statistics Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin 300060China Medicine Department of Breast Oncology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin 300060China China Anti-Cancer Association Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin 300060China Department of Breast Imaging Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin 300060China The 2nd Surgery Department of Breast Oncology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin 300060China Cancer Prevention center Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin 300060China Cancer molecular Diagnostics Core Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin 300060China Department of Gastrointestinal Cancer Biology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin 300060China Department of research and Education Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin 300060China

Breast cancer is the most common malignant tumor in Chinese *** screening is the best way to improve the rates of early diagnosis and survival of breast cancer *** peak onset age for breast cancer in Chinese women is considerably younger than those in European and American *** is imperative to develop breast cancer screening guideline that is suitable for Chinese *** summarizing the current evidence on breast cancer screening in Chinese women,and referring to the latest guidelines and consensus on breast cancer screening in Europe,the United States,and East Asia,the China Anti-Cancer Association and National Clinical research center for Cancer(Tianjin Medical University Cancer Institute and Hospital)have formulated population-based guideline for breast cancer screening in Chinese *** guideline provides recommendations on breast cancer screening for Chinese women at average or high risk of breast cancer according to the following three aspects:age of screening,screening methods,and screening *** article provides more detailed information to support the recommendations in this guideline and to provide more direction for current breast cancer screening practices in China.

关键词： Breast cancer screening ultrasound mammography guideline