Sustained abnormality with recovery of COVID-19 convalescents:a 2-year follow-up study

作     者：Hao Lin Xueyuan Liu Heqiang Sun Jie Zhang Shaobo Dong Maoshun Liu Lei Li Jinmin Tian Yaxin Guo Jinxian Gan Zhangfu Chen Xin Wang Ying Lin Danni Zhang Yaning Liu Xiaoshan Zhang Peipei Liu Ke Xu Xiangtian Zhou Hao Liang George F.Gao William J.Liu Guizhen Wu 林浩;刘雪媛;孙合;张杰;董少波;刘茂顺;李蕾;田金珉;郭雅欣;甘金籼;陈章馥;王鑫;林颖;张丹妮;刘亚宁;张小山;刘培培;徐柯;周翔天;梁浩;高福;刘军;武桂珍

作者机构：National Health Commission Key Laboratory of BiosafetyResearch Unit of Adaptive Evolution and Control of Emerging VirusesChinese Academy of Medical SciencesNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Department of EpidemiologySchool of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012China Department of Laboratory MedicineThe Second Medical Center&National Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalBeijing 100853China Macheng Center for Disease Control and PreventionHuanggang 438300China College of Laboratory Medicine and Life SciencesWenzhou Medical UniversityWenzhou 325035China School of Ophthalmology and OptometryWenzhou Medical UniversityWenzhou 325027China Collaborative Innovation Center of Regenerative Medicine and Medical Biological Resources Development and ApplicationGuangxi Medical UniversityNanning 530021China CAS Key Laboratory of Pathogen Microbiology and ImmunologyInstitute of MicrobiologyChinese Academy of SciencesBeijing 100101China Center for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China 

出 版 物：《Science Bulletin》 (科学通报（英文版）)

年 卷 期：2022年第67卷第15期

页      面：1556-1561,M0004页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(82161148008 and 81971501) the National Key Research and Development Program of China(2021YFC2301400,2020YFA0708103,and 2021YFC0863300) the Excellent Young Scientist Program of the National Natural Science Foundation of China(81822040) 

主　　题：康复者 随访研究 康复患者 健康干预 后续行动 肌红蛋白 碱性磷酸酶 血液指标 

摘      要：对COVID-19康复患者健康水平和康复后生活质量的评估是值得关注的重要问题.本研究建立了COVID-19康复者的随访队列,进行问卷调查和血液样本检测,血液指标共55项.参与者为2020年初大流行早期阶段湖北省麻城市的COVID-19患者(n=136),同时纳入对照人群(n=125).康复1年后,60.5%报告至少存在一种不适症状,2年后该比例下降至47.5%.在急性期异常的白细胞、血小板、胆红素等指标,1年后基本恢复正常并在2年随访时保持.部分康复者血红蛋白、肌酐等在1年后异常,但多在2年后恢复.少数康复者肌红蛋白、碱性磷酸酶等指标在康复2年仍未完全恢复正常.本研究结果提示,对于新冠康复者需要合理的健康干预措施和较长的后续行动以促进康复.