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Systematic analysis of innate immune-related genes in the silkworm:Application to antiviral research

Insect Science 2025年第1期32卷 151-171页

作者： Junming Xia Ruoxuan Peng Shigang Fei Mian Muhammad Awais Wenxuan Lai Yigui Huang Hailin Wu Yue Yu Lingying Liang Luc Swevers Jingchen Sun Min Feng Guangdong Provincial Key Laboratory of Agro-Animal Genomics and molecular Breeding College of Animal ScienceSouth China Agricultural UniversityGuangzhouChina Insect molecular Genetics and Biotechnology National Center for Scientific Research DemokritosInstitute of Biosciences and ApplicationsAthensGreece

The silkworm,a crucial model organism of the Lepidoptera,offers an excellent platform for investigating the molecular mechanisms underlying the innate immune response of insects toward *** the years,researchers worldwide have identified numerous immune-related genes in ***,these identified silkworm immune genes are not well classified and not well known to the scientific *** the availability of the latest genome data of silkworms and the extensive research on silkworm immunity,it has become imperative to systematically categorize the immune genes of silkworms with different database *** this study,we present a meticulous organization of prevalent immune-related genes in the domestic silkworm,using the SilkDB 3.0 database as a reliable source for updated gene ***,utilizing the available data,we classify the collected immune genes into distinct categories:pattern recognition receptors,classical immune pathways,effector genes and ***-depth data analysis has enabled us to predict some potential antiviral ***,we performed antiviral experiments on selected genes,exploring their impact on Bombyx mori nucleopolyhedrovirus *** outcomes of this research furnish novel insights into the immune genes of the silkworm,consequently fostering advancements in the field of silkworm immunity research by establishing a comprehensive classification and functional understanding of immune-related genes in the *** study contributes to the broader understanding of insect immune responses and opens up new avenues for future investigations in the domain of host–pathogen interactions.

关键词： antiviral defense BmNPV Bombyx mori innate immunity SilkDB 3.0

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research and development of the pulse acquisition system and the pulse biomimetic reproduction system

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Journal of Traditional Chinese medicine 2025年第1期45卷 213-220页

作者： YI Kai MA Yunjing GUO Shen LIU Heng XU Bin the First Clinical College Liaoning University of Traditional Chinese Medicine research and Development Department Shenyang Traditional Chinese Medicine Intelligent Medical Equipment Industry Technology Research Institute

The paper is an introduction to the front-end pulse acquisition and the back-end pulse biomimetic reproduction system. This system is capable of faithfully replicating the complete pulse waveform collected at the front end. Traditional Chinese medicine(TCM) practitioners analyze and diagnose the pulse patterns at the replication end. Meanwhile, the obtained pulse waveforms are analyzed and learnt by a neural network based on key diagnostic points in TCM pulse taking, which enables the determination of the corresponding relationships between different pulse waveforms and various pulse patterns in TCM pulse taking. With the support of clinical samples, an auxiliary diagnostic system for TCM pulse patterns ensures the accuracy of pulse pattern replication.

关键词： medicine, Chinese traditional pulse acquisition system pulse biomimetic reproduction system pulse taking

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Promotion of chronic wound healing by plant-derived active ingredients and research progress and potential of plant polysaccharide hydrogels

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Chinese Herbal medicines 2025年第1期17卷 70-83页

作者： Ru Yan Yanhong Wang Weinan Li Jialin Sun School of Pharmacy Heilongjiang University of Chinese Medicine Key Laboratory of Basic and Application research of Beiyao Ministry of Education Heilongjiang University of Chinese Medicine Department of medicine Heilongjiang Minzu College Postdoctoral research Station Heilongjiang University of Chinese Medicine

Wound healing is a complex biochemical *** use of herbal medicine in wound healing not only carries forward the wisdom of traditional medicine,with its anti-inflammatory and immune-regulating effects,but also reflects the direction of modern biopharmaceutical technology,such as its potential in developing new biomaterials like *** article first outlines the inherent structural properties of healthy skin,along with the physiological characteristics related to chronic wounds in patients with diabetes and ***,the article delves into the latest advancements in clinical and experimental research on the impact of active constituents in herbal medicine on wound tissue regeneration,summarizing existing studies on the mechanisms of various herbal medicines in the healing of diabetic and burn ***,the paper thoroughly examines the application and mechanisms of plant polysaccharide hydrogels containing active herbal compounds in chronic wound *** primary objective is to provide valuable resources for the clinical application and development of herbal medicine,thereby maximizing its therapeutic *** also represents the continuation of traditional medical wisdom,offering new possibilities for advancements in regenerative medicine and wound care.

关键词： active ingredient herbal medicine hydrogel polysaccharides in traditional herbal medicine wound healing

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Emerging potential of progranulin-dependent SorCS2 signaling in healthy and diseased nervous systems

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Neural Regeneration research 2025年第9期20卷 2591-2593页

作者： Alena Salasova Anders Nykjær Danish research Institute of Translational Neuroscience DANDRITE-Nordic EMBL Partnership for molecular medicine and Centre of Excellence PROMEMODepartment of BiomedicineAarhus UniversityAarhusDenmark

The formation of the mammalian nervous system and its maturation into sensory,motor,cognitive,and behavioral circuits is a complex process that begins during early embryogenesis and lasts until young *** neurodevelopm... 详细信息

关键词： progr jointly CS2

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Phosphodiesterase 9 localization in cytoplasm and nucleus:the gateway to selective targeting in neuroprotection?

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Neural Regeneration research 2025年第6期20卷 1701-1702页

作者： Giovanni Ribaudo Matteo Giannangeli Margrate Anyanwu Alessandra Gianoncelli Department of molecular and Translational medicine University of BresciaBresciaItaly

The umbrella term"neurodege ne rative disorders"(NDDs) refers to several conditions characterized by a progressive loss of structure and function of cells belonging to the nervous *** diseases affect more than 50million people *** disorders are characterized by sundry factors and pathophysiological mechanisms that a re challenging to be fully *** of these rely on cell signaling pathways to preserve homeostasis,involving second messengers such as cyclic adenosine monophosphate (cAMP)and cyclic guanosine 3',5'-monophosphate(cGMP).Their ability to control the duration and amplitude of the signaling cascade is given by the presence of several common and uncommon *** kinases A and G (PKA and PKG),phosphodiesterases (PDEs),and scaffold proteins are among them.

关键词： gateway homeostasis preserve

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Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration research 2025年第7期20卷 2013-2014页

作者： Nathanael J.Lee Ryota L.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of molecular medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

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Olfactory receptors in neural regeneration in the central nervous system

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Neural Regeneration research 2025年第9期20卷 2480-2494页

作者： Rafael Franco Claudia Garrigós Toni Capó Joan Serrano-Marín Rafael Rivas-Santisteban Jaume Lillo molecular Neurobiology Laboratory Department of Biochemistry and Molecular BiomedicineFacultat de BiologiaUniversitat de BarcelonaBarcelonaSpain CiberNed Network Center for Biomedical research in Neurodegenerative Diseases Spanish National Health Institute Carlos ⅢMadridSpain School of Chemistry Universitat de BarcelonaBarcelonaSpain Department of Biochemistry and Physiology School of Pharmacy and Food SciencesUniversitat de BarcelonaBarcelonaSpain Laboratory of Computational medicine Biostatistics UnitFaculty of MedicineAutonomous University of BarcelonaCampus BellaterraBarcelonaSpain

Olfactory receptors are crucial for detecting odors and play a vital role in our sense of smell,influencing behaviors from food choices to emotional *** receptors also contribute to our perception of flavor and have potential applications in medical diagnostics and environmental *** ability of the olfactory system to regenerate its sensory neurons provides a unique model to study neural regeneration,a phenomenon largely absent in the central nervous *** gained from how olfactory neurons continuously replace themselves and reestablish functional connections can provide strategies to promote similar regenerative processes in the central nervous system,where damage often results in permanent *** the molecular and cellular mechanisms underpinning olfactory neuron regeneration could pave the way for developing therapeutic approaches to treat spinal co rd injuries and neurodegenerative diseases like Alzheimer's *** ctory receptors are found in almost any cell of eve ry orga n/tissue of the mammalian *** ectopic expression provides insights into the chemical structures that can activate olfactory *** addition to odors,olfactory receptors in ectopic expression may respond to endogenous compounds and molecules produced by mucosal colonizing *** analysis of the function of olfactory receptors in ectopic expression provides valuable information on the signaling pathway engaged upon receptor activation and the receptor's role in proliferation and cell differentiation *** review explo res the ectopic expression of olfa ctory receptors and the role they may play in neural regeneration within the central nervous system,with particular attention to compounds that can activate these receptors to initiate regenerative *** suggests that olfactory receptors could serve as potential therapeutic targets for enhancing neural repair and recovery following central nervous syste

关键词： adenosine receptors adrenergic receptors ectopic expression G proteincoupled receptors glia neurons

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Promising effects of Persian shallot extract on the serum markers and blood pressure of patients with metabolic syndrome:a double-blinded randomized controlled trial

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Journal of Traditional Chinese medicine 2025年第1期45卷 100-106页

作者： Neda Naimipoor Zahra Bagheri-Hosseinabadi Mohammad Reza Hajizadeh Mitra Abbasifard Mohammad Reza Mirzaei Akram Ghadiri Anari Maryam Mohammad-Sadeghipour Mehdi Mahmoodi Department of Clinical Biochemistry School of MedicineRafsanjan University of Medical Sciences Department of Internal medicine School of MedicineAli-Ibn Abi-Talib HospitalRafsanjan University of Medical Sciences molecular medicine research Center Research Institute of Basic Medical SciencesRafsanjan University of Medical Sciences Diabetes research Center Shahid Sadoughi University of Medical Sciences Department of Clinical Biochemistry Afzalipour School of MedicineKerman University of Medical Sciences Physiology research Center Institute of NeuropharmacologyKerman University of Medical Sciences

OBJECTIVE: To evaluate the effect of Persian shallot extract on the serum markers and blood pressure of patients with metabolic syndrome(MetS). METHODS: Fifty patients with Met S diagnosis were randomly assigned to the intervention(Persian shallot extract) and the control(placebo) group. Both groups received treatment for three months. Before the study and at the end of the study, 5 mL peripheral blood was taken from each patient. The measured factors included total antioxidant capacity(TAC), superoxide dismutase enzyme(SOD), malondialdehyde, oxidized low-density lipoprotein(Ox-LDL), apolipoprotein H(Apo-H), fasting blood glucose(FBS), total cholesterol, triglycerides, high-density lipoprotein(HDL), LDL, and systolic and diastolic blood pressure. RESULTS: At baseline, the evaluated parameters were not significantly different between the intervention and control groups. At the end of the study, the mean serum levels of malondialdehyde and ox-LDL were significantly lower in the intervention group. The mean FBS, cholesterol, triglycerides, and LDL were significantly lower in the intervention group. The mean TAC and HDL were significantly higher in the intervention group(P < 0.05). Moreover, the intervention group significantly reduced systolic and diastolic blood pressure. No other significant association was observed. CONCLUSION: Persian shallot extract has several beneficial effects in Met S patients, including optimizing oxidative balance, reducing blood pressure, fasting blood sugar, and blood lipid profile.

关键词： antioxidants medicine, Persian metabolic syndrome shallots

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The emerging role of mesenchymal stem cell-derived extracellular vesicles to ameliorate hippocampal NLRP3 inflammation induced by binge-like ethanol treatment in adolescence

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Neural Regeneration research 2025年第4期20卷 1153-1163页

作者： Susana Mellado María JoséMorillo-Bargues Carla Perpiñá-Clérigues Francisco García-García Victoria Moreno-Manzano Consuelo Guerri María Pascual Department of Physiology School of Medicine and DentistryUniversity of ValenciaValenciaSpain Bioinformatics and Biostatistics unit Príncipe Felipe Research CenterValenciaSpain Neuronal and Tissue Regeneration Laboratory Príncipe Felipe Research CenterValenciaSpain

Our previous studies have reported that activation of the NLRP3(NOD-,LRR-and pyrin domain-containing protein 3)-inflammasome complex in ethanol-treated astrocytes and chronic alcohol-fed mice could be associated with neuroinflammation and brain *** stem cell-derived extracellular vesicles(MSC-EVs)have been shown to restore the neuroinflammatory response,along with myelin and synaptic structural alterations in the prefrontal cortex,and alleviate cognitive and memory dysfunctions induced by binge-like ethanol treatment in adolescent *** the therapeutic role of the molecules contained in mesenchymal stem cell-derived extracellular vesicles,the present study analyzed whether the administration of mesenchymal stem cell-derived extracellular vesicles isolated from adipose tissue,which inhibited the activation of the NLRP3 inflammasome,was capable of reducing hippocampal neuroinflammation in adolescent mice treated with binge *** demonstrated that the administration of mesenchymal stem cell-derived extracellular vesicles ameliorated the activation of the hippocampal NLRP3 inflammasome complex and other NLRs inflammasomes(e.g.,pyrin domain-containing 1,caspase recruitment domain-containing 4,and absent in melanoma 2,as well as the alterations in inflammatory genes(interleukin-1β,interleukin-18,inducible nitric oxide synthase,nuclear factor-kappa B,monocyte chemoattractant protein-1,and C–X3–C motif chemokine ligand 1)and miRNAs(miR-21a-5p,miR-146a-5p,and miR-141-5p)induced by binge-like ethanol treatment in adolescent *** analysis further revealed the involvement of miR-21a-5p and miR-146a-5p with inflammatory target genes and NOD-like receptor signaling *** together,these findings provide novel evidence of the therapeutic potential of MSC-derived EVs to ameliorate the hippocampal neuroinflammatory response associated with NLRP3 inflammasome activation induced by binge drinking in adolescence.

关键词： adolescence binge-like ethanol treatment extracellular vesicles hippocampus mesenchymal stem cells neuroinflammation NOD-,LRR-and pyrin domain-containing protein 3(NLRP3)

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Rapid and specific fluorescent probe visualizes dynamic correlation of Cys and HClO in OGD/R

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Chinese Chemical Letters 2025年第1期36卷 437-441页

作者： Pei Huang Weijie Zhang Junping Wang Fangjun Huo Caixia Yin Institute of molecular Science Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of EducationShanxi UniversityTaiyuan 030006China research Institute of Applied Chemistry Shanxi UniversityTaiyuan 030006China

Intracellular redox homeostasis is of indispensable importance in *** order to maintain the balance of the redox state within the cell,reactive oxygen species(ROS)and reactive sulfur species(RSS)react and transform with each other,and their levels also directly reflect the degree of oxidative stress and *** acid(HClO)and cysteine(Cys)usually co-exist in organisms,interacting with each other in many important physiological processes and synergistically maintaining the dynamic redox balance in the *** understand the relevance and pathophysiological effects of these two signaling molecules in oxidative stress,unique fluorescence imaging tools are ***,we designed and developed a dual-channel fluorescent probe HP,for the individual and continuous detection of HClO and *** probe could simultaneously monitor the changes in the concentrations of HClO and Cys in cells,and was characterized by a fast response,high sensitivity and high selectivity,especially compared with glutathione(GSH)and homocysteine(Hcy),the probe had a good specificity for ***,probe HP successfully observed dynamic changes in HCl O-and Cys-mediated redox status in the oxygenglucose deprivation/reperfusion(OGD/R)model of HeLa cells and dynamically monitored fluctuations in endogenous HClO levels in lipopolysaccharides(LPS)-induced peritonitis mice.

关键词： Redox homeostasis Dual-channel OGD/R Fluctuations Peritonitis

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