检索结果-南通市图书馆

MINIMIZING EXCITATION LIGHT LEAKAGE AND MAXIMIZING MEASUREMENT SENSITIVITY FOR molecular imaging WITH NEAR-INFRARED FLUORESCENCE

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Innovative Optical Health Sciences 2011年第3期4卷 301-307页

作者： BANGHE ZHU EVA M.SEVICK-MURACA Center for molecular imaging The Brown Foundation Institute of molecular Medicine The University of Texas Health Science Center at Houston Houston TX 77030USA

Near-infraredfluorescence(NIRF)imaging involves the separation of weakfluorescence signals from backscattered excitation *** measurement sensitivity of current NIRF imaging systems is limited by the excitation light leakage through *** this contribution,the authors demonstrate that the excitation light leakage can be suppressed upon using appropriatefilter combination and *** excitation light leakage and measurement sensitivity were assessed and compared in this study by computing the transmission ratios of excitation to emission light collected and the signal-to-noise ratios in well-controlled phantom studies with differentfilter combinations and *** appropriatefilter combinations and permutations,we observe as much as two orders of magnitude reduction in the transmission ratio and higher signal-to-noise ratio.

关键词： molecular imaging fluorescence opticalfilter excitation light leakage noise floor

Tumor molecular imaging with Nanoparticles

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Engineering 2016年第1期2卷 132-140页

作者： Zhen Cheng Xuefeng Ya Xilin Sun BaozhongShen Sanjiv Sam Gambhir a molecular imaging Program at Stanford Department of Radiology Stanford University Stanford CA 94305 USA molecular imaging research Center of Harbin Medical University Harbin 150001 China TOF-PET/CT/MR Center the Fourth Hospital of Harbin Medical University Harbin 150001 China ora Umverslty Stanford CA 94305 USA

molecular imaging(MI)can provide not only structural images using traditional imaging techniques but also functional and molecular information using many newly emerging imaging *** the past decade,the utilization of nanotechnology in MI has exhibited many significant advantages and provided new opportunities for the imaging of living *** is expected that multimodality nanoparticles(NPs)can lead to precise assessment of tumor biology and the tumor *** review addresses topics related to engineered NPs and summarizes the recent applications of these nanoconstructs in cancer optical imaging,ultrasound,photoacoustic imaging,magnetic resonance imaging(MRI),and radionuclide *** challenges involved in the translation of NPs to the clinic are discussed.

关键词： Tumor molecular imaging Nanoparticles

Mathematical method in optical molecular imaging

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2015年第3期58卷 4-16页

作者： LENG ChengCai TIAN Jie School of Mathematics and Information Sciences Nanchang Hangkong University Key Laboratory of molecular imaging Institute of Automation Chinese Academy of Sciences

Optical molecular imaging is an important technique of studies at molecular level and provides promising tools to non-invasively delineate in vivo physiological and pathological activities at cellular and molecular levels,and it has been widely used for diagnosing,managing diseases,metastasis detection and drug *** a mathematical perspective,this paper mainly focuses on the forward problem and inverse problem in biological tissues based on the radiative transfer equation(RTE).The forward problem is accustomed to describing photon propagation in biological tissues and the inverse problem is used to reconstruct internal source distribution from the signal detected on the external *** also introduce the detailed derivation of the RTE and Robin boundary condition and discretization of the forward problem,along with the reconstruction methods and iterative solution algorithms summarized for the inverse ***,the current and future challenges of optical molecular imaging are *** survey aims to construct a mathematical method,a state-of-the-art framework for optical molecular imaging,from which future research may benefit.

关键词： radiative transfer equation(RTE) regularization method source reconstruction optical molecular imaging mathematical method

Sequence-activated chemiluminescence probes: programmable illumination for high-contrast in vivo sensing and imaging

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2025年第01期 26-34页

作者： Yutao Zhang Juan Li Wei-Hong Zhu Zhiqian Guo Shanghai Key Laboratory of Functional Materials Chemistry Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Institute of Fine Chemicals School of Chemistry and Molecular Engineering East China University of Science and Technology State Key Laboratory of Bioreactor Engineering Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell MetabolismEast China University of Science & Technology

Sequence-activated chemiluminescence(CL) technique offers a unique approach to detecting specific biomolecules or cellular events with high sensitivity and spatial resolution. The fundamental principle behind sequence-activated CL probes involves tailoring highly-controllable CL signals in response to specific sequences or events of interest, thus enabling high-contrast signals under complex physiological conditions. This sequential activation could be triggered by enzymes, reactive oxygen species(ROS), biothiols or changes in the microenvironment. These unique sequence-activated CL probes bestow several advantages, including minimal background, deep-tissue penetration, and the ability of non-invasive or minimally invasive detection. The sequence-activated CL techniques represent a significant advancement in molecular imaging and diagnostics. In this mini-review, we focus on the latest developments in sequential CL probes, addressing the technical challenges and discussing the future trajectory by harnessing CL signaling and molecular recognition.

关键词：

同方期刊数据库

Application of machine learning method in optical molecular imaging: a review

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2020年第1期63卷 5-20页

作者： Yu AN Hui MENG Yuan GAO Tong TONG Chong ZHANG Kun WANG Jie TIAN CAS Key Laboratory of molecular imaging Beijing Key Laboratory of Molecular ImagingThe State Key Laboratory of Management and Control for Complex SystemsInstitute of Automation Chinese Academy of Sciences Beijing Advanced Innovation Center for Big Data-Based Precision Medicine School of MedicineBeihang University University of Chinese Academy of Sciences

Optical molecular imaging(OMI) is an imaging technology that uses an optical signal, such as near-infrared light, to detect biological tissue in organisms. Because of its specific and sensitive imaging performance, it is applied in both preclinical research and clinical surgery. However, it requires heavy data analysis and a complex mathematical model of tomographic imaging. In recent years, machine learning(ML)-based artificial intelligence has been used in different fields because of its ability to perform powerful data processing. Its analytical capability for processing complex and large data provides a feasible scheme for the requirement of OMI. In this paper, we review ML-based methods applied in different OMI modalities.

关键词： optical molecular imaging machine learning artificial intelligence

How crystal configuration affects the position detection accuracy in pixelated molecular SPECT imaging systems?

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2017年第4期28卷 24-30页

作者： Hojjat Mahani Gholamreza Raisali Alireza Kamali-Asl Mohammad Reza Ay Radiation Application research School Nuclear Science and Technology Research Institute Tehran Iran research Center for molecular and Cellular imaging Tehran University of Medical Science Tehran Iran Radiation Medicine Department Shahid Beheshti UniversityTehran Iran Department of Medical Physics and Biomedical Engineering Tehran University of Medical Science Tehran Iran

It is well known that inter-crystal scattering and penetration(ICS-P) are major spatial resolution limiting parameters in dedicated SPECT scanners with pixelated *** this study,the effect of ICS-P on crystal identification in different crystal configurations was evaluated using GATE Monte Carlo simulation.A ^(99m)Tc pencil-beam toward central crystal element was *** incident angle was assumed to vary from 0° to 45° in 5° *** effects of various crystal configurations such as pixel-size,pixel-gap,and crystal material were *** influence of photon energy on the crystal identification(CI) was also *** detection accuracy(PDA) was defined as a factor indicating performance of the ***,a set of ^(99m)Tc point-source simulations was performed in order to calculate peak-to-valley(PVR) ratio for each *** results show that the CsI(Na)manifests higher PDA than NaI(TI) and YAP(Ce).In addition,as the incident angle increases,the crystal becomes less accurate in positioning of the *** a crystal-dependent critical angle,the PDA monotonically *** PDA reaches 0.44 for the CsI(Na) at 45° beam *** PDAs obtained by the point-source evaluation also behave the same as for the pencil-beam *** addition,the PVRs derived from flood images linearly correlate their corresponding *** conclusion,quantitative assessment of ICS-P is mandatory for scanner design and modeling the system matrix during iterative reconstruction algorithms for the purpose of resolution modeling in ultra-high-resolution SPECT.

关键词： Monte Carlo GATE molecular SPECT Position detection accuracy Pixelated crystal

维普期刊数据库

Preclinical and clinical applications of specific molecular imaging for HER2-positive breast cancer

在线全文

学校读者我要写书评

暂无评论

Cancer Biology & Medicine 2017年第3期14卷 271-280页

作者： Wei Chen Xiaofeng Li Lei Zhu Jianjing Liu Wengui Xu Ping Wang Department of molecular imaging and Nuclear Medicine Department of Radiation Oncology Tianjin Medical University Cancer Institute and Hospital National Clinical research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin Tianjin's Clinical research Center for Cancer Tianjin 300060China

Precision medicine and personalized therapy are receiving increased attention, and molecular-subtype classification has become crucial in planning therapeutic schedules in clinical practice for patients with breast cancer. Human epidermal growth factor receptor 2(HER2) is associated with high-grade breast tumors, high rates of lymph-node involvement, high risk of recurrence, and high resistance to general chemotherapy. Analysis of HER2 expression is highly important for doctors to identify patients who can benefit from trastuzumab therapy and monitor the response and efficacy of treatment. In recent years, significant efforts have been devoted to achieving specific and noninvasive HER2-positive breast cancer imaging in vivo. In this work, we reviewed existing literature on HER2 imaging in the past decade and summarized the studies from different points of view, such as imaging modalities and HER2-specific probes. We aimed to improve the understanding on the translational process in molecular imaging for HER2 breast cancer.

关键词： Breast cancer human epidermal growth factor receptor 2(HER2) molecular imaging probes

维普期刊数据库

4-Nitrocatechol as a novel matrix for low-molecular-weight compounds in situ detection and imaging in biological tissues by MALDI-MSI

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第6期35卷 486-490页

作者： Hualei Xu Manman Han Haiqiang Liu Liang Qin Lulu Chen Hao Hu Ran Wu Chenyu Yang Hua Guo Jinrong Li Jinxiang Fu Qichen Hao Yijun Zhou Jinchao Feng Xiaodong Wang Key Laboratory of Mass Spectrometry imaging and Metabolomics(Minzu University of China) State Ethnic Affairs CommissionBeijing 100081China College of Life and Environmental Sciences Centre for Imaging&Systems BiologyMinzu University of ChinaBeijing 100081China

Low-molecular-weight(LMW)compounds are ubiquitous in living organisms and play essential roles in biological *** direct analysis of LMW compounds in biological tissues by matrix-assisted laser desorption/ionization mass spectrometry imaging(MALDI-MSI)could provide a more comprehensive understanding of their essential ***,we evaluated 4-nitrocatechol(4-NC)as a novel positive-ion matrix for enhancing in situ detection and imaging of LMW compounds from the rat liver,brain,and germinating Chinese-yew seed by *** results showed that the 4-NC possessed remarkable features,including strong ultraviolet absorption,uniform matrix crystal,excellent chemical stability,and fewer matrix-related background *** use of 4-NC led to the successful detection of 232,218,and193 LMW compounds from the three abovementioned tissue sections,***,the use of 4-NC improved the imaging quality of LMW compounds in tissue sections through MALDI-MSI and has the potential as a matrix for MALDI tissue imaging of LMW compounds.

关键词： MALDI-MSI 4-Nitrocatechol LMW compounds In situ detection Tissue imaging

维普期刊数据库

Diffusion magnetic resonance imaging: A molecular imaging tool caught between hope, hype and the real world of “personalized oncology”

在线全文

学校读者我要写书评

暂无评论

World Journal of Radiology 2017年第6期9卷 253-268页

作者： Abhishek Mahajan Sneha S Deshpande Meenakshi H Thakur Department of Radiodiagnosis and imaging Tata Memorial Hospital Tata Memorial Centre Department of Radiodiagnosis and imaging Tata Memorial Centre

"Personalized oncology" is a multi-disciplinary science, which requires inputs from various streams for optimal patient management. Humongous progress in the treatment modalities available and the increasing need to provide functional information in addition to the morphological data; has led to leaping progress in the field of imaging. Magnetic resonance imaging has undergone tremendous progress with various newer MR techniques providing vital functional information and is becoming the cornerstone of "radiomics/radiogenomics". Diffusionweighted imaging is one such technique which capitalizes on the tendency of water protons to diffuse randomly in a given system. This technique has revolutionized oncological imaging, by giving vital qualitative and quantitative information regarding tumor biology which helps in detection, characterization and post treatment surveillance of the lesions and challenging the notion that "one size fits all". It has been applied at various sites with different clinical experience. We hereby present a brief review of this novel functional imaging tool, with its application in "personalized oncology".

关键词： Functional magnetic resonance imaging molecular imaging Diffusion-weighted imaging Tumor biology Biomarker Radiomics