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Radioiodinated tyrosine based carbon dots with efficient renal clearance for single photon emission computed tomography of tumor

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Nano Research 2019年第12期12卷 3037-3043页

作者： Nian Liu Yiyue Shi Jingru Guo Hai Li Qiang Wang Menglin Song Zhiyuan Shi Le He Xinhui Su Jin Xie Xiaolian Sun State Key Laboratory of Natural Medicines Key Laboratory of Drug Quality Control and PharmacovigilanceDepartment of Pharmaceutical AnalysisChina Pharmaceutical UniversityNanjing 210009China Institute of Biological and Medical imaging Helmholtz Zentrum Miinchen and Technische Universitat MiinchenNeuherberg 85764Germany State Key Laboratory of molecular Vaccinology and molecular Diagnostics&Center for molecular imaging and Translational Medicine School of Public HealthXiamen UniversityXiamen 361005China Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou 215123China Department of Nuclear Medicine Zhongshan Hospital Xiamen UniversityXiamen 361004China Department of Chemistry Bio-Imaging Research CenterUniversity of GeorgiaAthensGeorgia 30602USA

Nan oparticles with effective tumor accumulation and efficient renal clearance have attracted significant interests for clinical *** 2.5 nm tyrosine based carbon dots(TCDs)with phenolic hydroxyl groups on the surface for directly 125I *** 125I labeledpolyethylene glycol(PEG)functionalized TCDs(125I-TCDPEGs)showed excellent radiochemical stability both in vitro and in *** to theenhanced permeability and retentio n effect,these 125I-TCDPEGs demonstrated a tumor accumulatio n around 4%-5%of the injected doseper gram(ID/g)for U87MG,4T1,HepG2 and MCF7 tumor-bearing mice at 1 h ***,the 125I-TCDPEGs also could befast renally excreted,with less than 0.6%ID/g left in the liver and spleen within 24 *** radioactive carb on dots not only can be used forcellular fluorescence imaging due to their intrinsic optical property,but are also effective single photon emission computed tomography(SPECT)imaging agents for *** with their excellent biocompatibility and stability,we anticipate these 125I-TCDPEGs of great potential for earlytumor diagnosis in *** more,our TCDPEGs are also proved to be feasible carriers for other iodine isotopes such as 127I and 131I fordifferent biomedical application.

关键词： radioiodination tyrosine based carbon dots single photon emissionrenal clearance

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Wuhan university Journal of Natural Sciences 2011年第1期16卷 69-72页

作者： CAI Ruikun CHENG Xi MA Chuang ZHOU Yanhong Hubei Bioinformatics and molecular imaging Key Laboratory Huazhong University of Science and Technology Wuhan 430074Hubei China

This research analyzed amino acid sequence similarity between non-self T cell epitopes recognized by mouse antibodies and mouse proteins. Using sequence alignment,we found that only 8 of 1 108 epitopes are highly similar to mouse protein sequences. The result shows that non-self T cell epitopes are not similar or have little similarity to mouse protein sequences. Furthermore,reviewing the related literature,we also found that the eight epitopes would trigger immune responses in some particular environment,which are ignored by T cells in normal condition. The result suggests that no or low-similarity peptide vaccines can reduce the chance of collateral cross-reactions and enhance the antigen-specific immune response to vaccine.

关键词： T cell epitopes mouse proteome vaccine design bioinformatics

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Recent developments of the reconstruction in magnetic particle imaging

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Visual Computing for Industry,Biomedicine,and Art 2022年第1期5卷 290-302页

作者： Lin Yin Wei Li Yang Du Kun Wang Zhenyu Liu Hui Hui Jie Tian CAS Key Laboratory of molecular imaging the State Key Laboratory of Management and Control for Complex SystemsInstitute of AutomationChinese Academy of SciencesBeijing 100190China Beijing Key Laboratory of molecular imaging Beijing 100190China university of Chinese Academy of Sciences Beijing 100049China Medical imaging Center the First Affiliated HospitalJinan UniversityGuangdong 510632China Beijing Advanced Innovation Center for Big Data-Based Precision Medicine School of MedicineBeihang UniversityBeijing 100083China

Magnetic particle imaging(MPI)is an emerging molecular imaging technique with high sensitivity and temporal-spatial *** reconstruction is an important research topic in MPI,which converts an induced voltage signal into the image of superparamagnetic iron oxide particles concentration *** reconstruction primarily involves system matrix-and x-space-based *** this review,we provide a detailed overview of the research status and future research trends of these two *** addition,we review the application of deep learning methods in MPI reconstruction and the current open sources of ***,research opinions on MPI reconstruction are *** hope this review promotes the use of MPI in clinical applications.

关键词： Magnetic particle imaging Image reconstruction System matrix X-space

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Development of a tRNA-derived small RNA diagnostic and prognostic signature in liver cancer

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Genes & Diseases 2022年第2期9卷 393-400页

作者： Yi Zuo Shaoqiu Chen Lingling Yan Ling Hu Scott Bowler Emory Zitello Gang Huang Youping Deng Tianyou Hospital Affiliated to Wuhan University of Science and TechnologyWuhan 430064PR China Department of Quantitative Health Sciences John A.Burns School of MedicineUniversity of Hawaii at ManoaHonoluluHI 96813USA molecular Biosciences and Bioengineering program College of Tropical Agriculture and Human ResourcesUniversity of Hawaii at ManoaHonoluluHI 96822USA Shanghai Key Laboratory for molecular imaging Shanghai University of Medicine and Health SciencesShanghai 201318PR China

Liver cancer presents divergent clinical *** remain opportunities for molecular markers to improve liver cancer diagnosis and prognosis,especially since tRNA-derived small RNAs(tsRNA)have rarely been *** this study,a random forests(RF)diagnostic model was built based upon tsRNA profiling of paired tumor and adjacent normal samples and validated by independent validation(IV).A LASSO model was used to developed a seven-tsRNA-based risk score signature for liver cancer *** performance was evaluated by a receiver operating characteristic curve(ROC curve)and Precision-Recall curve(PR curve).The five-tsRNA-based RF diagnosis model had area under the receiver operating characteristic curve(AUROC)88%and area under the precision–recall curve(AUPR)87%in the discovery cohort and 87%and 86%in IV-AUROC and IV-AUPR,*** seven-tsRNA-based prognostic model predicts the overall survival of liver cancer patients(Hazard Ratio 2.02,95%CI 1.36–3.00,P<0.001),independent of standard clinicopathological prognostic ***,the model successfully categorizes patients into high-low risk *** and prognostic modeling can be reliably utilized in the diagnosis of liver cancer and high-low risk classification of patients based upon tsRNA characterization.

关键词： Diagnosis Liver cancer Prognosis Random forests tRNA-derived small RNAs

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Coumarin derivative dye sensitized NaYGdF4:Yb,Er nanoparticles with enhanced NIR Ⅱ luminescence for bio-vascular imaging

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Journal of Rare Earths 2023年第12期41卷 1843-1849,I0001页

作者： Yaqun Ma Zhan Wang Yanxing Wang Zhenghao Liu Yukun Wang Ruichan Lv Xi'an Key Laboratory of Intelligent Sensing and Regulation of Trans-Scale Life Information Engineering Research Center of Molecular and Neuro ImagingMinistry of EducationSchool of Life Science and TechnologyXidian UniversityXi'an710071China

Lanthanide-doped biocompatible nanoparticles have promising applications in near-infrared second region imaging due to their high chemical stability,enhanced photostability and sharp emission ***,the weak light absorption capacity limits the application of rare-earth nanoparticles(RENPs) for *** prepared a coumarin-derived dye sensitized NaYGdF4:Yb,Er nanoparticle probe,in which the organic dye enhances photon absorption through the sensitization process,improving the luminescence efficiency of the rare earth particles near 1000 and 1500 *** addition,good water solubility and stability of the probe are imparted by coating the particles with amphiphilic polymers distearoyl phosphatidylethanolamine-polyethylene glycol(DSPE-PEG) and polyacrylic *** composite probe with good biocompatibility and NIR Ⅱ luminescence properties can be used for vascular imaging,providing a tool for the detection of hematologic-related diseases.

关键词： Rare earth doped nanoparticles Dye sensitization NIR imaging Angiography

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Copper-catalyzed chemoselective heterocyclization of two isocyanides:Facile access to pyrroloazepinone derivatives

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Chinese Chemical Letters 2023年第2期34卷 202-205页

作者： Xiaoyu Guo Jinhuan Dong Yunjie Zhu Lan Bao Zhongyan Hu Xianxiu Xu College of Chemistry Chemical Engineering and Materials ScienceCollaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of ShandongKey Laboratory of Molecular and Nano ProbesMinistry of EducationInstitute of Molecular and Nano ScienceShandong Normal UniversityJi'nan 250014China

A Cu-catalyzed chemoselective heterocyclization of o-cinnamoyl arylisocyanides with α-substituted tosylmethyl isocyanides is developed for the efficient synthesis benzopyrroloazepinones. An isocyanide insertion into ... 详细信息

关键词： Isocyanides Domino reactions Pyrroloazepinones

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[4+3]Cycloaddition of ketenimines with furocarbenoids:Divergent and efficient synthesis of fused cycloheptatriene and tropone scaffolds

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Chinese Chemical Letters 2023年第5期34卷 227-231页

作者： Jin Wang Zhaoyang Li Shengxin Bai Qinghua Zhou Tengteng Wu Zhongyan Hu Xianxiu Xu Chemical Engineering and Materials Science Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of ShandongKey Laboratory of Molecular and Nano ProbesCollege of ChemistryMinistry of EducationInstitute of Molecular and Nano ScienceShandong Normal UniversityJi’nan 250014China

An unprecedent[4+3]cycloaddition of furoketenimines with furocarbenoids has been disclosed for the divergent and efficient synthesis of cycloheptafuran and cycloheptapyrrole *** chloride acted as promoters for both the formation of these two transient intermediates from isocyanides and ene-yne-ketones,and the subsequent construction of seven-membered *** rings and five bonds were constructed successively in this three-component one-pot domino reaction.

关键词： Domino reactions Isocyanides Ene-yne-ketones Cycloheptafuran scaffolds [4+3]cycloaddition

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An endoplasmic reticulum-targeted organic photothermal agent for enhanced cancer therapy

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Chinese Chemical Letters 2022年第2期33卷 793-797页

作者： Kaiye Wang Yanan Xiang Wei Pan Hongyu Wang Na Li Bo Tang College of Chemistry Chemical Engineering and Materials ScienceKey Laboratory of Molecular and Nano ProbesMinistry of EducationCollaborative Innovation Centre of Functionalized Probes for Chemical Imaging in Universities of ShandongInstitute of Molecular and Nano ScienceShandong Normal UniversityJi’nan 250014China

Developing selectively targeted photothermal agents to reduce side effects in photothermal therapy remains a great challenge. Inspired by the key role of endoplasmic reticulum in the protein synthesis and intracellular signal transduction, particularly for the immunogenic cell death induced by endoplasmic reticulum stress, we developed an endoplasmic reticulum-targeted organic photothermal agent(Ts-PTRGD) for enhancing photothermal therapy of tumor. The photothermal agent was covalently attached with 4-methylbenzenesulfonamide and cyclic Arg-Gly-Asp(c RGD) peptide for realizing the targeting of endoplasmic reticulum and tumor cell. Owing to its amphiphilic properties, it readily self-assembles in water to form nanoparticles. The photothermal agent possesses excellent photophysical properties and biological compatibility. In vitro and in vivo experiments demonstrate that it can actively target endoplasmic reticulum and effectively ablate tumor with near-infrared laser.

关键词： Photothermal therapy Endoplasmic reticulum Dual-targeting delivery Organic photothermal agents Therapeutic agents

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Positron Emission Tomography imaging of Synaptic Dysfunction in Parkinson’s Disease

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Neuroscience Bulletin 2024年第6期40卷 743-758页

作者： Jiaqi Niu Yan Zhong Chentao Jin Peili Cen Jing Wang Chunyi Cui Le Xue Xingyue Cui Mei Tian Hong Zhang Department of Nuclear Medicine and PET Center The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou310009China Institute of Nuclear Medicine and molecular imaging Zhejiang UniversityHangzhou310009China Key Laboratory of Medical molecular imaging of Zhejiang Province Hangzhou310009China College of Biomedical Engineering&Instrument Science Zhejiang UniversityHangzhou310014China Key Laboratory for Biomedical Engineering of Ministry of Education Zhejiang UniversityHangzhou310014China Huashan Hospital and Human Phenome Institute Fudan UniversityShanghai200040China

Parkinson’s disease(PD)is one of the most common neurodegenerative diseases with a complex *** formed by abnormal deposition of alpha-synuclein(αSyn)lead to synapse dysfunction of the dopamine and non-dopamine *** loss of dopaminergic neurons and concomitant alterations in non-dopaminergic function in PD constitute its primary pathological *** emission tomography(PET),as a representative molecular imaging technique,enables the non-invasive visualization,characterization,and quantification of biological processes at cellular and molecular *** synaptic function with PET would provide insights into the mechanisms underlying PD and facilitate the optimization of clinical *** this review,we focus on the synaptic dysfunction associated with theαSyn pathology of PD,summarize various related targets and radiopharmaceuticals,and discuss applications and perspectives of PET imaging of synaptic dysfunction in PD.

关键词： Parkinson’s disease Positron emission tomography Synapse dysfunction Alpha-synuclein Dopamine system Non-dopamine system

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Refining biome labeling for large-scale microbial community samples:Leveraging neural networks and transfer learning

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Environmental Science and Ecotechnology 2024年第1期17卷 128-137页

作者： Nan Wang Teng Wang Kang Ning Key Laboratory of molecular Biophysics of the Ministry of Education Hubei Key Laboratory of Bioinformatics and Molecular-imagingCenter of AI BiologyDepartment of Bioinformatics and Systems BiologyCollege of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan430074HubeiChina

Microbiome research has generated an extensive amount of data,resulting in a wealth of publicly accessible *** annotation of these samples is crucial for effectively utilizing microbiome data across scientific ***,a notable challenge arises from the lack of essential annotations,particularly regarding collection location and sample biome information,which significantly hinders environmental microbiome *** this study,we introduce Meta-Sorter,a novel approach utilizing neural networks and transfer learning,to enhance biome labeling for thousands of microbiome samples in the MGnify database that have incomplete *** findings demonstrate that Meta-Sorter achieved a remarkable accuracy rate of 96.7%in classifying samples among the 16,507 lacking detailed biome ***,Meta-Sorter provides precise classifications for representative environmental samples that were previously ambiguously labeled as“Marine”in MGnify,thereby elucidating their specific origins in benthic and water column ***,Meta-Sorter effectively distinguishes samples derived from human-environment interactions,enabling clear differentiation between environmental and human-related *** improving the completeness of biome label information for numerous microbial community samples,our research facilitates more accurate knowledge discovery across diverse disciplines,with particular implications for environmental research.

关键词： Microbial community Transfer learning Sample classification Environmental scientific research Novel knowledge discovery

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