Radioiodinated tyrosine based carbon dots with efficient renal clearance for single photon emission computed tomography of tumor

作     者：Nian Liu Yiyue Shi Jingru Guo Hai Li Qiang Wang Menglin Song Zhiyuan Shi Le He Xinhui Su Jin Xie Xiaolian Sun 

作者机构：State Key Laboratory of Natural MedicinesKey Laboratory of Drug Quality Control and PharmacovigilanceDepartment of Pharmaceutical AnalysisChina Pharmaceutical UniversityNanjing 210009China Institute of Biological and Medical ImagingHelmholtz Zentrum Miinchen and Technische Universitat MiinchenNeuherberg 85764Germany State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics&Center for Molecular Imaging and Translational MedicineSchool of Public HealthXiamen UniversityXiamen 361005China Institute of Functional Nano&Soft Materials(FUNSOM)Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou 215123China Department of Nuclear MedicineZhongshan Hospital Xiamen UniversityXiamen 361004China Department of ChemistryBio-Imaging Research CenterUniversity of GeorgiaAthensGeorgia 30602USA 

出 版 物：《Nano Research》 (纳米研究（英文版）)

年 卷 期：2019年第12卷第12期

页      面：3037-3043页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：X.S.acknowledges the National Key Research and Development Program of China(No.2016YFA0203600) the National Natural Science Foundation of China(Nos.81971738 and 81571743) the Project Program of State Key Laboratory of Natural Medicines,and the China Pharmaceutical University(No.SKLNMZZRC05) 

主　　题：radioiodination tyrosine based carbon dots single photon emissionrenal clearance 

摘      要：Nan oparticles with effective tumor accumulation and efficient renal clearance have attracted significant interests for clinical *** 2.5 nm tyrosine based carbon dots(TCDs)with phenolic hydroxyl groups on the surface for directly 125I *** 125I labeledpolyethylene glycol(PEG)functionalized TCDs(125I-TCDPEGs)showed excellent radiochemical stability both in vitro and in *** to theenhanced permeability and retentio n effect,these 125I-TCDPEGs demonstrated a tumor accumulatio n around 4%-5%of the injected doseper gram(ID/g)for U87MG,4T1,HepG2 and MCF7 tumor-bearing mice at 1 h ***,the 125I-TCDPEGs also could befast renally excreted,with less than 0.6%ID/g left in the liver and spleen within 24 *** radioactive carb on dots not only can be used forcellular fluorescence imaging due to their intrinsic optical property,but are also effective single photon emission computed tomography(SPECT)imaging agents for *** with their excellent biocompatibility and stability,we anticipate these 125I-TCDPEGs of great potential for earlytumor diagnosis in *** more,our TCDPEGs are also proved to be feasible carriers for other iodine isotopes such as 127I and 131I fordifferent biomedical application.