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A NEAR-INFRARED FLUORESCENT DEOXYGLUCOSE DERIVATIVE FOR OPTICAL imaging OF EXPERIMENTAL ARTHRITIS

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Journal of Innovative Optical Health Sciences 2009年第2期2卷 179-187页

作者： XIUPING LIU ZHENGMING XIONG SHEEN-WOO LEE JELENA LEVI SHAHRIAR YAGHOUBI SANDIP BISWAL SANJIV SAM GAMBHIR ZHEN CHENG School of Life Science&Technology Huazhong university of Science and Technology Wuhan 430074 China molecular imaging program at stanford(MIPS)Departments of Radiology and Bioengineering Bio-X Program Stanford UniversityCalifornia 94305USA

The purpose of this study is to investigate whether a near-infrared fluorescence(NIRF)probe,Cy5.5-d-glucosamine(Cy5.5-2DG),can image arthritis in collagen-induced arthritic(CIA)*** presence of arthritis was verified by both visual examination and micro-computed tomography(MicroCT)*** mice were imaged by a micro-positron emission tomography(MicroPET)scanner one hour after intravenous injection of 2-deoxy-2-[18F]fluoro-d-glucose([18F]FDG).After radioactivity of[18F]FDG decayed away,Cy5.5-2DG was injected into a lateral tail vein of the *** tissue targeting and retention of Cy5.5-2DG in CIA mice were evaluated and quantified by an optical imaging *** tissue in CIA mice was clearly visualized by[18F]FDG-MicroPET *** imaging of Cy5.5-2DG in the same mice revealed that the pattern of localization of Cy5.5-2DG in the arthritic tissue was very similar to that of[18F]*** analysis further showed that[18F]FDG uptake in arthritic tissues at one hour post-injection(p.i.)and Cy5.5-2DG uptakes at different time points *** all well correlated(r2 over 0.65).In conclusion,Cy5.5-DG can detect arthritic tissues in living *** good correlation between the[18F]FDG uptake and Cy5.5-2DG accumulation in the same arthritic tissue warrants further investigation of Cy5.5-2DG as an approach for assessment of anti-inflammatory treatments.

关键词： Near-infrared fluorescence arthritis fluorescent deoxyglucose FDG

InAs/InP/ZnSe Core/Shell/Shell Quantum Dots as Near-Infrared Emitters:Bright,Narrow-Band,Non-Cadmium Containing,and Biocompatible

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Nano Research 2008年第6期1卷 457-464页

作者： Renguo Xie Kai Chen Xiaoyuan Chen Xiaogang Peng Department of Chemistry and Biochemistry University of ArkansasFayettevilleAR 72701USA molecular imaging program at stanford(MIPS) Department of Radiology and Bio-X ProgramStanford University School of MedicineStanfordCA 94305-5484USA

High quality InAs/InP/ZnSe core/shell/shell quantum dots have been grown by a one-pot *** engineered quantum dots with unique near-infrared(NIR)fluorescence,possessing outstanding optical properties,and the biocompatibility desired for in vivo *** resulting quantum dots have significantly lower intrinsic toxicity compared to NIR emissive dots containing elements such as cadmium,mercury,or ***,these newly developed ultrasmall non-Cd containing and NIR-emitting quantum dots showed signifi cantly improved circulation half-life and minimal reticuloendothelial system(RES)uptake.

关键词： Quantum dots InAs near-infrared(NIR) toxicity

Biological imaging without autofluorescence in the second near-infrared region

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Nano Research 2015年第9期8卷 3027-3034页

作者： Shuo Diao Guosong Hong Alexander L. Antaris Jeffrey L. Blackbum Kai Cheng Zhen Cheng Hongjie Dai Department of Chemistry Stanford University Stanford California 94305 USA Chemical and Materials Science Center National Renewable Energy Laboratory Colorado 8040 I USA molecular imaging program at stanford (MIPS) and Department of Radiology Stanford University California 94305 USA

Fluorescence imaging is capable of acquiring anatomical and functional infor- mation with high spatial and temporal resolution. This imaging technique has been indispensable in biological research and disease detection/diagnosis. imaging in the visible and to a lesser degree, in the near-infrared （NIR） regions below 900 nm, suffers from autofluorescence arising from endogenous fluorescent molecules in biological tissues. This autofluorescence interferes with fluorescent molecules of interest, causing a high background and low detection sensitivity. Here, we report that fluorescence imaging in the 1,500-1,700-nm region （termed ＂NIR-IIb＂） under 808-nm excitation results in nearly zero tissue autofluorescence, allowing for background-free imaging of fluorescent species in otherwise notoriously autofluorescent biological tissues, including liver. imaging of the intrinsic fluorescence of individual fluorophores, such as a single carbon nanotube, can be readily achieved with high sensitivity and without autofluorescence background in mouse liver within the 1,500-1,700-nm wavelength region.

关键词： fluorescence imaging,second near-infrared,nanotechnology autofluorescence

Stepwise assembly to construct stable copper(I) cluster-based circularly polarized luminescent MOFs

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Science China Chemistry 2025年

作者： Jing-Wen Xie Meng-Ting Wang Yan Jin Si Li Jian-Hua Qin Shuang-Quan Zang Tomas C.W.Mak College of Chemistry Henan Key Laboratory of Crystalline Molecular Functional Materials Zhengzhou University College of Chemistry and Chemical Engineering Luoyang Normal University Department of Chemistry The Chinese University of Hong Kong

Circularly polarized luminescence （CPL） materials have been extensively studied in recent years owing to their widespread applications in 3D display,optical storage,optical anti-counterfeiting,and biological imaging,***（I） clusters have emerged as a promising candidate for CPL materials,driven by their cost-effectiveness,superior luminescent properties,precise structure,and low ***,the poor environmental stability of copper（I） clusters renders their synthesis and preservation challenging,thereby significantly impeding their ***,we have designed and synthesised a chiral double-coordinated ligand in order to construct copper（I） cluster nodes that can be further *** anticipated,by utilizing stepwise assembly strategy,a Cu4cluster node co-modified by chiral alkynyl ligands and triphenylphosphine was further assembled with Cd2+ions to obtain 2D layers structure,L/*** L/D-Cu4-Cd exhibits excellent stability and optical properties,including bright yellow emission,solvent-responsive luminescence,and CPL activity with a maximum glumup to 2.0×10-3,which shows potential applications in the WLED and *** interestingly,the material also exhibits deflection ability towards different wavelengths of linearly polarized light,showing certain potential in the preparation of circular polarizer.

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Antimicrobial peptides and the gut microbiome in inflammatory bowel disease

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World Journal of Gastroenterology 2021年第43期27卷 7402-7422页

作者： John Gubatan Derek R Holman Christopher J Puntasecca Danielle Polevoi Samuel JS Rubin Stephan Rogalla Division of Gastroenterology and Hepatology Stanford University School of MedicineRedwood CityCA 94063United States Department of Radiology Molecular Imaging Program at StanfordStanford UniversityStanfordCA 94305United States stanford university School of Medicine Stanford UniversityStanfordCA 94063United States

Antimicrobial peptides(AMP)are highly diverse and dynamic molecules that are expressed by specific intestinal epithelial cells,Paneth cells,as well as immune cells in the gastrointestinal(GI)*** play critical roles in maintaining tolerance to gut microbiota and protecting against enteric *** that disruptions in tolerance to commensal microbiota and loss of barrier function play major roles in the pathogenesis of inflammatory bowel disease(IBD)and converge on the function of AMP,the significance of AMP as potential biomarkers and novel therapeutic targets in IBD have been increasingly recognized in recent *** this frontier article,we discuss the function and mechanisms of AMP in the GI tract,examine the interaction of AMP with the gut microbiome,explore the role of AMP in the pathogenesis of IBD,and review translational applications of AMP in patients with IBD.

关键词： Antimicrobial peptides Inflammatory bowel disease Ulcerative colitis Crohn’s disease Gut microbiome Biomarkers

Sequence-activated chemiluminescence probes: programmable illumination for high-contrast in vivo sensing and imaging

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Science China Chemistry 2025年第01期 26-34页

作者： Yutao Zhang Juan Li Wei-Hong Zhu Zhiqian Guo Shanghai Key Laboratory of Functional Materials Chemistry Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Institute of Fine Chemicals School of Chemistry and Molecular Engineering East China University of Science and Technology State Key Laboratory of Bioreactor Engineering Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell MetabolismEast China University of Science & Technology

Sequence-activated chemiluminescence(CL) technique offers a unique approach to detecting specific biomolecules or cellular events with high sensitivity and spatial resolution. The fundamental principle behind sequence-activated CL probes involves tailoring highly-controllable CL signals in response to specific sequences or events of interest, thus enabling high-contrast signals under complex physiological conditions. This sequential activation could be triggered by enzymes, reactive oxygen species(ROS), biothiols or changes in the microenvironment. These unique sequence-activated CL probes bestow several advantages, including minimal background, deep-tissue penetration, and the ability of non-invasive or minimally invasive detection. The sequence-activated CL techniques represent a significant advancement in molecular imaging and diagnostics. In this mini-review, we focus on the latest developments in sequential CL probes, addressing the technical challenges and discussing the future trajectory by harnessing CL signaling and molecular recognition.

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Photoacoustic detection of follicular thyroid carcinoma using targeted Nano-Au-Tripods

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Chinese Journal of Chemical Engineering 2022年第4期35卷 1-7页

作者： Yang Gui Kai Cheng Ruojiao Wang Sirui Liu Chenyang Zhao Rui Zhang Ming Wang Zhen Cheng Meng Yang Department of Ultrasound State Key Laboratory of Complex Severe and Rare DiseasesPecking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China molecular imaging program at stanford(MIPS) Department of Radiology and Bio-X ProgramSchool of MedicineStanford UniversityStanford CA 94305-5484USA

Follicular thyroid carcinoma(FTC)is the second most common form of thyroid malignancy,and it is associated with more aggressive growth and worse long-term survival outcomes relative to papillary thyroid carcinoma(PTC).Reliable approaches to preoperative FTC detection,however,remain to be ***,a targeted Affibody-Au-Tripod nanoprobe was developed and successfully utilized to facilitate the targeted photoacoustic imaging(PAI)of epidermal growth factor receptor(EGFR)-positive cells and *** Affibody-Au-Tripods were found to be highly sensitive and specific for cells expressing EGFR when used as a PA contrast agent in vitro,and studies conducted in an FTC-133 subcutaneous tumor model system in mice further revealed that these Affibody-Au-Tripods were able to specifically target these EGFR-expressing tumors while providing a strong photoacoustic signal in ***,these nanoprobes exhibited negligible cytotoxicity and robust chemical and physical stability,making Affibody-Au-Tripods promising candidates for targeted PAI-based FTC *** addition,these nanoprobes have the potential to facilitate the individualized treatment of patients harboring EGFRpositive tumors.

关键词： Affibody Follicular thyroid carcinoma Nano-Au-Tripods Nanoprobe Photoacoustic imaging

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Differential Responses of Transplanted Stem Cells to Diseased Environment Unveiled by a molecular NIR-II Cell Tracker

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Research 2021年第1期2021卷 935-950页

作者： Hao Chen Huaxiao Yang Chen Zhang Si Chen Xin Zhao Mark Zhu Zhiming Wang Yuebing Wang Hung-Ta Wo Kai Li Zhen Cheng Center for molecular imaging Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China molecular imaging program at stanford(MIPS) Bio-X Programand Department of RadiologyCanary Center at Stanford for Cancer Early DetectionStanford UniversityStanfordCA 94305-5344USA university of North Texas Biomedical EngineeringDentonTX 76207USA Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong 518055China Department of Neurology Xiangya HospitalCentral South UniversityXiangya Road 88ChangshaHunan 410008China stanford Cardiovascular Institute StanfordCA 94305USA Division of Cardiology Department of Internal MedicineChang Gung Memorial HospitalLinkouTaiwan33305China

Stem cell therapy holds high promises in regenerative *** major challenge of clinical translation is to precisely and quantitatively evaluate the in vivo cell distribution,migration,and engraftment,which cannot be easily achieved by current *** address this issue,for the first time,we have developed a molecular cell tracker with a strong fluorescence signal in the second near-infrared(NIR-II)window(1,000-1,700 nm)for real-time monitoring of in vivo cell behaviors in both healthy and diseased animal *** NIR-II tracker(CelTrac1000)has shown complete cell labeling with low cytotoxicity and profound long-term tracking ability for 30 days in high spatiotemporal resolution for semiquantification of the biodistribution of transplanted stem *** advantage of the unique merits of CelTrac1000,the responses of transplanted stem cells to different diseased environments have been discriminated and ***,we also demonstrate CelTrac1000 as a universal and effective technique for ultrafast real-time tracking of the cellular migration and distribution in a 100μm single-cell cluster spatial resolution,along with the lung contraction and heart *** such,this NIR-II tracker will shift the optical cell tracking into a single-cell cluster and millisecond temporal resolution for better evaluating and understanding stem cell therapy,affording optimal doses and efficacy.

关键词： doses distribution holds

Deep-Tissue Photothermal Therapy Using Laser Illumination at NIR-Ⅱa Window

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Nano-Micro Letters 2020年第3期12卷 129-141页

作者： Xunzhi Wu Yongkuan Suo Hui Shi Ruiqi Liu Fengxia Wu Tingzhong Wang Lina Ma Hongguang Liu Zhen Cheng Institute of molecular Medicine College of Life and Health SciencesNortheastern UniversityShenyang 110000People’s Republic of China Department of Neurosurgery The Fourth Affiliated Hospital of China Medical UniversityShenyang 110000People’s Republic of China Changchun Institute of Applied Chemistry Chinese Academy of ScienceChangchun 130000People’s Republic of China molecular imaging program at stanford Stanford UniversityPalo AltoCA 94301USA

Photothermal therapy(PTT)using near-infrared(NIR)light for tumor treatment has triggered extensive attentions because of its advantages of noninvasion and *** current research on PTT usually uses lasers in the first NIR window(NIR-I;700–900 nm)as irradiation ***,the second NIR window(NIR-II;1000–1700 nm)especially NIRIIa window(1300–1400 nm)is considered much more promising in diagnosis and treatment as its superiority in penetration depth and maximum permissible exposure over NIR-I ***,we propose the use of laser excitation at 1275 nm,which is approved by Food and Drug Administration for physical therapy,as an attractive technique for PTT to balance of tissue absorption and scattering with water ***,CuS-PEG nanoparticles with similar absorption values at 1275 and 808 nm,a conventional NIR-I window for PTT,were synthesized as PTT agents and a comparison platform,to explore the potential of 1275 and 808 nm lasers for PTT,especially in deep-tissue *** results showed that 1275 nm laser was practicable in *** exhibited much more desirable outcomes in cell ablation in vitro and deep-tissue antitumor capabilities in vivo compared to that of 808 nm ***-IIa laser illumination is superior to NIR-I laser for deep-tissue PTT,and shows high potential to improve the PTT outcome.

关键词： Photothermal therapy Deep-tissue NIR-IIa 1275 nm laser molecular imaging

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