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Can Social Support be Protective against Depressive Symptoms in Adolescents from 24 Low- and Middle-Income Countries?

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International Journal of Mental Health Promotion 2023年第3期25卷 375-387页

作者： Haowen Wu Zhanli Yi Tianyou Guo School of Government Institute of Urban GovernanceShenzhen UniversityShenzhen518052China Body-brain-mind Laboratory School of Psychology Shenzhen UniversityShenzhen518052China

Background:Adolescents are highly vulnerable to depressive symptoms worldwide partially because of limited social ***,it still remains largely unknown regarding the associations between social support(s)and depressive symptoms among adolescents living in low-and middle-income countries(LMICs).The aim of this study aimed to explore the associations between different types of social support and depressive symptoms in adolescents from ***:Data were retrieved from the Global School-based Health Survey(GSHS)in which 92,551 adolescents(50.6%females)were included with mean of 15.6 *** symptoms in the past one month as the dependent variable were measured in combination with social support(was measured by“During the past 30 days,how often were most of the students in your school kind and helpful?”).Multivariable logistic regression and meta-analysis of country-wise estimates were performed to investigate the associations between social support and depressive symptoms,and the heterogeneity of the associations across the countries,***:The prevalence of depressive symptoms was 30.9%of adolescents from *** support and parental connectedness were two major factors that were significantly associated with depression symptoms in ***,the associations of peer support and parental connectedness with depressive symptoms were significant in males and females,*** country-wise analysis indicated that varied inconsistency(small to large)across the associations of peer support and parental connectedness with depressive symptoms in ***:Results in this study provides multi-national evidence of the protective roles of social support against depressive symptoms among ***,the association between social support and depression symptoms may be moderated by sex and types of social *** we found that social sup-port may be an important protective factor against depre

关键词： Peer support parental supervision parental connectedness parental bonding depressive symptoms adolescents low-and middle-income countries

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A PROSENCEPHALIC NEURONAL CIRCUIT POSSIBLY INVOLVED IN MODULATION OF PAIN

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Science in China,Ser.B 1984年第1期27卷 48-60页

作者：张香桐何淑舫陈国光 Shanghai brain Research institute Academia Sinica

Both anatomical and physiological studies in cats substantiated the existence of a tha-lamus-cortex-thalamus neuronal circuit in which neurons in the centre median send fibers towide areas of the cerebral cortex and the cerebral cortex, the motor cortex in particular, maysend the fibers back to the parafascicular nucleus. The cortical neurons concerned tend todischarge spontaneously and constantly. These spontancous discharges can be readily inhib-ited by the corticopetal impulses from the centre median, which itself can be activated bygeneral afferent impulses. On the basis of this observation it is assumdd that constantly dis-charging corticothalamic neurons may exert a tonic excitatory influence on the pain-receivingcenter, parafascicular nucleus, so as to keep it in a state of constant alertness to the tissue-damaging danger signals and that the inhibitory action of the ascending fibers from centremedian would serve to suspend the excitatory action of the cortex on the parafascicular nucleus,resulting in relief of pain. The corticofugal fibers in this forebrain circuit terminating in thecentromedian nucleus may reinforce the inhibitory action of the centromedian neurons so as toinhibit the spotaneous discharges of the cortical neurous. A self-regulating mechanism is thusformed by which a stabilized state of brain excitability can be maintained.

关键词： A PROSENCEPHALIC NEURONAL CIRCUIT POSSIBLY INVOLVED IN MODULATION OF PAIN

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PGLYRP1 protein as a novel mediator of cellular dialogue in neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 1993-1994页

作者： Anup Bhusal Won-Ha Lee Kyoungho Suk Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea BK21 Plus KNU Biomedical Convergence Program Department of Biomedical ScienceSchool of MedicineKyungpook National UniversityDaeguRepublic of Korea School of Life Sciences BK21 plus KNU Creative BioResearch GroupKyungpook National UniversityDaeguRepublic of Korea brain Science and Engineering institute Kyungpook National UniversityDaeguRepublic of Korea

Neuroinflammation has been identified as a crucial element in several neurological disorders. Glial cells play a critical role in directing neuroinflammation, both in deleterious and beneficial ways.

关键词： inflammation considerably

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Formation of the Looming-evoked Innate Defensive Response during Postnatal Development in Mice

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Neuroscience Bulletin 2022年第7期38卷 741-752页

作者： Shanping Chen Huiying Tan Zhijie Wang Yu-ting Tseng Xiaotao Li Liping Wang Shenzhen Key Lab of Neuropsychiatric Modulation Guangdong Provincial Key Laboratory of Brain Connectome and BehaviorCAS Key Laboratory of Brain Connectome and Manipulationthe Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Brain Science-ShenzhenFundamental Research InstitutionsAcademy of SciencesShenzhen-Hong Kong Institute of Shenzhen 518055China Department of brain and Cognitive Sciences MeGovern Institute forBrain ResearchMassachusetts Institute of TechnologyCambridgeMA 02139USA University of Chinese Academy of Sciences Beijing 100049China

Environmental threats often trigger innate defensive responses in ***,the gradual development of functional properties of these responses during the postnatal development stage remains ***,we report that looming stimulation in mice evoked fight behavior commencing at P14-16 and had fully developed by *** visual-evoked innate defensive response was not significantly altered by sensory deprivation at an early postnatal ***,the percentages of wide-field and horizontal cells in the superior colliculus were notably elevated at *** findings define a developmental time window for the formation of the visual innate defense response during the early postnatal period and_provide important insight into the underlying mechanism.

关键词： Innate defensive response Postnatal stage Superiorcolliculus

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Angiogenesis and neuronal remodeling after ischemic stroke

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Neural Regeneration Research 2020年第1期15卷 16-19页

作者： Masahiro Hatakeyama Itaru Ninomiya Masato Kanazawa Department of Neurology Brain Research Institute Niigata University

Increased microvessel density in the peri-infarct region has been reported and has been correlated with longer survival times in ischemic stroke patients and has improved outcomes in ischemic animal *** raises the possibility that enhancement of angiogenesis is one of the strategies to facilitate functional recovery after ischemic *** vessels and neuronal cells communicate with each other using various mediators and contribute to the pathophysiology of cerebral ischemia as a *** this mini-review,we discuss how angiogenesis might couple with axonal outgrowth/neurogenesis and work for functional recovery after cerebral *** occurs within 4 to 7 days after cerebral ischemia in the border of the ischemic core and ***-ischemic angiogenesis may contribute to neuronal remodeling in at least two ways and is thought to contribute to functional ***,new blood vessels that are formed after ischemia are thought to have a role in the guidance of sprouting axons by vascular endothelial growth factor and laminin/β1-integrin ***,blood vessels are thought to enhance neurogenesis in three stages:1)Blood vessels enhance proliferation of neural stem/progenitor cells by expression of several extracellular signals,2)microvessels support the migration of neural stem/progenitor cells toward the peri-infarct region by supplying oxygen,nutrients,and soluble factors as well as serving as a scaffold for migration,and 3)oxygenation induced by angiogenesis in the ischemic core is thought to facilitate the differentiation of migrated neural stem/progenitor cells into mature ***,the regions of angiogenesis and surrounding tissue may be coupled,representing novel treatment targets.

关键词： angiogenesis axonal outgrowth cerebral ischemia coupling functional recovery guidance neurogenesis stroke

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Glia-to-neuron reprogramming to the rescue?

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Neural Regeneration Research 2025年第5期20卷 1395-1396页

作者： Jack W.Hickmott Cindi M.Morshead Department of Surgery University of TorontoTorontoONCanada Donnelly Centre for Cellular and Biomolecular Research TorontoONCanada institute of Biomedical Engineering University of TorontoTorontoONCanada The KITE Research institute Toronto Rehabilitation InstituteUniversity Health NetworkTorontoONCanada

Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative *** brea kth rough discovery that induced pluripotent stem cells could be generated from adult mouse fibroblasts is powerful proof that cell fate can be *** exciting extension of the discovery of cell fate impermanence is the direct cellular reprogram ming hypothesis-that terminally differentiated cells can be reprogrammed into other adult cell fates without first passing through a stem cell state.

关键词： programming passing proof

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Analytically determining frequency and amplitude of spontaneous alpha oscillation in Jansen's neural mass model using the describing function method

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Chinese Physics B 2018年第4期27卷 551-558页

作者： Yao Xu Chun-Hui Zhang Ernst Niebur Jun-Song Wang School of Biomedical Engineering Tianjin Medical University Tianjin 300070 China Qingdao Stomatological Hospital Department of Medical Technology Equipment Qingdao 266001 China Zanvyl Krieger mind/brain institute and Solomon Snyder Department of Neuroscience Johns Hopkins University Baltimore 21218 MD USA

Spontaneous alpha oscillations are a ubiquitous phenomenon in the brain and play a key role in neural information processing and various cognitive ***＇s neural mass model（NMM） was initially proposed to study the origin of alpha *** of previous studies of the spontaneous alpha oscillations in the NMM were conducted using numerical *** this study,we aim to propose an analytical approach using the describing function method to elucidate the spontaneous alpha oscillation mechanism in the ***,the sigmoid nonlinear function in the NMM is approximated by its describing function,allowing us to reformulate the NMM and derive its standard form composed of one nonlinear part and one linear ***,by conducting a theoretical analysis,we can assess whether or not the spontaneous alpha oscillation would occur in the NMM and,furthermore,accurately determine its amplitude and *** results reveal analytically that the interaction between linearity and nonlinearity of the NMM plays a key role in generating the spontaneous alpha ***,strong nonlinearity and large linear strength are required to generate the spontaneous alpha oscillations.

关键词： neural mass model spontaneous alpha oscillation describing function

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A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： Xiao Liang Xingping Quan Xiaorui Geng Yujing Huang Yonghua Zhao Lei Xi Zhen Yuan Ping Wang Bin Liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and brain Sciences University of MacaoMacao Special Administrative RegionChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

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Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder

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Neural Regeneration Research 2025年第6期20卷 1541-1554页

作者： Jinmei Ye Cong Duan Jiaxin Han Jinrong Chen Ning Sun Yuan Li Tifei Yuan Daihui Peng Division of Mood Disorder Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Shanghai Key Laboratory of Psychotic Disorders Brain Health InstituteNational Center for Mental DisordersShanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Co-Innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

In the pathogenesis of major depressive disorder, chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response. Mitochondrial DNA may be an inflammatory trigger, after its release from stress-induced dysfunctional central nervous system mitochondria into peripheral circulation. This evidence supports the potential use of peripheral mitochondrial DNA as a neuroinflammatory biomarker for the diagnosis and treatment of major depressive disorder. Herein, we critically review the neuroinflammation theory in major depressive disorder, providing compelling evidence that mitochondrial DNA release acts as a critical biological substrate, and that it constitutes the neuroinflammatory disease pathway. After its release, mitochondrial DNA can be carried in the exosomes and transported to extracellular spaces in the central nervous system and peripheral circulation. Detectable exosomes render encaged mitochondrial DNA relatively stable. This mitochondrial DNA in peripheral circulation can thus be directly detected in clinical practice. These characteristics illustrate the potential for mitochondrial DNA to serve as an innovative clinical biomarker and molecular treatment target for major depressive disorder. This review also highlights the future potential value of clinical applications combining mitochondrial DNA with a panel of other biomarkers, to improve diagnostic precision in major depressive disorder.

关键词： biomarker cytokine exosomes inflammasome major depressive disorder microglia mitochondrial DNA mitochondrial dysfunction neuroinflammation Toll-like receptor

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Deep brain-machine interfaces:sensing and modulating the human deep brain

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National Science Review 2022年第10期9卷 19-33页

作者： Yanan Sui Huiling Yu Chen Zhang Yue Chen Changqing Jiang Luming Li National Engineering Research Center of Neuromodulation Tsinghua University Precision Medicine & Healthcare Research Center Tsinghua-Berkeley Shenzhen Institute Tsinghua University IDG/Mc Govern institute for brain Research at Tsinghua University institute of Epilepsy Beijing Institute for Brain Disorders

Different from conventional brain-machine interfaces that focus more on decoding the cerebral cortex,deep brain-machine interfaces enable interactions between external machines and deep brain *** sense and modulate deep brain neural activities,aiming at function restoration,device control and therapeutic *** this article,we provide an overview of multiple deep brain recording and stimulation techniques that can serve as deep brain-machine *** highlight two widely used interface technologies,namely deep brain stimulation and stereotactic electroencephalography,for technical trends,clinical applications and brain connectivity *** discuss the potential to develop closed-loop deep brain-machine interfaces and achieve more effective and applicable systems for the treatment of neurological and psychiatric disorders.

关键词： deep brain–machine interface sensing and modulation deep brain stimulation stereotactic electroencephalography

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