检索结果-南通市图书馆

HIV and intestinal parasite co-infections among a Chinese population: an immunological profile

Infectious Diseases of Poverty 2013年第1期2卷 144-151,143页

作者： Li-Guang Tian Tian-Ping Wang Shan Lv Feng-Feng Wang Jian Guo Xiao-Mei Yin Yu-Chun Cai Mary Kathryn Dickey Peter Steinmann Jia-Xu Chen National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention(China CDC) WHO Collaborating Centre for Malaria Schistosomiasis and FilariasisKey Laboratory of Parasite and Vector BiologyMinistry of HealthShanghai 200025People’s Republic of China Anhui Institute of Parasitic Disease Control Hefei 241000People’s Republic of China University of Oklahoma Midwest 73110OKUSA Department of Epidemiology and Public Health Swiss Tropical and Public Health Institu

Background:Parasite infections often result in a switch of the human body’s predominant immune reaction from T-helper 1(Th1)-type to ***,parasite infections are widely expected to accelerate the progression of human immunodeficiency virus(HIV)infections to acquired immunodeficiency syndrome(AIDS).In the People’s Republic of China,both parasitic diseases and AIDS are epidemic in certain rural areas,and co-infections are relatively ***,no population-based studies have yet investigated the frequency of HIV and parasite co-infections,and its effects on immune *** studied(1)the immune status of an HIV-infected population,and(2)the effect of co-infection of HIV and intestinal parasites on selected parameters of the human immune ***:A total of 309 HIV-infected individuals were recruited and compared to an age-matched and sex-matched control group of 315 local HIV-negative *** were administered to all participants to obtain information on sociodemographic characteristics,sanitation habits,family income,and recent clinical *** consecutive stool samples and 10 ml samples of venous blood were also collected from each individual for the diagnosis of parasite infections and quantitative measurements of selected cytokines and CD4+T-lymphocytes,***:During the study period,79 HIV-infected individuals were not under highly active antiretroviral therapy(HAART)and were thus included in our analysis;the prevalence of intestinal helminth infections was 6.3%and that of protozoa was 22.8%.The most common protozoan infections were Blastocystis hominis(***)(13.9%)and Cryptosporidium spp.(10.1%).The prevalence of Cryptosporidium *** HIV-infected individuals was significantly higher than that in HIV negative individuals(P0.05).However,the following trend

关键词： HIV Intestinalparasite Co-infection Immunological profile People’s Republic of China

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Regenerative engineering and bionic limbs

引用

Rare Metals 2015年第3期34卷 143-155页

作者： Roshan James Cato T.Laurencin Institute for Regenerative Engineering University of Connecticut Health Center Raymond and Beverly Sackler center for Biological Physical and Engineering SciencesUniversity of Connecticut Health Center Department of Orthopaedic Surgery University of Connecticut Health Center Connecticut Institute for Clinical and Translational Science Department of Chemical Materials and Biomolecular EngineeringUniversity of Connecticut

Amputations of the upper extremity are severely debilitating, current treatments support very basic limb movement, and patients undergo extensive physiotherapy and psychological counseling. There is no prosthesis that allows the amputees near normal function. With increasing number of amputees due to injuries sustained in accidents, natural calamities, and international conflicts, there is a growing requirement for novel strategies and new discov- eries. Advances have been made in technological, material, and in prosthesis integration where researchers are now exploring artificial prosthesis that integrate with the residual tissues and function based on signal impulses received from the residual nerves. Efforts are focused on challenging experts in different disciplines to integrate ideas and tech- nologies to allow for the regeneration of injured tissues,recording on tissue signals and feedback to facilitate responsive movements and gradations of muscle force. A fully functional replacement and regenerative or integrated prosthesis will rely on interface of biological process with robotic systems to allow individual control of movement such as at the elbow, forearm, digits, and thumb in the upper extremity. Regenerative engineering focused on the regen- eration of complex tissue and organ systems will be realized by the cross-fertilization of advances over the past 30 years in the fields of tissue engineering, nanotechnology, stem cell science, and developmental biology. The convergence of toolboxes crated within each discipline will allow interdis- ciplinary teams from engineering, science, and medicine to realize new strategies, mergers of disparate technologies, such as biophysics, smart bionics, and the healing power of the mind. Tackling the clinical challenges, interfacing the biological process with bionic technologies, engineering biological control of the electronic systems, and feedback will be the important goals in regenerative engineering over the next

关键词： Bionic Electrical stimulation Regenerativeengineering Muscle Nerve Prosthetic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

关节置换术后手术部位感染细菌的抗生素敏感性研究

引用

骨科动态 2006年第4期2卷 205-210页

作者： ERIC FULKERSON CRAUG J DELLA VALLE BRENT WISE MICHAEL WALSH CHARLES PRESTON PAUL E DI CESARE 张晖（译）裴福兴（校） Investigation performed at the Musculoskeletal Research center New York University Hospital for Joint Diseases New York NY and Rush University Medical Center Midwest Orthopaedics Chicago Illinois 四川大学华西医院骨科 610041

背景：目前，对于治疗疑似全髋或全膝关节置换术后假体周围感染的抗生素使用原则还没有共识。本研究旨在建立这样一个用药原则。方法：对146例患者进行回顾性研究。在这些患者进行全髋或全膝关节置换术后的翻修术时，共194个标本得到了... 详细信息

背景：目前，对于治疗疑似全髋或全膝关节置换术后假体周围感染的抗生素使用原则还没有共识。本研究旨在建立这样一个用药原则。方法：对146例患者进行回顾性研究。在这些患者进行全髋或全膝关节置换术后的翻修术时，共194个标本得到了细菌培养阳性结果。患者的一般信息、并存疾病情况、细菌种类、抗生素敏感性资料以及翻修术后细菌培养出现阳性结果所需要的天数均被记录。结果：共110髋、84膝得到的标本培养结果为阳性。其中70％为慢性感染，17％为急性术后局部感染，13％为急性血源性感染。翻修术后出现阳性培养结果的平均时间为3天。革兰氏阳性菌感染占绝大多数。在这些细菌中，88％对庆大霉素敏感，96％对万古霉素敏感，61％对头孢唑林敏感。多数的耐药菌来自于先前有过抗生素治疗失败史的患者。术后急性感染的菌株比慢性感染或血源性感染的菌株更易发生耐药。血源性感染患者分离得到的菌株对庆大霉素和头孢唑林都有高度的敏感性。结论：对疑似假体周围感染的经验性抗生素用药应该在对感染进行分类和确定革兰氏染色结果的指导下进行。我们认为，在得到培养结果之前，急性血源性感染应该一开始就使用头孢唑林和庆大霉素的联合治疗。所有术后慢性或急性革兰氏阳性菌感染或不能明确革兰氏染色结果的细菌感染都应该用万古霉素。革兰氏阴性菌感染应该用第三代或第四代头孢霉素。革兰氏阳性菌和阴性菌的混合感染应该联合使用万古霉素和第三代或第四代头孢霉素。另外，我们认为如果在术后第4天还没有得到细菌培养或是其他确诊的阳性结果就应该结束经验性抗生素治疗。可信水平：诊断性研究，Ⅳ级。进一步可信度参见作者介绍。

关键词：抗生素敏感性全膝关节置换感染细菌术后革兰氏阳性菌感染手术部位革兰氏阴性菌感染经验性抗生素治疗

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A FAIR-compliant parts catalogue for genome engineering and expression control in Saccharomyces cerevisiae

引用

Synthetic and Systems Biotechnology 2022年第2期7卷 657-663页

作者： Vasil D’Ambrosio Lea G.Hansen Jie Zhang Emil D.Jensen Dushica Arsovska Marcos Laloux Tadas Jakociunas Pernille Hjort Davide De Lucrezia Serena Marletta Jay D.Keasling Michael K.Jensen Novo Nordisk Foundation center for Biosustainability Technical University of DenmarkKgs.LyngbyDenmark Explora Biotech Srl Italy joint BioEnergy Institute EmeryvilleCAUSA Biological Systems and Engineering Division Lawrence Berkeley National LaboratoryBerkeleyCAUSA Department of Chemical and Biomolecular Engineering Department of BioengineeringUniversity of CaliforniaBerkeleyCAUSA center for Synthetic Biochemistry Institute for Synthetic BiologyShenzhen Institutes of Advanced TechnologiesShenzhenChina

The synthetic biology toolkit for baker’s yeast,Saccharomyces cerevisiae,includes extensive genome engineering toolkits and parts ***,with the increasing complexity of engineering tasks and versatile applications of this model eukaryote,there is a continued interest to expand and diversify the rational engineering capabilities in this chassis by FAIR(findable,accessible,interoperable,and reproducible)*** this study,we designed and characterised 41 synthetic guide RNA sequences to expand the CRISPR-based genome engineering capabilities for easy and efficient replacement of genomically encoded ***,we characterize in high temporal resolution 20 native promoters and 18 terminators using fluorescein and LUDOX CL-X as references for GFP expression and OD600 measurements,***,all data and reported analysis is provided in a publicly accessible jupyter notebook providing a tool for researchers with low-coding skills to further explore the generated data as well as a template for researchers to write their own *** expect the data,parts,and databases associated with this study to support a FAIR-compliant resource for further advancing the engineering of yeasts.

关键词： gRNA Promoter Terminator Yeast Standardization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Multiphasic bone-ligament-bone integrated scaffold enhances ligamentization and graft-bone integration after anterior cruciate ligament reconstruction

引用

Bioactive Materials 2024年第1期31卷 178-191页

作者： Xianrui Xie Jiangyu Cai Dan Li Yujie Chen Chunhua Wang Guige Hou Thorsten Steinberg Bernd Rolauffs Mohamed EL-Newehy Hany EL-Hamshary Jia Jiang Xiumei Mo Jinzhong Zhao Jinglei Wu State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative MedicineCollege of Biological Science and Medical EngineeringDonghua UniversityShanghai201620PR China Department of Sports Medicine Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200233China School of Pharmacy Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of ChinaBinzhou Medical UniversityYantai264003China National Engineering Laboratory for Modern Silk Soochow UniversitySuzhou215123China Division of Oral Biotechnology Center for Dental MedicineMedical Center-University of FreiburgFaculty of MedicineUniversity of FreiburgHugstetter Str.5579106FreiburgGermany G.E.R.N.Research center for Tissue replacement Regeneration&NeogenesisDepartment of Orthopedics and Trauma SurgeryFaculty of MedicineMedical Center-Albert-Ludwigs-University of Freiburg79085Freiburg im BreisgauGermany Department of Chemistry College of ScienceKing Saud UniversityP.O.Box 2455Riyadh11451Saudi Arabia

The escalating prevalence of anterior cruciate ligament(ACL)injuries in sports necessitates innovative strategies for ACL *** this study,we propose a multiphasic bone-ligament-bone(BLB)integrated scaffold as a potential *** BLB scaffold comprised two polylactic acid(PLA)/deferoxamine(DFO)@mesoporous hydroxyapatite(MHA)thermally induced phase separation(TIPS)scaffolds bridged by silk fibroin(SF)/connective tissue growth factor(CTGF)@Poly(L-lactide-co-ε-caprolactone)(PLCL)nanofiber yarn braided *** combination mimics the native architecture of the ACL *** mechanical properties of the BLB scaffolds were determined to be compatible with the human *** vitro experiments demonstrated that CTGF induced the expression of ligament-related genes,while TIPS scaffolds loaded with MHA and DFO enhanced the osteogenic-related gene expression of bone marrow stem cells(BMSCs)and promoted the migration and tubular formation of human umbilical vein endothelial cells(HUVECs).In rabbit models,the BLB scaffold efficiently facilitated ligamentization and graft-bone integration processes by providing bioactive *** double delivery of DFO and calcium ions by the BLB scaffold synergistically promoted bone regeneration,while CTGF improved collagen formation and ligament ***,the findings indicate that the BLB scaffold exhibits substantial promise for ACL *** investigation and advancement of this scaffold may yield enhanced results in the management of ACL injuries.

关键词： Electrospun Thermally induced phase separation Integrated scaffold Anterior cruciate ligament reconstruction Graft-bone integration

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Restoring nervous system structure and function using tissue engineered living scaffolds

引用

Neural Regeneration Research 2015年第5期10卷 679-685页

作者： Laura A.Struzyna James P.Harris Kritika S.Katiyar H.Isaac Chen D.Kacy Cullen center for Brain Injury and Repair Department of NeurosurgeryPerelman School of MedicineUniversity of Pennsylvania center for Neurotrauma Neurodegenerationand RestorationPhiladelphia Veterans Affairs Medical Center School of Biomedical Engineering Drexel University

Neural tissue engineering is premised on the integration of engineered living tissue with the host nervous system to directly restore lost function or to augment regenerative capacity following ner- vous system injury or neurodegenerative disease. Disconnection of axon pathways - the long-distance fibers connecting specialized regions of the central nervous system or relaying peripheral signals - is a common feature of many neurological disorders and injury. However, functional axonal regenera- tion rarely occurs due to extreme distances to targets, absence of directed guidance, and the presence of inhibitory factors in the central nervous system, resulting in devastating effects on cognitive and sensorimotor function. To address this need, we are pursuing multiple strategies using tissue engi- neered ＂living scaffolds＂, which are preformed three-dimensional constructs consisting of living neural cells in a defined, often anisotropic architecture. Living scaffolds are designed to restore function by serving as a living labeled pathway for targeted axonal regeneration - mimicking key developmental mechanisms- or by restoring lost neural circuitry via direct replacement of neurons and axonal tracts. We are currently utilizing preformed living scaffolds consisting of neuronal dusters spanned by long axonal tracts as regenerative bridges to facilitate long-distance axonal regeneration and for targeted neurosurgical reconstruction of local circuits in the brain. Although there are formidable challenges in predinical and clinical advancement, these living tissue engineered constructs represent a promising strategy to facilitate nervous system repair and functional recovery.

关键词： living scaffolds neural tissue engineering cell transplant biomaterials regeneration neurotrauma neurodegeneration axon pathfinding cell migration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Strategies to anode protection in lithium metal battery:A review

引用

InfoMat 2021年第12期3卷 1333-1363页

作者： Jiawei Li Zhao Kong Xiaoxi Liu Bocong Zheng Qi Hua Fan Elias Garratt Thomas Schuelke Keliang Wang Hui Xu Hong Jin Xi'an Jiaotong University Suzhou AcademySuzhouChina Nano Science and Technology Institute University of Science and Technology of ChinaSuzhouChina College of Materials Science and Engineering Huaqiao UniversityXiamenChina Fraunhofer USA Inc.Center MidwestMichigan State UniversityEast LansingMichiganUSA Department of Electrical Engineering and Computer Engineering Michigan State University East LansingMichiganUSA Department of Chemical Engineering and Materials Science Michigan State University East LansingMichiganUSA

Lithium metal batteries(LMBs)are considered the most promising energy stor-age devices for applications such as electrical vehicles owing to its tremendous theoretical capacity(3860 mAh g−1).However,the serious safety issues and poor cycling performance caused by the dendritic crystal growth during deposi-tion are concerned for any rechargeable batteries with a lithium metal *** make widespread adoption a possibility,considerable efforts have been devoted to suppressing lithium(Li)dendrite *** this review,the recent strategies to developing dendrite free Li anode,including constructing an artifi-cial solid electrolyte interface,current collector modification,separator film improvement,and electrolyte additive,are *** merits and short-comings for different strategies are reviewed and a general summary and per-spective on the next generation rechargeable batteries are presented.

关键词： dendrite Li metal batteries solid electrolyte interface

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Single Cyanide-Bridged Mo（W）/S/Cu Cluster-Based Coordination Polymers:Reactant-and Stoichiometry-Dependent Syntheses

Single Cyanide-Bridged Mo（W）/S/Cu Cluster-Based Coordinati...

引用

中国化学会第九届全国无机化学学术会议

作者： Jinfang Zhang Yuhang Liu Gang Yang Linpei Gong China-Australia joint Research center for Functional Molecular Materials School of Chemical and Material EngineeringJiangnan University

Heterothiometallic Mo（W）/S/Cu cluster-based coordination polymers（CPs）have attracted increasing interest in recent years for their fascinating architectures1 and potential applications.2-3 In this article,the systematic study on the reaction variables affecting the Mo（W）/S/Cu cluster-based CPs is firstly *** anionic single cyanide-bridged Mo（W）/S/Cu cluster-based CPs 1-5 were prepared by varying the molar ratios of the starting materials,and the specific cations,cluster building blocks and central metal atoms in the cluster building blocks.1 possesses an anionic 3D diamondoid framework constructed from 4-connected T-shaped clusters[WS4Cu3]+and single CN-bridges.2 is fabricated from 6-connected planar‘open’clusters[WS4Cu4]2+and single CN-bridges,forming an anionic 3D architecture with an"ACS"topology.3 and 4 exhibit novel anionic 2-D double-layer networks,both constructed from nest-shaped clusters[WOS3Cu3]+linked by single CN-bridges,but containing the different cations[Pr4N]+and[Bu4N]+,respectively.5 is constructed from nest-shaped clusters[Mo OS3Cu3]+and single CN-bridges,with an anionic 3D diamondoid *** anionic frameworks of 1-5,all sustained by single CN-bridges,are non-interpenetrating and exhibit huge free *** differing molar ratios of the reactants and varying the cluster building blocks resulted in differing single cyanide-bridged Mo（W）/S/Cu cluster-based CPs,while replacing the cation（[Pr4N]+vs.[Bu4N]+）was found to have negligible impact on the nature of the ***,replacement of the central metal atom（W ***）in the cluster building blocks had a pronounced effect on the framework.

关键词： Coordination polymers Mo(W)/S/Cu cluster Reaction variables

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Atomically dispersed N-coordinated Fe-Fe dual-sites with enhanced enzyme-like activities

引用

Nano Research 2022年第2期15卷 959-964页

作者： Lei Jiao Wei Ye Yikun Kang Yu Zhang Weiqing Xu Yu Wu Wenling Gu Weiyu Song Yujie Xiong Chengzhou Zhu Key Laboratory of Pesticide and Chemical Biology of Ministry of Education International Joint Research Center for Intelligent Biosensing Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan 430079China College of Material Chemistry and Chemical EngineeringHangzhou Normal UniversityHangzhou 311121China State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing 102249China Hefei National Laboratory for Physical Sciences at the Microscale Collaborative Innovation Center of Chemistry for Energy Materials(iChEM)School of Chemistry and Materials Scienceand National Synchrotron Radiation LaboratoryUniversity of Science and Technology of ChinaHefei 230026China

replacement of enzymes with nanomaterials such as atomically dispersed metal catalysts is one of the most crucial steps in addressing the challenges in *** the breakthroughs of single-atom catalysts in enzyme-mimicking,a fundamental investigation on the development of an instructional strategy is still required for mimicking biatomic/multiatomic active sites in natural enzymes and constructing synergistically enhanced metal atom active ***,Fe_(2)NC catalysts with atomically dispersed Fe-Fe dual-sites supported by the metal-organic frameworks-derived nitrogen-doped carbon are employed as biomimetic catalysts to perform proof-of-concept *** effect of Fe atom number toward typical oxidase(cytochrome C oxidase,NADH oxidase,and ascorbic acid oxidase)and peroxidase(NADH peroxidase and ascorbic acid peroxidase)activities is systematically evaluated by experimental and theoretical investigations.A peroxo-like O_(2) adsorption in Fe_(2)NC nanozymes could accelerate the O-O activation and thus achieve the enhanced enzyme-like *** work achieves the vivid simulation of the enzyme active sites and provides the theoretical basis for the design of high-performance *** a concept application,a colorimetric biosensor for the detection of S^(2-) in tap water is established based on the inhibition of enzyme-like activity of Fe_(2)NC nanozymes.

关键词： nanozymes atomically dispersed dual-metal sites oxidase-like activities single-atom catalysis sensors

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Assimilation of Doppler Radar Observations with an Ensemble Square Root Filter:A Squall Line Case Study

引用

Journal of Meteorological Research 2014年第2期28卷 230-251页

作者：秦琰琰龚建东李泽椿盛日锋 National Marine Environment Forecast center Key Laboratory of Research on Marine Hazards Forecasting National Marine Environmental Forecast center center for Numerical Weather Prediction CMA National Meteorological center CMA Weather Modification Office of People's Government of Shandong

The effectiveness of using an Ensemble Square Root Filter（EnSRF） to assimilate real Doppler radar observations on convective scale is investigated by applying the technique to a case of squall line on 12July 2005 in midwest Shandong Province using the Weather Research and Forecasting（WRF） *** experimental results show that：（1） The EnSRF system has the potential to initiate a squall line accurately by assimilation of real Doppler radar *** convective-scale information has been added into the WRF model through radar data assimilation and thus the analyzed fields are improved *** model spin-up time has been shortened,and the precipitation forecast is improved accordingly.（2） Compared with the control run,the deterministic forecast initiated with the ensemble mean analysis of EnSRF produces more accurate prediction of microphysical *** predicted wind and thermal fields are reasonable and in accordance with the characteristics of convective storms.（3） The propagation direction of the squall line from the ensemble mean analysis is consistent with that of the observation,but the propagation speed is larger than the *** effective forecast period for this squall line is about 5-6 h,probably because of the nonlinear development of the convective storm.

关键词： radar data assimilation ensemble square root filter squall line

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：