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Role of dietary amino acids and microbial metabolites in the regulation of pig intestinal health

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Animal Nutrition 2022年第2期9卷 1-6页

作者： Yong Ma Xuebing Han Jun Fang Hongmei Jiang College of Bioscience and biotechnology Hunan Agricultural UniversityHunan Provincial Engineering Research Center of Applied Microbial Resources Development for Livestock and PoultryChangsha410128China

With the rapid development of sequencing technology,research on pigs has focused on intestinal *** evidence suggests that the metabolites of intestinal microbes are the key medium for interactions between microbes and the *** acid metabolism is involved in the growth and immune processes of *** gut microbes of pigs are heavily involved in the metabolism of amino acids in their ***,we review the latest relevant *** findings show that microbial metabolites,such as indoles,short-chain fatty acids,and ammonia,play a key role in gut ***,we summarize the effects of amino acids on the structure of the gut microbial community and the metabolism of amino acids by pig gut *** shows that microbial amino acid metabolites act as signal molecules in the intestine and play an important role in the intestinal health of pigs.

关键词： Pig Amino acid Intestinal microbe Metabolite

The impact of probiotics on gut health via alternation of immune status of monogastric animals

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Animal Nutrition 2021年第1期7卷 24-30页

作者： Sujuan Ding Wenxin Yan Yong Ma Jun Fang College of Bioscience and biotechnology Hunan Agricultural UniversityHunan Provincial Engineering Research Center of Applied Microbial Resources Development for Livestock and PoultryChangsha410128China

The intestinal immune system is affected by various factors during its development,such as maternal antibodies,host genes,intestinal microbial composition and activity,and various stresses(such as weaning stress).Intestinal microbes may have an important impact on the development of the host immune *** interventions such as probiotics may have a positive effect on intestinal immunity by regulating the composition and activity of intestinal ***,probiotics participate in the regulation of host health in many ways;for instance,by improving digestion and the absorption of nutrients,immune response,increasing the content of intestinal-beneficial microorgan-isms,and inhibiting intestinal-pathogenic bacteria,and they participate in regulating intestinal diseases in various *** are widely used as additives in livestock and the poultry industry and bring health benefits to hosts by improving intestinal microbes and growth performance,which provides more choices for promoting strong and efficient productivity.

关键词： Probiotic Animal Gut microbiota Immune response

Potential role of Lactobacillus plantarum in colitis induced by dextran sulfate sodium through altering gut microbiota and host metabolism in murine model

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Science China(Life Sciences) 2021年第11期64卷 1906-1916页

作者： Sujuan Ding Wenxin Yan Jun Fang Hongmei Jiang Gang Liu College of Bioscience and biotechnology Hunan Agricultural UniversityHunan Provincial Engineering Research Center of Applied Microbial Resources Development for Livestock and PoultryChangsha 410128China

Inflammatory bowel disease(IBD) is a chronic lifelong disease characterized by inflammation of the gastrointestinal *** more and more treatment options serve IBD, there is still no cure. It is important to find an effective treatment for *** study aims to investigate whether Lactobacillus plantarum(L. plantarum) could alleviate colitis induced by dextran sulfate sodium(DSS). Following the DSS challenge, L. plantarum on DSS-mediated inflammatory colon lesions in mice, and *** therapy heightened the relative abundance of the colon-resident Actinobacteria. Analysis of serum metabolomics also indicated that the content of MG(18:4(6 Z, 9 Z, 12 Z, 15 Z)/0:0/0:0) was increased in response to L. plantarum therapy, and this was also the case for indolepyruvate and 1-hydroxyibuprofen. However, 13-oxooctadecadienoic acid(13-oxo ODE) and indolylacryloylglycine content fell following the DSS challenge. Based on these results, the study elucidates the mitigatory effects of L. plantarum in colitis, which depend on its regulation of the colonic microbial community and its modification of serum metabolites. The results revealed that L. plantarum mitigated inflammatory colon lesions, reprogrammed the microbial community and altered the level of serum metabolites in a murine model challenged with DSS. The study may present a potential therapeutic strategy for colitis.

关键词： Lactobacillus plantarum colitis DSS microbiota metabolism

Inactivation of the positive LuxR-type oligomycin biosynthesis regulators OlmRI and OlmRII increases avermectin production in Streptomyces avermitilis

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Chinese Science Bulletin 2012年第8期57卷 869-876页

作者： YU Qing BAI LinQuan ZHOU XiuFen DENG ZiXin State Key Laboratory of microbial Metabolism and School of Life Sciences&BiotechnologyShanghai Jiao Tong UniversityShanghai 200030China

Oligomycins are a group of 26 macrocyclic lactones that exhibit broad biological activities,including antifungal,anticancer and nematocidal *** of the oligomycin biosynthetic gene cluster (olm) in *** revealed 2 tandem LuxR-type regulators,OlmRI (931 aa) and OlmRII (941 aa),with shared identity of 38%.Gene replacement of olmRI or olmRII abolished oligomycin production,and this production could be partially restored in the disruptants by introducing cloned olmRI and olmRII with their native promoters,demonstrating the essential role of OlmRI and OlmRII for oligomycin *** real-time RT-PCR analysis revealed that transcription of 14 olm genes was differentially affected by the deletion of olmRI and ***,avermectin production in both mutants was enhanced at least *** identification of the positive cluster-situated regulators,OlmRI and OlmRII,paves the way for the transcriptional analysis of oligomycin biosynthesis and for the enhancement of oligomycin and avermectin production through regulator engineering.

关键词：生物合成基因簇阿维菌素生产监管 R型链霉菌 RT-PCR分析灭活

Fatty acids of Pleurotus florida mushroom:Potential molecules for blood glucose control

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Food Bioscience 2022年第2期46卷 395-402页

作者： Shefali Madaan Sanaa Ismael Abdul Jabar Bibhu Prasad Panda microbial&Pharmaceutical biotechnology Laboratory Department of Pharmacognosy and PhytochemistrySchool of Pharmaceutical Education and ResearchJamia HamdardNew DelhiIndia

In Vitro-In Vivo antidiabetic effect of Pleurotus florida mycelia was evaluated using enzymes,yeast cell and in streptozotocin induced type 2 diabetic(T2D)animal *** mycelia was prepared by submerged fermentation *** fungal biomass was organically extracted using mixture of ethanol and *** extractives yield of 14.3%w/w was obtained in hydroalcoholic solvent with dielectric constant-δvalue of 78.2(EX78).*** mycelia extract(EX 78)shows higher antioxidant power with 86.87%free radical scavenging activity and with 75.29 reducing ***-vitroα-amylase inhibition,α-glucosidase inhibition and glucose uptake activity of EX 78 shows higher *** *** mycelia extract(EX 78)is also found to be effective in controlling of blood glucose and insulin level in streptozotocin-nicotinamide induced T2D *** blood glucose was reduced to 216±6.21 mg/dl from 357±0.34 mg/dl and the insulin level was increased to 0.423±0.006 ng per mL from 0.164±0.03 ng/mL in *** treated *** higher fatty acids,C20-eicosane;C24-tetracosane and C30-squalene present in *** mycelium extract was found to be effective in inhibiting human intestinalα-glucosidase and pancreaticα-*** *** mushroom is found to be effective in controlling high blood glucose elevated liver and cardiac *** of this mushroom is suitable for controlling blood glucose level in person with hyperglycaemia.

关键词： Pleurotus florida Oyster mushroom Bioactive molecules Hyperglycaemia Type 2 diabetic

Trace metal elements: a bridge between host and intestinal microorganisms

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中国科学:生命科学英文版 2023年第9期66卷 1976-1993页

作者： Yong Ma Yanquan Fei Sujuan Ding Hongmei Jiang Jun Fang Gang Liu College of Bioscience and biotechnology Hunan Agricultural UniversityHunan Provincial Engineering Research Center of Applied Microbial Resources Development for Livestock and PoultryChangsha 410128China

Trace metal elements, such as iron, copper, manganese, and zinc, are essential nutrients for biological processes. Although their intake demand is low, they play a crucial role in cell homeostasis as the cofactors of various enzymes. Symbiotic intestinal microorganisms compete with their host for the use of trace metal elements. Moreover, the metabolic processes of trace metal elements in the host and microorganisms affect the organism's health. Supplementation or the lack of trace metal elements in the host can change the intestinal microbial community structure and function. Functional changes in symbiotic microorganisms can affect the host's metabolism of trace metal elements. In this review, we discuss the absorption and transport processes of trace metal elements in the host and symbiotic microorganisms and the effects of dynamic changes in the levels of trace metal elements on the intestinal microbial community structure. We also highlight the participation of trace metal elements as enzyme cofactors in the host immune process. Our findings indicate that the host uses metal nutrition immunity or metal poisoning to resist pathogens and improve immunity.

关键词： trace metal elements intestinal microorganisms host immunity metal metabolism

Pollution and biodegradation of hexabromocyclododecanes:A review

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Frontiers of Environmental Science & Engineering 2020年第1期14卷 35-42页

作者： Ling Huang Syed Bilal Shah Haiyang Hu Ping Xu Hongzhi Tang State Key Laboratory of microbial Metabolism Joint International Research Laboratory of Metabolic and Developmental SciencesSchool of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China

Hexabromocyclododecanes(HBCDs)are the most common brominated flame-retardants after polybrominated diphenyl *** can induce cancer by causing inappropriate antidiuretic hormone *** contamination with HBCDs has been detected globally,with concentrations ranging from ng to|*** to degrade HBCDs include physicochemical methods,bioremediation,and *** photodegradation of HBCDs using simulated sunlight or ultraviolet lamps,or chemical catalysts are inefficient and expensive,as is physicochemical ***,bioremediation is considered as the most cost-effective and clean *** date,five bacterial strains capable of degrading HBCDs have been isolated and identified:Pseudomonas ***01,Bacillus ***-sjtu,Achromobacter ***-1,Achromobacter ***-2,and Pseudomonas aeruginosa *** molecular mechanisms of biodegradation of HBCDs are discussed in this *** microbial resources should be explored to increase the resource library in order to identify more HBCD-degrading microbes and functional *** biology methods may be exploited to accelerate the biodegradation capability of existing bacteria,including modification of the degrading strains or functional enzymes,and artificial construction of the degradation *** most potentially useful method is combining microdegradation with physicochemical methods and *** example,exogenous microorganisms might be used to stimulate the adsorption capability of plants for HBCDs,or to utilize an interaction between exogenous microorganisms and rhizosphere microorganisms to form a new rhizosphere microbial community to enhance the biodegradation and absorption of HBCDs.

关键词： Hexabromocyclododecane Biodegradation Bioremediation Phytoremediation Bacterium

Indole methylation protects diketopiperazine configuration in the maremycin biosynthetic pathway

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Science China Chemistry 2016年第9期59卷 1224-1228页

作者： Yingxia Lan Yi Zou Tingting Huang Xiaozheng Wang Nelson L. Brock Zixin Deng Shuangjun Lin State Key Laboratory of microbial Metabolism:Joint International Laboratory on Metabolic & Developmental Sciences School of Life Sciences & Biotechnology Shanghai Jiao Tong University Shanghai 200030 China

The maremycin biosynthetic gene cluster has been identified in Streptomyces sp. B9173. Comparative metabolic profiling with knockout mutant strains led to the identification of new products correlated to the maremycin biosynthesis, in particular the ＂demethyl＂-maremycins with an unexpected D-tryptophan unit. A biosynthetic pathway for the maremycins is proposed and plausible reasoning for tryptopban epimerization in the demethylmaremycin biosynthesis is also provided.

关键词： biosynthesis maremycin N-methylation methyltransferase epimerization

Multi-omics Data Reveal the Effect of Sodium Butyrate on Gene Expression and Protein Modification in Streptomyces

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Genomics, Proteomics & Bioinformatics 2023年第6期21卷 1149-1162页

作者： Jiazhen Zheng Yue Li Ning Liu Jihui Zhang Shuangjiang Liu Huarong Tan State Key Laboratory of microbial Resources Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of microbial biotechnology Shandong UniversityQingdao 266237China

Streptomycetes possess numerous gene clusters and the potential to produce a large amount of natural *** deacetylase(HDAC)inhibitors play an important role in the regulation of histone modifications in fungi,but their roles in prokaryotes remain poorly ***,we investigated the global effects of the HDAC inhibitor,sodium butyrate(SB),on marine-derived Streptomyces olivaceus FXJ 8.021,particularly focusing on the activation of secondary metabolite *** antiSMASH analysis revealed 33 secondary metabolite biosynthetic gene clusters(BGCs)in strain FXJ 8.021,among which the silent lobophorin BGC was activated by *** data showed that the expression of genes involved in lobophorin biosynthesis(ge00097–ge00139)and CoA-ester formation(e.g.,ge02824),as well as the glycolysis/gluconeogenesis pathway(e.g.,ge01661),was significantly up-regulated in the presence of *** CoA-ester analysis confirmed that SB triggered the biosynthesis of CoA-ester,thereby increasing the precursor supply for lobophorin *** acetylomic analysis revealed that the acetylation levels on 218 sites of 190 proteins were up-regulated and those on 411 sites of 310 proteins were *** acetylated proteins were particularly enriched in transcriptional and translational machinery components(e.g.,elongation factor GE04399),and their correlations with the proteins involved in lobophorin biosynthesis were established by protein–protein interaction network analysis,suggesting that SB might function via a complex hierarchical.

关键词： Silent gene cluster Streptomyces Sodium butyrate Protein modification Acetylome