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World Journal of Clinical Oncology 2025年第2期16卷 130-143页

作者： Wei-Wu Chen Yue-Hong Kong Li-Yuan Zhang center for Cancer diagnosis and Treatment The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

BACKGROUND Bone is a major site of metastasis in nasopharyngeal carcinoma(NPC).Recently,nuclear factor kappa-beta ligand(RANKL)inhibitors have garnered attention for their ability to inhibit osteoclast formation and bone resorption,as well as their potential to modulate immune functions and thereby enhance the efficacy of programmed cell death protein 1(PD-1)inhibitor *** SUMMARY We present a case of a patient with NPC who developed sternal stalk metastasis and multiple bone metastases with soft tissue invasion following radical chemoradiotherapy and targeted *** to chemotherapy,the patient experienced severe bone marrow suppression and opted out of further chemotherapy ***,the patient received combination therapy,including RANKL inhibitors(denosumab)alongside PD-1,radiotherapy,and granulocyte-macrophage colonystimulating factor(PRaG)therapy(NCT05435768),and achieved 16 months of progression-free survival and more than 35 months of overall survival,without encountering any grade 2 or higher treatment-related adverse *** Denosumab combined with PRaG therapy could be a new therapeutic approach for the second-line treatment in patients with bone metastases.

关键词： Nasopharyngeal carcinoma Bone metastasis Radiotherapy Programmed cell death protein 1 inhibitors Denosumab Case report

Function, energy and environment orientation in innovation research of rare earth materials

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Science China(Technological Sciences) 2019年第12期62卷 2302-2305页

作者： ZHOU XueZhen LI HongYang LIU YanZhu LI YongXiu research center for Rare Earths & micro/nano Functional Materials Nanchang University

Rare earths(REs),as a kind of key elements widely used in high-tech industry,have been paid more and more attention all over the *** a time when the world trade war is raging,dignitaries and executives are trying to control this strategic resource,while scientific and technological re-searchers are trying to solve the scientific and technological problems in the development of RE *** innovation research of RE materials are orientated by three main aspects as shown in Figure 1:one is to make the production process of RE materials more green and sustainable,the second is to strengthen the material properties and save energy,and the third is to find new functional materials with improved quality..

关键词： Figure energy technological

The autophagy-lysosome pathway:a potential target in the chemical and gene therapeutic strategies for Parkinson’s disease

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Neural Regeneration research 2025年第1期20卷 139-158页

作者： Fengjuan Jiao Lingyan Meng Kang Du Xuezhi Li School of Mental Health Jining Medical UniversityJiningShandong ProvinceChina Shandong Collaborative Innovation center for diagnosis Treatment and Behavioral Interventions of Mental DisordersInstitute of Mental HealthJining Medical UniversityJiningShandong ProvinceChina

Parkinson’s disease is a common neurodegenerative disease with movement disorders associated with the intracytoplasmic deposition of aggregate proteins such asα-synuclein in *** one of the major intracellular degradation pathways,the autophagy-lysosome pathway plays an important role in eliminating these *** evidence has shown that upregulation of the autophagy-lysosome pathway may contribute to the clearance ofα-synuclein aggregates and protect against degeneration of dopaminergic neurons in Parkinson’s ***,multiple genes associated with the pathogenesis of Parkinson’s disease are intimately linked to alterations in the autophagy-lysosome ***,this pathway appears to be a promising therapeutic target for treatment of Parkinson’s *** this review,we briefly introduce the machinery of ***,we provide a description of the effects of Parkinson’s disease–related genes on the autophagy-lysosome ***,we highlight the potential chemical and genetic therapeutic strategies targeting the autophagy–lysosome pathway and their applications in Parkinson’s disease.

关键词： autophagy chemical therapy gene therapy Parkinson’s disease α-synuclein

LiZnPO_4:Tb^(3+),Ce^(3+) green phosphors with high efficiency

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Journal of Rare Earths 2012年第7期30卷 637-640页

作者：欧阳春梅马帅饶阳周新木周雪珍李永绣 research center for Rare Earths&micro/nano-Functional Materials Nanchang University

Tb^3＋ and Ce^3＋ co-activated LiZnPO4 phosphors with high luminescence efficiency were synthesized by a high temperature solid-state reaction at 1000 ℃ for 3 h. The XRD patterns, photoluminescence spectra and SEM were recorded and the effects ofTb^3＋and Ce^3＋ concentration, sintering condition on the luminescent properties of as-synthesized phosphors were investigated. The emission spectra under ultraviolet （200-300 nm） radiation showed a dominant peak at 543 nm attributed to the ^5D4→^7F5 transition of Tb^3＋, which was greatly enhanced by the co-doping of Ce^3＋, indicating that there occurred an efficient non-radiative energy transfer from Ce^3＋ to Th^3＋. The optimal doping concentrations of Tb^3＋ and Ce^3＋ were determined to be 9% and 10%, respectively.

关键词： green phosphor high luminescence efficiency LiZnPO4:Tb^3+,Ce^3+ rare earths

Subretinal fibrosis secondary to neovascular age-related macular degeneration:mechanisms and potential therapeutic targets

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Neural Regeneration research 2025年第2期20卷 378-393页

作者： Jingxiang Zhang Xia Sheng Quanju Ding Yujun Wang Jiwei Zhao Jingfa Zhang Department of Ophthalmology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Urology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Ophthalmology Shanghai General Hospital(Shanghai First People’s Hospital)Shanghai Jiao Tong University School of MedicineShanghaiChina National Clinical research center for Eye Diseases Shanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghaiChina

Subretinal fibrosis is the end-stage sequelae of neovascular age-related macular *** causes local damage to photoreceptors,retinal pigment epithelium,and choroidal vessels,which leads to permanent central vision loss of patients with neovascular age-related macular *** pathogenesis of subretinal fibrosis is complex,and the underlying mechanisms are largely ***,there are no effective treatment options.A thorough understanding of the pathogenesis of subretinal fibrosis and its related mechanisms is important to elucidate its complications and explore potential *** current article reviews several aspects of subretinal fibrosis,including the current understanding on the relationship between neovascular age-related macular degeneration and subretinal fibrosis;multimodal imaging techniques for subretinal fibrosis;animal models for studying subretinal fibrosis;cellular and non-cellular constituents of subretinal fibrosis;pathophysiological mechanisms involved in subretinal fibrosis,such as aging,infiltration of macrophages,different sources of mesenchymal transition to myofibroblast,and activation of complement system and immune cells;and several key molecules and signaling pathways participating in the pathogenesis of subretinal fibrosis,such as vascular endothelial growth factor,connective tissue growth factor,fibroblast growth factor 2,platelet-derived growth factor and platelet-derived growth factor receptor-β,transforming growth factor-βsignaling pathway,Wnt signaling pathway,and the axis of heat shock protein 70-Toll-like receptors 2/*** review will improve the understanding of the pathogenesis of subretinal fibrosis,allow the discovery of molecular targets,and explore potential treatments for the management of subretinal fibrosis.

关键词： choroidal neovascularization epithelial-mesenchymal transition mesenchymal transition myofibroblast neovascular age-related macular degeneration submacular fibrosis subretinal fibrosis therapeutic targets transforming growth factor-β vascular endothelial growth factor

Effects of Particle Sizes on the Electromagnetic Property of Flaky FeSi Composites

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Acta Metallurgica Sinica(English Letters) 2013年第4期26卷 366-372页

作者： Yonggang XU Liming YUAN Jun CAI Jianlu LV Deyuan ZHANG Bionic and micro/nano/Bio Manufacturing Technology research center School of Mechanical Engineering and AutomationBeihang University

Flaky FeSi absorbents with different size ranges were fabricated by sintering after mechanical milling process. X-ray diffraction （XRD） was used to analyze the particle crystal grain structure. The complex permittivity and permeability of FeSi/paraffin composites were measured in frequency of 2-12 GHz using a vector network analyzer, and the DC electric conductivity was measured by the standard four-point contact method, then microwave reflection loss （RL） and shielding effectiveness （SE） were calculated. It was obtained that c^-Fe appeared in the super-lattice diffraction peaks in XRD pattern. As the particles size decreased, the permittivity decreased due to the inferior microwave electrical conductivity and dielectric loss tangent, while the permeability increased due to the decrease of diameter-thickness ratio, which could be demonstrated in the comparison between the experiment and calculation results. When thickness is 1 mm, the composites with the smallest FeSi particles addition had a better absorbing property for the better impedance matching characteristic, and the minimum RL was -7.9 dB at 4.6 GHz. While the composites with larger FeSi particles addition had an excellent shielding property due to the higher permittivity, the SE value ranged from 15 dB to 30 dB at the frequency band.

关键词： FeSi alloy Absorbing property Shielding property Mechanical milling

Development of Raman acousto-optic frequency shifter based on SAW

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Journal of Semiconductors 2014年第8期35卷 104-109页

作者：王春梅温志渝张祖伟张颖异 Key Laboratory of Fundamental Science on micro/nano-Device and System Technology Chongqing University National center for International research of micro/nano-System and New Material Technology Chongqing University microsystem research center of Chongqing University

A Raman acousto-optic frequency shifter （AOFS） based on surface acoustic wave （SAW） is presented. It consists of a double-ended SAW resonator and optical waveguide system. The structure parameters of the SAW resonator are optimized using COM software and the optical waveguide system is designed using an effective index method. The AOFS prototype fabricated using MEMS technology is detected. The optical beat signals su- perimposed by ± 1st-order and ±2nd-order diffracted beams are detected. The frequency shift of 78.2201 MHz related to the 1 st-order diffracted beams and 156.2306 MHz related to the 2nd-order diffracted beams are obtained respectively.

关键词： SAW Raman AOFS frequency shift

Feasibility analysis of angles-only navigation algorithm with multisensor data fusion for spacecraft noncooperative rendezvous

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Astrodynamics 2023年第2期7卷 179-196页

作者： Ronghua Du Wenhe Liao Xiang Zhang micro/nano Satellite research center Nanjing University of Science and TechnologyNanjing 210094China

Relative navigation is crucial for spacecraft noncooperative rendezvous,and angles-only navigation using visible and infrared cameras provides a feasible ***,an angles-only navigation algorithm with multisensor data fusion is proposed to derive the relative motion states between two noncooperative ***,the design model of the proposed algorithm is introduced,including the derivation of the state propagation and measurement ***,models for the sensor and actuator are introduced,and the effects of various factors on the sensors and actuators are *** square-root unscented Kalman filter is used to design the angles-only navigation filtering ***,the Clohessy-Wiltshire terminal guidance algorithm is introducedto obtain the theoretical relative motion trajectories during the rendezvous operations of two noncooperative ***,the effectiveness of the proposed angles-only navigation algorithm is verified using a semi-physical simulation *** results prove that an optical navigation camera combined with average accelerometers and occasional orbital maneuvers is feasible for spacecraft noncooperative rendezvous using angles-only navigation.

关键词： angles-only navigation feasibility analysis multisensor data fusion spacecraft noncooperative rendezvous

Calculation of surface acoustic waves in a multilayered piezoelectric structure

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Journal of Semiconductors 2013年第1期34卷 6-11页

作者：张祖伟温志渝胡晶 Key Laboratory of Fundamental Science on micro/nano-Device and System Technology Chongqing University National center for International research of micro/nano-System and New Material Technology Chongqing University microsystem research center Chongqing University

The propagation properties of the surface acoustic waves（SAWs） in a ZnO-SiO2-Si multilayered piezoelectric structure are calculated by using the recursive asymptotic *** phase velocities and the electromechanical coupling coefficients for the Rayleigh wave and the Love wave in the different ZnO-SiO2-Si structures are calculated and *** Love mode wave is found to be predominantly generated since the c-axis of the ZnO film is generally perpendicular to the *** order to prove the calculated results,a Love mode SAW device based on the ZnO-SiO2-Si multilayered structure is fabricated by micromachining,and its frequency responses are *** experimental results are found to be mainly consistent with the calculated ones,except for the slightly larger velocities induced by the residual stresses produced in the fabrication process of the *** deviation of the experimental results from the calculated ones is reduced by thermal annealing.

关键词： SAW RAM multilayered structure

PARAMETRIC MATCHING SELECTION OF MULTI-MEDIUM COUPLING SHOCK ABSORBER

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Chinese Journal of Mechanical Engineering 2006年第1期19卷 124-127页

作者： YANG Ping DING Jianning YANG Jichang LI Changsheng FAN Zhen LIN Zhiyong research center of micro-nano Science and Technology Jiangsu University Zhenjiang 212013 China

To achieve the dual demand of resisting violent impact and attenuating vibration in vibration-impact-safety of protection for precision equipment such as MEMS packaging system, a theo- retical mathematical model of multi-medium coupling shock absorber is presented. The coupling of quadratic damping, linear damping, Coulomb damping and nonlinear spring are considered in the model. The approximate theoretical calculating formulae are deduced by introducing transformation-tactics. The contrasts between the analytical results and numerical integration results are developed. The resisting impact characteristics of the model are also analyzed in progress. In the meantime, the optimum model of the parameters matching selection for design of the shock absorber is built. The example design is illustrated to confirm the validity of the modeling method and the theoretical solution.

关键词： Multi-damping medium Shock absorber Model Parametric matching selection Resisting impact and attenuating vibration