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Journal of Geriatric Cardiology 2019年第10期16卷 785-788页

作者： Zhao-Qing SUN Ying-Hua CUI Bo YAN Cheeloo College of Medicine Shandong UniversityJinanShandongChina Division of Cardiology the Affiliated Hospital of Jining Medical UniversityJining Medical UniversityJiningShandongChina The center for Molecular Genetics of Cardiovascular Diseases the Affiliated Hospital of Jining Medical UniversityJining Medical UniversityJiningShandongChina Shandong Provincial Key Laboratory of Cardiac Disease Diagnosis and Treatment the Affiliated Hospital of Jining Medical UniversityJining Medical UniversityJiningShandongChina Shandong Provincial Sino-US Cooperation research center for translational Medicine the Affiliated Hospital of Jining Medical UniversityJining Medical UniversityJiningShandongChina

With the aging of the world’s population, the incidence of coronary atherosclerotic disease (CAD) is gradually increasing, which places a heavy burden on social development.[ 1] Acute myocardial infarction (AMI) is t... 详细信息

关键词： GATA binding protein 6 Gene therapy Human diseases Sequence variations Single nucleotide polymorphisms

Muscle strength cut-offs for the detection of metabolic syndrome in a nonrepresentative sample of collegiate students from Colombia

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Journal of Sport and Health Science 2020年第3期9卷 283-290页

作者： Antonio Garcia-Hermoso Alejandra Tordecilla-Sanders Jorge Enrique Correa-Bautista Mark D.Peterson Mikel Izquierdo Aura Cristina Quino-ávila Carolina Sandoval-Cuellar Katherine González-Ruíz Robinson Ramíez-Vélez Physical Activity Sport and Health Sciences LaboratoryUniversity of Santiago de ChileSantiago de Chile 7500618Chile center of Studies in Physical Activity Measurements School of Medicine and Health SciencesUniversidad del RosarioBogot a 111221Colombia Department of Physical Medicine and Rehabilitation University of MichiganAnn ArborMichigan 48109USA Department of Health Sciences Public University of NavarreCIBERFES(CB16/10/00315)Navarre 31009Spain CORPS Group Faculty of Health SciencesUniversity of BoyacáBoyac aTunja 153610Colombia Physical Exercise and Sports research Group Manuela Beltrán UniversityBogot a 111221Colombia

Background: Evidence shows an association between grip strength and health;however, grip strength cut-offs for the detection of metabolic syndrome(MetS) in Latin American populations are scarce. The purpose of this study was to determine cut-offs of normalized grip strength(NGS)for the detection of MetS in a large nonrepresentative sample of a collegiate student population from ***: A total of 1795 volunteers(61.4% female;age = 20.68 ± 3.10 years, mean ± SD), ranging between 18 and 30 years of age participated in the study. Strength was estimated using a handheld dynamometer and normalized to body mass(handgrip strength(kg)/body mass(kg)). Anthropometrics, serum lipids indices, blood pressure, and fasting plasma glucose were measured. Body composition was measured by bioelectrical impedance analysis. MetS was defined as including ≥3 of the 5 metabolic abnormalities according to the International diabetes Federation definition. A metabolic risk score was computed from the following components: waist circumference, triglycerides, high-density lipoprotein cholesterol, glucose, and systolic and diastolic blood ***: Receiver operating curve analysis showed significant discriminatory accuracy of NGS in identifying the thresholds and risk *** strength was associated with increased prevalence of MetS. In males, weak, intermediate, and strong NGS values at these points were0.615, respectively. In females, these cut-off points were 0.437, ***: Our sex-specific cut-offs of NGS could be incorporated into a clinical setting for identifying college students at cardiometabolic disease risk.

关键词： Cardiometabolic risk Muscular fitness Receiver operating characteristic curve Thresholds

An international Delphi consensus statement on metabolic dysfunction-associated fatty liver disease and risk of chronic kidney disease

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Hepatobiliary Surgery and Nutrition 2023年第3期12卷 386-403,I0014-I0016页

作者： Dan-Qin Sun Giovanni Targher Christopher D.Byrne David C.Wheeler Vincent Wai-Sun Wong Jian-Gao Fan Herbert Tilg Wei-Jie Yuan Christoph Wanner Xin Gao Michelle T.Long Mehmet Kanbay Mindie H.Nguyen Sankar D.Navaneethan Yusuf Yilmaz Yuli Huang Rino A.Gani Pierluigi Marzuillo Jérôme Boursier Huijie Zhang Chan-Young Jung Jin Chai Luca Valenti George Papatheodoridis Giovanni Musso Yu-Jun Wong Mohamed El-Kassas Nahum Méndez-Sánchez Silvia Sookoian Michael Pavlides Ajay Duseja Adriaan G.Holleboom Junping Shi Wah-Kheong Chan Yasser Fouad Junwei Yang Sombat Treeprasertsuk Helena Cortez-Pinto Masahide Hamaguchi Manuel Romero-Gomez Mamun Al Mahtab Ponsiano Ocama Atsushi Nakajima Chunsun Dai Mohammed Eslam Lai Wei Jacob George Ming-Hua Zheng Department of Nephrology Jiangnan University Medical CenterWuxiChina Affiliated Wuxi Clinical College of Nantong University WuxiChina Section of Endocrinology Diabetes and MetabolismDepartment of MedicineAzienda Ospedaliera Universitaria Integrata VeronaVeronaItaly Southampton National Institute for Health and Care research Biomedical research Centre University Hospital Southamptonand Southampton General HospitalUniversity of SouthamptonSouthamptonUK Department of Renal Medicine University College LondonLondonUK Department of Medicine and Therapeutics Chinese University of Hong KongHong KongChina center for Fatty Liver Department of GastroenterologyXin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Internal Medicine I GastroenterologyEndocrinology&MetabolismMedical University InnsbruckInnsbruckAustria Department of Nephrology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Division of Nephrology Department of MedicineWürzburg University ClinicWürzburgGermany Department of Endocrinology and Metabolism Zhongshan HospitalFudan UniversityShanghaiChina Section of Gastroenterology Boston Medical CenterBoston University School of MedicineBostonMAUSA Division of Nephrology Department of Medicine(M.K.)Koc University School of MedicineIstanbulTurkey Division of Gastroenterology and Hepatology Department of MedicineStanford University Medical CenterPalo AltoCAUSA Department of Epidemiology and Population Health Stanford University Medical CenterPalo AltoCAUSA Section of Nephrology and Institute of Clinical and translational research Baylor College of Medicineand Michael E.DeBakey VA Medical CenterHoustonTXUSA Department of Gastroenterology School of MedicineMarmara UniversityIstanbulTurkey Department of Gastroenterology School of MedicineRecep Tayyip Erdoğan UniversityRizeTurkey Department of Cardiology Shunde HospitalSouthern Medical UniversityFoshanChina Division of Hepat

Background:With the rising global prevalence of fatty liver disease related to metabolic dysfunction,the association of this common liver condition with chronic kidney disease(CKD)has become increasingly *** 2020,the more inclusive term metabolic dysfunction-associated fatty liver disease(MAFLD)was proposed to replace the term non-alcoholic fatty liver disease(NAFLD).The observed association between MAFLD and CKD and our understanding that CKD can be a consequence of underlying metabolic dysfunction support the notion that individuals with MAFLD are at higher risk of having and developing CKD compared with those without ***,to date,there is no appropriate guidance on CKD in individuals with ***,there has been little attention paid to the link between MAFLD and CKD in the Nephrology *** and Results:Using a Delphi-based approach,a multidisciplinary panel of 50 international experts from 26 countries reached a consensus on some of the open research questions regarding the link between MAFLD and ***:This Delphi-based consensus statement provided guidance on the epidemiology,mechanisms,management and treatment of MAFLD and CKD,as well as the relationship between the severity of MAFLD and risk of CKD,which establish a framework for the early prevention and management of these two common and interconnected diseases.

关键词： Metabolic dysfunction-associated fatty liver disease(MAFLD) non-alcoholic fatty liver disease(NAFLD) chronic kidney disease(CKD) consensus

Methylglyoxal activation of TRPA1 contributes to diabetic itch in a murine model of type 1 diabetes

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Methylglyoxal activation of TRPA1 contributes to diabetic it...

Post-translational modification of Parkin and its research progress in cancer

中国神经科学学会第十二届全国学术会议

作者： Ruo-Xiao Cheng Yu Feng Di Liu Teng-Teng Liu Feng-Ming Zhou Cun-Jun Su Yan Zhou Bing Wang Ya Huang Li-Hua Chen Ji Hu Ru-Rong Ji Tong Liu The Second Affiliated Hospital of Soochow University Jiangsu Key Laboratory of translational research and Therapy for Neuro-Psycho-Diseases and Institute of Neuroscience Soochow University Departments of Anesthesiology Duke University Medical Center Jiangsu Key Laboratory of Preventive and translational Medicine for Geriatric Diseases Department of Nutrition and Food Hygiene School of Public Health Soochow University Department of Neurobiology Duke University Medical Center

Itch（pruritus） is a common symptom in diabetic patients and maybe a indicator of diabetic neuropathy. However, the molecular mechanisms underlying diabetic itch are still largely unknown. Methylglyoxal（MGO）, an endogenous carbonyl compound generated as an intermediate during glycolysis, is demonstrated to be elevated in diabetic patients and rodent models. In the present study, we evaluated the role of in chronic itch in a murine model of type 1 diabetes. Intradermal injection of MGO was sufficient to evoke scratching behavior in a dose-dependent manner in mice. MGO directly activated TRPA1, but not TRPV1, to induce inward currents and calcium influx in dorsal root ganglia neurons in vitro. Consistently, TRPA1, but not TRPV1, was required for MGO-induced scratching in mice. In STZ-induced type 1 diabetic mice, the mechanical itch was found to be significantly increased, but there was no obvious spontaneous scratching behavior. Furthermore, TRPA1 was also required for this mechanical itch in STZ-induced type 1 diabetic mice. Thus, the results suggested that the activation of TRPA1 by MGO contributes to diabetic itch in a murine model of type 1 diabetes. Targeting this MGO-TRPA1 pathway may be beneficial for chronic itch treatment in diabetes.

关键词： Itch diabetes TRPA1 Methylglyoxal

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Cancer Communications 2019年第1期39卷 655-664页

作者： Dan Ding Xiang Ao Ying Liu Yuan-Yong Wang Hong-Ge Fa Meng-Yu Wang Yu-Qi He Jian-Xun Wang School of Basic Medical Sciences Qingdao UniversityNo.38 Dengzhou RoadShibei DistrictQingdao 266000ShandongP.R.China center for Regenerative Medicine Institute for Translational MedicineCollege of MedicineQingdao UniversityQingdao 266000ShandongP.R.China Department of Thoracic Surgery Affiliated Hospital of Qingdao UniversityQingdao 266000ShandongP.R.China Department of Gastroenterology The Seventh Medical Center of PLA General HospitalBeijing 100700China

Clinical practice has shown that Parkin is the major causative gene found in an autosomal recessive juvenile parkin-sonism(AR-JP)via Parkin mutations and that the Parkin protein is the core expression product of the Parkin gene,which itself belongs to an E3 ubiquitin *** the discovery of the Parkin gene in the late 1990s,researchers in many countries have begun extensive research on this gene and found that in addition to AR-JP,the Parkin gene is associated with many diseases,including type 2 diabetes,leprosy,Alzheimer’s,autism,and *** studies have found that the loss or dysfunction of Parkin has a certain relationship with *** general,the Parkin gene,a well-established tumor suppressor,is deficient and mutated in a variety of *** overexpres-sion inhibits tumor cell growth and promotes ***,the functions of Parkin in tumorigenesis and its regulatory mechanisms are still not fully *** article describes the structure,functions,and post-transla-tional modifications of Parkin,and summarizes the recent advances in the tumor suppressive function of Parkin and its underlying mechanisms.

关键词： Parkin E3 ubiquitin ligase Cancer Post-translational modification Parkin/PTEN-induced kinase 1(PINK1) NIP3-like protein X Ubiquitination Sumoylation Neddylation Phosphorylation

Associations of Hydroxysteroid 17-beta Dehydrogenase 13 Variants with Liver Histology in Chinese Patients with Metabolicassociated Fatty Liver Disease

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Journal of Clinical and translational Hepatology 2021年第2期9卷 194-202页

作者： Wen-Yue Liu Mohammed Eslam Kenneth I.Zheng Hong-Lei Ma Rafael S.Rios Min-Zhi Lv Gang Li Liang-Jie Tang Pei-Wu Zhu Xiao-Dong Wang Christopher D.Byrne Giovanni Targher Jacob George Ming-Hua Zheng Department of Endocrinology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Storr Liver Centre Westmead Institute for Medical ResearchWestmead Hospital and University of SydneyWestmeadSydneyAustralia NAFLD research center Department of HepatologyThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Department of Biostatistics Zhongshan HospitalFudan UniversityShanghaiChina Department of Laboratory Medicine The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Institute of Hepatology Wenzhou Medical UniversityWenzhouZhejiangChina Southampton National Institute for Health research Biomedical research Centre University Hospital SouthamptonSouthampton General HospitalSouthamptonUK Section of Endocrinology Diabetes and MetabolismDepartment of MedicineUniversity and Azienda Ospedaliera Universitaria Integrata of VeronaVeronaItaly Key Laboratory of Diagnosis and Treatment for The Development of Chronic Liver Disease in Zhejiang Province WenzhouZhejiangChina

Background and Aims:In Europeans,variants in the hydroxysteroid 17-beta dehydrogenase 13(HSD17B13)gene impact liver histology in metabolic-associated fatty liver disease(MAFLD).The impact of these variants in ethnic Chinese is *** aim of this study was to investigate the potential associations in Chinese ***:In total,427 Han Chinese with biopsy-confirmed MAFLD were *** single nucleotide polymorphisms in HSD17B13 were genotyped:rs72613567 and *** regression was used to test the association between the single nucleotide polymorphisms and liver ***:In our cohort,the minor allele TA of the rs72613567 variant was related to an increased risk of fibrosis[odds ratio(OR):2.93(1.20–7.17),p=0.019 for the additive model;OR:3.32(1.39–7.91),p=0.007 for the recessive model],representing an inverse association as compared to the results from European *** contrast,we observed a protective effect on fibrosis for the minor A allele carriers of the HSD17B13 rs6531975 variant[OR:0.48(0.24–0.98),p=0.043 for the additive model;OR:0.62(0.40–0.94),p=0.025 for the dominant model].HSD17B13 variants were only associated with fibrosis but no other histological ***,HSD17B13 rs6531975 modulated the effect of PNPLA3 rs738409 on hepatic ***:HSD17B13 rs72613567 is a risk variant for fibrosis in a Han Chinese MAFLD population but with a different direction for allelic association to that seen in *** data exemplify the need for studying diverse populations in genetic studies in order to fine map genome-wide association studies signals.

关键词： Metabolic-associated fatty liver disease(MAFLD) Nonalcoholic fatty liver disease(NAFLD) Hydroxysteroid 17-beta dehydrogenase 13(HSD17B13) Single nucleotide polymorphism(SNP)

research progress of gut flora in improving human wellness

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Food Science and Human Wellness 2019年第2期8卷 102-105页

作者： Chenggang Zhang Wenjing Gong Zhihui Li Dawen Gao Yan Gao Institute of Radiation Medicine Academy of Military Medical SciencesAcademy of Military SciencesResearch Center for the Military Cognitive and Mental Health of PLABeijing 100850China

Human wellness is the ultimate goal of our efforts in improving the human *** foods are undoubtedly important in achieving human ***,overeating significantly leads to obesity and *** chronic diseases will in turn affect the human ***,“dietary restriction and proper exercise”were introduced in the human daily *** foods cause various effects on the human *** diversification of diet is a priority for nutritionists to keep our body *** avoid diabetes mellitus,special foods for ketogenic diet,low-carbon diet,and low-calorie intake are also gradually attracting *** addition,the hypothesis that“hunger sensation comes from gut flora”brings new light to the research on the biological motivation for humans to eat *** hypothesis has been gradually demonstrated using the flexible fasting technology by providing special foods,such as plant polysaccharides and dietary *** response to food-needing signals from the gut flora to these foods demonstrates the importance of the gut flora in improving human *** gut flora is probably an essential factor for translating the food-eating signals and converting the nutrition to our ***,“gut flora priority principle”is developed to guarantee human *** 16S rRNA sequencing and mass spectrometric techniques can be used to identify the gut flora,which may guide us to a new era of human wellness based on gut flora wellness.

关键词： Hunger sensation comes from gut flora Gut flora-centric theory Flexible fasting Gut flora priority principle Universal reproducing power of the microbiota Gut flora wellness Human wellness

Endoplasmic reticulum stress and cardiovascular diseases

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Journal of Geriatric Cardiology 2009年第1期6卷 49-55页

作者： Xiaohui Duan Yongfen Qi Chaoshu Tang Institute of Cardiovascular research Peking University First Hospital Beijing 100034 China Department of Physiology and Pathophysiology Peking University Health Science Center Beijing 100191 China Institute of Cardiovascular Research Peking University First Hospital Beijing 100034 China Department of Physiology and Pathophysiology Peking University Health Science Center Beijing 100191 China

The endoplasmic reticulum (ER) serves several important functions, mainly post-translational modification, folding and assembly of newly synthesized secretary proteins, synthesizing lipids and cellular calcium storage. Various factors can disrupt ER homeostasis and disturb its functions, which leads to the accumulation of unfolded and misfolded proteins and to potential cellular dysfunction and pathological consequences, collectively termed ER stress. Recent progress suggests that ER stress plays a key role in the immune response, diabetes, tumor growth, and some neurodegenerative diseases. In particular, ER stress is involved in several processes of cardiovascular diseases, such as ischemia/reperfusion injury, cardiomyopathy, cardiac hypertrophy, heart failure, and atherosclerosis. Further research on the relation of ER stress to cardiovascular diseases will greatly enhance the understanding of these pathological processes and provide novel avenues to potential therapies.

关键词： endoplasmic reticulum stress cardiovascular diseases

Regulation of immune-related diseases by multiple factors: a meeting report of 2017 International Workshop of the Chinese Academy of Medical Sciences Initiative for Innovative Medicine on Tumor Immunology

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Acta Pharmaceutica Sinica B 2017年第4期7卷 532-540页

作者： Bing Cui Xuetao Cao Weiping Zou Yonghong Wan Ning Wang Yaohe Wang Pingping Li Fang Hua Yuying Liu Xiaowei Zhang Ke Li Xiaoxi Lv Bo Huang Zhuowei Hu State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical College National Key Laboratory of Medical Molecular Biology Department of ImmunologyInstitute of Basic Medical SciencesPeking Union Medical CollegeChinese Academy of Medical Sciences Department of Surgery University of Michigan School of Medicine The University of michigan Comprehensive Cancer center University of Michigan Graduate Programs in Immunology and Tumor Biology University of Michigan Department of Pathology and Molecular Medicine Mc Master Immunology Research CentreMc Master University Department of Mechanical Science and Engineering University of Illinois at Urbana-Champaign Laboratory for Cellular Biomechanics and Regenerative Medicine Department of Biomedical EngineeringSchool of Life Science and TechnologyHuazhong University of Science and Technology center for Molecular Oncology Barts Cancer InstituteQueen Mary University of London School of Basic Medical Sciences Academy of Medical SciencesZhengzhou University Sino-British research Centre for Molecular Oncology National Center for International Research in Cell and Gene TherapyZhengzhou University diabetes research center of Chinese Academy of Medical Sciences Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical College Clinical Immunology center Chinese Academy of Medical Sciences Department of Biochemistry&Molecular Biology Tongji Medical CollegeHuazhong University of Science&Technology

Immune cells play key roles in cancer and chronic inflammatory disease. A better understanding of the mechanisms and risks will help develop novel target therapies. At the 2017 International Workshop of the Chinese Academy of Medical Sciences Initiative for Innovative Medicine on Tumor Immunology held in Beijing, China, on May 12, 2017, a number of speakers reported new findings and ongoing studies on immune-related diseases such as cancer, fibrotic disease, diabetes, and others. A considerably insightful overview was provided on cancer immunity, tumor microenvironments,and new immunotherapy for cancer. In addition, chronic inflammatory diseases were discussed. These findings may offer new insights into targeted immunotherapy.

关键词： Tumor Immunology Chromatin Exosomes Microparticles Vaccines Oxidative stress Dormancy Protein quality control Inflammation

The zinc transporter Slc39a5 controls glucose sensing and insulin secretion in pancreatic β-cells via Sirt1- and Pgc-1α-mediated regulation of Glut2

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Protein & Cell 2019年第6期10卷 436-449页

作者： Xinhui Wang Hong Gao Wenhui Wu Enjun Xie Yingying Yu Xuyan He Jin Li Wanru Zheng Xudong Wang Xizhi Cao Zhuoxian Meng Ligong Chen Junxia Min Fudi Wang School of Public Health The First Affiliated Hospital Institute of Translational Medicine Zhejiang University School of Medicine Hangzhou 310058 China School of Pharmaceutical Sciences State Key Laboratory of Membrane Biology Tsinghua-Peking Center for Life Sciences School of Life Sciences Tsinghua University Beijing 100084 China Department of Pathology and Pathophysiology Key Laboratory of Disease Proteomics of Zhejiang Province Zhejiang University School of Medicine Hangzhou 310058 China

Zinc levels are high in pancreatic β-cells, and zinc is involved in the synthesis, processing and secretion of insulin in these cells. However, precisely how cellular zinc homeostasis is regulated in pancreatic β-cells is poorly understood. By screening the expression of 14 Slc39a metal importer family member genes, we found that the zinc transporter Slc39a5 is significantly downregulated in pancreatic β-cells in diabetic db/db mice, obese ob/ob mice and high-fat diet-fed mice. Moreover,β-cell-specific Slc39a5 knockout mice have impaired insulin secretion. In addition, Slc39a5-deficient pancreatic islets have reduced glucose tolerance accompanied by reduced expression of Pgc-1α and its downstream target gene Glut2. The down-regulation of Glut2 in Slc39a5-deficient islets was rescued using agonists of Sirt1, Pgc-1α and Ppar-γ. At the mechanistic level, we found that Slc39a5-mediated zinc influx induces Glut2 expression via Sirt1-mediated Pgc-1α activation. These findings suggest that Slc39a5 may serve as a possible therapeutic target for diabetes-related conditions.

关键词： zinc zinc transporter pancreatic islets β-cells insulin secretion