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Bioactive Materials 2023年第7期25卷 239-255页

作者： Zeqian Xu Xuanyu Qi Minyue Bao Tian Zhou Junfeng Shi Zhiyan Xu Mingliang Zhou Aldo R.Boccaccini Kai Zheng Xinquan Jiang Department of Prosthodontics Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineNo.639 Zhizaoju RoadShanghai200011People’s Republic of China College of Stomatology Shanghai Jiao Tong UniversityNo.639 Zhizaoju RoadShanghai200011People’s Republic of China National center for Stomatology No.639 Zhizaoju RoadShanghai200011People’s Republic of China National Clinical research center for Oral Diseases No.639 Zhizaoju RoadShanghai200011People’s Republic of China Shanghai Key Laboratory of Stomatology No.639 Zhizaoju RoadShanghai200011People’s Republic of China Shanghai Engineering research center of Advanced Dental Technology and Materials No.639 Zhizaoju RoadShanghai200011People’s Republic of China Department of Oral Maxillofacial-Head and Neck Oncology Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghai200023People’s Republic of China Institute of Biomaterials University of Erlangen-NurembergCauerstrasse 691058ErlangenGermany Jiangsu Province Engineering research center of Stomatological translational Medicine Nanjing Medical UniversityNanjing210029People’s Republic of China Jiangsu Key Laboratory of Oral Diseases Nanjing Medical UniversityNanjing210029People’s Republic of China

TypeⅡdiabetes mellitus(TIIDM)remains a challenging clinical issue for both dentists and *** virtue of persistent hyperglycemia and altered host metabolism,the pathologic diabetic micromilieu with chronic inflammation,advanced glycation end products accumulation,and attenuated biomineralization severely impairs bone regeneration *** to“remodel”the pathologic diabetic micromilieu,we 3D-printed bioscaffolds composed of Sr-containing mesoporous bioactive glass nanoparticles(Sr-MBGNs)and gelatin methacrylate(GelMA).Sr-MBGNs act as a biomineralization precursor embedded in the GelMA-simulated extracellular matrix and release Sr,Ca,and Si ions enhancing osteogenic,angiogenic,and immunomodulatory *** addition to angiogenic and anti-inflammatory outcomes,this innovative design reveals that the nanocomposites can modulate extracellular matrix reconstruction and simulate biomineralization by activating lysyl oxidase to form healthy enzymatic crosslinked collagen,promoting cell focal adhesion,modulating osteoblast differentiation,and boosting the release of OCN,the noncollagenous proteins(intrafibrillar mineralization dependent),and thus orchestrating osteogenesis through the Kindlin-2/PTH1R/OCN *** 3D-printed bioscaffold provides a multifunctional biomineralization-inspired system that remodels the“barren”diabetic microenvironment and sheds light on the new bone regeneration approaches for TIIDM.

关键词： Biomineralization TypeⅡdiabetes mellitus 3D printing Sr-containing mesoporous bioactive glass nanoparticles Enzymatic cross-links

M2 macrophage-derived exosomes promote diabetic fracture healing by acting as an immunomodulator

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Bioactive Materials 2023年第10期28卷 273-283页

作者： Yili Wang Qiushui Lin Hao Zhang Sicheng Wang Jin Cui Yan Hu Jinlong Liu Mengmeng Li Kun Zhang Fengjin Zhou Yingying Jing Zhen Geng Jiacan Su Institute of translational Medicin5 Shanghai UniversityShangha9200444China School of Medicin5 Shanghai UniversityShangha9200444China School of Life Sciences Shanghai UniversityShangha9200444China Organoid research center Shanghai UniversityShangha9200444China National center for translational Medicine(Shanghai)SHU Branc8 Shanghai UniversityShangha9200444China Department of Spine Surgery First Affiliated Hospital of Naval Medical UniversityShangha9200433China Department of Orthopedics Shanghai Zhongye HospitalShangha9200941China Department of Orthopedics Traum1 Changhai HospitalSecond Military Medical UniversityShangha9200433China Department of Orthopedics Honghui HospitalXi’an Jiao Tong UniversityXi’an710000China Suzhou Innovation center of Shanghai University Suzhou215000JiangsuChina Shaoxing Institute of Technology at Shanghai University Shaoxin7312000Zhejian7China Department of Orthopedics Xinhua HospitalShanghai Jiao Tong University School of Medicin5Shangha9200092China

diabetes mellitus is a chronically inflamed disease that predisposes to delayed fracture *** play a key role in the process of fracture healing by undergoing polarization into either M1 or M2 subtypes,which respectively exhibit pro-inflammatory or anti-inflammatory ***,modulation of macrophage polarization to the M2 subtype is beneficial for fracture *** perform an important role in improving the osteoimmune microenvironment due to their extremely low immunogenicity and high *** this study,we extracted the M2-exosomes and used them to intervene the bone repair in diabetic *** results showed that M2-exosomes significantly modulate the osteoimmune microenvironment by decreasing the proportion of M1 macrophages,thereby accelerating diabetic fracture *** further confirmed that M2-exosomes induced the conversion of M1 macrophages into M2 macrophages by stimulating the PI3K/AKT *** study offers a fresh perspective and a potential therapeutic approach for M2-exosomes to improve diabetic fracture healing.

关键词： M2-exosomes Diabetic fracture healing Osteoimmune microenvironment Macrophage polarization PI3K/AKT signaling pathway

The neuroprotective effects of oxygen therapy in Alzheimer’s disease:a narrative review

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Neural Regeneration research 2023年第1期18卷 57-63页

作者： Cui Yang Qiu Yang Yang Xiang Xian-Rong Zeng Jun Xiao Wei-Dong Le School of Medicine University of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Institute of Neurology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Chinese Academy of Sciences Sichuan translational Medicine research Hospital ChengduSichuan ProvinceChina Department of Hyperbaric Oxygen Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Sichuan Provincial center for Mental Health Sichuan Academy of Medical Sciences&Sichuan Provincial People’s HospitalChengduSichuan ProvinceChina

Alzheimer’s disease(AD)is a degenerative neurological disease that primarily affects the *** therapy is the main strategy for AD treatment,but current treatments suffer from poor efficacy and a number of side ***-drug therapy is attracting more attention and may be a better strategy for treatment of *** is one of the important factors that contribute to the pathogenesis of *** cellular processes synergistically promote hypoxia,including aging,hypertension,diabetes,hypoxia/obstructive sleep apnea,obesity,and traumatic brain *** evidence has shown that hypoxia may affect multiple pathological aspects of AD,such as amyloid-beta metabolism,tau phosphorylation,autophagy,neuroinflammation,oxidative stress,endoplasmic reticulum stress,and mitochondrial and synaptic *** targeting hypoxia may delay or mitigate the progression of *** studies have shown that oxygen therapy could improve the risk factors and clinical symptoms of *** evidence also suggests that oxygen therapy may improve many pathological aspects of AD including amyloid-beta metabolism,tau phosphorylation,neuroinflammation,neuronal apoptosis,oxidative stress,neurotrophic factors,mitochondrial function,cerebral blood volume,and protein *** this review,we summarized the effects of oxygen therapy on AD pathogenesis and the mechanisms underlying these *** expect that this review can benefit future clinical applications and therapy strategies on oxygen therapy for AD.

关键词： Alzheimer’s disease amyloid-beta metabolism clinical symptoms hypoxia neuroinflammation neuronal apoptosis oxygen therapy pathogenesis risk factor tau phosphorylation

Muscle strength cut-offs for the detection of metabolic syndrome in a nonrepresentative sample of collegiate students from Colombia

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Journal of Sport and Health Science 2020年第3期9卷 283-290页

作者： Antonio Garcia-Hermoso Alejandra Tordecilla-Sanders Jorge Enrique Correa-Bautista Mark D.Peterson Mikel Izquierdo Aura Cristina Quino-ávila Carolina Sandoval-Cuellar Katherine González-Ruíz Robinson Ramíez-Vélez Physical Activity Sport and Health Sciences LaboratoryUniversity of Santiago de ChileSantiago de Chile 7500618Chile center of Studies in Physical Activity Measurements School of Medicine and Health SciencesUniversidad del RosarioBogot a 111221Colombia Department of Physical Medicine and Rehabilitation University of MichiganAnn ArborMichigan 48109USA Department of Health Sciences Public University of NavarreCIBERFES(CB16/10/00315)Navarre 31009Spain CORPS Group Faculty of Health SciencesUniversity of BoyacáBoyac aTunja 153610Colombia Physical Exercise and Sports research Group Manuela Beltrán UniversityBogot a 111221Colombia

Background: Evidence shows an association between grip strength and health;however, grip strength cut-offs for the detection of metabolic syndrome(MetS) in Latin American populations are scarce. The purpose of this study was to determine cut-offs of normalized grip strength(NGS)for the detection of MetS in a large nonrepresentative sample of a collegiate student population from ***: A total of 1795 volunteers(61.4% female;age = 20.68 ± 3.10 years, mean ± SD), ranging between 18 and 30 years of age participated in the study. Strength was estimated using a handheld dynamometer and normalized to body mass(handgrip strength(kg)/body mass(kg)). Anthropometrics, serum lipids indices, blood pressure, and fasting plasma glucose were measured. Body composition was measured by bioelectrical impedance analysis. MetS was defined as including ≥3 of the 5 metabolic abnormalities according to the International diabetes Federation definition. A metabolic risk score was computed from the following components: waist circumference, triglycerides, high-density lipoprotein cholesterol, glucose, and systolic and diastolic blood ***: Receiver operating curve analysis showed significant discriminatory accuracy of NGS in identifying the thresholds and risk *** strength was associated with increased prevalence of MetS. In males, weak, intermediate, and strong NGS values at these points were0.615, respectively. In females, these cut-off points were 0.437, ***: Our sex-specific cut-offs of NGS could be incorporated into a clinical setting for identifying college students at cardiometabolic disease risk.

关键词： Cardiometabolic risk Muscular fitness Receiver operating characteristic curve Thresholds

Post-translational modification of Parkin and its research progress in cancer

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Cancer Communications 2019年第1期39卷 655-664页

作者： Dan Ding Xiang Ao Ying Liu Yuan-Yong Wang Hong-Ge Fa Meng-Yu Wang Yu-Qi He Jian-Xun Wang School of Basic Medical Sciences Qingdao UniversityNo.38 Dengzhou RoadShibei DistrictQingdao 266000ShandongP.R.China center for Regenerative Medicine Institute for Translational MedicineCollege of MedicineQingdao UniversityQingdao 266000ShandongP.R.China Department of Thoracic Surgery Affiliated Hospital of Qingdao UniversityQingdao 266000ShandongP.R.China Department of Gastroenterology The Seventh Medical Center of PLA General HospitalBeijing 100700China

Clinical practice has shown that Parkin is the major causative gene found in an autosomal recessive juvenile parkin-sonism(AR-JP)via Parkin mutations and that the Parkin protein is the core expression product of the Parkin gene,which itself belongs to an E3 ubiquitin *** the discovery of the Parkin gene in the late 1990s,researchers in many countries have begun extensive research on this gene and found that in addition to AR-JP,the Parkin gene is associated with many diseases,including type 2 diabetes,leprosy,Alzheimer’s,autism,and *** studies have found that the loss or dysfunction of Parkin has a certain relationship with *** general,the Parkin gene,a well-established tumor suppressor,is deficient and mutated in a variety of *** overexpres-sion inhibits tumor cell growth and promotes ***,the functions of Parkin in tumorigenesis and its regulatory mechanisms are still not fully *** article describes the structure,functions,and post-transla-tional modifications of Parkin,and summarizes the recent advances in the tumor suppressive function of Parkin and its underlying mechanisms.

关键词： Parkin E3 ubiquitin ligase Cancer Post-translational modification Parkin/PTEN-induced kinase 1(PINK1) NIP3-like protein X Ubiquitination Sumoylation Neddylation Phosphorylation

Spatial proteomics in three-dimensional intact specimens

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四川生理科学杂志 2022年第12期44卷 2202-2202页

作者： Harsharan Singh Bhatia Insititute for Tissue Engineering and Regenerative Medicine (iTERM) Helmholtz Zentrum München 85764 Neuherberg Germany Institute for Stroke and Dementia research Klinikum der Universität München Ludwig-Maximilians University Munich 81377 Munich Germany Institute of Anatomy University of Leipzig 04109 Leipzig Germany center for translational Cancer research (TranslaTUM) of the TUM 81675 Munich Germany Institute for diabetes and Obesity Helmholz Zentrum München 85764 Neuherberg Germany Department for Proteomics and Signal Transduction Max Planck Institute of Biochemistry 82152 Martinsried Germany

Spatial molecular profiling of complex tissues is essential to investigate cellular function in physiological and pathological ***,methods for molecular analysis of large biological specimens imaged in 3D are ***,we present DISCO-MS,a technology that combines whole-organ/whole-organism clearing and imaging,deep-learning-based image analysis,robotic tissue extraction,and ultra-high-sensitivity mass spectrometry.

关键词： Spatial combine analysis

Metagenomic and targeted metabolomic analyses reveal distinct phenotypes of the gut microbiota in patients with colorectal cancer and type 2 diabetes mellitus

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Chinese Medical Journal 2023年第23期136卷 2847-2856页

作者： Yong Yang Zihan Han Zhaoya Gao Jiajia Chen Can Song Jingxuan Xu Hanyang Wang An Huang Jingyi Shi Jin Gu Department of Gastrointestinal Surgery Key Laboratory of Carcinogenesis and Translational Research(Ministry of EducationBeijing)Peking University Cancer Hospital and InstituteBeijing 100142China Department of Gastrointestinal Surgery Peking University Shougang HospitalBeijing 100144China Department of Gastrointestinal Oncology Peking University Cancer Hospital and InstituteBeijing 100142China Peking-Tsinghua center for Life Science Peking University International Cancer CenterBeijing 100142China

Background:Type 2 diabetes mellitus(T2DM)is an independent risk factor for colorectal cancer(CRC),and the patients with CRC and T2DM have worse *** human gut microbiota(GM)is linked to the development of CRC and T2DM,***,the GM characteristics in patients with CRC and T2DM remain ***:We performed fecal metagenomic and targeted metabolomics studies on 36 samples from CRC patients with T2DM(DCRC group,n=12),CRC patients without diabetes(CRC group,n=12),and healthy controls(Health group,n=12).We analyzed the fecal microbiomes,characterized the composition and function based on the metagenomics of DCRC patients,and detected the short-chain fatty acids(SCFAs)and bile acids(BAs)levels in all fecal ***,we performed a correlation analysis of the differential bacteria and metabolites between different ***:Compared with the CRC group,LefSe analysis showed that there is a specific GM community in DCRC group,including an increased abundance of Eggerthella,Hungatella,Peptostreptococcus,and Parvimonas,and decreased Butyricicoccus,Lactobacillus,and *** metabolomics analysis results revealed that the butyric acid level was lower but the deoxycholic acid and 12-keto-lithocholic acid levels were higher in the DCRC group than other groups(P<0.05).The correlation analysis showed that the dominant bacterial abundance in the DCRC group(Parvimonas,Desulfurispora,Sebaldella,and Veillonellales,among others)was negatively correlated with butyric acid,hyodeoxycholic acid,ursodeoxycholic acid,glycochenodeoxycholic acid,chenodeoxycholic acid,cholic acid and ***,the abundance of mostly inferior bacteria was positively correlated with these metabolic acid levels,including Faecalibacterium,Thermococci,and ***:Unique fecal microbiome signatures exist in CRC patients with T2DM compared to those with non-diabetic *** in GM composition and SCFAs and secondary BAs levels may pro

关键词： Bile acids Colorectal cancer Gut microbiota Short-chain fatty acids Type 2 diabetes mellitus

research progress of gut flora in improving human wellness

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Food Science and Human Wellness 2019年第2期8卷 102-105页

作者： Chenggang Zhang Wenjing Gong Zhihui Li Dawen Gao Yan Gao Institute of Radiation Medicine Academy of Military Medical SciencesAcademy of Military SciencesResearch Center for the Military Cognitive and Mental Health of PLABeijing 100850China

Human wellness is the ultimate goal of our efforts in improving the human *** foods are undoubtedly important in achieving human ***,overeating significantly leads to obesity and *** chronic diseases will in turn affect the human ***,“dietary restriction and proper exercise”were introduced in the human daily *** foods cause various effects on the human *** diversification of diet is a priority for nutritionists to keep our body *** avoid diabetes mellitus,special foods for ketogenic diet,low-carbon diet,and low-calorie intake are also gradually attracting *** addition,the hypothesis that“hunger sensation comes from gut flora”brings new light to the research on the biological motivation for humans to eat *** hypothesis has been gradually demonstrated using the flexible fasting technology by providing special foods,such as plant polysaccharides and dietary *** response to food-needing signals from the gut flora to these foods demonstrates the importance of the gut flora in improving human *** gut flora is probably an essential factor for translating the food-eating signals and converting the nutrition to our ***,“gut flora priority principle”is developed to guarantee human *** 16S rRNA sequencing and mass spectrometric techniques can be used to identify the gut flora,which may guide us to a new era of human wellness based on gut flora wellness.

关键词： Hunger sensation comes from gut flora Gut flora-centric theory Flexible fasting Gut flora priority principle Universal reproducing power of the microbiota Gut flora wellness Human wellness

Associations of Hydroxysteroid 17-beta Dehydrogenase 13 Variants with Liver Histology in Chinese Patients with Metabolicassociated Fatty Liver Disease

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Journal of Clinical and translational Hepatology 2021年第2期9卷 194-202页

作者： Wen-Yue Liu Mohammed Eslam Kenneth I.Zheng Hong-Lei Ma Rafael S.Rios Min-Zhi Lv Gang Li Liang-Jie Tang Pei-Wu Zhu Xiao-Dong Wang Christopher D.Byrne Giovanni Targher Jacob George Ming-Hua Zheng Department of Endocrinology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Storr Liver Centre Westmead Institute for Medical ResearchWestmead Hospital and University of SydneyWestmeadSydneyAustralia NAFLD research center Department of HepatologyThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Department of Biostatistics Zhongshan HospitalFudan UniversityShanghaiChina Department of Laboratory Medicine The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Institute of Hepatology Wenzhou Medical UniversityWenzhouZhejiangChina Southampton National Institute for Health research Biomedical research Centre University Hospital SouthamptonSouthampton General HospitalSouthamptonUK Section of Endocrinology Diabetes and MetabolismDepartment of MedicineUniversity and Azienda Ospedaliera Universitaria Integrata of VeronaVeronaItaly Key Laboratory of Diagnosis and Treatment for The Development of Chronic Liver Disease in Zhejiang Province WenzhouZhejiangChina

Background and Aims:In Europeans,variants in the hydroxysteroid 17-beta dehydrogenase 13(HSD17B13)gene impact liver histology in metabolic-associated fatty liver disease(MAFLD).The impact of these variants in ethnic Chinese is *** aim of this study was to investigate the potential associations in Chinese ***:In total,427 Han Chinese with biopsy-confirmed MAFLD were *** single nucleotide polymorphisms in HSD17B13 were genotyped:rs72613567 and *** regression was used to test the association between the single nucleotide polymorphisms and liver ***:In our cohort,the minor allele TA of the rs72613567 variant was related to an increased risk of fibrosis[odds ratio(OR):2.93(1.20–7.17),p=0.019 for the additive model;OR:3.32(1.39–7.91),p=0.007 for the recessive model],representing an inverse association as compared to the results from European *** contrast,we observed a protective effect on fibrosis for the minor A allele carriers of the HSD17B13 rs6531975 variant[OR:0.48(0.24–0.98),p=0.043 for the additive model;OR:0.62(0.40–0.94),p=0.025 for the dominant model].HSD17B13 variants were only associated with fibrosis but no other histological ***,HSD17B13 rs6531975 modulated the effect of PNPLA3 rs738409 on hepatic ***:HSD17B13 rs72613567 is a risk variant for fibrosis in a Han Chinese MAFLD population but with a different direction for allelic association to that seen in *** data exemplify the need for studying diverse populations in genetic studies in order to fine map genome-wide association studies signals.

关键词： Metabolic-associated fatty liver disease(MAFLD) Nonalcoholic fatty liver disease(NAFLD) Hydroxysteroid 17-beta dehydrogenase 13(HSD17B13) Single nucleotide polymorphism(SNP)