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International Journal of Ophthalmology(English edition) 2022年第5期15卷 760-765页

作者： Gang Qiao Xiao-Juan Zhang Zi-Yan Tang Qiang-Xing Zou Chun-Mei He Xian-Ming Lei Long Zhao Yu Quan Hua-Qing Yang Kui Cao Wan-Jiang Dong wanjiang Eye hospital of mianyang MianyangSichuan ProvinceChina

AIM:To evaluate the therapeutic effect of amniotic membrane(AM)for covering high myopic macular hole associated with retinal detachment following failed primary ***:Seventeen eyes of 17 patients whose axial length was more than 29 mm suffered from macular hole(MH)or MH associated with retinal detachment(RD),and had previously surgery of pars plana vitrectomy(PPV)with internal limiting membrane(ILM)peeling and silicone oil(SO)*** a year after the surgery,optical coherence tomography(OCT)showed that MH did not heal in all 17 eyes and RD was still maintained in 13 eyes of these 17 *** performed SO removal combined with AM covering on macular area and C3 F8 tamponade,and phacoemulsification combined with intraocular lens implantation simultaneously cataract *** followed up these patients for one ***:In all 17 eyes,SO was removed successfully,MHs were healed and RDs were *** eye(5.89%,1/17)had AM shifted half a month after surgery and underwent a second surgery to adjust the position of the AM and supplement C3 *** surgery,the visual acuity(VA)improved in 15 eyes(88.24%,15/17),no change in two eyes(11.76%,2/17).No serious complications occurred in all ***:AM covering is helpful to rescue the previous failure surgery of high myopic MH.

关键词： amniotic membrane high myopia macular hole retinal detachment

Trametinib boosts palbociclib’s efficacy in breast cancer via autophagy inhibition

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Oncology Research 2024年第7期32卷 1197-1207页

作者： ANGUO WU JIAO YAN TING SU CHI FENG XIN LONG YIRU PAN RUPEI YE TIAN XIA HANAN LONG JIANMING WU XIULI XIAO Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia MedicaKey Laboratory of Medical Electrophysiology of Ministry of EducationSchool of PharmacySouthwest Medical UniversityLuzhou646000China The Department of Pathology The Affiliated Hospital of Southwest Medical UniversityLuzhou646000China The Department of Pathology Mianyang Central HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaMianyang621000China The Department of Pathology Yongchuan Hospital of Chongqing Medical UniversityChongqing402160China School of Basic Medical Sciences Southwest Medical UniversityLuzhou646000China School of Clinical Medical Sciences Southwest Medical UniversityLuzhou646000China

Breast cancer,a predominant global health issue,requires ongoing exploration of new therapeutic ***(PAL),a well-known cyclin-dependent kinase(CDK)inhibitor,plays a critical role in breast cancer *** its efﬁcacy is recognized,the interplay between PAL and cellular autophagy,particularly in the context of the RAF/MEK/ERK signaling pathway,remains insufﬁciently *** study investigates PAL’s inhibitory effects on breast cancer using both in vitro(MCF7 and MDA-MB-468 cells)and in vivo(tumor-bearing nude mice)*** at elucidating the impact of PAL on autophagic processes and exploring the potential of combining it with trametinib(TRA),an MEK inhibitor,our research seeks to address the challenge of PAL-induced drug ***ﬁndings reveal that PAL signiﬁcantly decreases the viability of MCF7 and MDA-MB-468 cells and reduces tumor size in mice while showing minimal cytotoxicity in MCF10A ***,PAL also induces protective autophagy,potentially leading to drug resistance via the RAF/MEK/ERK pathway *** TRA effectively neutralized this autophagy,enhancing PAL’s anti-tumor efﬁcacy.A combination of PAL and TRA synergistically reduced cell viability and proliferation,and in vivo studies showed notable tumor size *** conclusion,the PAL and TRA combination emerges as a promising strategy for overcoming PAL-induced resistance,offering a new horizon in breast cancer treatment.

关键词： Palbociclib Trametinib Protective autophagy RAF/MEK/ERK MCF7 MDA-MB-468

Sustainable development of electroencephalography materials and technology

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SusMat 2024年第2期4卷 125-144页

作者： Ling Xiong Nannan Li Yi Luo Lei Chen Institutes for Breast Health Medicine West China HospitalSichuan UniversityChengduChina Micro/Nano Fabrication Laboratory Microsystem and Terahertz Research CenterChina Academy of Engineering PhysicsChengduChina Institute of Electronic Engineering China Academy of Engineering PhysicsMianyangChina Department of Neurology Joint Research Institution of Altitude HealthWest China HospitalSichuan UniversityChengduChina

Electroencephalogram(EEG)is one of the most important bioelectrical signals related to brain activity and plays a crucial role in clinical *** by continuously expanding applications,the development of EEG materials and technology has attracted considerable ***,systematic analysis of the sustainable development of EEG materials and technology is still *** review discusses the sustainable development of EEG materials and ***,the developing course of EEG is introduced to reveal its significance,particularly in clinical ***,the sustainability of the EEG materials and technology is discussed from two main aspects:integrated systems and EEG *** integrated systems,sustainability has been focused on the developing trend toward mobile EEG systems and big-data monitoring/analyzing of EEG *** is related to miniaturized,wireless,portable,and wearable systems that are integrated with big-data modeling *** EEG electrodes and materials,sustainability has been comprehensively analyzed from three perspectives:performance of different material/structural categories,sustainablematerials for EEGelectrodes,and sustainable manufacturing *** addition,sustainable applications of EEG have been ***,the sustainable development of EEG materials and technology in recent decades is summarized,revealing future possible research directions as well as urgent challenges.

关键词： clinical medicine electroencephalography technology limitations and future directions materials and electrodes sustainable development

Naoxueshu Oral Liquid Accelerates Post-Craniotomy Hematoma Absorption in Patients:An Open-Label,Multicenter,and Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第8期30卷 675-683页

作者： HE Qiu LIN Fu-xin SU Jin-ye ZHUO Ling-yunn ZHU Qing SUN Xiao-chuan JIANG Rong-cai YAO Zhi-gang WANG Lei DANG Yan-wei LIU De-zhong LIU Yang FANG Wen-hua WANG Fang-yu LIN Yuan-xiang WANG An-xin WANG Deng-liang KANG De-zhi Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated Hospital of Fujian Medical UniversityFuzhou350004China Department of Neurosurgery Binhai Branch of National Regional Medical CenterThe First Affiliated HospitalFujian Medical UniversityFuzhou350209China Clinical Research and Translation Center The First Affiliated Hospital of Fujian Medical UniversityFuzhou350004China Fujian Clinical Research Center for Neurological Diseases The First Affiliated Hospital of Fujian Medical UniversityFuzhou350004China Fujian Provincial Institutes of Brain Disorders and Brain Sciences The First Affiliated Hospital of Fujian Medical UniversityFuzhou350004China Department of Neurosurgery The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu Province215000China Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing400000China Department of Neurosurgery Tianjin Medical University General HospitalTianjin300000China Department of Neurosurgery The Third Hospital of ShijiazhuangShijiazhuang050000China Department of Neurosurgery The First College of Clinical Medical ScienceChina Three Gorges UniversityYichangHubei Province443000China Department of Neurosurgery Yichang Central People’s HospitalYichangHubei Province443000China Department of Neurosurgery Xiangyang No.1 People’s Hospital Affiliated to Hubei University of MedicineXiangfanHubei Province441100China Department of Neurosurgery Zhoukou Central HospitalZhoukouHenan Province466000China Department of Neurosurgery The Third Hospital of MianyangMianyangSichuan Province621000China Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijing100000China China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijing100000China Department of Clinical Epidemiology and Clinical Trial Capital Medical UniversityBeijing100000China Beijing Municipal Key Laboratory of Clinical

Objective To investigate whether Naoxueshu Oral Liquid(NXS)could promote hematoma absorption in post-craniotomy hematoma(PCH)*** This is an open-label,multicenter,and randomized controlled trial conducted at 9 hospitals in *** aged 18–80 years with post-craniotomy supratentorial hematoma volume ranging from 10 to 30 mL or post-craniotomy infratentorial hematoma volume less than 10 mL,or intraventricular hemorrhage following cranial surgery were *** were randomly assigned at a 1:1 ratio to the NXS(10 mL thrice daily for 15 days)or control groups using a randomization code *** medical care was administered in both *** primary outcome was the percentage reduction in hematoma volume from day 1 to day *** secondary outcomes included the percentage reduction in hematoma volume from day 1 to day 7,the absolute reduction in hematoma volume from day 1 to day 7 and 15,and the change in neurological function from day 1 to day 7 and *** safety was closely monitored throughout the ***,subgroup analysis was performed based on age,gender,history of diabetes,and etiology of intracerebral hemorrhage(ICH).Results A total of 120 patients were enrolled and randomly assigned between March 30,2018 and April 15,*** patient was lost to follow-up in the control ***,there were 119 patients(60 in the NXS group and 59 in the control group)included in the *** the full analysis set(FAS)analysis,the NXS group had a greater percentage reduction in hematoma volume from day 1 to day 15 than the control group[median(Q1,Q3):85%(71%,97%)vs.76%(53%,93%),P0.05).Furthermore,no adverse events were reported during the *** the FAS analysis,the NXS group exhibited a higher percentage reduction in hematoma volume on day 15 in the following subgroups:male patients,patients younger than 65 yea

关键词： post-craniotomy hematoma Naoxueshu Oral Liquid hematoma absorption randomized controlled trial Chinese medicine

Multi-functional metasurface:ultra-wideband/multi-band absorption switching by adjusting guided-mode resonance and local surface plasmon resonance effects

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Communications in Theoretical Physics 2024年第6期76卷 174-184页

作者： Wenxin Li Shubo Cheng Huafeng Zhang Zao Yi Bin Tang Can Ma Pinghui Wu Qingdong Zeng Rizwan Raza School of Physics and Optoelectronic Engineering Yangtze UniversityJingzhouHubei 434023China Joint Laboratory for Extreme Conditions Matter Properties Southwest University of Science and TechnologyMianyang 621010China School of Chemistry and Chemical Engineering Jishou UniversityJishou 416000China School of Microelectronics and Control Engineering Changzhou UniversityChangzhou 213164China Department of Oncology Sichuan Science City HospitalMianyangSichuan Province 621000China Office of Science and Technology Quanzhou Normal UniversityQuanzhou 362000China School of Physics and Electronic-information Engineering Hubei Engineering UniversityXiaogan 432000China Department of Physics COMSATS Institute of Information Technology 54000 LahorePakistan

This study introduces an innovative dual-tunable absorption film with the capability to switch between ultra-wideband and narrowband *** manipulating the temperature,the film can achieve multi-band absorption within the 30-45 THz range or ultra-wideband absorption spanning 30-130 THz,with an absorption rate exceeding ***,the structural parameters of the absorption film are optimized using the particle swarm optimization(PSO)algorithm to ensure the optimal absorption *** absorption response of the film is primarily attributed to the coupling of guided-mode resonance and local surface plasmon resonance *** film's symmetric structure enables polarization incoherence and allows for tuning through various means such as doping/voltage,temperature and structural *** the case of a multi-band absorption response,the film exhibits good sensitivity to refractive index changes in multiple absorption ***,the absorption spectrum of the film remains effective even at large incidence angles,making it highly promising for applications in fields such as biosensing and infrared stealth.

关键词： PSO optimization ultra-wideband/narrowband absorption switching intelligent absorption film vanadium dioxide

Quantitative analysis of the morphing wing mechanism of raptors: Analysis methods, folding motions, and bionic design of Falco Peregrinus

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Fundamental Research 2024年第2期4卷 344-352页

作者： Di Tang Xipeng Huang Jinqi Che Weijie Jin Yahui Cui Yangjun Chen Yuxiao Yuan Zhongyong Fan Weiwei Lu Siyu Wang Yin Yang Dawei Liu College of Mechanical Engineering Zhejiang University of TechnologyHangzhou 310014China Affiliated HangZhou XiXi hospital Zhejiang University School of MedicineHangzhou 310023China Zhejiang Museum of Natural History Hangzhou 310014China High Speed Aerodynamic Institute China Aerodynamics Research and Development CenterMianyang 621000China

Raptors can change the shape and area of their wings to an exceptional degree in a fast and efficient manner,surpassing other birds,insects,or *** researchers have focused on the functional properties of muscle skeletons,mechanics,and flapping robot ***,the wing motion of the birds of prey has not been measured quantitatively,and synthetic bionic wings with morphing abilities similar to raptors are far from ***,in the current study,a 3D suspension system for holding bird carcasses was designed and fabricated to fasten the wings of Falco Peregrinus with a series of morphing ***,the wing skeleton of the falcon was scanned during extending motions using the computed tomography(CT)approach to obtain three consecutive ***,the skeleton was reconstructed to identify the contribution of the forelimb bones to the extending/folding *** by these findings,we propose a simple mechanical model with four bones to form a wing-morphing mechanism using the proposed pose optimisation ***,a bionic wing mechanism was implemented to imitate the motion of the falcon wing—divided into inner and outer wings with folding and twisting *** results show that the proposed four-bar mechanism can track bone motion paths with high fidelity.

关键词： Falco Peregrinus Raptor Suspension system CT scan Bionic wings Four-bar mechanism

Metamaterial terahertz device with temperature regulation function that can achieve perfect absorption and complete reflection conversion of ultrawideband

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Communications in Theoretical Physics 2024年第7期76卷 123-133页

作者： Hao Sun Zao Yi Can Ma Shubo Cheng Bin Tang Qingdong Zeng Sohail Ahmad School of Mathematics and Science Joint Laboratory for Extreme Conditions Matter PropertiesState Key Laboratory of Environment-Friendly Energy MaterialsTianfu Institute of Research and InnovationSouthwest University of Science and TechnologyMianyang 621010China Department of Oncology Sichuan Science City HospitalMianyangSichuan Province621000China School of Chemistry and Chemical Engineering Jishou UniversityJishou 416000China School of Physics and Optoelectronic Engineering Yangtze UniversityJingzhouHubei 434023China School of Microelectronics and Control Engineering Changzhou UniversityChangzhou 213164China School of Physics and Electronic Information Engineering Hubei Engineering UniversityXiaogan 432000China Institute of Physics Bahauddin Zakariya UniversityMultan 66000Pakistan

The field of terahertz devices is important in terahertz ***,most of the current devices have limited functionality and poor *** improve device performance and achieve multifunctionality,we designed a terahertz device based on a combination of VO_(2)and *** device can be tuned using the phase-transition characteristics of VO_(2),which is included in the triple-layer structure of the device,along with SiO_(2)and *** terahertz device exhibits various advantageous features,including broadband coverage,high absorption capability,dynamic tunability,simple structural design,polarization insensitivity,and incidentangle *** simulation results showed that by controlling the temperature,the terahertz device achieved a thermal modulation range of spectral absorption from 0 to *** 313 K,the device exhibited complete reflection of terahertz *** the temperature increased,the absorption rate also *** the temperature reached 353 K,the device absorption rate exceeded 97.7%in the range of 5-8.55 *** study used the effective medium theory to elucidate the correlation between conductivity and temperature during the phase transition of VO_(2).Simultaneously,the variation in device performance was further elucidated by analyzing and depicting the intensity distribution of the electric field on the device surface at different ***,the impact of various structural parameters on device performance was examined,offering valuable insights and suggestions for selecting suitable parameter values in real-world *** characteristics render the device highly promising for applications in stealth technology,energy harvesting,modulation,and other related fields,thus showcasing its significant potential.

关键词： terahertz perfect absorption complete reflection temperature regulation ultrawideband smart device

Signaling pathways governing the behaviors of leukemia stem cells

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Genes & Diseases 2024年第2期11卷 830-846页

作者： Shirin Azizidoost Ava Nasrolahi Mohadeseh Sheykhi-Sabzehpoush Amir Anbiyaiee Seyed Esmaeil Khoshnam Maryam Farzaneh Shahab Uddin Atherosclerosis Research Center Ahvaz Jundishapur University of Medical SciencesAhvaz ***Iran Infectious ophthalmologic Research Center Ahvaz Jundishapur University of Medical SciencesAhvaz ***Iran Department of Laboratory Imam Khomeini Hospital ComplexTehran University of Medical SciencesTehran ***Iran Department of Surgery School of MedicineAhvaz Jundishapur University of Medical SciencesAhvaz ***Iran Persian Gulf Physiology Research Center Medical Basic Sciences Research InstituteAhvaz Jundishapur University of Medical SciencesAhvaz ***Iran Fertility Infertility and Perinatology Research CenterAhvaz Jundishapur University of Medical SciencesAhvaz ***Iran Translational Research Institute and Dermatology Institute Academic Health SystemHamad Medical CorporationDoha 3050Qatar

Leukemia is a malignancy in the blood that develops from the lymphatic system and bone *** various treatment options have been used for different types of leukemia,understanding the molecular pathways involved in the development and progression of leukemia is *** studies showed that leukemia stem cells(LSCs)play essential roles in the pathogenesis of leukemia by targeting several signaling pathways,including Notch,Wnt,Hedgehog,and *** are highly proliferative cells that stimulate tumor initiation,migration,EMT,and drug *** review summarizes cellular pathways that stimulate and prevent LSCs'self-renewal,metastasis,and tumorigenesis.

关键词： Leukemia Leukemia stem cells Pathogenesis Signaling pathways Stem cells

Comparative study of bacterial status from conjunctival sac of the elder Qiang minority and Han people with dry eye in Sichuan,China

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International Journal of Ophthalmology(English edition) 2012年第3期5卷 343-347页

作者： Yue Zhang, Kui Cao Department of Ophthalmology Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital Chengdu 610072 Sichuan Province China mianyang wanjiang ophthalmologic hospital Mianyang 621000 Sichuan Province China Department of Clinical Laboratory Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital Chengdu 610072 Sichuan Province China hospital of Traditional Chinese Medclicine Affiliated to Luzhou Medical College Luzhou 646000 Sichuan ProvinceChina The Fourth People's hospital of Zigong City. Zigong 643000 Sichuan Province China

AIM: To compare the status of bacteria in the conjunctival sac from the elder Qiang minority and Han people with dry eyes in Sichuan, China. METHODS: Total of 54 elder Qiang people with dry eyes (108 eyes) were examined by cluster sampling. In the similar habitation region of Han people, 80 (160 dry eyes) Han people were analyzed as the control group. The bacteria was separated from the inferior palpebral conjunctiva, then inoculated on blood plate for 48 hours and identified. RESULTS: Totally 24 strains of bacteria were cultured in either Qiang minority or Han c populations with 3 strains of them existed in both ethnic groups. The commonest bacteria in conjunctival sac in two ethnic groups were non-pathogenic bacterium. The composition of Corynebacterium in Han people (54.1%) was significantly higher than that in Qiang minority (27.4%) (chi(2)=11.6721, P=0.0006). The percentage of Sphingomonas Paucimobilis in Qiang people was higher than that in Han people (chi(2)=18.6442, P=0.0000). However, there was no significant difference between Qiang minority and Han people either in bacterial positive rate in conjunctival sac, or the composition of bacteria species and strains, or the composition of staphylococcus epidemids between two ethnic populations. CONCLUSION:There was no significant difference of bacterial positive rate in conjunctival sac from the elder of Qiang minority and Han people with dry eye, but the species of bacteria were different.

关键词： conjunctival sac bacteria dry eye

Quantitative analysis of the morphing wing mechanism of raptors:IMMU-based motion capture system and its application on gestures of a Falco peregrinus

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Chinese Physics B 2024年第1期33卷 734-742页

作者：唐迪朱力文施文熙刘大伟杨茵姚国荣严森祥范忠勇陆祎玮王思宇 College of Mechanical Engineering Zhejiang University of TechnologyHangzhou 310014China High Speed Aerodynamic Institute China Aerodynamics Research and Development CenterMianyang 621000China Department of Radiation Oncology The First Affiliated HospitalZhejiang UniversityHangzhou 310009China Zhejiang Museum of Natural History Hangzhou 310014China

This paper presented a novel tinny motion capture system for measuring bird posture based on inertial and magnetic measurement units that are made up of micromachined gyroscopes, accelerometers, and magnetometers. Multiple quaternion-based extended Kalman filters were implemented to estimate the absolute orientations to achieve high *** the guidance of ornithology experts, the extending/contracting motions and flapping cycles were recorded using the developed motion capture system, and the orientation of each bone was also analyzed. The captured flapping gesture of the Falco peregrinus is crucial to the motion database of raptors as well as the bionic design.

关键词： Falco peregrinus IMMU-based motion capture system flapping gesture