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Soluble p75 neurotrophic receptor as a reliable biomarker in neurodegenerative diseases: what is the evidence?

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Neural Regeneration Research 2024年第3期19卷 536-541页

作者： Georges Jourdi Samuel Fleury Imane Boukhatem Marie Lordkipanidzé Research Center Montreal Heart InstituteMontrealQCCanada Faculty of Pharmacy Universitéde MontréalMontrealQCCanada UniversitéParis Cité INSERMInnovative Therapies in HaemostasisParisFrance service d’Hématologie Biologique AP-HPHôpital LariboisièreParisFrance

Neurodegenerative diseases are often misdiagnosed,especially when the diagnosis is based solely on clinical *** p75 neurotrophic receptor(p75^(NTR))has been studied as an index of sensory and motor nerve development and *** cleavable extracellular domain(ECD)is readily detectable in various biological fluids including plasma,serum and *** is evidence for increased p75NTR ECD levels in neurodegenerative diseases such as Alzheimer’s disease,amyotrophic lateral sclerosis,age-related dementia,schizophrenia,and diabetic *** p75^(NTR) ECD could be used as a biomarker for diagnosis and/or prognosis in these disorders,and whether it could potentially lead to the development of targeted therapies,remains an open *** this review,we present and discuss published studies that have evaluated the relevance of this emerging biomarker in the context of various neurodegenerative *** also highlight areas that require further investigation to better understand the role of p75^(NTR) ECD in the clinical diagnosis and management of neurodegenerative disorders.

关键词： Alzheimer’s disease amyotrophic lateral sclerosis biomarker dementia diabetic neuropathy nerve growth factor receptor(NGFR) neurodegeneration p75^(NTR) schizophrenia

Critical Analysis of the Origins of Heisenberg's Uncertainty Principle

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Journal of Modern Physics 2024年第6期15卷 765-795页

作者： André Michaud service de Recherche Pé dagogique Qu&#233bec Canada

Analysis of the initial stages of the logical process followed by Louis de Broglie in establishing the electron phase wave equation in his 1924 thesis, which triggered the development of Wave Mechanics when Erwin Schrödinger formalized this concept with his vectorial wave equation. This development was soon followed by Quantum Mechanics, when Schrödinger proved that the Matrix Mechanics independently developed by Werner Heisenberg was equivalent to Wave Mechanics, with both theories leaving room for some degree of uncertainty as to the physical localization of the moving electron. This is what led Heisenberg to also formalize the Uncertainty Principle to take this situation into account. This principle was soon regarded as a fundamental axiomatic principle that seemed to make further exploration of the subatomic level of magnitude appear impossible to most researchers. We will analyze in this article the reason why the phase-wave velocity established by de Broglie generated this uncertainty in the localization of the moving electron in light of the current state of knowledge on the behavior of the electron in motion, in view of establishing the relevance of maintaining the Uncertainty Principle in the study of the subatomic level of magnitude.

关键词： Phase Wave Velocity Wave Mechanics Matrix Mechanics Quantum Mechanics Uncertainty Principle

Tracking Surface Cyclones with Moist Potential Vorticity

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Advances in Atmospheric Sciences 2004年第5期21卷 830-835页

作者： Zuohao CAO Da-Lin ZHANG meteorological service of canada Ontario Canada Department of Meteorology University of Maryland College Park Maryland

Surface cyclone tracks are investigated in the context of moist potential vorticity (MPV). A prognostic equation of surface absolute vorticity is derived which provides a basis for using negative MPV (NMPV) in the troposphere as an alternative approach to track surface cyclones. An observed case study of explosive lee cyclogenesis is performed to test the e?ectiveness of the MPV approach. It is shown that when a surface cyclone signal is absent due to the blocking of the Rocky Mountains, the surface cyclone can be well identi?ed by tracing the peak NMPV.

关键词： cyclone track moist potential vorticity lee cyclogenesis

Sensitivity of Cyclone Tracks to the Initial Moisture Distribution:A Moist Potential Vorticity Perspective

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Advances in Atmospheric Sciences 2005年第6期22卷 807-820页

作者： Zuohao CAO Da-Lin ZHANG meteorological service of canada Ontario Canada Department of Meteorology University of Maryland College Park Maryland USA

In this study, the characteristics of moist potential vorticity （MPV） in the vicinity of a surface cyclone center and their physical processes axe investigated. A prognostic equation of surface absolute vorticity is then used to examine the relationship between the cyclone tracks and negative MPV （NMPV） using numerical simulations of the life cycle of an extratropical cyclone. It is shown that the MPV approach developed herein, i.e., by tracing the peak NMPV, can be used to help trace surface cyclones during their development and mature stages. Sensitivity experiments are conducted to investigate the impact of different initial moisture fields on the effectiveness of the MPV approach. It is found that the lifetime of NMPV depends mainly on the initial moisture field, the magnitude of condensational heating, and the advection of NMPV. When NMPV moves into a saturated environment at or near a cyclone center, it can trace better the evolution of the surface cyclone due to the conservative property of MPV. It is also shown that the NMPV generation is closely associated with the coupling of large potential temperature and moisture gradients as a result of frontogenesis processes. Analyses indicate that condensation, confluence and tilting play important but different roles in determining the NMPV generation. NMPV is generated mainly through the changes in the strength of baroclinicity and in the direction of the moisture gradient due to moist and/or dry air mass intrusion into the baroclinic zone.

关键词： cyclone tracks moist potential vorticity mid-latitude cyclones

Is there hybridization between 2 species of the same genus in sympatry?——The genetic relationships between Anoplophora glabripennis,Anoplophora chinensis,and putative hybrids

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Insect Science 2024年第2期31卷 633-645页

作者： Haiwen Qin Huachao Xu Arnaud Capron Ilga Porth Mingming Cui Melody A.Keena Xiaofang Deng Juan Shi Richard C.Hamelin Sino-French Joint Laboratory for Invasive Forest Pests in Eurasia Department of ForestBejing Forestry UniversityBejingChina Department of Forest and Conservation Sciences The University of British ColumbiaVancouverCanada College of Forestry and Biotechnology Zhejiang A&F UniversityHangzhouChina Department of Wood and Forest Sciences Laval UniversityQuebecCanada 5 Department of AgricultureNorthern Research StationUSDA Forest ServiceHamdenConnecticutUSA Changchun Landscape Plant Conservation Station Bureau of Forestry and Landscaping of ChangchunChangchunChina

Anoplophora glabripennis(Asian longhorn beetle,ALB)and Anoplophora chinensis(Citrus longhorn beetle,CLB)are native forest pests in China;they have become important international quarantine *** are found using the same Salix aureopendula host tree of Cixi,Zhejiang province,*** this host tree,we collected additional beetles that appeared to be morphologically intermediate between ALB and *** using a stereoscope,we observed that there were several bumps on the base of the elytra,which was inconsistent with ALB,which typically has a smooth elytral base,but was more like CLB,which has numerous short tubercles on the elytral *** their sympatry and intermediate morphology,we hypothesized that these may represent ALB×CLB *** studied the genomic profiles for 46 samples(ALB,CLB,and putative hybrids)using genotyping-by-sequencing(GBS)providing a reduced representation of the entire *** principal component analyses on the 163 GBS-derived single nucleotide polymorphism data,we found putative hybrids tightly clustered with ALB,but genetically distinct from the CLB ***,our initial hybrid hypothesis was not supported by genomic ***,while mating experiments between adult ALB and CLB were successful in 4 separate years(2017,2018,2020,and 2021),and oviposition behavior was observed,no progeny was *** employed population genomic analysis and biological hybridization experiments,we conclude that the putative hybrids represent newly discovered morphological variants within *** approach further confirmed the advantage of genome-wide information for Anoplophora species assignment in certain ambiguous classification cases.

关键词： Anoplophora chinensis Anoplophora glabripenni sg enotyping-bysequencing invasive pest mating putative hybrid

Effects of Topographic Slopes on Hydrological Proecsses and Climate

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Advances in Atmospheric Sciences 2001年第5期18卷 733-741页

作者： Jinliang Liu Climate Processes and Earth Observation Division, meteorological service of canada, 4905 Dufferin Street, Downsview, Ontario M3H 5T4, canada Han-Ru Cho Department of Atmospheric Science, National Central University, Chungli 320, Taiwan Climate Processes and Earth Observation Division Meteorological Service of Canada Downsview Canada National Central University Chungli Taiwan

Based on previous research results on river re-distribution models, a modification on the effects of topographic slopes for a runoff parameterization was proposed and implemented to the NCAR's land sur- face model (LSM). This modification has two aspects firstly, the topographic slopes cause outflows from higher topography and inflows into the lower topography points; secondly, topographic slopes also cause decrease of infiltration at higher topography and increases of infiltration at lower topography. Then changes in infiltration result in changes in soil molsture, surface fluxes and then in surface temperature, and eventual- ly in the upper atmosphere and the climate. This mechanism is very clearly demonstrated in the point bud- gets analysis at the Andes Mountains vicinities. Analysis from a regional scale perspective in the Mackenzie GEWEX Study (MAGS) area, the focus of the ongoing Canadian GEWEX program, shows that the modi- fied runoff parameterization does bring significant changes in the regional surface climate More important- ly, detailed analysis from a global perspective shows many encouraging improvements introduced by the modified LSM over the original model in simulating basic atmospheric climate properties such as thermodynamic features (temperature and humidity). All of these improvements in the atmospheric climate simulation illustrate that the inclusion of topographic effects in the LSM can force the AGCM to produce a more realistic model climate.

关键词： Hydrological processes Runoff,Parameterization Topographic slope Climate model Land surface model

Modeling Study of Aerosol Indirect Effectson Global Climate with an AGCM

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Advances in Atmospheric Sciences 2010年第5期27卷 1064-1077页

作者：王志立张华沈学顺龚山陵张小曳 Chinese Academy of meteorological Sciences National Climate Center China Meteorological Administration Center for Numerical Prediction Research and State Key Laboratory of Severe Weather Chinese Academy of Meteorological Sciences Center for Atmosphere Watch and services China Meteorological Administration Air Quality Research Branch Meteorological Service of Canada Toronto Ontario Canada

Aerosol indirect effects （AIEs） on global climate were quantitatively investigated by introducing aerosol–cloud interaction parameterizations for water stratus clouds into an AGCM （BCC AGCM2.0.1）, which was developed by the National Climate Center of the China meteorological Administration. The study yielded a global annual mean of -1.14 W m^-2 for the first indirect radiative forcing （IRF）, with an obvious seasonal change. In summer, large forcing mainly occurred in mid to high latitudes of the Northern Hemisphere, whereas in winter, large values were found at 60°S. The second indirect effect led to global annual mean changes in net shortwave flux of -1.03 W m^-2 at the top of the atmosphere （TOA）, which was relatively significant in mid-latitude regions of both hemispheres. The total AIE reduced the global annual means of net shortwave flux at the TOA and of surface temperature by 1.93 W m^-2 and 0.12 K, respectively. Change in surface temperature induced by the total AIE was clearly larger in the Northern Hemisphere （-0.23 K） than in the Southern Hemisphere, where changes were negligible. The interhemispheric asymmetry in surface cooling resulted in significant differences in changes of the interhemispheric annual mean precipitation rate, which could lead to a tendency for the ITCZ to broaden. The total AIE decreased the global annual mean precipitation rate by 0.055 mm df^-1.

关键词： aerosol cloud radiation indirect effect

Changes in Seasonal Patterns of Temperature and Precipitation in China During 1971-2000

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Advances in Atmospheric Sciences 2007年第3期24卷 459-473页

作者：宋连春 A.J.CANNON P.H.WHITFIELD Institue of Arid Meteorology China meteorological Administration Department of Earth and Ocean Sciences University of British Columbia VancouverBritish Columbia V6T 1Z2Canada Meteorological Service of CanadaEnvironment Canada#201-401 Burrard Street VancouverBritish Columbia V6C 3S5Canada meteorological service of canada Environment canada #201-401 Burrard Street VancouverBritish Columbia V6C 3S5Canada

Many studies have shown evidence for significant changes in surface climate in different regions of the world and during different seasons over the past 100 years. Based on daily temperature and precipitation data from 720 climate stations in China, cluster analysis was used to identify regions in China that have experienced similar changes in the seasonal cycle of temperature and precipitation during the 1971-2000 climate normal period. Differences in 11-day averages of daily mean temperature and total precipitation between the first （1971-1985） and second （1986-2000） halves of the record were analyzed using the Mann- Whitney U test and the global κ-means clustering algorithm. Results show that most parts of China experienced significant increases in temperature between the two periods, especially in winter, although some of this warming may be attributable to the urban heat island effect in large cities. Most of western China experienced more precipitation in 1986-2000, while precipitation decreased in the Yellow River valley. Changes in the summer monsoon were also evident, with decreases in precipitation during the onset and decay phases, and increases during the wettest period.

关键词： κ-means clustering seasonality trends temperature precipitation China

Long range trans-Pacific transport and deposition of Asian dust aerosols

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Journal of Environmental Sciences 2008年第4期20卷 424-428页

作者： HAN Yongxiang FANG Xiaomin ZHAO Tianliang KANG Shichang Lanzhou Arid meteorological Institute and Key Laboratory of Arid Climatic Change and Reducing Disaster China Meteorological Administration Lanzhou 730020 China Institute of Tibetan Plateau Research Chinese Academy of Sciences Beijing 100085 China Air Quality Research Branch Meteorological Service of Canada Toronto Ontario m3H 5T4 Canada

The deposition of Asian dust aerosols during their trans-Pacific transport might cause significant marine phytoplankton biomass increases. However, the knowledge of the trans-Pacific dust transport, deposition, and spatial distribution is still poor due to a lack of continuous and simultaneous observations in the Asian subcontinent, the north Pacific Ocean, and North America. The severe Asian dust storm during 6 to 9 April 2001 provided an opportunity to gain a better understanding of trans-Pacific dust transport and deposition, using a comprehensive set of observations from satellites, ground-based light detection and ranging, aircraft, and surface observation networks. The observations and model simulations outline the general pattern of dust transport, deposition, vertical profile, and spatial distribution. The following points were observed：（1） the surface dust concentrations decreased exponentially with the increasing dust transport distance from 80°E to 120°W along the transport pathway; （2） the altitude of the dust concentration peak increased with increasing transport distance in the north Pacific region; and （3） the spatial distribution of dust deposition mainly depended on the trans-Pacific transport route.

关键词： dust aerosol trans-Pacific dust transport and deposition spatial distribution