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Journal of Huazhong University of Science and Technology(Medical Sciences) 1996年第1期16卷 1-5页

作者：武忠弼官阳周泽斌 Forschungsabteilung der Ultrastrukturellen Pathologie Tongji Medizinische Universität Wuhan

Durch die systematische Untersuchung und grundliche Studie uber eine Leiche von der Zeit der Streitenden Reiche aus dem Grab Nr. 1 am GuoJia-Gang in der Stadt Jingmen der Provinz Hubei wurde festgestellt , daβdiese Leiche vor mehr als 2300 Jahren, namlich in dem mittleren Zeitabschnitt der Streitenden Reiche Chinas , in einem Holzsarg beerdigt wurde und die alteste unter allen bisher in China gefundenen alten Sargleichen ist. Sie gehort grundsatzlich auch zu dem Typ der jeweils 1972 in Changsha und 1975 in Jiangling gefundenen alten Leichen der Westlichen Han-Dynastie. Die kollagenen Bindegewebsfasern aus allen Korperteilen dieser Leiche zeigten eine sehr gut erhaltene Ultrastruktur mit ganz deutlichen, ordentlichen, periodischen Querstreifungen. Zwischen den Kollagenfibrillen war interessanterweise wie bei den beiden Leichen der Westlichen HanDynastie auch eine Menge von Bakteriensporen vorhanden. Auβerdem wurde noch eine groβe Menge von Clonorchis sinensis-und Trichuris trichiura-Eier in dem Darminhalt der alten Leiche gefunden. Uber den Erhaltungszustand und die Faktoren der guten Erhaltung der Leiche wurde diskutiert. Unserer Ansicht nach sei die Erhaltung der Leiche ein Resultat aus einem kombiniertem Effekt von internen und externen Faktoren der Leiche.

关键词： alte Leiche Ultrastruktur Clonorchis sinensis Trichuris trichiura kollagene Faser

Study　of　HCV　Infection　and　Viremia　in　Patients　with　Posttransfusion　Hepatitis　in　China

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Journal of Huazhong University of Science and Technology(Medical Sciences) 1995年第4期15卷 204-204页

作者： TANG Zhen-ya YANG Dong-liang YU Zhi-qun HAO Lian-jie(Clinical Immunology Research Unit, Tongji Hospital,Tongji Medical University, Wuhan 430030) Abteilung für Klinische Immunologie Tongji Klinik Tongji Medizinische Universität Wuhan

Abstract

关键词： China HCV

静脉DSA时中心法造影剂注入后导管诱发的心房血栓

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放射学实践 1991年第1期6卷 5-7页

作者： H.A.Kaltenborn A.Brunier G.Zocholl R.Erbel 陈绍红 Institut fr Klinische Strahlenkunde und Ⅱ medizinische klinik am klinikum der Johannes-Gutenberg-Universitt Mainz medizinische klinik am klinikum der Johannes-Gutenberg-Universitt Mainz 同济医科大学附属同济医院

静脉DSA时中心法注入造影剂的适应证,在于它能比周围法更好地解决某些特殊问题。它能在心排出量少、肥胖患者和血管口径细小、纡曲的情况下,使血管内的造影剂团块更少稀释,从而清楚地显示肺部血管以提供更好的诊断依据。检查时常选用5.0... 详细信息

静脉DSA时中心法注入造影剂的适应证,在于它能比周围法更好地解决某些特殊问题。它能在心排出量少、肥胖患者和血管口径细小、纡曲的情况下,使血管内的造影剂团块更少稀释,从而清楚地显示肺部血管以提供更好的诊断依据。检查时常选用5.0F猪尾状导管,它在高压注射时可改变喷射效应。

关键词：静脉DSA 中心法造影剂注入

TLR3-dependent immune regulatory functions of human mesangial cells

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Cellular & Molecular Immunology 2012年第4期9卷 334-340页

作者： Monika Merkle Andrea Ribeiro Simone Koppel Joachim Pircher Hanna Mannell Maximilian Roeder Markus Wornle medizinische Poliklinik--Campus Innenstadt Klinikum der LMU Munich Germany Walter-Brendel-Centre of Experimental Medicine University of Munich MunichGermany

In glomerulonephritis, the migration of inflammatory cells into the glomerulus is an important step in disease initiation and progression. The viral receptor Toll-like receptor 3 （TLR3） is known to play a role in virus-associated glomerulonephritis. Based on this knowledge, this study aimed to define the effects of the TLR3 ligand polyriboinosinic：polyribocytidylic acid （poly（hC）） on the expression of adhesion molecules and macrophage colony-stimulating factor （M-CSF） on resident glomerular cells. Experiments in MCs demonstrated that the activation of viral receptors by poly（I.C） leads to a time- and dose-dependent induction of intercellular adhesion molecule 1 （ICAM-1）, vascular cell adhesion molecule 1 （VCAM-1） and M-CSF at both the mRNA and protein levels; these results were confirmed by incubating MCs with HCV RNA. As shown in knockdown experiments, this effect is specifically mediated by TLR3. The prestimulation of MCs with proinfiammatory cytokines increases the effects of poly（hC）, except for its induction of VCAM-I. Tumor-necrosis factor （TNF）-a, likewise, induces ICAM-1, VCAM-1 and M-CSF, and amplifies the mesangial response to poly（hC）. These results were confirmed by incubating MCs with HCV RNA. We thus provide evidence that human MCs represent a potential target of the leukocytes and monocytes that infiltrate the glomerulus in viral disease-associated GN, highlighting the possibility that MCs may act as resident antigen-presenting cells.

关键词： adhesion molecules glomerulonephritis hepatitis C Toll-like receptor 3

An algorithm for molecular weight prediction from EI mass spectra

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Chinese Science Bulletin 1995年第13期40卷 1087-1089页

作者：杨伯宇朱大模洪群发孙国强刘人余 Hartmut M. Liebich Elke Gesele Dalian Institute of Chemical Physics Dalian 116011 China medizinische Universittklinik Tuebingen 72076 Germany

It is very important to predict the molecular weight of a compound from its EI massspectrum, because molecular weight is one of the most important information for its struc-ture determination. The program for molecular weight prediction is always an importantpart in a structure elucidation system. One cannot directly get the molecular weight fromEI mass spectra in the case of no molecular ions for many compounds, but it is possible tobe predicted in terms of the fragmentation rules. A program for this purpose is

关键词： mass spectrum molecular weight prediction structure elucidation.

Patient age and duration of colonoscopy are predictors for adenoma detection in both proximal and distal colon

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World Journal of Gastroenterology 2015年第2期21卷 525-532页

作者： Peter Klare Stefan Ascher Alexander Hapfelmeier Petra Wolf Analena Beitz Roland M Schmid Stefan von Delius Ⅱ.medizinische klinik Klinikum rechts der IsarTechnischen Universit?t München81675 MunichGermany Institut für medizinische Statistik und Epidemiologie Klinikum rechts der IsarTechnische Universit?t München81675 MunichGermany

AIM: To investigate the relation of patient characteristics and procedural parameters to the endoscopic detection rate of colonic adenomas. Further to study,which factors may be capable to predict the localization of adenomatous ***: We used the data base of a prospective randomized colonoscopy study(The Colo Cap trial) to identify patients being diagnosed with colon adenoma. Logistic regression analysis was conducted to reveal predictors for adenoma detection in the entire colon and also with respect to the proximal and distal part. Covariates including age, gender, duration of colonoscopy and comorbidities were defined to determine association between predictors and adenoma ***: Equal numbers of adenomas were detected in the proximal and distal side of the splenic flexure [126(57%) vs 94(43%), P = 0.104]. Simultaneous occurrence of adenomas in both sides of the colon was rare. The appearance of both proximal and distal adenoma was associated with increasing age(P = 0.008 and P = 0.024) and increasing duration of colonoscopy(P < 0.001 and P = 0.001). Male gender was a predictor for adenoma detection in the proximal colon(P = 0.008) but statistical significance was slightly missed with respect to the distal colon(P = 0.089). Alcohol abuse was found to be a predictor for the detection of distal adenoma(P = 0.041). CONCLUSION: Increasing age and longer duration of colonoscopy are factors with a strong impact on adenoma detection both in the proximal and distal colon. Since proximal adenomas occurred in absence of distal adenomas, complete colonoscopy should be performed for screening.

关键词： Adenoma Colorectal carcinoma Distal Colonoscopy Pr

Implementation of a Return to Work Strategy in Germany—Are There Changes in Work-Related Rehabilitation Measures and Employment Status in Chronic Conditions?

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Open Journal of Therapy and Rehabilitation 2016年第1期4卷 55-66页

作者： Cornelia Gerdau-Heitmann Monika Schwarze Abt. Technik und Gesundheit für Menschen (TGM) Jade Hochschule Oldenburg Oldenburg Germany klinik für Rehabilitationsmedizin Medizinische Hochschule Hannover Hanover Germany

Objectives: Aging workforces with increasing numbers of chronic conditions require health initiatives with greater workplace focus. A regional pension insurance introduced a Return To Work (RTW) strategy for insurants with chronic conditions. The objective was to identify the degree of implementation of work related measures in medical rehabilitation and the extent of RTW outcomes. Methods: 5883 insurants were considered. Severe Restriction of Work Ability (SRWA), Work-related Medical Rehabilitation (WMR), and Case Management (CM) were examined for 2008 and 2012. An Index of Employment status (IoE) was used in a logistic regression. Results: Utilization of WMR raised from 12.3% in 2008 to 66.1% in 2012. The proportion of insurants with SRWA and WMR grew from 8% up to 40.1%. In 2008, 14.7% of insurants with SRWA received WMR;in 2012, it grew to 76.6%. On the other hand, in 2012 26% got WMR without SRWA and 12.2% had SRWA and got no WMR. CM was not conducted in 2008 but reached 20.2% in 2012. Across all indications, WMR resulted in positive RTW as measured by IoE: OR = 0.75 (KI-95%: 0.67 - 0.86). Conclusion: WMR was successfully implemented according to the German guideline. There is a need to optimize the linkage between SRWA and WMR and CM to provide need-based care.

关键词： Chronic Conditions Return to Work (RTW) Work-Related Medical Rehabilitation (WMR) Case Management (CM) Severe Restrictions of Work Ability (SRWA)

New aspects in the pathomechanism and diagnosis of the laryngopharyngeal reflux-clinical impact of laryngeal proton pumps and pharyngeal p H metry in extraesophageal gastroesophageal reflux disease

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World Journal of Gastroenterology 2015年第3期21卷 982-987页

作者： Valentin Becker Romina Drabner Simone Graf Christoph Schlag Simon Nennstiel Anna Maria Buchberger Roland M Schmid Dieter Saur Monther Bajbouj Ⅱ.medizinische klinik Klinikum rechts der IsarTechnische Universit?t München81675 MünchenGermany Hals-Nasen Ohren klinik Klinikum rechts der IsarTechnische Universit?t München81675 MünchenGermany

AIM:To determine the laryngeal H+K+-ATPase and pharyngeal p H in patients with laryngopharyngeal reflux(LPR)-symptoms as well as to assess the symptom scores during PPI ***:Endoscopy was performed to exclude neoplasia and to collect biopsies from the posterior cricoid area(immunohistochemistry and PCR analysis).Immunohistochemical staining was performed with monoclonal mouse antibodies against human H+K+-*** real-time RT-PCR for each of the H+K+-ATPase subunits was *** p H values were assessed in the aerosolized environment of the oropharynx(Dxp H Catheter) and compared to a subsequently applied combined p H/MII ***:Twenty patients with LPR symptoms were *** only one patient,the laryngeal H+K+-ATPase was verified by immunohistochemical *** another patient,real-time RT-PCR for each H+K+-ATPase subunit was *** out of twenty patients had pathological results in Dxp H,and 6/20 patients had pathological results in p H/*** patients had pathological results in both functional *** out of twenty patients responded to ***:The laryngeal H+K+-ATPase can only be sporadically detected in patients with LPR symptoms and is unlikely to cause the LPR *** hypotheses for the pathomechanism are *** role of pharyngeal p H-metry remains unclearand its use can only be recommended for patients in a research study setting.

关键词： Laryngopharyngeal reflux Proton pump inhibitor Gas

在无ST段抬高的高危急性冠状动脉综合征患者中应用依诺肝素的临床获益

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世界核心医学期刊文摘（心脏病学分册） 2006年第11期2卷 31-32页

作者： Zeymer U. Gitt A. JüngerC. 高登峰 Herzzentrum Ludwigshafen Medizinische Klinik B Ludwigshafen Germany Dr.

In randomized clinical trials, low-molecular-weight heparin enoxaparin has been shown to decrease ischemic complications in patients with acute coronary syndromes(ACSs) without ST elevations who are treated conservatively. Enoxaparin has been shown to be equally effective as unfractionated heparin in high-risk patients with an early invasive approach. Little is known about the use and efficacy of enoxaparin in unselected patients with non-ST-elevation ACSs in clinical practice. In a retrospective analysis of the prospective ACOS registry, we compared the outcome of patients who were >60 years of age with non-ST-elevation myocardial infarction or unstable angina with ST-segment changes who were treated with enoxaparin or unfractionated heparin. In total,4,806 patients(55%) with non-ST-ele-vation ACS fulfilled our inclusion criteria for this analysis; 1,178(25%) were treated with enoxaparin and 3,628(75%) with unfractionated heparin. There were no differences between groups in baseline characteristics. We observed a significant decrease in the combined end point of death or nonfatal reinfarction with enoxaparin in the entire study group(odds ratio 0.51, 95%confidence interval 0.37 to 0.70) and in subgroups treated with early percutaneous coronary intervention(n=1,333, odds ratio 0.36, 95%confidence interval 0.17 to 0.80), coronary artery bypass grafting during the index hospitalization(n=270, odds ratio 0.31, 95%confidence interval 0.04 to 2.42), or conservatively(n=3,203, odds ratio 0.57, 95%confidence interval 0.40 to 0.81). There was no significant increase in severe bleeding complications with enoxaparin(5.2%vs 4.5%). In conclusion, in clinical practice, in unselected high-risk patients with non-ST-elevation ACSs who are treated conservatively or with early percutaneous coronary intervention, early treatment with enoxaparin is associated with a significant decrease in the combined end point of in-hospital death and reinfarction, without a significant increase in s

关键词：依诺肝素 ST段抬高临床获益普通肝素出血并发症稳定性心绞痛低分子肝素非致死性性治疗亚

DNA methylation,microRNAs,and their crosstalk as potential biomarkers in hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第24期20卷 7894-7913页

作者： Sumadi Lukman Anwar Ulrich Lehmann Department of Surgery Faculty of Medicine Universitas Gadjah MadaYogyakarta 55281Indonesia Institute of Pathology Medizinische Hochschule HannoverD30625 HannoverGermany

Epigenetic alterations have been identified as a major characteristic in human *** in the field of epigenetics have contributed significantly in refining our knowledge of molecular mechanisms underlying malignant *** methylation and microRNA expression are epigenetic mechanisms that are widely altered in human cancers including hepatocellular carcinoma(HCC),the third leading cause of cancer related mortality *** DNA methylation and microRNA expression patterns are regulated in developmental stage specific-,cell type specific-and tissue-specific *** aberrations are inferred in the maintenance of cancer stem cells and in clonal cell evolution during *** availability of genome-wide technologies for DNA methylation and microRNA profiling has revolutionized the field of epigenetics and led to the discovery of a number of epigenetically silenced microRNAs in cancerous cells and primary *** of these microRNAs affects several key signalling pathways in hepatocarcinogenesis suggesting that modulation of DNA methylation and/or microRNA expression can serve as new therapeutic targets for *** evidence shows that aberrant DNA methylation of certain microRNA genes is an event specifically found in HCC which correlates with unfavorable ***,it can potentially serve as a biomarker for detection as well as for prognosis,monitoring and predicting therapeutic responses in HCC.

关键词： DNA methylation MicroRNA Epigenetics Hepatocellular carcinoma Biomarker