DNA methylation,microRNAs,and their crosstalk as potential biomarkers in hepatocellular carcinoma

作     者：Sumadi Lukman Anwar Ulrich Lehmann 

作者机构：Department of SurgeryFaculty of Medicine Universitas Gadjah MadaYogyakarta 55281Indonesia Institute of PathologyMedizinische Hochschule HannoverD30625 HannoverGermany 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2014年第20卷第24期

页      面：7894-7913页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by Grant from the German Research Council(DFG) SFB-TRR77"Liver cancer"(Project B1) 

主　　题：DNA methylation MicroRNA Epigenetics Hepatocellular carcinoma Biomarker 

摘      要：Epigenetic alterations have been identified as a major characteristic in human *** in the field of epigenetics have contributed significantly in refining our knowledge of molecular mechanisms underlying malignant *** methylation and microRNA expression are epigenetic mechanisms that are widely altered in human cancers including hepatocellular carcinoma(HCC),the third leading cause of cancer related mortality *** DNA methylation and microRNA expression patterns are regulated in developmental stage specific-,cell type specific-and tissue-specific *** aberrations are inferred in the maintenance of cancer stem cells and in clonal cell evolution during *** availability of genome-wide technologies for DNA methylation and microRNA profiling has revolutionized the field of epigenetics and led to the discovery of a number of epigenetically silenced microRNAs in cancerous cells and primary *** of these microRNAs affects several key signalling pathways in hepatocarcinogenesis suggesting that modulation of DNA methylation and/or microRNA expression can serve as new therapeutic targets for *** evidence shows that aberrant DNA methylation of certain microRNA genes is an event specifically found in HCC which correlates with unfavorable ***,it can potentially serve as a biomarker for detection as well as for prognosis,monitoring and predicting therapeutic responses in HCC.