DNA methylation,microRNAs,and their crosstalk as potential biomarkers in hepatocellular carcinoma
DNA methylation,microRNAs,and their crosstalk as potential biomarkers in hepatocellular carcinoma作者机构:Department of SurgeryFaculty of Medicine Universitas Gadjah MadaYogyakarta 55281Indonesia Institute of PathologyMedizinische Hochschule HannoverD30625 HannoverGermany
出 版 物:《World Journal of Gastroenterology》 (世界胃肠病学杂志(英文版))
年 卷 期:2014年第20卷第24期
页 面:7894-7913页
核心收录:
学科分类:1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金:Supported by Grant from the German Research Council(DFG) SFB-TRR77"Liver cancer"(Project B1)
主 题:DNA methylation MicroRNA Epigenetics Hepatocellular carcinoma Biomarker
摘 要:Epigenetic alterations have been identified as a major characteristic in human *** in the field of epigenetics have contributed significantly in refining our knowledge of molecular mechanisms underlying malignant *** methylation and microRNA expression are epigenetic mechanisms that are widely altered in human cancers including hepatocellular carcinoma(HCC),the third leading cause of cancer related mortality *** DNA methylation and microRNA expression patterns are regulated in developmental stage specific-,cell type specific-and tissue-specific *** aberrations are inferred in the maintenance of cancer stem cells and in clonal cell evolution during *** availability of genome-wide technologies for DNA methylation and microRNA profiling has revolutionized the field of epigenetics and led to the discovery of a number of epigenetically silenced microRNAs in cancerous cells and primary *** of these microRNAs affects several key signalling pathways in hepatocarcinogenesis suggesting that modulation of DNA methylation and/or microRNA expression can serve as new therapeutic targets for *** evidence shows that aberrant DNA methylation of certain microRNA genes is an event specifically found in HCC which correlates with unfavorable ***,it can potentially serve as a biomarker for detection as well as for prognosis,monitoring and predicting therapeutic responses in HCC.