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The detrimental effects of lipopolysaccharideinduced neuroinflammation on adult hippocampal neurogenesis depend on the duration of the pro-inflammatory response

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Neural Regeneration Research 2019年第5期14卷 817-825页

作者： Martha Pérez-Domínguez Evangelina ávila-Mu?oz Eduardo Domínguez-Rivas Angélica Zepeda Departamento de medicina genómica y toxicología ambiental Instituto de Investigaciones Biomédicas.Universidad Nacional Autónoma de MéxicoCDMX

Adult hippocampal neurogenesis is a finely tuned process regulated by extrinsic factors. Neuroinflammation is a hallmark of several pathological conditions underlying dysregulation of neurogenesis. In animal models, lipopolysaccharide(LPS)-induced neuroinflammation leads to a neurogenic decrease mainly associated to the early inflammatory response. However, it is not well understood how the neuroinflammatory response progresses over time and if neurogenesis continues to be diminished during the late neuroinflammatory response. Moreover, it is unknown if repeated intermittent administration of LPS along time induces a greater reduction in neurogenesis. We administered one single intraperitoneal injection of LPS or saline or four repeated injections(one per week) of LPS or saline to young-adult mice. A cohort of new cells was labeled with three 5-bromo-2-deoxyuridine injections(one per day) 4 days after the last LPS injection. We evaluated systemic and neuroinflammation-associated parameters and compared the effects of the late neuroinflammatory response on neurogenesis induced by each protocol. Our results show that 1) a single LPS injection leads to a late pro-inflammatory response characterized by microglial activation, moderate astrocytic reaction and increased interleukin-6 levels. This response correlates in time with decreased neurogenesis and 2) a repeated intermittent injection of LPS does not elicit a late pro-inflammatory response although activated microglia persists. The latter profile is not accompanied by a continued longterm hippocampal neurogenic decrease. Hereby, we provide evidence that the neuroinflammatory response is a dynamic process that progresses in a milieu-dependent manner and does not necessarily lead to a neurogenic decrease, highlighting the complex interaction between the immune system and neurogenesis.

关键词： dentate gyrus subgranular zone inflammation microglia astrocytes IL-6 cytokines cell proliferation neural progenitor cells immature neurons long-term short-term adult hippocampal neurogenesis

Control of tendon cell fate in the embryonic limb: A molecular perspective

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BIOCELL 2023年第3期47卷 465-471页

作者： JESSICA CRISTINA MARÍN-LLERA CARLOS AMAURy JIMÉNEZ-CÁRDENAS JESÚS CHIMAL-MONROy Departamento de medicina genómica y toxicología ambiental Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de México Ciudad UniversitariaApartado Postal 70228MéxicoDF 04510México

The molecular cascade underlying tendon formation starts when progenitor cells begin to express the Scleraxis(Scx)*** knockout mice develop some but not all tendons,suggesting that additional factors are necessary for tendon commitment,maintenance,and *** transcription factors,such as Mohawk(Mkx)or early growth response(Egr),maintain Scx expression and extracellular matrix formation during *** inhibition of wingless and int-related protein signaling is necessary and sufficient to induce the expression of *** the commitment of tenogenic lineage occurs,transforming growth factor-beta(TGFβ)induces the Scx gene expression,becoming involved in the maintenance of tendon cell *** this point of view,we discussed two phases of the tenogenic process during limb development:dependent and independent of mechanical ***,we highlight the importance of understanding embryonic tendon development to improve therapeutic strategies in regenerative medicines for tendons.

关键词： Tendon differentiation Tenocyte Scleraxis Mohawk Early growth response Tendon development WNT TGFβ

Commitment of human mesenchymal stromal cells to skeletal lineages is independent of their morphogenetic capacity

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World Journal of Stem Cells 2023年第7期15卷 701-712页

作者： Jessica Cristina Marín-Llera Damián García-García Estefania Garay-Pacheco Victor Adrian Cortes-Morales Juan Jose Montesinos-Montesinos Jesus Chimal-Monroy medicina genómica y toxicología ambiental Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoCoyoacan 04510Mexico Laboratorio de Células Troncales Mesenquimales Unidad de Investigación Médica en Enfermedades OncológicasHospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Departamento de medicina genómica y toxicología ambiental Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoCoyoacan 04510Mexico

BACKGROUND Mesenchymal stromal cells(MSCs)are multipotent cell populations obtained from fetal and adult *** share some characteristics with limb bud mesodermal cells such as differentiation potential into osteogenic,chondrogenic,and tenogenic lineages and an embryonic mesodermal *** MSCs differentiate into skeletal-related lineages in vitro,they have not been shown to selforganize into complex skeletal structures or connective tissues,as in the *** this work,we demonstrate that the expression of molecular markers to commit MSCs to skeletal lineages is not sufficient to generate skeletal elements in *** To evaluate the potential of MSCs to differentiate into skeletal lineages and generate complex skeletal structures using the recombinant limb(RL)*** We used the experimental system of RLs from dissociated-reaggregated human placenta(PL)and umbilical cord blood(UCB)*** being harvested and reaggregated in a pellet,cultured cells were introduced into an ectodermal cover obtained from an early chicken limb ***,this filled ectoderm was grafted into the back of a donor chick *** these conditions,the cells received and responded to the ectoderm’s embryonic signals in a spatiotemporal manner to differentiate and pattern into skeletal *** response to differentiation and morphogenetic signals was evaluated by quantitative poly-merase chain reaction,histology,immunofluorescence,scanning electron microscopy,and in situ *** We found that human PL-MSCs and UCB-MSCs constituting the RLs expressed chondrogenic,osteogenic,and tenogenic molecular markers while differentially committing into limb lineages but could not generate complex structures in ***-RL from PL or UCB were committed early to chondrogenic ***,the UCB-RL osteogenic commitment was favored,although preferentially to a tenogenic cell *** findings suggest that the commitment of MSCs to differentiate int

关键词： Human mesenchymal stromal cells Recombinant limbs Mesenchymal stromal cell morphogene-sis Mesenchymal stromal cell in vivo differentiation Skeletal tissues

The impact of maternal immune activation on the morphology and electrophysiological properties of postnatally-born neurons in the offspring

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Neural Regeneration Research 2024年第2期19卷 399-400页

作者： Emilio J.Galván Angelica Zepeda Departamento de Farmacobiología CINVESTAV Unidad Sur CdMxMéxico、Centro de Investigaciones sobre el EnvejecimientoCIE-CinvestavCdMxMéxico Departamento de medicina genómica y toxicología ambiental Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoUNAMCdMxMéxico

Pregnancy comes with a combination of physical changes and physiological immunosuppression that increases the susceptibility of women to pathogens and in turn,rises the prevalence of infectious diseases.

关键词： prevalence activation impact

Seasonal variation and chemical composition of particulate matter： A study by XPS, ICP-AES and sequential microanalysis using Raman with SEM/EDS

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Journal of Environmental Sciences 2018年第12期30卷 32-49页

作者： Lucy T.González Francisco E.Longoria-Rodríguez Margarita Sánchez-Domínguez Cesar Leyva-Porras Karim Acuna-Askar Boris I.Kharissov Alejandro Arizpe-Zapata Juan M.Alfaro-Barbosa Universidad Autónoma de Nuevo León Facultad de Ciencias Químicas Laboratorio de Química Analítica AmbientalCódigo Postal 64570MaonterreyN.L.Mexico Centro de Investigación en Materiales Avanzados SC Unidad MonterreyAlianza Notre 202 Código Postal 66628 Apodaca Nueuo León Mexico Centro de Investigación en Materiales Avanzados SC Miguel de Cervantes # 120 Código Postal 31109 Chihuahua Chih. Mexico Universidad Autónoma de Nuevo León Facultad de Medicina Laboratorio de Biorremediación AmbientalCódigo Postal 64460 MonterreyN.L. Mexico

During the winter period（January–March 2016）, the total suspended particles（TSP） and particulate matter smaller than 2.5 μm（PM2.5） were characterized by the application of various analytical techniques in four zones of the Metropolitan Area of Monterrey in Mexico. To evaluate the seasonal variation of some elements in the particulate matter, the results of this study were compared with those obtained during the summer season（July–September 2015）. The speciation of the C_（1s） signal by X-ray photoelectron spectroscopy revealed the contribution of aromatic and aliphatic hydrocarbons as the main components in both seasons. Conversely, carboxylic groups associated with biogenic emissions were detected only in winter. The percentages of SO_4^（2-） ions were lower in winter, possibly caused by the decrease in the solar radiation, and relative humidity recorded. The results of the ICP analysis revealed that Fe, Zn and Cu were the most abundant metals in both TSP and PM2.5 in the two seasons. There were significant seasonal variations for concentrations of As, Ni and Zn in the urban area and for Fe, As, Cd, Ni and Zn in the industrial zone. This was attributed to the greater burning of fuels as well as to an increase in vehicular traffic, the effect of thermal inversion and changes in some meteorological parameters. The results of the sequential microanalysis by Raman spectroscopy and SEM/EDS allowed observation of deposits of carbonaceous material on the particles and to perform the speciation of particles rich in Fe and Pb, which helped infer their possible emission sources.

关键词： Seasonal variation Total suspended particles PM2.5 X-ray photoelectron spectroscopy Micro-Raman spectroscopy

Evaluation of the frequency of micronucleus in epithelial cells of children exposed to arsenic and heavy metals pollution in a mining area of Mexico

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Chinese Journal Of Geochemistry 2006年第B08期25卷 72-73页

作者： Sandra P. Gamino Fernando Diaz-Barriga Eugenia M. Gonsebatt Marcos Monroy Laboratorio de Geoquimica y Geomicrobiologia ambiental Instituto de Metalurgia UASLP / San Luis Potosi S.L.P. México Laboratorio de toxicologia ambiental Facultad de Medicina UASLP / San Luis Potosl S.L.P. México Instituto de Investigaciones Biomédicas UNAM/Mexico D.E México

Food and Nutritional Insecurity before and during the COVID-19 Pandemic in Households of Women Belonging to a Social Program

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Food and Nutrition Sciences 2021年第7期12卷 742-758页

作者： Monserrat Méndez-Pérez Rebeca Monroy-Torres Silvia Delgado-Sandoval Karen Medina-Jiménez Laboratorio de Nutrición ambiental y Seguridad Alimentaria. Departamento de medicina y Nutrición Universidad de Guanajuato Campus León Leon Mexico Observatorio Universitario de Seguridad Alimentaria y Nutricional del Estado de Guanajuato Leon Mexico División de Ciencias de la Salud e Ingenierías Universidad de Guanajuato Campus Celaya-Salvatierra Celaya México

Introduction: According to the National Health and Nutrition Survey, the Mexican households in 2018 had food insecurity at 55.5% while in 2012 it was 70%. Food insecurity is a global health problem and now with the COVID-19 pandemic, it has increased. Objective: To compare the levels of food and nutritional insecurity in women’s households from two Social Impulse Centers of the Secretary for Human Social Development (SEDESHU) before and during the COVID-19 pandemic. Methods: A comparative and cross-sectional study was carried out in 41 women participating in a nutritional intervention program in two social promotion centers. Food security was measured with the Latin American and Caribbean Food Security Scale (ELCSA), comparing it in a period from January to April 2020: before and during the health contingency. Socio-economic and demographic variables were also measured, as well as access to water during the COVID-19 pandemic. Results: Food insecurity levels during the COVID-19 contingency were found to have increased by more than 60% (from 31.7% to 93%);the main risk factors associated with unemployment and access to healthy food. The COVID-19 contingency reflects impacts on households, but because women participated in the nutritional intervention program, it could influence by observing that, at least, the use of food was adequate since apparently food waste was minimal. yle="font-famil

关键词： Food Insecurity Access Water Loss Employment COVID-19 Social Pro-grams

胆固醇介导的星形胶质细胞活化与淀粉样前体蛋白表达升高和进展相关

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神经损伤与功能重建 2015年第6期10卷 525-525页

作者： Evangelina Avila-Mu?oz Clorinda Arias 王晶 Departamento De medicina genómica y toxicología ambiental Instituto De Investigaciones BiomédicasUniversidad Nacional Autónoma De México

胆固醇对于保持脂筏的完整性起必要作用,其被认为是阿尔茨海默病(AD)中淀粉样蛋白生成的关键调节因子。大多数关于淀粉样前体蛋白(APP)代谢和β淀粉样蛋白(Aβ)生成的研究都聚焦于神经元。虽然在大多数AD患者和AD转基因模型脑内发现活... 详细信息

胆固醇对于保持脂筏的完整性起必要作用,其被认为是阿尔茨海默病(AD)中淀粉样蛋白生成的关键调节因子。大多数关于淀粉样前体蛋白(APP)代谢和β淀粉样蛋白(Aβ)生成的研究都聚焦于神经元。虽然在大多数AD患者和AD转基因模型脑内发现活化的星形胶质细胞,但星形胶质细胞在AD中的作用尚未得到充分探索。在神经元Aβ生成中胆固醇的作用已得到充分研究,并归因于APP代谢中脂筏的参与。因此,本研究分析星形胶质细胞中胆固醇的作用,以及APP的表达和进展。本研究发现,胆固醇的表达导致星形胶质细胞活化,提高APP水平,增强APP和BACE-1的交互作用。这些作用与星形胶质细胞细胞膜的神经节苷脂GM1-胆固醇斑块和增高的ROS相关。

关键词： APP代谢 ROS 培养的星形胶质细胞脂筏

Exposure to Fine Particles by Mine Tailing and Lung Function Effects in a Panel of Schoolchildren,Chanaral,Chile

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Journal of Environmental Protection 2015年第2期6卷 118-128页

作者： Karla yohannessen Vasquez Sergio Alvarado Orellana Stephanie Mesias Monsalve Jose Klarian Vergara Claudio Silva Zamora Daniella Vidal Munoz Dante D.Caceres Lillo Programa de Salud ambiental Escuela de Salud PublicaFacultad de MedicinaUniversidad de ChileSantiago de ChileChile Grups de Recerca d’America i AfricaLlatines Unitat de BioestadisticaFacultat de MedicinaUniversitat Autonoma de BarcelonaBarcelonaEspana Facultad de Ciencias de la Salud Universidad de TarapacaAricaChile Departamento de Prevencion de Riesgos y Medio Ambiente Universidad Tecnologica MetropolitanaSantiagoChile

There is much literature on the effects of fine particulate matter (PM2.5) on respiratory and cardiovascular health. However, few studies have evaluated the impact of PM2.5 on a population living in the vicinity of a massive deposit of mine tailings. A longitudinal panel study was performed to evaluate the association between exposure to PM2.5 and acute effects on lung function in schoolchildren from November 2012 to May 2013. Ambient levels of PM2.5 and its metal composition were measured. Lung function was evaluated using spirometric testing. Associations were quantified using GEE multilevel analysis controlling for confounders by using different lag time periods. The chemical characterization of PM2.5 had high levels of S > Na > Cl > Ca > Si > Fe > Al > Mg > K > Cu > Ti > and Zn, which would be associated with metals present in tailings. We found a negative association between the temporal variation of PM2.5 and changes in lung function specifically on forced vital capacity. Our results suggest that schoolchildren exposed to fine particulate matter from tailings deposited in the bay of Chanaral have their forced vital capacity decreased, which would affect their present and future lung development, increasing the risk of developing chronic respiratory diseases.

关键词： Mine Tailings Fine Particulate Matter Heavy Metals Lung Function Schoolchildren