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Chinese Journal of Traumatology 2014年第6期17卷 323-326页

作者： Mohammad Reza Sharif Ali Akbarnejad Alireza Moravveji Rasool Hamayattalab Mansour Sayyah Trauma research center College of Medicine Kashan University of Medical Sciences Kashan 87159- 81158 I.R. Iran

损害打的 ObjectiveAmong，运动组成指医学中心的病人的一个可观的比例。这研究被进行检验从 2005 ～ 2011 .MethodsThis 指医药科学损伤研究中心的 Kashan 大学的运动相关的损害的频率是从医药科学损伤研究中心的 Kashan 大学的数据银... 详细信息

损害打的 ObjectiveAmong，运动组成指医学中心的病人的一个可观的比例。这研究被进行检验从 2005 ～ 2011 .MethodsThis 指医药科学损伤研究中心的 Kashan 大学的运动相关的损害的频率是从医药科学损伤研究中心的 Kashan 大学的数据银行的存在数据在被采用的回顾的研究。数据被社会科学统计套装软体版本 16.0 从主要来源提取。象年龄，教育，职业和性那样的变量最高是 analyzed.ResultsThe 损害的比例在工人(11.8%) 跟随的学生(59.4%) 被观察。上面、更低的极限最通常被伤害。最经常的损害是紧张(35.4%) ，由这研究的 .ConclusionThe 结果显示出的扭伤(27.7%) 列在后面在学生的运动损伤 occurrs 的多数；因此，他们关于运动损害需要更多的注意。预防措施象象增加 students’ 一样通知客车和教师那样关于损害风险的了解能减少运动损害的发生。

关键词：运动损伤医学科学科学院创伤流行病学大学医疗中心工伤认定

Colorectal Cancer Screening in China:Status,Challenges,and Prospects——China,2022

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China CDC weekly 2022年第15期4卷 322-328页

作者： Hongda Chen Bin Lu Min Dai Medical Research Center Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Colorectal cancer(CRC)ranks third among the most commonly diagnosed cancers in China.Despite proof that screening can decrease CRC incidence and mortality,there are still gaps remaining between CRC screening objectives and reality in China.In this review,we provided an overview of the status of CRC screening in China.First,we summarized the current CRC screening programs and strategies in China.Second,we reviewed the authoritative CRC screening and early detection guidelines in China to orient future evidence-based guideline development.Finally,we identified current challenges and further provided some suggestions to improve the implementation of CRC screening programs.To maximize the effectiveness of CRC screening,further research on risk prediction models including polygenic risk scores and prior screening outcomes,novel biomarkers and artificial intelligence,and personalized screening strategies are recommended.Both cohort study and microsimulation techniques are recommended for long-term evaluations of the effectiveness of CRC screening strategies.

关键词： summarized spite screening

Evaluation of direct intramural injection to the bladder wall as a method for developing orthotopic tumor models

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Animal Models and Experimental Medicine 2022年第6期5卷 575-581页

作者： Masoud Bitaraf Samad Muhammadnejad Ashkan Azimzadeh Saman Behboodi Tanourlouee Erfan Amini Masoumeh Majidi Zolbin Abdol-Mohammad Kajbafzadeh Pediatric Urology and Regenerative Medicine research center GeneCell and Tissue Research InstituteTehran University of Medical SciencesTehranIran Gene Therapy research center Digestive Diseases Research InstituteTehran University of Medical SciencesTehranIran Uro-oncology research center Tehran University of Medical SciencesTehranIran

Background:Bladder cancer poses a great burden on society and its high rate of recurrence and treatment failure necessitates use of appropriate animal models to study its pathogenesis and test novel treatments.Orthotopic models are superior to other types since they provide a normal microenvironment.Four methods are described for developing bladder cancer models inside the animal’s bladder.Direct intramural injection is one of these methods and is widely used.However,its efficacy in model development has not yet been studied.We aimed to evaluate the efficacy and success rate of the direct intramural injection method of developing an orthotopic model for the study of bladder cancer.Method:Tumor cell lines were prepared in four microtubes.Aliquots of 200×10^(3) cells were injected through a 27 gauge needle into the ventral wall of the bladders of 4male and 4 female BALB/c mice following a midline 1 cm laparotomy incision.In addition,1 million cells from each microtube were injected into the flanks of control mice.To prevent infection and alleviate pain,5 mg/kg enrofloxacin and 2.5 mg/kg flunixin meglumine,respectively,were injected subcutaneously.Results:Tumors formed in all mice,resulting in 100% take rate and zero post-operation mortality.Surgery time was≤15 min per mouse.In two mice,tumors were found in the peritoneal space as well.Conclusion:Direct intramural injection is a rapid,reliable,and reproducible method for developing orthotopic models of bladder cancer.It can be done on both male and female mice and only requires readily available surgical tools.However,needle track can result in cell spillage and peritoneal tumors.

关键词： animal model bladder cancer bladder wall injection model evaluation orthotopic model

Comparison of post-urethroplasty complication rates in pediatric cases with hypospadias using Vicryl or polydioxanone sutures

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Asian Journal of Urology 2022年第2期9卷 165-169页

作者： Mehdi Shirazi Abdolreza Haghpanah Anahita Dehghani Sezaneh Haghpanah Mehdi Ghahartars Mahdi Rahmanian Shiraz Nephro-urology research center Shiraz University of Medical SciencesShirazIran Hematology research center Shiraz University of Medical SciencesShirazIran Molecular Dermatology research center Shiraz University of Medical SciencesShirazIran medical School MPH DepartmentShiraz University of Medical SciencesShirazIran

Objective:Hypospadias is a common congenital problem among male newborns.Both rapid absorbable sutures(polyglactin,Vicryl)and delayed absorbable sutures(polydioxanone,PDO)are used in hypospadias repair based on the surgeon's preference.This study was conducted to compare post-urethroplasty complication rates in pediatric patients with hypospadias using Vicryl or PDO sutures.Methods:This is a retrospective study which was designed and performed on 583 children aged 1-7 years old who had undergone hypospadias repair from January 2012 to December 2018.Required data were obtained from the patients'medical records.Results:Overall,post-surgical complications were observed in 60(10.3%)patients comprising urethro-cutaneous fistula(n=39,6.7%),meatal stenosis(n=10,1.7%),urethral stricture(n=7,1.2%),and glans dehiscence(n=4,0.7%).The mean age of the children with complications was 3.0±1.3 years.According to Kaplan-Meier estimate,the interval between surgery and development of complications was significantly shorter in the Vicryl group(p=0.037).Overall,complications were more prevalent in Vicryl suture than PDO suture(15.1%vs.5.3%,p<0.001).Regression model revealed that in comparison to the distal type,proximal hypospadias(odds ratio[OR]:103.9,95%confidence interval[CI]:32.2-334.9,p<0.001)and mid-shaft hypospadias(OR:82.9,95%CI:25.9-264.6,p<0.001)while using Vicryl suture instead of PDO suture(OR:62.4,95%CI:21.2-183.8,p<0.001)increased the odds of developing post-urethroplasty complications.Conclusion:We suggest PDO suture in the repair of hypospadias due to its lower complication rate,especially in cases of proximal and mid-shaft hypospadias which can get more complicated than the distal type.

关键词： Hypospadias Urinary fistula Polyglactin Polydioxanone

research of medical Expenditure among Inpatients with Unstable Angina Pectoris in a Single center

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Chinese medical Journal 2017年第13期130卷 1529-1533页

作者： Suo-Wei Wu Qi Pan Tong Chen Liang-Yu Wei Yong Xuan Qin Wang Chao Li Jing-Chen Song Department of medical Administration Beijing Hospital National Center of Gerontology Beijing 100730 China

Background： With the rising incidence as well as the medical expenditure among patients with unstable angina pectoris, the research aimed to investigate the inpatient medical expenditure through the combination of diagnosis-related groups （DRGs） among patients with nnstable angina pectoris in a Grade A tertiary hospital to conduct the referential standards of medical costs for the diagnosis. Methods： Single-factor analysis and multiple linear stepwise regression method were used to investigate 3933 cases between 2014 and 2016 in Beijing Hospital （China） whose main diagnosis was defined as unstable angina pectoris to determine the main factors influencing the inpatient medical expenditure,and decision tree method was adopted to establish the model of DRGs grouping combinations. Results： The major influential factors of inpatient medical expenditure included age, operative method, therapeutic effects as well as comorbidity and complications （CCs） of the disease, and the 3933 cases were divided into ten DRGs by four factors： age, CCs, therapeutic effects, and the type of surgery with corresponding inpatient medical expenditure standards setup. Data of nonparametric test on medical costs among different groups were all significant （P 〈 0.001, by Kruskal-Wallis test）, with R2 = 0.53 and coefficient of variation （CV） 0.524. Conclusions： The classification of DRGs by adopting the type of surgery as the main branch node to develop cost control standards in inpatient treatment of unstable angina pectoris is conducive in standardizing the diagnosis and treatment behaviors of the hospital and reducing economic burdens among patients.

关键词： Angina, Unstable Decision Trees Diagnosis-related Groups Health Care Costs

Potential unreliability of ALK variant allele frequency in the efficacy prediction of targeted therapy in NSCLC

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Frontiers of Medicine 2023年第3期17卷 493-502页

作者： Wei Rao Yutao Liu Yan Li Lei Guo Tian Qiu Lin Dong Jianming Ying Weihua Li Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Anaplastic lymphoma kinase(ALK)is the most common fusion gene involved in non-small cell lung cancer(NSCLC),and remarkable response has been achieved with the use of ALK tyrosine kinase inhibitors(ALK-TKIs).However,the clinical efficacy is highly variable.Pre-existing intratumoral heterogeneity(ITH)has been proven to contribute to the poor treatment response and the resistance to targeted therapies.In this work,we investigated whether the variant allele frequencies(VAFs)of ALK fusions can help assess ITH and predict targeted therapy efficacy.Through the application of next-generation sequencing(NGS),7.2%(326/4548)of patients were detected to be ALK positive.On the basis of the adjusted VAF(adjVAF,VAF normalization for tumor purity)of four different threshold values(adjVAF<50%,40%,30%,or 20%),the association of ALK subclonality with crizotinib efficacy was assessed.Nonetheless,no statistical association was observed between median progression-free survival(PFS)and ALK subclonality assessed by adjVAF,and a poor correlation of adjVAF with PFS was found among the 85 patients who received first-line crizotinib.Results suggest that the ALK VAF determined by hybrid capture-based NGS is probably unreliable for ITH assessment and targeted therapy efficacy prediction in NSCLC.

关键词： ALK fusion next-generation sequencing fluorescence in situ hybridization immunohistochemistry variant allele frequency intratumoral heterogeneity targeted therapy

Optimizing the cancer research landscape for the benefit of patients and society: A strategic perspective of the German Cancer research center (DKFZ) and its partnerships with university medical centers

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Cancer Biology & Medicine 2022年第11期19卷 1517-1522页

作者： Michael Baumann German Cancer research center(DKFZ) Heidelberg 69120Germany

This issue of Cancer Biology & Medicine, a premium Chinese international scientific journal in this field, focuses on cooperation between Chinese and German cancer research, particularly between the Tianjin medical University Cancer Institute & Hospital and the German Cancer research center(DKFZ) with its networking partners. This editorial provides a brief overview on DKFZ’s research strategy with a focus on how a national integrated cancer research and care ecosystem is evolving that benefits patients and society.

关键词： Cancer landscape centers

Combined chemo-endocrine therapy as a potential new option for HR+/HER2−advanced breast cancer:a prospective study of fulvestrant plus oral vinorelbine

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Cancer Biology & Medicine 2023年第4期20卷 287-296页

作者： Xue Wang Jian Yue Yikun Kang Zhong Dai Jie Ju Jiayu Wang Pin Zhang Fei Ma Binghe Xu Peng Yuan Department of VIP medical Services National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Comprehensive Oncology Huanxing Cancer HospitalBeijing 100026China Department of medical Oncology and Clinical Trial center National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Objective:Endocrine therapy with fulvestrant has shown synergistic antitumor effects with some chemotherapy drugs in vitro.This study evaluated the efficacy and safety of fulvestrant with vinorelbine in patients with hormone receptor positive(HR+)/human epidermal growth factor receptor-2-negative(HER2−)recurrent or metastatic breast cancer.Methods:Patients were intramuscularly administered fulvestrant 500 mg(day 1 per cycle for 28 days)and oral vinorelbine(60 mg/m2 on days 1,8,and 15 of each cycle).The primary endpoint was progression-free survival(PFS).Secondary endpoints included overall survival,objective response rate,disease control rate,duration of response,and safety.Results:A total of 38 patients with HR+/HER2−advanced breast cancer included in the study were followed up for a median time of 25.1 months.The overall median PFS was 9.86 months[95%confidence interval(CI)7.2-23.13],and the median PFS of the first-line and the second-line treatment population was 20.73 months(95%CI 9.82 to NR)and 4.27 months(95%CI 3.68 to NR),respectively.Most adverse events reported were of grade 1/2,and none were of grade 4/5.Conclusions:This is the first exploratory study of a fulvestrant and oral vinorelbine regimen in the treatment of HR+/HER2−recurrent and metastatic breast cancer.The combination chemo-endocrine therapy was efficacious,safe,and promising for patients with HR+/HER2−advanced breast cancer.

关键词： HR+/HER2−breast cancer recurrence metastasis fulvestrant oral vinorelbine

Association between homologous recombination deficiency and outcomes with platinum and platinum-free chemotherapy in patients with triple-negative breast cancer

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Cancer Biology & Medicine 2023年第2期20卷 155-168页

作者： Yimeng Chen Xue Wang Feng Du Jian Yue Yiran Si Xiaochen Zhao Lina Cui Bei Zhang Ting Bei Binghe Xu Peng Yuan Department of medical Oncology and Clinical Trial center National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of VIP medical Services National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China The medical Department 3D Medicines Inc.Shanghai 201114China

Objective:The choice of chemotherapeutic regimen for triple-negative breast cancer(TNBC)remains controversial.Homologous recombination deficiency(HRD)has attracted increasing attention in informing chemotherapy treatment.This study was aimed at investigating the feasibility of HRD as a clinically actionable biomarker for platinum-containing and platinum-free therapy.Methods:Chinese patients with TNBC who received chemotherapy between May 1,2008 and March 31,2020 were retrospectively analyzed with a customized 3D-HRD panel.HRD positivity was defined by an HRD score≥30 or deleterious BRCA1/2 mutation.A total of 386 chemotherapy-treated patients with TNBC were screened from a surgical cohort(NCT01150513)and a metastatic cohort,and 189 patients with available clinical and tumor sequencing data were included.Results:In the entire cohort,49.2%(93/189)of patients were identified as HRD positive(40 with deleterious BRCA1/2 mutations and 53 with BRCA1/2 intact with an HRD score of≥30).In the first-line metastatic setting,platinum therapy was associated with longer median progression-free survival(mPFS)than platinum-free therapy[9.1 vs.3.0 months;hazard ratio(HR),0.43;95%confidence interval 0.22–0.84;P=0.01].Among HRD-positive patients,the mPFS was significantly longer in those treated with platinum rather than platinum-free therapy(13.6 vs.2.0 months;HR,0.11;P=0.001).Among patients administered a platinum-free regimen,HRD-negative patients showed a PFS significantly superior to that of HRD-positive patients(P=0.02;treatment-biomarker P-interaction=0.001).Similar results were observed in the BRCA1/2-intact subset.In the adjuvant setting,HRD-positive patients tended to benefit more from platinum chemotherapy than from platinum-free chemotherapy(P=0.05,P-interaction=0.02).Conclusions:HRD characterization may guide decision-making regarding the use of platinum treatment in patients with TNBC in both adjuvant and metastatic settings.

关键词： Homologous recombination deficiency triple-negative breast cancer platinum survival BRCA

Cell therapy for the treatment of reproductive diseases and infertility:an overview from the mechanism to the clinic alongside diagnostic methods

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Frontiers of Medicine 2022年第6期16卷 827-858页

作者： Kosar Babaei Mohsen Aziminezhad Seyedeh Elham Norollahi Sogand Vahidi Ali Akbar Samadani Non-Communicable Disease research center Neyshabur University of Medical SciencesNeyshaburIran UMR INSERM U 1122 IGE-PCVInteractions Gène-Environment En Physiopathologie Cardiovascular UniversitéDe LorraineNancyFrance Cancer research center and Department of Immunology Semnan University of Medical SciencesSemnanIran medical Biology research center Kermanshah University of Medical SciencesKermanshahIran Guilan Road Trauma research center Guilan University of Medical SciencesRashtIran

Infertility is experienced by 8%–12%of adults in their reproductive period globally and has become a prevalent concern.Besides routine therapeutic methods,stem cells are rapidly being examined as viable alternative therapies in regenerative medicine and translational investigation.Remarkable progress has been made in understanding the biology and purpose of stem cells.The affected pluripotent stem cells(iPSCs)and mesenchymal stem cells(MSCs)are further studied for their possible use in reproductive medicine,particularly for infertility induced by premature ovarian insufficiency and azoospermia.Accordingly,this study discusses current developments in the use of some kinds of MSCs such as adipose-derived stem cells,bone marrow stromal cells,umbilical cord MSCs,and menstrual blood MSCs.These methods have been used to manage ovarian and uterine disorders,and each technique presents a novel method for the therapy of infertility.

关键词： infertility stem cell therapy mesenchymal stem cells pluripotent stem cells