检索结果-南通市图书馆

Hypidone hydrochloride(YL-0919)ameliorates functional deficits after traumatic brain injury in mice by activating the sigma-1 receptor for antioxidation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2325-2336页

作者： Yafan Bai Hui Ma Yue Zhang Jinfeng Li Xiaojuan Hou Yixin Yang Guyan Wang Yunfeng Li Department of Anesthesiology Beijing Tongren HospitalCapital Medical UniversityBeijingChina Beijing institute of Basic Medical Sciences BeijingChina Hebei North University ZhangjiakouHebei ProvinceChina Beijing institute of Pharmacology and Toxicology State Key Laboratory of Toxicology and Medical CountermeasuresBeijing Key Laboratory of NeuropsychopharmacologyBeijingChina

Traumatic brain injury involves complex pathophysiological mechanisms,among which oxidative stress significantly contributes to the occurrence of secondary *** this study,we evaluated hypidone hydrochloride(YL-0919),a self-developed antidepressant with selective sigma-1 receptor agonist properties,and its associated mechanisms and targets in traumatic brain *** experiments to assess functional deficits were followed by assessment of neuronal damage through histological analyses and examination of blood-brain barrier permeability and brain ***,we investigated the antioxidative effects of YL-0919 by assessing the levels of traditional markers of oxidative stress in vivo in mice and in vitro in HT22 ***,the targeted action of YL-0919 was verified by employing a sigma-1 receptor antagonist(BD-1047).Our findings demonstrated that YL-0919 markedly improved deficits in motor function and spatial cognition on day 3 post traumatic brain injury,while also decreasing neuronal mortality and reversing blood-brain barrier disruption and brain ***,YL-0919 effectively combated oxidative stress both in vivo and in *** protective effects of YL-0919 were partially inhibited by *** results indicated that YL-0919 relieved impairments in motor and spatial cognition by restraining oxidative stress,a neuroprotective effect that was partially reversed by the sigma-1 receptor antagonist ***-0919 may have potential as a new treatment for traumatic brain injury.

关键词： antidepressant drug blood-brain barrier cognitive function hypidone hydrochloride(YL-0919) neurological function nuclear factor-erythroid 2 related factor 2 oxidative stress sigma-1 receptor superoxide dismutase traumatic brain injury

Efficient dispersion modeling in optical multimode fiber

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Light(Science & Applications) 2023年第2期12卷 194-206页

作者： Szu-Yu Lee Vicente J.Parot Brett E.Bouma Martin Villiger Harvard Medical School and massachusetts general hospital Wellman Center for PhotomedicineBostonMA 02114USA Harvard-MIT Health Sciences and technology Massachusetts Institute of TechnologyCambridgeMA 02140USA institute for Biological and Medical Engineering Pontificia Universidad Catolica de ChileSantiago 7820244Chile institute for Medical Engineering and Science Massachusetts Institute of TechnologyCambridgeMA 02140USA

Dispersion remains an enduring challenge for the characterization of wavelength-dependent transmission through optical multimode fiber(MMF).Beyond a small spectral correlation width,a change in wavelength elicits a seemingly independent distribution of the transmitted *** we report on a parametric dispersion model that describes mode mixing in MMF as an exponential map and extends the concept of principal modes to describe the fiber's spectrally resolved transmission matrix(TM).We present computational methods to fit the model to measurements at only a few,judiciously selected,discrete *** validate the model in various MMF and demonstrate an accurate estimation of the full TM across a broad spectral bandwidth,approaching the bandwidth of the best-performing principal modes,and exceeding the original spectral correlation width by more than two orders of *** model allows us to conveniently study the spectral behavior of principal modes,and obviates the need for dense spectral measurements,enabling highly effcient reconstruction of the multispectral TM of MMF.

关键词： fiber optical dispersion

Enhancing direct-path relative transfer function using deep neural network for robust sound source localization

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CAAI Transactions on Intelligence technology 2022年第3期7卷 446-454页

作者： Bing Yang Runwei Ding Yutong Ban Xiaofei Li Hong Liu Key Laboratory of Machine Perception Shenzhen Graduate SchoolPeking UniversityBeijingChina Westlake University&Westlake institute for Advanced Study HangzhouChina SAIIL Massachusetts General HospitalBostonMassachusettsUSA CSAIL Massachusetts Institute of Technology(MIT)CambridgeMassachusettsUSA

This article proposes a deep neural network(DNN)-based direct-path relative transfer function(DP-RTF)enhancement method for robust direction of arrival(DOA)estimation in noisy and reverberant *** DP-RTF refers to the ratio between the directpath acoustic transfer functions of the two microphone ***,the complex-value DP-RTF is decomposed into the inter-channel intensity difference,and sinusoidal functions of the inter-channel phase difference in the time-frequency ***,the decomposed DP-RTF features from a series of temporal context frames are utilized to train a DNN model,which maps the DP-RTF features contaminated by noise and reverberation to the clean ones,and meanwhile provides a time-frequency(TF)weight to indicate the reliability of the *** DP-RTF enhancement network can help to enhance the DP-RTF against noise and ***,the DOA of a sound source can be estimated by integrating the weighted matching between the enhanced DP-RTF features and the DP-RTF *** results on simulated data show the superiority of the proposed DP-RTF enhancement network for estimating the DOA of the sound source in the environments with various levels of noise and reverberation.

关键词： network sound transfer

Wide-field three-photon excitation in biological samples

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2016年第1期5卷 65-73页

作者： Christopher J Rowlands Demian Park Oliver T Bruns Kiryl D Piatkevich Dai Fukumura Rakesh K Jain Moungi G Bawendi Edward S Boyden Peter TC So Department of Biological Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA Media Lab Massachusetts Institute of TechnologyCambridgeMA 02139USA Department of Chemistry Massachusetts Institute of TechnologyCambridgeMA 02139USA Edwin L.Steele Laboratories Department of Radiation OncologyMassachusetts General Hospital and Harvard Medical SchoolBostonMA 02114USA Department of Brain and Cognitive Sciences McGovern Institute and MIT Center for Neurobiological EngineeringMassachusetts Institute of TechnologyCambridgeMA 02139-4307USA Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA

Three-photon wide-field depth-resolved excitation is used to overcome some of the limitations in conventional point-scanning two-and three-photon *** of chromophores as diverse as channelrhodopsins and quantum dots is shown,and a penetration depth of more than 700μm into fixed scattering brain tissue is achieved,approximately twice as deep as that achieved using two-photon wide-field *** with live animal experiments is confirmed by imaging the cerebral vasculature of an anesthetized mouse;a complete focal stack was obtained without any evidence of *** an additional validation of the utility of wide-field three-photon excitation,functional excitation is demonstrated by performing threephoton optogenetic stimulation of cultured mouse hippocampal neurons expressing a channelrhodopsin;action potentials could reliably be excited without causing photodamage.

关键词： biophotonics multiphoton microscopy optogenetics temporal focusing three-photon

Layer-by-layer functionalized nanotube arrays:A versatile microfluidic platform for biodetection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Microsystems & Nanoengineering 2015年第1期1卷 1-7页

作者： Allison L.Yost Setareh Shahsavari Grinia M.Bradwell Roberta Polak Fabio Fachin Robert E.Cohen Gareth H.McKinley Mehmet Toner Michael F.Rubner Brian L.Wardle Department of Mechanical Engineering Massachusetts Institute of Technology77 Massachusetts AvenueCambridgeMA 02139USA Department of Materials Science and Engineering Massachusetts Institute of Technology77 Massachusetts AvenueCambridgeMA 02139USA Department of Chemical Engineering Massachusetts Institute of Technology77 Massachusetts AvenueCambridgeMA 02139USA Department of Aeronautics and Astronautics Massachusetts Institute of Technology77 Massachusetts AvenueCambridgeMA 02139USA Center for Engineering in Medicine and BioMEMS Resource Center Massachusetts General HospitalHarvard Medical Schooland Shriners Hospital for ChildrenBostonMA 02139USA

We demonstrate the layer-by-layer(LbL)assembly of polyelectrolyte multilayers(PEM)on three-dimensional nanofiber *** porosity(99%)aligned carbon nanotube(CNT)arrays are photolithographically patterned into elements that act as textured scaffolds for the creation of functionally coated(nano)porous ***-scale bilayers of poly(allylamine hydrochloride)/poly(styrene sulfonate)(PAH/SPS)are formed conformally on the individual nanotubes by repeated deposition from aqueous solution in microfluidic *** and experimental results show that the LbL deposition is dominated by the diffusive transport of the polymeric constituents,and we use this understanding to demonstrate spatial tailoring on the patterned nanoporous elements.A proof-of-principle application,microfluidic bioparticle capture using N-hydroxysuccinimide-biotin binding for the isolation of prostate-specific antigen(PSA),is demonstrated.

关键词： layer-by-layer carbon nanotube microfluidic nanoporous functionalization bioparticle capture

redPATH:Reconstructing the Pseudo Development Time of Cell Lineages in Single-cell RNA-seq Data and Applications in Cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2021年第2期19卷 292-305页

作者： Kaikun Xie Zehua Liu Ning Chen Ting Chen institute for Artificial Intelligence State Key Lab of Intelligent Technology and SystemsDepartment of Computer Science and TechnologyTsinghua UniversityBeijing 100084China Tsinghua-Fuzhou institute of Digital technology Beijing National Research Center for Information Science and TechnologyTsinghua UniversityBeijing 100084China Center for Computational and Integrative Biology Massachusetts General HospitalHarvard Medical SchoolBostonMA 02114USA Department of Molecular Biology Massachusetts General HospitalHarvard Medical SchoolBostonMA 02114USA Broad institute of massachusetts institute of technology and Harvard CambridgeMA 02142USA

The recent advancement of single-cell RNA sequencing(scRNA-seq)technologies facilitates the study of cell lineages in developmental processes and *** this study,we developed a computational method,called redPATH,to reconstruct the pseudo developmental time of cell lineages using a consensus asymmetric Hamiltonian path ***,we developed a novel approach to visualize the trajectory development and implemented visualization methods to provide biological *** validated the performance of redPATH by segmenting different stages of cell development on multiple neural stem cell and cancer datasets,as well as other single-cell transcriptome *** particular,we identified a stem cell-like subpopulation in malignant glioma *** cells express known proliferative markers,such as GFAP,ATP1A2,IGFBPL1,and ALDOC,and remain silenced for quiescent markers such as ***,we identified MCL1 as a significant gene that regulates cell apoptosis and CSF1R for reprogramming macrophages to control tumor *** conclusion,redPATH is a comprehensive tool for analyzing scRNA-seq datasets along the pseudo developmental *** is available at https://***/tinglabs/redPATH.

关键词： Single-cell pseudotime reconstruction Consensus Hamiltonian path Cell differentiation Cell proliferation Cell development and diseases

Maternal helminth infection protects offspring from high-fat-diet-induced obesity through altered microbiota and SCFAs

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2023年第4期20卷 389-403页

作者： Chien-Wen Su Chih-Yu Chen Tangyou Mao Ning Chen Nicholas Steudel Lefei Jiao Jinggang Lan Alessio Fasano WAllan Walker Hai Ning Shi Mucosal Immunology and Biology Research Center Massachusetts General Hospital and Harvard Medical SchoolCharlestownMAUSA Laboratory for Lipid Medicine and technology Department of MedicineMassachusetts General Hospital and Harvard Medical SchoolCharlestownMAUSA Department of Gastroenterology Dongfang HospitalBeijing University of Chinese MedicineBeijingChina Shenzhen institute for Drug Control ShenzhenChina.

Helminth-induced Th2 immunity and gut microbiota have been recently shown to be highly effective in modulating metabolic syndromes in animal *** study aimed to determine whether maternal immunity and microbial factors affect the induction and development of obesity in ***,Heligomosomoides polygyrus(Hp)-infected or control female C57BL/6J mice mated with normal males and their offspring were fed a high-fat diet(HFD)for 9 weeks after *** results showed that Hp-induced maternal outcomes during gestation and lactation significantly impacted offspring metabolic *** was evidenced by results showing that offspring from helminth-infected mothers on an HFD(Hp-offspring+HFD)gained significantly less body weight than those from uninfected mothers(Cont-offspring+HFD).Hp-offspring+HFD exhibited no Th2 phenotype but displayed a pattern of gut microbiota composition similar to that of Hp-infected ***-fostering experiments confirmed that the helminth-induced maternal attenuation of offspring obesity was mediated through both prenatal and postnatal *** results further showed that helminth-infected dams and their offspring had a markedly altered gut microbiome composition,with increased production of short-chain fatty acids(SCFAs).Intriguingly,Hp-infected mothers and Hp-offspring+HFD showed increased SCFA receptor(GPR)expression in adipose and colonic tissues compared to noninfected mothers and Cont-offspring+HFD,***,SCFA supplementation to the pups of uninfected control mothers during lactation protected against HFD-induced weight gain,which corresponded with changes in gut bacterial ***,our findings provide new insights into the complex interaction of maternal immune status and gut microbiome,Hp infection,and the immunity and gut microbiome in obese-prone offspring in infant life.

关键词： Helminth Maternal Th2 immunity Microbiota Offspring Obesity SCFAs

High-resolution microendoscopy for esophageal cancer screening in China: A cost-effectiveness analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第18期21卷 5513-5523页

作者： Chin Hur Sung Eun Choi Chung Yin Kong Gui-Qi Wang Hong Xu Alexandros D Polydorides Li-Yan Xue Katherine E Perzan Angela C Tramontano Rebecca R Richards-Kortum Sharmila Anandasabapathy institute for technology assessment Massachusetts General Hospital Harvard Medical School Boston MA 02114 United States Gastrointestinal Unit Massa- chusetts General Hospital Department of Endoscopy Cancer Institute and Hospital Chinese Academy of Medical Sciences Department of Endoscopy The First Hospital of Jilin University Department of Pathology The Mount Sinai Medical Center Icahn School of Medicine Department of Pathology Cancer Institute and Hospital Chinese Academy of Medical Sciences Department of Bioengineering Rice University Baylor Global Initiatives and the Baylor Global Innovation Center Baylor College of Medicine

AIM:To study the cost-effectiveness of high-resolution microendoscopy(HRME)in an esophageal squamous cell carcinoma(ESCC)screening program in ***:A decision analytic Markov model of ESCC was *** model analyses were conducted for cohorts consisting of an averagerisk population or a high-risk population in *** 50-year-old individuals were followed until age 80 or *** compared three different strategies for both cohorts:(1)no screening;(2)standard endoscopic screening with Lugol’s iodine staining;and(3)endoscopic screening with Lugol’s iodine staining and an *** parameters were estimated from the literature as well as from GLOBOCAN,the Cancer Incidence and Mortality Worldwide cancer *** states in the model included non-neoplasia,mild dysplasia,moderate dysplasia,high-grade dysplasia,intramucosal carcinoma,operable cancer,inoperable cancer,and *** ESCC incidence transition rates were generated for the average-risk and high-risk *** in Chinese currency were converted to international dollars(I$)and were adjusted to 2012dollars using the Consumer Price ***:The main outcome measurements for this study were quality-adjusted life years(QALYs)and incremental cost-effectiveness ratio(ICER).For the average-risk population,the HRME screening strategy produced 0.043 more QALYs than the no screening strategy at an additional cost of I$646,resulting in an ICER of I$11808 per QALY *** endoscopic screening was weakly *** the high-risk population,when the HRME screening strategy was compared with the standard screening strategy,the ICER was I$8173 per *** both the high-risk and average-risk screening populations,the HRME screening strategy appeared to be the most cost-effective strategy,producing ICERs below the willingness-topay threshold,I$23500 per ***-way sensitivity analysis showed that,for the average-risk population,higher specificity of Lugol’s i

关键词： Cost-effectiveness analysis Diagnostic imaging Endoscopy Esophageal squamous cell cancer Simulation disease model

乳腺癌局部肿瘤分期:数字乳腺摄影与数字乳腺摄影加断层成像组合的对比

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

国际医学放射学杂志 2019年第4期 485-486页

作者：陈萍 M.Bahl N.Pinnamaneni S.Mercaldo A.M.McCarthy C.D.Lehman Department of Radiology institute for technology assessment and Department of Medicine Massachusetts General Hospital

摘要与仅用数字乳腺摄影相比,数字乳腺摄影(DM)和数字乳腺断层成像(DBT)的结合(DM+DBT)提高了癌症检出率。然而,关于DBT作为已知乳腺癌分期中数字乳腺摄影辅

关键词：数字乳腺摄影乳腺癌肿瘤分期断层成像