Layer-by-layer functionalized nanotube arrays:A versatile microfluidic platform for biodetection

作     者：Allison L.Yost Setareh Shahsavari Grinia M.Bradwell Roberta Polak Fabio Fachin Robert E.Cohen Gareth H.McKinley Mehmet Toner Michael F.Rubner Brian L.Wardle 

作者机构：Department of Mechanical EngineeringMassachusetts Institute of Technology77 Massachusetts AvenueCambridgeMA 02139USA Department of Materials Science and EngineeringMassachusetts Institute of Technology77 Massachusetts AvenueCambridgeMA 02139USA Department of Chemical EngineeringMassachusetts Institute of Technology77 Massachusetts AvenueCambridgeMA 02139USA Department of Aeronautics and AstronauticsMassachusetts Institute of Technology77 Massachusetts AvenueCambridgeMA 02139USA Center for Engineering in Medicine and BioMEMS Resource CenterMassachusetts General HospitalHarvard Medical Schooland Shriners Hospital for ChildrenBostonMA 02139USA 

出 版 物：《Microsystems & Nanoengineering》 (微系统与纳米工程（英文）)

年 卷 期：2015年第1卷第1期

页      面：1-7页

核心收录：

学科分类：08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：This work was supported by the MRSEC Program of the National Science Foundation under award number DMR-0819762 

主　　题：layer-by-layer carbon nanotube microfluidic nanoporous functionalization bioparticle capture 

摘      要：We demonstrate the layer-by-layer(LbL)assembly of polyelectrolyte multilayers(PEM)on three-dimensional nanofiber *** porosity(99%)aligned carbon nanotube(CNT)arrays are photolithographically patterned into elements that act as textured scaffolds for the creation of functionally coated(nano)porous ***-scale bilayers of poly(allylamine hydrochloride)/poly(styrene sulfonate)(PAH/SPS)are formed conformally on the individual nanotubes by repeated deposition from aqueous solution in microfluidic *** and experimental results show that the LbL deposition is dominated by the diffusive transport of the polymeric constituents,and we use this understanding to demonstrate spatial tailoring on the patterned nanoporous elements.A proof-of-principle application,microfluidic bioparticle capture using N-hydroxysuccinimide-biotin binding for the isolation of prostate-specific antigen(PSA),is demonstrated.