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Exploration for the Priority of HIV Intervention:Modelling Health Impact and Cost-Effectiveness—Six Cities,Eastern China,2019-2028

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China CDC weekly 2024年第20期6卷 463-468,I0008-I0014页

作者： Youran Zhang Lili Wang Zhen Jiang Hongjing Yan Xiaoxia Liu Jing Gu Guoyong Wang Xiaosong Cheng Qiyan Leng Qisui Long Zimian Liang Jing Wang Liang Liang Yanchao Qiu Lin Chen Hang Hong School of Health Service Management Anhui Medical UniversityHefei CityAnhui ProvinceChina Division of Prevention and intervention National Center for AIDS and STD Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Jiangsu Provincial center for Disease control and Prevention Nanjing CityJiangsu ProvinceChina Zhenjiang center for Disease control and Prevention Zhenjiang CityJiangsu ProvinceChina Wuxi center for Disease control and Prevention Wuxi CityJiangsu ProvinceChina Shandong Provincial center for Disease control and Prevention Jinan CityShandong ProvinceChina Yantai center for Disease control and Prevention Yantai CityShandong ProvinceChina Guangdong Provincial center for Disease control and Prevention Guangzhou CityGuangdong ProvinceChina Foshan center for Disease control and Prevention Foshan CityGuangdong ProvinceChina Hebei Provincial center for Disease control and Prevention Shijiazhuang CityHebei ProvinceChina Shijiazhuang center for Disease control and Prevention Shijiazhuang CityChina Zhejiang Provincial center for Disease control and Prevention Hangzhou CityZhejiang ProvinceChina Ningbo center for Disease control and Prevention Ningbo CityZhejiang ProvinceChina

Introduction:In order to enhance the effectiveness of resource allocation,regions must tailor their responses to their specific epidemiological and economic ***:Utilizing Spectrum software,we projected the cost-effectiveness of 10 chosen HIV interventions in six cities in eastern China from 2019 to *** assessed three scenarios—Base,Achievable,and Idealized—for each *** analysis included the projected number of HIV infections and deaths averted,as well as the incremental costeffectiveness ratios for each intervention in the six ***:In Shijiazhuang,Wuxi,Yantai,and Zhenjiang,cities with initially low antiretroviral therapy(ART)coverage,ART showed significant effectiveness,especially for ***,in Foshan and Ningbo,where ART coverage was notably high,oral pre-exposure prophylaxis(PrEP)for men who have sex with men(MSM)proved effective in the Idealized *** outreach,ART for males,and ART for females demonstrated cost-effectiveness across all six cities in both Achievable and Idealized scenarios at the predefined thresholds for each ***:Maintaining an appropriate coverage rate for outreach to MSM can lead to *** cities with low ART coverage,scaling up ART remains a crucial *** regions with high ART coverage,consideration may be given to the utilization of oral PrEP for MSM individuals,requiring budget allocation.

关键词： Eastern Ningbo Impact

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Coverage of the Combined DTaP-IPV/Hib Vaccine Among Children Aged 2-18 Months—9 PLADs,China,2019-2021

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China CDC weekly 2024年第19期6卷 418-423,I0001页

作者： Li Li Hui Liang Yifan Song Zhaonan Zhang Jing An Ning Li Huifeng Sun Ying Bao Leijin Mao Lin Ding Jie Yan Zhiguo Wang Lei Cao Jiakai Ye Wenzhou Yu National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases BeijingChina National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina Zhejiang center for Disease control and Prevention Hangzhou CityZhejiang ProvinceChina Gansu center for Disease control and Prevention Lanzhou CityGansu ProvinceChina Hubei center for Disease control and Prevention Wuhan CityHubei ProvinceChina Shandong center for Disease control and Prevention Jinan CityShandong ProvinceChina Sichuan center for Disease control and Prevention Chengdu CitySichuan ProvinceChina Anhui center for Disease control and Prevention Hefei CityAnhui ProvinceChina Guizhou center for Disease control and Prevention Guiyang CityGuizhou ProvinceChina Hunan center for Disease control and Prevention Changsha CityHunan ProvinceChina Jiangsu center for Disease control and Prevention Nanjing CityJiangsu ProvinceChina

Summary What is already known on this topic?In China,there is limited data available on the use and coverage of the non-program,combined diphtheria,tetanus toxoid,acellular pertussis adsorbed,inactivated poliovirus and haemophilus influenzae type b(DTaPIPV/Hib)pentavalent vaccine,and its role as a substitute for the separately administered standalone program vaccines.

关键词： vaccine Hib DTaP

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Comparative Study on the Immunogenicity and Efficacy of Different Post-exposure Intramuscular Rabies Vaccination Regimens in China

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Biomedical and Environmental Sciences 2024年第2期37卷 178-186页

作者： SONG Yun HE Ying LU Xue Xin ZHANG Xiao Mei JIANG XIAO Lin SONG Qing HUANG Xue Yong MA Hong Xia YU Peng Cheng ZHU Wu Yang Henan Provincial center for Disease control and Prevention Infectious Disease Prevention and Control InstituteHenan Provincial Key Laboratory of Infectious Disease PathogensZhengzhou 450000HenanChina National Institute for Viral Disease control and Prevention China CDCKey Laboratory of BiosafetyNational Health CommissionBeijing 102206China Shandong Provincial center for Disease control and Prevention Jinan 250014ShandongChina Qingdao Chengyang District center for Disease control and Prevention Qingdao 266108ShandongChina

Objective This study aimed to compare the current Essen rabies post-exposure immunization schedule(0-3-7-14-28)in China and the simple 4-dose schedule(0-3-7-14)newly recommended by the World Health Organization in terms of their safety,efficacy,and *** Mice were vaccinated according to different immunization schedules,and blood was collected for detection of rabies virus neutralizing antibodies(RVNAs)on days 14,21,28,35,and 120after the first ***,different groups of mice were injected with lethal doses of the CVS-11 virus on day 0,subjected to different rabies immunization schedules,and assessed for morbidity and death *** a clinical trial,185 rabies-exposed individuals were selected for post-exposure vaccination according to the Essen schedule,and blood was collected for RVNAs detection on days 28and 42 after the first *** A statistically significant difference in RVNAs between mice in the Essen and 0-3-7-14 schedule groups was observed on the 35th day(P0.05)in RVNAs levels at any time *** post-exposure immune protective test showed that the survival rate of mice in the control group was 20%,whereas that in the immunization groups was 40%.In the clinical trial,the RVNAs positive conversion rates on days 28(14 days after 4 doses)and 42(14 days after 5 doses)were both 100%,and no significant difference in RVNAs levels was observed(P>0.05).Conclusion The simple 4-dose schedule can produce sufficient RVNAs levels,with no significant effect of a delayed fourth vaccine dose(14–28 d)on the immunization potential.

关键词： Rabies Post-exposure immunization Essen regimen RVNAs

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Analysis of Epidemiological and Issues Encountered in Case Reports on Echinococcosis—China,2022

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China CDC weekly 2024年第6期6卷 100-104页

作者： Yan Kui Shuai Han Xiaojuan Zhang Guangzhong Shi Yale Yu Ruirui Li Peizheng Zhan Hongju Duan Wenbo Luo Benfu Li Shaoqi Ning Yalan Zhang Aiya Zhu Jingbo Xue National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)National Health Commission Key Laboratory of Parasite and Vector BiologyWorld Health Organization Collaborating Center for Tropical DiseasesNational Center for International Research on Tropical DiseasesShanghaiChina Gansu Provincial center for Disease control and Prevention Lanzhou CityGansu ProvinceChina The center for Disease control and Prevention of Xinjiang Uygur Autonomous Region Urumuqi CityXinjiang Uygur Autonomous RegionChina Xinjiang Production and Construction Corps center for Disease control and Prevention Urumuqi CityXinjiang Uygur Autonomous RegionChina Sichuan Provincial center for Disease control and Prevention Chengdu CitySichuan ProvinceChina Qinhai Institute for Endemic Disease control and Prevention Xining CityQinghai ProvinceChina Ningxia center for Disease control and Prevention Yinchuan CityNingxia Hui Autonomous RegionChina Inner Mongolia Autonomous Region center for Comprehensive Disease control and Prevention Hohhot CityInner Mongolia AutonomousChina Yunnan Institute of Parasitic Diseases Puer CityYunnan ProvinceChina Shaanxi Provincial center for Disease control and Prevention Xi'an CityShaanxi ProvinceChina Henan Provincial center for Disease control and Prevention Zhengzhou CityHenan ProvinceChina Guizhou Provincial center for Disease control and Prevention Guiyang CityGuizhou ProvinceChina

Summary What is already known about this topic?Echinococcosis is classified as a Class C infectious disease in *** is endemic in 370 counties located in the agricultural and pastoral regions of western *** is added by this report?This report provides a comprehensive overview of the cases of echinococcosis reported in China in *** a thorough evaluation conducted by provincial CDCs.

关键词： China Ech counties

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Development of a High-throughput Sequencing Platform for Detection of Viral Encephalitis Pathogens Based on Amplicon Sequencing

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Biomedical and Environmental Sciences 2024年第3期37卷 294-302页

作者： ZHANG Ya Li SU Wen Zhe WANG Rui Chen LI Yan ZHANG Jun Feng LIU Sheng Hui HU Dan He XU Chong Xiao YIN Jia Yu YIN Qi Kai HE Ying LI Fan FU Shi Hong NIE Kai LIANG Guo Dong TAO Yong XU Song Tao MA Chao Feng WANG Huan Yu Shaanxi University of Chinese Medicine Xianyang 712000ShaanxiChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Guangzhou center for Disease control and Prevention Guangzhou 510000GuangdongChina Shandong center for Disease control and Prevention Jinan 250000ShandongChina Department of Ophthalmology Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Xi'an center for Disease control and Prevention Xi’an 710054ShaanxiChina

Objective Viral encephalitis is an infectious disease severely affecting human *** is caused by a wide variety of viral pathogens,including herpes viruses,flaviviruses,enteroviruses,and other *** laboratory diagnosis of viral encephalitis is a worldwide ***,high-throughput sequencing technology has provided new tools for diagnosing central nervous system ***,In this study,we established a multipathogen detection platform for viral encephalitis based on amplicon *** We designed nine pairs of specific polymerase chain reaction(PCR)primers for the 12 viruses by reviewing the relevant *** detection ability of the primers was verified by software simulation and the detection of known positive *** sequencing was used to validate the samples,and consistency was compared with Sanger *** The results showed that the target sequences of various pathogens were obtained at a coverage depth level greater than 20×,and the sequence lengths were consistent with the sizes of the predicted *** sequences were verified using the National center for Biotechnology Information BLAST,and all results were consistent with the results of Sanger *** Amplicon-based high-throughput sequencing technology is feasible as a supplementary method for the pathogenic detection of viral *** is also a useful tool for the high-volume screening of clinical samples.

关键词： Viral encephalitis Amplicon sequencing High-throughput sequencing Multipathogen detection

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Understanding the Novel Approach of Nanoferroptosis for Cancer Therapy

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Nano-Micro Letters 2024年第9期16卷 501-556页

作者： Afsana Sheikh Prashant Kesharwani Waleed H.Almalki Salem Salman Almujri Linxin Dai Zhe‑Sheng Chen Amirhossein Sahebkar Fei Gao Department of Pharmaceutics School of Pharmaceutical Education and ResearchJamia HamdardNew Delhi 110062India Department of Pharmacology and Toxicology Faculty of PharmacyUmm Al-Qura UniversityMakkahSaudi Arabia Department of Pharmacology College of PharmacyKing Khalid University61421 Asir‑AbhaSaudi Arabia State Key Laboratory of Southwestern Chinese Medicine Resources Pharmacy SchoolChengdu University of Traditional Chinese MedicineChengdu 611130People’s Republic of China Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John’s UniversityNew York 11439USA Biotechnology Research center Pharmaceutical Technology InstituteMashhad University of Medical SciencesMashhadIran Applied Biomedical Research center Mashhad University of Medical SciencesMashhadIran

As a new form of regulated cell death,ferroptosis has unraveled the unsolicited theory of intrinsic apoptosis resistance by cancer *** molecular mechanism of ferroptosis depends on the induction of oxidative stress through excessive reactive oxygen species accumulation and glutathione depletion to damage the structural integrity of *** to their high loading and structural tunability,nanocarriers can escort the delivery of ferro-therapeutics to the desired site through enhanced permeation or retention effect or by active *** review shed light on the necessity of iron in cancer cell growth and the fascinating features of ferroptosis in regulating the cell cycle and ***,we discussed the effect of ferroptosis-mediated therapy using nanoplatforms and their chemical basis in overcoming the barriers to cancer therapy.

关键词： Ferroptosis Nanoparticles Ferrotherapy Cancer Genes Nanotechnology Toxicity Reactive oxygen species

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Neglected Time Intervals Before “1-3-7” Approach About Imported Malaria Cases-China, 2014–2021

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China CDC weekly 2024年第17期6卷 363-367页

作者： Zhiquan He Yuanjing Kou Dan Wang Ying Liu Xiaofeng Lyu Hui Yan Wen Lin Xuan Zhang Duoquan Wang Shizhu Li Hongwei Zhang Henan Provincial center for Disease control and Prevention Zhengzhou CityHenan ProvinceChina Anhui Provincial center for Disease control and Prevention Hefei CityAnhui ProvinceChina Guangxi Zhuang autonomous Region center for Disease control and Prevention Nanning CityGuangxi Zhuang Autonomous RegionChina Hubei Provincial center for Disease control and Prevention Wuhan CityHubei ProvinceChina Zhejiang Provincial center for Disease control and Prevention Hangzhou CityZhejiang ProvinceChina National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)National Health Commission Key Laboratory of Parasite and Vector BiologyShanghaiChina School of Global Health Chinese Center for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghaiChina

Summary What is already known about this topic?China’s“1-3-7”approach outlines specific targets to guide and monitor the processes of case reporting,investigation,and ***,few studies have examined the time intervals preceding the initial step,and the timeline from the arrival of imported malaria cases in China to their diagnosis has been largely *** is added by this report?The study demonstrated that the median duration from arrival in China to the onset of symptoms for *** was 78 days,with 71.59%of imported cases manifesting symptoms after more than one *** ***,the median interval was 42 days,with 55.91%exceeding one ***,the median time from symptom onset to malaria treatment in China between 2014 and 2021 was 2 days,with an interquartile range(IQR)of 1-4 *** are the implications for public health practice?This study represents the initial effort to delineate the chronology of imported malaria cases,from their arrival in China to their subsequent *** results underscore the importance of providing malaria health education to populations arriving from ***,enhancing physician training is crucial for improving the diagnosis of malaria.

关键词： diagnosis Malaria exceeding

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The COVID-19 Vaccines Evaluation Program:Implementation,Management,and Experiences,2021-2023

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China CDC weekly 2024年第26期6卷 642-648页

作者： Tingting Yan Hui Zheng Mingshuang Li Chao Ma Xuanyi Wang Xiaoqi Wang Zhenjun Li Yuansheng Chen Wenshang Hu Lance Rodewald Zhijie An Zundong Yin Zijian Feng National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases(NITFID).National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina Institutes of Biomedical Sciences Fudan UniversityShanghaiChina Office of International Cooperation Chinese Center for Disease Control and PreventionBeijingChina Office of Science and Technology Chinese Center for Disease Control and PreventionBeijingChina Office of Finance Chinese Center for Disease Control and PreventionBeijingChina Chinese Preventive Medicine Association BeijingChina

In 2021,China’s domestically produced coronavirus disease 2019(COVID-19)vaccines received approval from regulatory bodies and were administered *** to a low number of infections within China during that period,it became imperative to evaluate the vaccines’real-world effectiveness through international *** facilitate this,China CDC launched the COVID-19 Vaccines Evaluation Program(COVEP).This program formed research collaboration agreements with health institutes across five World Health Organization regions,addressing key questions about vaccine performance through ten cooperative *** findings from COVEP projects reinforced confidence,both domestically and globally,in the effectiveness of the vaccines produced in ***,the outcomes observed internationally were frequently mirrored by later studies conducted within *** thus pioneered a novel approach for fostering cross-national research collaborations,addressing significant public health issues and exemplifying a framework for international *** approach is in line with the strategic objectives and other development efforts of China CDC’s national disease control and prevention initiatives.

关键词： approval COV prevention

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Characterization of whole genomes from recently emerging Mpox cases in several regions of China,2023

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Science China(Life Sciences) 2024年第5期67卷 1079-1081页

作者： Changcheng Wu Lunbiao Cui Yang Pan Ziquan Lv Mingxiao Yao Wenling Wang Fei Ye Weibang Huo Li Zhao Baoying Huang Fengcai Zhu Roujian Lu Yao Deng Quanyi Wang Wenjie Tan NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China NHC Key Laboratory of Enteric Pathogenic Microbiology Jiangsu Provincial Medical Key Laboratory of Pathogenic Microbiology in Emerging Major Infectious DiseasesJiangsu Provincial Center for Disease Control and PreventionNanjing 210009China Beijing center for Disease Prevention and control Beijing 100013China Central Laboratory Shenzhen Center for Disease Control and PreventionShenzhen 518055China Shandong center for Disease control and Prevention Jinan 250014China

Dear Editor,Mpox(formerly known as monkeypox)is a zoonotic disease caused by infection with the monkeypox virus(MPXV).Mpox cases have been sporadic over the past few decades,with outbreaks occurring in only a limited ... 详细信息

关键词： cases primarily imported

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Community Incidence Estimates of Five Pathogens Based on Foodborne Diseases Active Surveillance—China,2023

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China CDC weekly 2024年第24期6卷 574-579,I0002页

作者： Penghui Fan Haihong Han Jikai Liu Xiaochen Ma Ronghua Zhang Hong Liu Yijing Zhou Zunhua Chu Jian Wen Li Lin Weiwei Li Yunchang Guo NHC Key Laboratory of Food Safety Risk Assessment China National Center for Food Safety Risk AssessmentBeijingChina Beijing center for Disease Prevention and control BeijingChina Zhejiang Provincial center for Disease control and Prevention Hangzhou CityZhejiang ProvinceChina Shanghai center for Disease control and Prevention ShanghaiChina Jiangsu Provincial center for Disease control and Prevention Nanjing CityJiangsu ProvinceChina Shandong Province center for Disease control and Prevention Jinan CityShandong ProvinceChina Guangdong Province center for Disease control and Prevention Guangzhou CityGuangdong ProvinceChina Sichuan Province center for Disease control and Prevention Chengdu CitySichuan ProvinceChina

Summary What is already known about this topic?Foodborne diseases,representing significant food safety and public health challenges globally,are not welldocumented in terms of incidence,particularly for cases characterized by acute gastroenteritis(AGI)in *** is added by this report?This study developed a pyramid model to estimate the incidence of five pathogens,stratified by gender and age.

关键词： acute diseases stratified

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