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THE ROLE OF PRESS FABRIC PRESSURE UNIFORMITY AND PORE SIZE ON DEWATERING AND REWET DURING PRESSING

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天津科技大学学报 2004年第S2期 327-327页

作者： Mary Toney,Jorgen Gullbrand,Fawaad Qamar Albany International Research Co. 777 West Street mansfield MA 02048 USA Albany International AB S-30 80 Halmstad Sweden Albany International Research Co. 777 West Street mansfield MA 02048 USA

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Interactions of complement proteins C1q and factor H with lipid A and Escherichia coli:further evidence that factor H regulates the classical complement pathway

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Protein & Cell 2011年第4期2卷 320-332页

作者： Lee Aun Tan Andrew C.Yang Uday Kishore Robert B.Sim Medical Research Council Immunochemistry Unit Department of BiochemistryUniversity of OxfordSouth Parks RoadOxford OX13QUUK Present address:Department of Immunology Faculty of MedicineImperial College LondonHammersmith HospitalDu Cane RoadLondon W120NNUK St Peter’s College New Inn Hall St.Oxford OX12DLUK Present address:SUNY Downstate College of Medicine 450 Clarkson Avenue BrooklynNY 11203USA Weatherall Institute of Molecular Medicine John Radcliffe HospitalUniversity of OxfordHeadingtonOxford OX39DSUK Present address:Center for Infection Immunity and Disease MechanismsBiosciencesSchool of Health Sciences and Social CareBrunel UniversityUxbridge UB83PH West LondonUK Present address:Department of Pharmacology University of OxfordMansfield RoadOxford OX13QTUK

Proteins of the complement system are known to interact with many charged *** recently characterized binding of C1q and factor H to immobilized and liposomal anionic *** H inhibited C1q binding to anionic phospholipids,suggesting a role for factor H in regulating activation of the complement classical pathway by anionic *** extend this finding,we examined interactions of C1q and factor H with lipid A,a well-characterized activator of the classical *** report that C1q and factor H both bind to immobilized lipid A,lipid A liposomes and intact Escherichia coli *** H competes with C1q for binding to these ***,increasing the factor H:C1q molar ratio in serum diminished C4b fixation,indicating that factor H diminishes classical pathway *** recombinant forms of the Cterminal,globular heads of C1q A,B and C chains bound to lipid A and *** in a manner qualitatively similar to native C1q,confirming that C1q interacts with these targets via its globular head *** observations reinforce our proposal that factor H has an additional complement regulatory role of down-regulating classical pathway activation in response to certain *** is distinct from its role as an alternative pathway *** suggest that under physiological conditions,factor H may serve as a downregulator of bacterially-driven inflammatory responses,thereby finetuning and balancing the inflammatory response in infections with Gram-negative bacteria.

关键词： complement lipid A bacteria factor H C1q

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Digital staining in optical microscopy using deep learning-a review

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PhotoniX 2023年第1期4卷 64-95页

作者： Lucas Kreiss Shaowei Jiang Xiang Li Shiqi Xu Kevin C.Zhou Kyung Chul Lee Alexander Mühlberg Kanghyun Kim Amey Chaware Michael Ando Laura Barisoni Seung Ah Lee Guoan Zheng Kyle J.Lafata Oliver Friedrich Roarke Horstmeyer Department of Biomedical Engineering Duke UniversityDurhamNC 27708USA Institute of Medical Biotechnology Friedrich-Alexander University(FAU)ErlangenGermany Department of Biomedical Engineering University of ConnecticutMansfieldConnecticutUSA Department of Radiation Physics Duke UniversityDurhamNC 27708USA Department of Electrical Engineering&Computer Sciences University of CaliforniaBerkeleyCAUSA School of Electrical&Electronic Engineering Yonsei UniversitySeoul 03722Republic of Korea Google Inc.Mountain ViewCA 94043USA Department of Pathology Duke UniversityDurhamNC 27708USA

Until recently,conventional biochemical staining had the undisputed status as well-established benchmark for most biomedical problems related to clinical diagnostics,fundamental research and *** this role as gold-standard,staining protocols face several challenges,such as a need for extensive,manual processing of samples,substantial time delays,altered tissue homeostasis,limited choice of contrast agents,2D imaging instead of 3D tomography and many ***-free optical technologies,on the other hand,do not rely on exogenous and artificial markers,by exploiting intrinsic optical contrast mechanisms,where the specificity is typically less obvious to the human *** the past few years,digital staining has emerged as a promising concept to use modern deep learning for the translation from optical contrast to established biochemical contrast of actual *** this review article,we provide an in-depth analysis of the current state-of-the-art in this field,suggest methods of good practice,identify pitfalls and challenges and postulate promising advances towards potential future implementations and applications.

关键词： Deep learning Digital staining Optical microscopy Virtual staining In-silica Pseudo-H&E Virtual fluorescence Generative models Image translation

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毛竹小RNA高通量测序及病毒分析

林业科学研究 2014年第3期27卷 335-340页

作者：范春节王晖卢孟柱中国林业科学研究院林业研究所林木遗传育种国家重点实验室北京100091 中国林业科学研究院热带林业研究所广东广州510520 NERC/Centre for Ecology and Hydrology(CEH)Oxford Mansfield RoadOxford OX1 3SRUK

以毛竹叶片为材料,采用小RNA高通量测序结合生物信息学对小RNA数据库进行组装,进一步分析了毛竹中存在的病毒和类病毒,并采用RT-PCR和RACE进行验证。结果表明:在竹子样品中存在水稻东格鲁病毒(RTBV),覆盖率达到91.0%。在毛竹样品中扩增... 详细信息

以毛竹叶片为材料,采用小RNA高通量测序结合生物信息学对小RNA数据库进行组装,进一步分析了毛竹中存在的病毒和类病毒,并采用RT-PCR和RACE进行验证。结果表明:在竹子样品中存在水稻东格鲁病毒(RTBV),覆盖率达到91.0%。在毛竹样品中扩增得到1 992 bp RTBV病毒类似序列,占其基因组的24.9%。RTBV病毒在多个毛竹样品中存在且不存在多态性。RTBV病毒可能是一个古老的植物病毒,在进化过程中禾本科植物将其序列整合到基因组中来防御RTBV病毒的浸染。

关键词：毛竹高通量测序小RNA RTBV病毒

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A Holistic Approach to Enhance FRCS General Surgery Examination Training Using Adult Learning Model: A Non-Profit Initiative

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Surgical Science 2023年第8期14卷 565-574页

作者： Rahul Winayak Sanjay V. Joshi Goran Ahmed Anne O’Neill Ishy Gurung Muhammad Nadeem Muhammed Alwahid Sudeendra Doddi Manas Kumar Dube Ahmad Mirza Rishabha D. Sharma Bristol Medical School University of Bristol Bristol UK Medway Maritime Hospital Gillingham Kent UK Frimley Park Hospital Portsmouth Road Camberley UK University Hospitals Plymouth NHS Trust Plymouth UK Northern Devon Healthcare NHS Trust Barnstaple UK Yeovil District Hospital NHS Foundation Trust Yeovil UK Inverclyde Royal Hospital Greenock Scotland UK Princes Royal University Hospital Orpington UK Sherwood Forest Hospitals NHS Foundation Trust Mansfield UK Augusta University Medical Center Augusta GA USA

Objectives: To evaluate the impact of adult learning and simulation-based learning (SBL) on surgical trainees’ learning experiences and Fellowship of the Royal College of Surgeons (FRCS) Section 2 General Surgery examination pass rate. Methods: This was a cross-sequential study involving 148 surgical candidates (72 UK trainees, 75 non-UK trainees) who had attended our revision course (Phoenix FRCS Course) from June 2017 until 2023. Each course comprised a two-day weekend preparation with dedicated sections for clinical, viva, and academic reading, incorporating SBL as its key learning style. We maintained a prospective database of candidate and course details, examination results, and feedback since the course inception. Results: We found that 97% of candidates passed the FRCS examination after their first attempt. The course was attended once by 89% of candidates, and only 3 of the 148 candidates exhausted all four attempts at the examination. Candidate feedback for the course and its style of learning was positive, with simulation-based table viva sessions and virtual clinical sessions proving the most popular learning sessions (95% and 80% of candidates attending courses run in December 2017, April 2018, and May 2021 rated them “Excellent” respectively). Conclusions: The course is centered around shared adult learning and mindfulness tools to encourage candidates to learn from each other and develop confidence and mastery in all domains of surgical practice. These methods have been shown to be effective in achieving high success rates in the Intercollegiate and International FRCS examinations for UK and overseas surgeons.

关键词： Simulation-Based Learning (SBL) Adult Learning Mindfulness Tools FRCS Examination Interleaving

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扫描电镜图像去噪的研究与实现

光学与光电技术 2014年第5期12卷 77-82页

作者：雷燕燕王睿姚净明蔡剑虹北京航空航天大学仪器科学与光电工程学院精密光机电一体化教育部重点实验室 ODIS Inc.STORRS-mansfield CT 06268 USA

扫描电镜能直观观察样品的表面结构,但其高分辨形貌成像图固有的噪声不利于图像分析。针对集成电路器件扫描电镜成像图的去噪声问题,采用了通过滑动条方式自适应设置图像二值化阈值,将数学形态学处理方法与图像二值化相结合,实现了对图... 详细信息

扫描电镜能直观观察样品的表面结构,但其高分辨形貌成像图固有的噪声不利于图像分析。针对集成电路器件扫描电镜成像图的去噪声问题,采用了通过滑动条方式自适应设置图像二值化阈值,将数学形态学处理方法与图像二值化相结合,实现了对图像噪声的自动去除处理;同时还设计了通过手动勾勒图像中的多边形区域实现去除噪声的功能;为使图像达到更好的效果,系统还可允许针对自动去噪后的图像自行选择是否进行手动去噪,并设计实现了风格直观简洁,易于操作的交互式用户界面。对多幅集成电路器件扫描电镜成像图进行去噪声处理的结果和对去噪前后的图像进行无参考图像质量评价的数据表明,该方法有效地改善了扫描电镜图的信噪比,获得了突出前景等有用信息。

关键词：扫描电镜图图像去噪自适应阈值质量评价

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儿童口腔健康与牙齿保健的差距

美国医学会杂志（中文版） 2002年第3期21卷 153-157页

作者：马骥超 WendyE.Mouradian Departments of Pediatrics Pediatric Dentistry Medical History and Ethics and Health Services University of Washington and Children's Hospital and Regional Medical Center Seattle Center for Health Services Research and Policy George Washington University School of Pubbic Hearth and Health Services Washington DC Department of Pediatric Dentistry University of Connecticut Health Center Storrs-Mansfield

龋齿可以通过联合使用社会、专业和个人的方法加以预防,包括水的氟化,局部使用氟化物和封剂,以及氟化牙膏的使用.然而,牙齿的蛀蚀仍为儿童最为常见的慢性疾患.在美国儿童,牙齿保健最不健全的保健,口腔健康与牙齿保健两者存在巨大差距.... 详细信息

龋齿可以通过联合使用社会、专业和个人的方法加以预防,包括水的氟化,局部使用氟化物和封剂,以及氟化牙膏的使用.然而,牙齿的蛀蚀仍为儿童最为常见的慢性疾患.在美国儿童,牙齿保健最不健全的保健,口腔健康与牙齿保健两者存在巨大差距.享受公共医疗补助(Medicaid)的儿童,5例中仅有1例接受了适宜的预防性口腔保健服务.来自低收入家庭或少数民族家庭的儿童口腔保健结果更差,他们更少到牙科就诊,保护性密封剂的使用亦更少.水的氟化是预防龋齿的最有效的措施,但是仅有62%的供水经过氟化处理,缺氟可以不成比例地影响贫穷和少数民族儿童.

关键词：儿童口腔健康牙齿保健龋齿预防