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Plasma Metabonomics of Human Adenovirus-infected Patients with Pneumonia and Upper Respiratory Tract Infection

Current Medical science 2024年第1期44卷 121-133页

作者： Ting-ting WEI Wen XU Bo TU Wan-xue ZHANG Xin-xin YANG Yiguo ZHOU Shan-shan ZHANG Jun-lian YANG Ming-zhu XIE Juan DU Wei-wei CHEN Qing-bin LU Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Department of Infectious Disease The Fifth Medical Center of Chinese PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijing 100039China Department of Laboratorial science and Technology&Vaccine Research Center School of Public HealthPeking UniversityBeijing 100191China Department of health Policy and management School of Public HealthPeking UniversityBeijing 100191China Global Center for Infectious Disease and Policy Research&Global health and Infectious Diseases Group Peking UniversityBeijing 100191China Key Laboratory of Epidemiology of Major Diseases(Peking University) Ministry of EducationBeijing 100191China

Objective Human adenovirus(HAdV)infection is common and can develop to serious conditions with high mortality,yet the mechanism of HAdV infection remains *** the present study,the serum metabolite profiles of HAdV-7-infected patients with pneumonia or upper respiratory tract infection(URTI)were *** In total,35 patients were enrolled in the study following an outbreak of HAdV-7 in the army,of whom 14 had pneumonia and 21 had *** samples were collected at the acute stage and at the recovery stage and were analyzed by untargeted *** Over 90% of the differential metabolites identified between the pneumonia patients and URTI patients were lipids and lipid-like molecules,including glycerophospholipids,fatty acyls,and *** metabolic pathways that were significantly enriched were primarily the lipid metabolism pathways,including sphingolipid metabolism,glycerophospholipid metabolism,and linoleic acid *** sphingolipid metabolism was identified as a significantly differential pathway between the pneumonia patients and URTI patients and between the acute and recovery stages for the pneumonia patients,but not between the acute and recovery stages for the URTI *** and lactosylceramide,involved in sphingolipid metabolism,were significantly higher in the pneumonia patients than in the URTI patients with good discrimination abilities[area under curve(AUC)0.742 and 0.716,respectively;combination AUC 0.801].Conclusion Our results suggested that HAdV modulated lipid metabolism for both the patients with URTI and pneumonia,especially the sphingolipid metabolism involving ceramide and lactosylceramide,which might thus be a potential intervention target in the treatment of HAdV infection.

关键词： human adenovirus metabonomic lipids pneumonia upper respiratory tract infection

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Can the integration between urban and rural areas be realized?A new theoretical analytical framework

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Journal of Geographical sciences 2024年第1期34卷 3-24页

作者： WANG Yi LU Yuqi ZHU Yingming Research Base of Jiangsu Industrial Cluster School of Economics and ManagementNanjing University of Science and TechnologyNanjing 210094China School of Geography Nanjing Normal UniversityNanjing 210023China

Urban-rural integration is an advanced form resulting from the future evolution of urban-rural ***,little research has explored whether urban and rural areas can move from dual segmentation to integrated development from a theoretical or empirical *** on the research framework of welfare economics,which offers an appealing paradigm to frame the underlying game between cities and villages,this study clarifies the ideal state of urban-rural *** then proposes a series of basic assumptions,and constructs a corresponding objective function and its ***,it assesses the possibility of seeing the transmutation from division to integration between urban and rural areas with continuous socio-economic *** authors argue that the ideal state of urban-rural integration should be a Pareto-driven optimal allocation of urban-rural resources and outputs,and the maximization of social welfare in the entire *** on a systematic demonstration using mathematical models,the study proposes that urban and rural areas can enter this ideal integrated development pattern when certain parameter conditions are *** general,this study demonstrates the theoretical logic and scientific foundations of urban-rural integration,enriches theoretical studies about urban-rural relationships,and provides basic theoretical support for large developing countries to build a coordinated and orderly urban-rural community with a shared future.

关键词： urban-rural integration development ideal state parameter conditions welfare economics theoretical framework

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Digital CEOs in Digital Enterprises:Automating,Augmenting,and Parallel in Metaverse/CPSS/TAOs

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 820-823页

作者： Juanjuan Li Rui Qin Sangtian Guan Xiao Xue Peng Zhu Fei-Yue Wang with State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China the College of Intelligence and Computing Tianjin UniversityTianjin 300072China School of Economics and management Nanjing University of Science and TechnologyNanjing 210094China the State Key Laboratory for management and Control of Complex Systems Chinese Academy of SciencesBeijing 100190 Faculty of Innovation Engineering Macao University of Science and TechnologyMacao 999078China

BIG models or foundation models are rapidly emerging as a key force in advancing intelligent societies[1]–[3]Their significance stems not only from their exceptional ability to process complex data and simulate advan... 详细信息

关键词： exceptional Auto advancing

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Effects of oat β-glucan–based prebiotic blended formulas on defecation and gut microbiota in Chinese adults: a randomized clinical trial

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Food science and Human Wellness 2024年

作者： Aiqi Li Lei Jin Hui Xia Meiyuan Feng Xirui Zhou Yifang Chu Feng Liu Lanxing Jia Ximin Chen Dengfeng Xu Shanjie Ma Xiaofan Xu Xinyu Wang Xiaoqing Li Guiju Sun Liegang Liu Key Laboratory of Environmental Medicine and Engineering of Ministry of Education， and Department of Nutrition and Food Hygiene， School of Public health Southeast University Department of Nutrition and Food Hygiene， Hubei Key Laboratory of Food Nutrition and Safety， School of Public health， Tongji Medical College， Huazhong University of science and Technology Department of R&D Life science，PepsiCo Inc Nutrition and healthy Food Committee of Chinese Nutrition Society health management Branch of Chinese Nutrition Society

Digestive health is important for overall well-being， but gut health problems are common in the Chinese population. The objective of this study was to investigate the effects of oat β-glucan–based prebiotic blended formulas in humans on digestive health by assessing defecation frequen-cy， defecation symptoms， stool quality， self-reported digestive feelings， defecation satisfaction， and gut bacteria. A parallel， randomized， double-blind， controlled trial was conducted in 168 eli-gible adults randomized to three groups for 14 days: Intervention Groups A and B received two different doses of oat β-glucan–based prebiotic blended formulas and a Control Group received oat β-glucan mixed with hydroxypropylmethyl-cellulose and microcrystalline cellulose. Partici-pants completed a defecation diary and Bristol stool chart daily and digestive system question-naires weekly. Fecal samples were collected on Day 0 and Day 14 to evaluate gut bacteria using 16S rDNA analysis. Both formulas improved defecation frequency， stool quality， defecation symptoms， defecation satisfaction， and on digestive health of human， compared with baseline (P health in generally healthy Chinese adults. These formulas are a feasible nutritional strategy for digestive health.

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Progress and Implications from Genetic Studies of Bipolar Disorder

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Neuroscience Bulletin 2024年第8期40卷 1160-1172页

作者： Lingzhuo Kong Yiqing Chen Yuting Shen Danhua Zhang Chen Wei Jianbo Lai Shaohua Hu Department of Psychiatry the First Affiliated HospitalZhejiang University School of MedicineHangzhou310003China The Key Laboratory of Mental Disorder management in Zhejiang Province Hangzhou310003China Brain Research Institute of Zhejiang University Hangzhou310003China Zhejiang Engineering Center for Mathematical Mental health Hangzhou310003China Department of Neurobiology NHC and CAMS Key Laboratory of Medical NeurobiologySchool of Brain Science and Brian Medicineand MOE Frontier Science Center for Brain Science and Brain-machine IntegrationZhejiang University School of MedicineHangzhou310003China

With the advancements in gene sequencing technologies,including genome-wide association studies,polygenetic risk scores,and high-throughput sequencing,there has been a tremendous advantage in mapping a detailed blueprint for the genetic model of bipolar disorder(BD).To date,intriguing genetic clues have been identified to explain the development of BD,as well as the genetic association that might be applied for the development of susceptibility prediction and pharmacogenetic *** genes of BD,such as CACNA1C,ANK3,TRANK1,and CLOCK,have been found to be involved in various pathophysiological processes correlated with *** the specific roles of these genes have yet to be determined,genetic research on BD will help improve the prevention,therapeutics,and prognosis in clinical *** latest preclinical and clinical studies,and reviews of the genetics of BD,are analyzed in this review,aiming to summarize the progress in this intriguing field and to provide perspectives for individualized,precise,and effective clinical practice.

关键词： Bipolar disorder Genetics Risk gene Genome-wide association study Sequencing technology

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Hybrid Optimization Algorithm for Handwritten Document Enhancement

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Computers, Materials & Continua 2024年第3期78卷 3763-3786页

作者： Shu-Chuan Chu Xiaomeng Yang Li Zhang Václav Snášel Jeng-Shyang Pan College of Computer science and Engineering Shandong University of Science and TechnologyQingdao266590China School of Information and Control Engineering Qingdao University of TechnologyQingdao266520China Faculty of Electrical Engineering and Computer science VŠB-TU OstravaOstrava70080Czech Republic Department of Information management Chaoyang University of TechnologyTaichung41349Taiwan

The Gannet Optimization Algorithm (GOA) and the Whale Optimization Algorithm (WOA) demonstrate strong performance;however, there remains room for improvement in convergence and practical applications. This study introduces a hybrid optimization algorithm, named the adaptive inertia weight whale optimization algorithm and gannet optimization algorithm (AIWGOA), which addresses challenges in enhancing handwritten documents. The hybrid strategy integrates the strengths of both algorithms, significantly enhancing their capabilities, whereas the adaptive parameter strategy mitigates the need for manual parameter setting. By amalgamating the hybrid strategy and parameter-adaptive approach, the Gannet Optimization Algorithm was refined to yield the AIWGOA. Through a performance analysis of the CEC2013 benchmark, the AIWGOA demonstrates notable advantages across various metrics. Subsequently, an evaluation index was employed to assess the enhanced handwritten documents and images, affirming the superior practical application of the AIWGOA compared with other algorithms.

关键词： Metaheuristic algorithm gannet optimization algorithm hybrid algorithm handwritten document enhancement

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Multi-Perspective Data Fusion Framework Based on Hierarchical BERT: Provide Visual Predictions of Business Processes

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Computers, Materials & Continua 2024年第1期78卷 1227-1252页

作者： Yongwang Yuan Xiangwei Liu Ke Lu School of Mathematics and Big Data Anhui University of Science and TechnologyHuainan232001China School of Economics and management Anhui University of Science and TechnologyHuainan232001China The Key Laboratory of Embedded System and Service Computing Ministry of Education Tongji UniversityShanghai201804China

Predictive Business Process Monitoring(PBPM)is a significant research area in Business Process management(BPM)aimed at accurately forecasting future behavioral *** present,deep learning methods are widely cited in PBPM research,but no method has been effective in fusing data information into the control flow for multi-perspective process ***,this paper proposes a process prediction method based on the hierarchical BERT and multi-perspective data ***,the first layer BERT network learns the correlations between different category attribute ***,the attribute data is integrated into a weighted event-level feature vector and input into the second layer BERT network to learn the impact and priority relationship of each event on future predicted ***,the multi-head attention mechanism within the framework is visualized for analysis,helping to understand the decision-making logic of the framework and providing visual ***,experimental results show that the predictive accuracy of the framework surpasses the current state-of-the-art research methods and significantly enhances the predictive performance of BPM.

关键词： Business process prediction monitoring deep learning attention mechanism BERT multi-perspective

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Preparation of TiO_(2) Nano-Flower Coating on Ti Substrates with Good Physical Sterilization Effect and Biocompatibility

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Acta Metallurgica Sinica(English Letters) 2024年第9期37卷 1581-1589页

作者： Ruoyu Di Yonghua Sun Runhua Yao Sen Pei Xiaohong Yao Ruiqiang Hang Shanxi Key Laboratory of Biomedical Metal Materials College of Materials Science and EngineeringTaiyuan University of TechnologyTaiyuan030024China College of Safety and Emergency management Engineering Taiyuan University of TechnologyTaiyuan030024China

We report a facile solution method to form titanium oxide(TiO_(2))nano-flower structure on the titanium(Ti)substrates for realizing good physical sterilization and *** first prepare TiO_(2) nanotubes(NT)with a diameter of about 80-100 nm and a length of about 5μm on Ti substrates by anodization,which is utilized as ***,we employ immersion treatment in different concentrations of phosphoric acid solution at 75℃ for 5 h to realize the transformation from TiO_(2) NT to TiO_(2) nano-flower *** addition,we studied the effects of phosphoric acid concentration(1 wt%,2.5 wt%,5 wt% and 10 wt%)on the TiO_(2) nano-flower structure,and the antibacterial properties and biocompatibility of the TiO_(2) nano-flower *** results show that TiO_(2) nano-flower structure become larger and thicker with the increase in the phosphoric acid concentration,and the thickness of the coating can reach 6.88μ***,the TiO_(2) nano-flower structure shows good physical sterilization effect,especially for the TiO_(2) nano-flower structure formed in 10 wt%H^(3)PO_(4) solution,the antibacterial rate can reach 95%.In addition,the TiO_(2) nano-flower structure have no toxicity to the osteoblasts and support cell growth.

关键词： Anodization Biocompatibility Physical sterilization TiO_(2)nano-flower

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The Uptake and Distribution Evidence of Nano-and Microplastics in vivo after a Single High Dose of Oral Exposure

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Biomedical and Environmental sciences 2024年第1期37卷 31-41页

作者： HONG Tao SUN Wei DENG Yuan LYU Jian Da JIN Cui Hong BAI Ying Long NA Jun ZHANG Rui GAO Yuan PAN Guo Wei YANG Zuo Sen YAN Ling Jun Research Center for Universal health School of Public HealthChina Medical UniversityShenyang 110122LiaoningChina Department of Pain management Shengjing Hospital of China Medical UniversityShenyang 110004LiaoningChina Department of Toxicology School of Public HealthChina Medical UniversityShenyang 110122LiaoningChina Department of Maternal and Child health School of Public HealthChina Medical UniversityShenyang 110122LiaoningChina Institute of Preventive Medicine China Medical UniversityShenyang 110122LiaoningChina Institute of Chronic Diseases Liaoning Provincial Center for Disease Control and PreventionShenyang 110000LiaoningChina

Objective Tissue uptake and distribution of nano-/microplastics was studied at a single high dose by gavage in *** Fluorescent microspheres(100 nm,3μm,and 10μm)were given once at a dose of 200 mg/(kg∙body weight).The fluorescence intensity(FI)in observed organs was measured using the IVIS Spectrum at 0.5,1,2,and 4 h after *** was performed to corroborate these *** In the 100 nm group,the FI of the stomach and small intestine were highest at 0.5 h,and the FI of the large intestine,excrement,lung,kidney,liver,and skeletal muscles were highest at 4 h compared with the control group(P<0.05).In the 3μm group,the FI only increased in the lung at 2 h(P<0.05).In the 10μm group,the FI increased in the large intestine and excrement at 2 h,and in the kidney at 4 h(P<0.05).The presence of nano-/microplastics in tissues was further verified by *** peak time of nanoplastic absorption in blood was *** Nanoplastics translocated rapidly to observed organs/tissues through blood circulation;however,only small amounts of MPs could penetrate the organs.

关键词： Microplastics Nanoplastics IVIS Spectrum small-animal imaging system Tissue distribution Blood

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A Two-stage Service-oriented Task Offloading Framework with Edge-cloud Collaboration:A Game Theory Approach

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Journal of Systems science and Systems Engineering 2024年第5期33卷 521-551页

作者： Shiyong Li Wenzhe Li Huan Liu Wei Sun School of Economics and management Yanshan UniversityQinhuangdao 066004

With the fast development of Mobile Internet,data traffic generated by end devices is anticipated to witness substantial growth in the future ***,processing tasks locally will cause latency due to the limited resources of the end ***-cloud collaboration,an effective solution for latency-sensitive applications,is attracting greater attention from both industry and *** combines the advantages of the cloud center with abundant computing resources and edge nodes with low-latency *** this paper,we propose a two-stage task offloading framework with edge-cloud collaboration to assist end devices processing latency-sensitive tasks either on the edge servers or in the cloud *** for homogeneous task offloading,in the first stage,the competitive end devices offload tasks to the edge *** formulate the selfish task offloading problem among end devices as a potential *** the second stage,the edge nodes request resources from the cloud center to process end devices tasks due to their limited ***,we consider the heterogeneous task offloading problem and use intelligent optimization algorithm to obtain the optimal offloading *** results show that the service prices of edge nodes influence the decisions and task offloading costs of end *** also verify the intelligent optimization algorithm can achieve optimal performance with low complexity and fast convergence.

关键词： Edge-cloud collaboration task offloading potential game simulation annealing algorithm

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