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Assessment of the Drafting Quality of Request Forms Submitted to the malaria and Parasitology units at the Institut Pasteur de Cote d’Ivoire

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Journal of Biosciences and Medicines 2024年第5期12卷 330-339页

作者： Yao Serge-Stéphane Ako Ako Bérenger Aristide Sylvain Beourou Ouattara Yacouba N’Guessan Tiacoh Landry N’Dri Kouadio Thierry-Borel Toure André Offianan malaria unit Institut Pasteur de Cote d&#8217Ivoire Abidjan Cote d&#8217Ivoire Parasitology unit Institut Pasteur de Cote d&#8217Ivoire Abidjan Cote d&#8217Ivoire

Biological tests provide information on the medical analysis requested by both the patient and the prescriber. It is a communication link between the prescriber and the laboratory staff. The lack of some information on request forms not only affects the drafting quality of the test and patient care, but could also make thousands of data produced by healthcare centers unusable. The aim of this study was to assess the drafting quality of request forms submitted to the malaria and Parasitology units at the Institut Pasteur de Côte d’Ivoire. Methods: It was a descriptive cross-sectional study to assess the drafting quality of request forms of various prescribers received at the Institut Pasteur de Côte d’Ivoire. This study was conducted at the malaria and Parasitology units, department of Parasitology and Mycology (Institut Pasteur de Côte d’Ivoire), from 6th December 2020 to 6th December 2021. The information on each request forms was recorded on a data collection form designed for this purpose. Each data collection form corresponds to a request forms and each test to a patient. Results: Out of a total of 1990 request forms received, the patient’s age and sex were missing on 18% and 26.8% of the tests respectively. More than half (51.80%) of request forms did not indicate the patient’s place of residence. Clinical information was not provided on 45.90% of the tests. Prescribers omitting their signatures were 51%, stamps were 50.3% and contacts were 71.2%. Only 5.4% of request forms were of good drafting quality. Providing all the required information on the forms could facilitate the use and analysis of data and samples.

关键词： Laboratory Quality Request Forms Information

Diagnosis and management of malaria in the intensive care unit

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Journal of Intensive Medicine 2024年第1期4卷 3-15页

作者： George Akafity Nicholas Kumi Joyce Ashong Department of Research Monitoringand EvaluationCape Coast Teaching HospitalCape CoastGhana Intensive Care unit Department of Critical Care and AnesthesiaCape Coast Teaching HospitalCape Coast Department of Paediatrics and Child Health Cape Coast Teaching HospitalCape CoastGhana

malaria is responsible for approximately three-quarters of a million deaths in humans globally each *** of the morbidity and mortality reported are from Sub-Saharan Africa and Asia,where the disease is *** non-endemic areas,malaria is the most common cause of imported infection and is associated with significant mortality despite recent advancements and investments in elimination *** malaria often requires intensive care unit admission and can be complicated by cerebral malaria,respiratory distress,acute kidney injury,bleeding complications,and *** care management includes prompt diagnosis and early initiation of effective antimalarial therapy,recognition of complications,and appropriate supportive ***,the lack of diagnostic capacities due to limited advances in equipment,personnel,and infrastructure presents a challenge to the effective diagnosis and management of *** article reviews the clinical classification,diagnosis,and management of malaria as relevant to critical care clinicians,highlighting the role of diagnostic capacity,treatment options,and supportive care.

关键词： malaria Intensive care unit Severe malaria Antimicrobial resistance Antimalarials Artemisinin-based combination therapy

Coverage and Factors Associated with Acceptance and Satisfaction of Seasonal malaria Chemoprevention in Six Health Zones in Benin

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Open Journal of Preventive Medicine 2024年第3期14卷 49-60页

作者： Cyriaque Affoukou Georgia Damien Thibaud Lègba Olarewadjou Richard Biaou Boni Géraud Padonou Rock Aïkpon William Houndjo Camille Houetohossou Elysé Sohizoun Aurore Ogouyemi Badirou Aguèmon Community Health and Epidemiology unit Faculty of Health Sciences University of Abomey-Calavi Cotonou Benin National malaria Control Program of Benin Cotonou Benin Ministry of Health Cotonou Benin Laboratory of Epidemiology of Chronic and Neurological Diseases (LEMACEN) Faculty of Health Sciences University of Abomey-Calavi Cotonou Benin

Introduction: Seasonal malaria chemoprevention (SMC) was adopted in 2019 in two health zones in Benin where malaria transmission is very high. Positive results led to the extension of the intervention to other zones with additional financial support. Annual SMC campaigns from 2021 to 2023 were carried out in all six health zones in the Atacora and Alibori departments. In five years of implementation, various approaches have been developed on the basis of a communication plan facilitating buy-in and acceptance by all stakeholders. The aim of this study was to assess the effective coverage and acceptance of the SMC by their beneficiary populations in 2023. Methods: It was a cross-sectional study with an analytical focus. Data collection took place from November 30 to December 13, 2023. The study population consisted of children under 5 years of age residing in the departments of Atacora and Alibori in northern Benin. A total of 3573 children under 5 years of age were included in the study, and their parents or guardians were interviewed. Results: During the 2023 campaign, 87.7% of targets were reached by SMC administration and 100.00% of children had received at least one dose of SMC by the fourth visit. Effective therapeutic coverage of SMC was 70.55%, with 99.60% in BNK, 69.40% in KGS, 16.20% in MK, 56.10% in 2KP, 92.40% in NBT and 89.60% in TMC. This coverage was statistically related to child and respondent ages (p Conclusion: SMC is a strategy accepted by the population, and the main reasons for non-participation in SMC were dominated by the absence of mothers or babysitters when the agents visited.

关键词： Coverage Acceptance SMC Benin

The Entomological Efficacy of Piperonyl Butoxide (PBO) Combined with a Pyrethroid in Insecticide-Treated Nets for malaria Prevention: A Village-Based Cohort Study Prior to Large-Scale Deployment of New Generation Mosquito Nets in Burkina Faso

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Advances in Entomology 2024年第3期12卷 224-248页

作者： Aristide S. Hien Samina Maiga Koama Bayili Adissa Y. Ouattara Dieudonné D. Soma Richard Bationo Georges Benson Meda Delphine O. Karama Tiecoura Camara Georges Anicet Ouedraogo Roch K. Dabiré Abdoulaye Diabaté malaria and Neglected Tropical Disease Department Institut de Recherche en Sciences de la Sant (IRSS) Bobo-Dioulasso Burkina Faso Sciences and Techniques Department Institut du Developpement Rural Universit Nazi Boni Bobo-Dioulasso Burkina Faso Vector Control Department Permanent Secretariat for Malaria Elimination Ouagadougou Burkina Faso

The efficacy of insecticide-treated nets (ITNs) is increasingly compromised by the prevalence of malaria vectors resistant to pyrethroids. In response to this issue, a new generation of ITNs has been developed that incorporate synergistic components, such as piperonyl butoxide (PBO). The purpose of this study is to provide entomological evidence for the efficacy of a PBO-based ITN brand at the village level, serving as a basis for decision-making before large-scale net deployment. During the high malaria transmission period, ITNs were distributed in each group and vector sampling was conducted biweekly in selected households. Bionomic data were collected to assess the resistance of wild An. gambiae populations to various chemical insecticides. There was a significant disparity in total An. gambiae sl. collected between the ITN arms, the intervention arm (ITN arms), and the control arm (P = 0.003). An. coluzzi was identified as the predominant species in the study area, as confirmed by PCR analysis. Analysis of the blood-feeding inhibition rate revealed that 100% permethrin + PBO ITN exhibited significantly greater inhibition than 66.81% permethrin only ITN. According to the log-time probit regression analysis, permethrin exhibited a knockdown time of 256 min without synergists, while it decreased to 139 min (P = 0.001) when pre-exposed to PBO. The evidence from this trial supports the use of PBO ITNs over standard ITNs for pyrethroids to combat pyrethroid resistance and improve protection against malaria for both individuals and communities, particularly in areas with high pyrethroid resistance.

关键词： Pyrethroid Resistance Permethrin + PBO ITNs Permethrin ITN Bionomic Data Insecticide Susceptibility Data Burkina Faso

Epidemiological survey of cystic echinococcosis in southwest China:From the Qinghai-Tibet plateau to the area of Yunnan

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World Journal of Hepatology 2024年第2期16卷 229-240页

作者： Jin-Rong Zi Dan Xiao Jia Peng Fang-Wei Wu Jian-Xiong Li Xin-Liu Yan Zheng-Qing Wang Xuan Cai Qian Xu Ben-Fu Li Ya-Ming Yang Yunnan Provincial Center of malaria Research Yunnan Institute of Parasitic DiseasesPuer 665000Yunnan ProvinceChina Yunnan Institute of Parasitic Diseases Yunnan Institute of Parasitic DiseasesPuer 665000Yunnan ProvinceChina Tibet Center for Disease Control and Prevention Tibet Center for Disease Control and PreventionLhasa 85000Tibet Autonomous RegionChina Yunnan Provincial Center of malaria Research Yunnan Institute of Parasitic DiseasesPuer 655000Yunnan ProvinceChina

BACKGROUND Echinococcosis is prevalent in 9 provinces in Western and Northern *** epidemiological survey of echinococcosis in 2012 and 2016 showed cases of echinococcosis in Yunnan *** To understand the spatial distribution and epidemiological characteristics of echinococcosis in Yunnan for the prevention and control of echinococcosis and to reduce the risk of infection in Yunnan *** Based on the China Information System for Disease Control and Prevention(CISDCP),echinococcosis cases reported from 36 hospitals and 34 Centers for Disease Control were investigated and epidemiologically analyzed from 2021 to *** exclusion criteria included suspected cases,same case only counted once and cases not from Yunnan.A total of 705 cases were investigated,of which 397 cases were suitable for statistical *** these 397 cases,epidemiological investigation was tracked in 187 *** data were inputted using double entry in the Excel database,with error correction by double-entry *** data on echinococcosis cases in Yunnan Province were analyzed by ArcGIS 10.1 software to generate a density map of echinococcosis *** statistical analyses were conducted using SPSS 17.0,including the chi-square test,linear regression test and logistic univariate and multivariate regression *** A total of 397 cases were found in 89 counties in Yunnan *** number of cases in the top three prefectures were Dali(38.1%),Diqing(10.1%),and Kunming(8.3%),and the top five counties were Jianchuan(9.1%),Shangri La(8.3%),Eryuan(7.6%),Heqing(6.9%),and Dali Districts(5.0%).There were significant differences between the different *** case reporting rate by CISDCP(33.8%)was low;the first case was reported by CISDCP in 2002,and the highest number of cases was 50(2017).Confirmed and clinical cases accounted for 62.5%and 37.5%,***,90.9%of the cases of hydatid disease were reported by the hospital system,and only 9

关键词： Echinococcosis Cases Epidemiological analysis Yunnan province

Recent advances on vaccines against malaria: A review

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Asian Pacific Journal of Tropical Medicine 2024年第4期17卷 143-159页

作者： Shiza Malik Yasir Waheed Bridging Health Foundation Rawalpindi 46000Pakistan Gilbert and Rose-Marie Chagoury School of Medicine Lebanese American UniversityByblos 1401Lebanon MEU Research unit Middle East UniversityAmman11831Jordan

This review aims to summarize the currently viable vaccine strategies including the approved vaccines and the those in trials for next-generation malaria *** on malaria vaccine development was collected through a comprehensive *** literature search was performed using databases including Google Scholar,PubMed,NIH,and Web of *** novel approaches of vaccination are being developed,including those based on radiation-attenuated strategies,monoclonal antibodies,targeted immunogenic peptides,RNA and DNA vaccines,nanoparticle-based vaccines,protein-based vaccination protocols,and whole organism-based vaccination *** on RTS,S have entered phase Ⅲtesting,and those based on blood-stage vaccines and vaccines to interrupt malarial transmission have advanced to higher stages of *** modeling,combined drug and vaccine strategies,mass drug administration,polyvalent vaccine formulations,and targeted vaccination campaigns is playing an important role in malarial ***,assessing coverage,accessibility,acceptability,deployment,compilation,and adherence to specific vaccination strategies in endemic regions is essential for vaccination drives against malaria.

关键词： Vaccines against malaria Drugs and adjuvant malarial treatment Plasmodium RTS,S vaccine

Microbiological Quality of “Rabilé”, a Yeast Used for Fermentation of Dolo, a Local Beer in Dédougou, Burkina Faso

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Open Journal of Applied Sciences 2024年第4期14卷 849-864页

作者： Amana Metuor Dabiré Nicolas Ouédraogo Cheick Alassane Djibila Damis Yves Patrik Bouniounou Molecular Biology and Genetics Laboratory (LABIOGENE) Universit&#233 Joseph Ki-Zerbo Ouagadougou Burkina Faso Training and Research unit in Applied Sciences and Technologies Department of Biochemistry Microbiology University of Dedougou Dedougou Burkina Faso National Center for Research and Training on malaria (CNRFP) Ouagadougou Burkina Faso

Sorghum beer or dolo is part of the eating habits of part of the population of Dédougou because of its low price compared with industrial beers. Its production is an ancestral tradition that uses traditional equipment and gives dolo organoleptic properties that are not found in industrial beers. The production process involves several stages, including fermentation, which itself comprises natural lactic fermentation followed by alcoholic fermentation using traditional yeasts, which are not controlled in any way. The general aim of this study is to assess the microbiological quality of these fermentative yeasts in the town of Dédougou, in order to contribute to the health safety of the population and the promotion of these local beers. Twenty samples of fermenting yeast were analyzed according to ISO standards, to isolate enterobacteria, total and faecal coliforms according to standard procedures for isolating these micro-organisms. The isolated strains were identified using the API20E gallery. Microbiological analyses revealed the presence of 51.17% enterobacteria, 45.38% total coliforms and 3.45% thermotolerant coliforms. We counted 40% Escherichia coli, 20% Enterobacter cloacae, 20% Klebsiella pneumoniae and 20% Klebsiella spp. All the strains detected are capable of surviving in hostile conditions and could harm the quality of the dolo, consumer health and cause real collective food poisoning in the town of Dédougou. This enabled us to assess the microbial quality of these yeasts and to propose more suitable measures for producing and preserving dolo under hygienic conditions to protect consumer health.

关键词： Dolo Yeast Rabilé Microbiological Quality Bacteria

Hurdles in achieving the goal of malaria elimination by India

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Asian Pacific Journal of Tropical Medicine 2022年第7期15卷 287-289页

作者： Gaurav Kumar Jaspreet Kaur Shweta Pasi ICMR-National Institute of malaria Research Sector-8DwarkaDelhiIndia

India is a major contributor to the malaria burden in Southeast Asia, with 83% estimated cases and 82% estimated deaths reported in 2020[1]. As per the National Center for Vector-Borne Disease Control(NCVBDC) estimates, around 0.19 million cases and 93 deaths occurred in the country due to malaria in 2020. Since 2002, India has made impressive progress in malaria control with an approximately 90% reduction in malaria cases over the last two decades and is on the road to malaria elimination by 2030.

关键词： malaria elimination cases

R21 vaccine:A ray of hope for malaria elimination

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Asian Pacific Journal of Tropical Medicine 2023年第6期16卷 243-244页

作者： Nitika Nitika Shrikant Nema Praveen Kumar Bharti ICMR-National Institute of malaria Research Sector 8DwarkaNew DelhiIndia

The steady decline in malaria cases and deaths in recent years is a step ahead toward elimination;however,an increasing number of reports of antimalarial and insecticide resistance highlight the importance of having newer approaches to achieve the goal in the stipulated time ***,having an effective and durable malaria vaccine is extremely crucial,which can complement the tools currently in *** the malaria vaccine development efforts initiated in the 1910’s with the first attempts to develop a malaria vaccine involved inoculating humans with live,attenuated strains of the malaria parasite but the efforts have been intensified over the previous decade,resulting in several significant developments.

关键词： malaria vaccine elimination