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An assessment of racial differences in epidemiological, clinical and psychosocial factors among head and neck cancer patients at the time of surgery

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2020年第1期6卷 41-48页

作者： Anvesh Kompelli Kathleen B.Cartmell Katherine R.Sterba Anthony J.Alberg Christopher C.Xiao Amit J.Sood Elizabeth Garrett-Mayer Shai J.White-Gilbertson Steven A.Rosenzweig Terry A.Day Department of Otoloryngology-Head and Neck Surgery Medical University of South Carolina(MUSC)CharlestonSC29425USA College of Nursing MUSCCharlestonSC29425USA hollings cancer center MUSCCharlestonSC29425USA Department of Public Health Sciences MUSCCharlestonSC29425USA cancer Resistry Hollings Cancer CenterMUSCCharlestonSC29425USA Department of Pharmacology MUSCCharlestonSC29425USA

Objective:Racial disparities have been well characterized and African American(AA)patients have 30%lower 5-year survival rates than European Americans(EAs)for head and neck squamous carcinoma(HNSCC).This poorer survival can be attributed to a myriad of different *** purpose of this study was to characterize AA-EA similarities and differences in sociodemographic,lifestyle,clinical,and psychosocial characteristics in HNSCC patients near the time of ***:Setting:Single tertiary care ***:Thirty-nine newly diagnosed,untreated HNSCC patients(n=24 EAs,n=15 AAs)who were to undergo surgery were *** Design:Cross-sectional study Sociodemographic,lifestyle factors,and disease factors(cancer site,AJCC clinical and pathologic stage,and HPV status)were *** factors,leisure time,quality of life and social support were also assessed using validated ***:EA and AA patients were similar in the majority of sociodemographic factors *** had a higher trend toward pathologically later stage disease compared to EAs and significantly increased time to ***:EA and AA patients were similar in the majority of sociodemographic factors *** had a higher trend toward pathologically later stage disease compared to *** also had significantly increased time to treatment(P=0.05).The majority of AA patients(62%)had later stage pathologic *** were less likely to complete high school or college(P=0.01)than their EA ***,AAs were more likely to report having a gap in health insurance during the past decade(37%vs.15%).Conclusions:This preliminary study demonstrates a similar profile of demographics,clinical and psychosocial characteristics preoperatively for AAs and *** differences were AAs tending to have later pathologic stage disease,educational status,delays in treatment initiation,and gaps in health insurance.

关键词： Head and neck cancer Healthcare disparities Treatment delay Health services Quality care HPV

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Changes in otolaryngology application requirements and match outcomes:Are we doing any better?

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2023年第2期9卷 144-152页

作者： Emma De Ravin Ariel S.Frost Neal R.Godse Amber D.Shaffer Noel Jabbour Barry M.Schaitkin Jason Newman Leila J.Mady Department of Otorhinolaryngology-Head and Neck Surgery University of Pennsylvania Health SystemPhiladelphiaPennsylvaniaUSA Head and Neck Institute Cleveland ClinicClevelandOhioUSA Division of Pediatric Otolaryngology Children's Hospital of Pittsburgh of UPMCPittsburghPennsylvaniaUSA Department of Otolaryngology University of Pittsburgh Medical CenterPittsburghPennsylvaniaUSA Department of Otolaryngology-Head and NeckSurgery Medical Universityof South CarolinaCharlestonSouth CarolinaUSA musc hollings cancer center CharlestonSouthCarolinaUSA Department of Otolaryngology-Head and Neck Surgery Thomas Jefferson UniversityPhiladelphiaPennsylvaniaUSA cancer Risk and Control Program of Excellence Sidney Kimmel Cancer CenterPhiladelphiaPennsylvaniaUSA

Objectives:Otolaryngology-specific requirements were piloted to minimize applicant and program *** investigated the impact of introducing and then removing these requirements on Match ***:2014-2021 National Resident Matching Program?data were *** primary outcome was the impact of Otolaryngology Resident Talent Assessment(ORTA;prematch 2017,postmatch 2019)and Program-Specific Paragraph(PSP;implemented 2016,optional 2018)on applicant numbers and match *** survey analysis assessed candidate perceptions of PSP/***:Applicant numbers declined significantly during PSP/ORTA(18.9%;p=0.001).With the optional PSP and postmatch ORTA,applicant numbers increased significantly(39.0%;p=0.002).Examined individually,mandatory PSP was associated with a significant decline in applicants(p=0.007),whereas postmatch ORTA was associated with significant increases in applicants(p=0.010).ORTA and PSP negatively impacted the decision to apply to otolaryngology in 59.8%and 51.3%of applicants,***,match rate success improved significantly from 74.8%to 91.2%during PSP/ORTA(p=0.014),followed by a significant decline to 73.1%after PSP was made optional and ORTA moved to postmatch(p=0.002).Conclusions:ORTA and PSP correlated with decreased applicant numbers and increased match rate *** programs seek ways to remove barriers to applying to otolaryngology,the potential consequences of an increasing pool of unmatched candidates must also be considered.

关键词： academic success internship and residency medical students otolaryngology surveys and questionnaires

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Neuron specific enolase is a potential target for regulating neuronal cell survival and death: implications in neurodegeneration and regeneration

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Neuroimmunology and Neuroinflammation 2017年第12期4卷 254-257页

作者： Rachel Polcyn Mollie Capone Azim Hossain Denise Matzelle Naren L.Banik Azizul Haque Department of Microbiology and Immunology Hollings Cancer CenterMedical University of South CarolinaCharlestonSC 29425USA Department of Neurosurgery Medical University of South CarolinaCharlestonSC 29425USA Ralph H.Johnson Veterans Administration Medical center CharlestonSC 29401USA.

Enolase is a multifunctional enzyme primarily involved in catalyzing the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis[1-4].Though typically ... 详细信息

关键词： Neuron specific enolase potential target regulating neuronal cell survival

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Regulation of muscle stem cell fate

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Cell Regeneration 2022年第1期11卷 413-425页

作者： Xin Fu Cheng-le Zhuang Ping Hu Spine center Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Colorectal cancer center/Department of Gastrointestinal Surgery Shanghai Tenth People’s Hospital Affiliated to Tongji UniversityShanghai 200072China Guangzhou Laboratory Guanghzou International Bio LslandNo.9 XingDaoHuan RoadGuangzhou 510005China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China

Skeletal muscle plays a critical role in human *** stem cells(muscs)serve as the major cell type contribut-ing to muscle regeneration by directly differentiating to mature muscle *** usually remain quiescent with occasionally self-renewal and are activated to enter cell cycle for proliferation followed by differentiation upon muscle injury or under pathological *** quiescence maintenance,activation,proliferation,and differentiation of muscs are tightly *** musc cell-intrinsic regulatory network and the microenvironments work coordi-nately to orchestrate the fate transition of *** heterogeneity of muscs further complicates the regulation of *** review briefly summarizes the current progress on the heterogeneity of muscs and the microenviron-ments,epigenetic,and transcription regulations of muscs.

关键词： muscle stem cells Skeletal muscle regeneration Asymmetric division musc heterogeneity Microenvironments Transcription regulation

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Myogenesis controlled by a long non-coding RNA 1700113A16RIK and post-transcriptional regulation

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Cell Regeneration 2022年第1期11卷 120-130页

作者： Xin Fu Sheng Li Minzhi Jia Bo Xu Lele Yang Ruimiao Ma Hong Cheng Wenjun Yang Ping Hu Spine center Department of Pediatric OrthopedicsXin Hua Hospital Affiliated to Shanghai Jiao Tong UniversitySchool of MedicineShanghai 200092China State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China Guangzhou Laboratory Guangzhou 510700GuangdongChina State Key Laboratory of Molecular Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China

Long non-coding(lnc)RNA plays important roles in many cellular *** function of the vast majority of lncRNAs remains *** we identified that lncRNA-1700113A16RIK existed in skeletal muscle stem cells(muscs)and was significantly elevated during musc *** of 1700113A16RIK inhibits the differentiation of muscle stem *** contrast,overexpression of 1700113A16RIK promotes the differentiation of muscle stem *** study shows the muscle specific transcription factor Myogenin(MyoG)positively regulates the expression of 1700113A16RIK by binding to the promoter region of ***,1700113A16RIK may regulate the expression of myogenic genes by directly binding to 3’UTR of an important myogenic transcription factor MEF2D,which in turn promotes the translation of *** together,our results defined 1700113A16RIK as a positive regulator of musc differentiation and elucidated a mechanism as to how 1700113A16RIK regulated musc differentiation.

关键词： Long non-coding RNA(lncRNA) 1700113A16RIK muscle stem cell(musc)differentiation Myocyte-specific enhancer binding factor 2(MEF2D)

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Endoscopic balloon dilation for management of stricturing Crohn’s disease in children

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World Journal of Gastrointestinal Endoscopy 2021年第9期13卷 382-390页

作者： Brianna McSorley Robert A Cina Candi Jump Johanna Palmadottir J Antonio Quiros Department of Pediatrics Medical University of South CarolinaCharlestonSC 29425United States Department of Surgery Medical University of South CarolinaCharlestonSC 29425United States Department of Pediatric Gastroenterology Medical University of South CarolinaCharlestonSC 29425United States Department of Pediatric Gastroenterology MUSC Children's HospitalCharlestonSC 29425United States Department of Pediatric Gastroenterology and Nutrition Mount Sinai Kravis Children's HospitalNew YorkNY 10029United States

BACKGROUND Crohn’s disease(CD)has a multitude of complications including intestinal strictures from fibrostenotic *** disease has been reported in 10%-17%of children at presentation and leads to surgery in 20%-50%of cases within ten years of *** symptoms develop from these strictures,the treatment in children has primarily been surgical *** balloon dilation(EBD)has been shown to be a safe and efficacious alternative to surgery in adults,but evidence is poor in the literature regarding its safety and efficacy in *** To evaluate the outcomes of children with fibrostenosing CD who underwent EBD vs surgery as a *** In a single-center retrospective study,we looked at pediatric patients(ages 0-18)who carry the diagnosis of CD,who were diagnosed after opening a dedicated Inflammatory Bowel Disease clinic on July 1,2012 through May 1,*** used diagnostic codes through our electronic medical record to identify patients with CD with a stricturing *** type of intervention for patients’strictures was then identified through procedural and surgical billing *** evaluated their demographics,clinical variables,whether they underwent EBD vs surgery or both,and their clinical *** Of the 139 patients with CD,25(18%)developed *** initial intervention for a stricture was surgical resection in 12 patients(48%)and EBD in 13 patients(52%).However,4(33%)patients whom initially had surgical resection required follow up EBD,and thus 17 total patients(68%)underwent EBD at some point in their treatment *** those 8 patients who underwent successful surgical resection alone,4 of these patients(50%)had a fistula present near the stricture site and 4(50%)had strictures greater than 5 cm in *** patients who underwent EBD had no procedural complications,such as a ***-two(88%)of the treated strictures were successfully managed by EBD and did not require any furth

关键词： Crohn’s disease Intestinal strictures Endoscopic dilation Pediatrics Endoscopic balloon dilation

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Pilot study of atomoxetine in patients with Parkinson’s disease and dopa-unresponsive Freezing of Gait

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Translational Neurodegeneration 2015年第1期4卷 205-208页

作者： Gonzalo J.Revuelta Aaron Embry Jordan J.Elm Chris Gregory Amy Delambo Steve Kautz Vanessa K.Hinson Movement Disorders Division Department of NeurologyCollege of MedicineMedical University of South Carolina208B Rutledge AvenueMSC 108CharlestonSC 29425USA Department of Health Sciences and Research Center for Rehabilitation Research in Neurological ConditionsCollege of Health ProfessionsMedical University of South CarolinaCharlestonSCUSA Department of Public Health Sciences College of MedicineMedical University of South CarolinaCharlestonSC 29425USA Ralph H.Johnson VA Medical center CharlestonSCUSA

Background:Freezing of gait(FoG)is a common and debilitating condition in Parkinson’s disease(PD)associated with executive dysfunction.A subtype of FoG does not respond to dopaminergic therapy and may be related to noradrenergic *** pilot study explores the effects of atomoxetine on gait in PD patients with dopaunresponsive FoG using a novel paradigm for objective gait ***:Ten patients with PD and dopa-unresponsive FoG were enrolled in this eight-week open label pilot *** included an exploratory gait analysis protocol that quantified spatiotemporal parameters during straight-away walking and turning,while performing a dual ***,and subjective assessments of gait,quality of life,and safety were also *** primary outcome was a validated subjective assessment for FoG(FOG-Q).Atomoxetine was well tolerated,however,no significant change was observed in the primary *** gait analysis protocol correlated well with clinical scales,but not with subjective *** patients were more likely to increase gait velocity(p=0.033),and improved in other clinical ***:Objective gait analysis protocols assessing gait while dual tasking are feasible and useful for this patient population,and may be superior correlates of FoG severity than subjective *** findings can inform future trials in this population.

关键词： Parkinson’s disease Freezing of gait Noradrenaline Atomoxetine Dopa-response

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GDNF-Enhanced Axonal Regeneration and Myelination Following Spinal Cord Injury is Mediated by Primary Effects on Neurons

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神经损伤与功能重建 2009年第4期4卷 268-281页

作者： LIQUN ZHANG ZHENGWEN MA GEORGE M. SMITH XUEJUN WEN YELENA PRESSMAN PATRICK M. WOOD AND XIAO-MING XU Kentucky Spinal Cord Injury Research center Departments of Neurological Surgery and Ana-tomical Sciences and NeurobiologyUniversity of Louisville School of Medicine Louisville Kentueky Department of Orthopedics The First Affiliated Hospital of Fujian Medical University Fuzhou Fujian People＇s Republic of China Spinal Cord and Brain Injury Research center Department of Physiology University of Kentucky Chandler Medical Center Lexington Kentucky Clemson-musc Joint Bioengi- neering Program Charleston South Carolina The Miami Project to Cure Paralysis Departments of Neurological Surgery University of Miami School of Medicine MiamiFlorida Spinal Cord and Brain Injury Research Group Stark Neurosciences Research Institute and Department of Neurological Surgery Indiana University School of Medicine Indianapolis Indiana

我们先前研究表明胶质细胞源性神经营养因子(GDNF)联合施万细胞移植能促进脊髓损伤后轴突再生和髓鞘形成。然而,GDNF介导这一过程的细胞靶点尚不清楚。在此,我们报道了GDNF可增加在体再生轴突的数目和直径,并促进体外背根神经节神经元... 详细信息

我们先前研究表明胶质细胞源性神经营养因子(GDNF)联合施万细胞移植能促进脊髓损伤后轴突再生和髓鞘形成。然而,GDNF介导这一过程的细胞靶点尚不清楚。在此,我们报道了GDNF可增加在体再生轴突的数目和直径,并促进体外背根神经节神经元的轴突向外生长,提示GDNF对神经元有直接作用。在施万细胞-背根神经节神经元共培养下,GDNF显著增加施万细胞生成的髓鞘数目;GDNF处理对孤立培养的施万细胞增殖无作用,但可促进已与神经轴突有突触联系的施万细胞增殖;GDNF可增加孤立施万细胞中分子量为140kDa的神经细胞黏附分子(NCAM)的表达,但对黏附分子L1表达或神经营养因子NGF、NT3及BDNF分泌没有影响。总之,这些结果支持假设:GDNF提高轴突再生和施万细胞髓鞘形成主要是通过GDNF对神经元的直接作用介导的,并且提示GDNF联合施万细胞移植可能是促进脊髓损伤后轴突再生和髓鞘形成的有效策略之一。

关键词： GDNF 轴突髓鞘形成再生施万细胞脊髓损伤

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Mechanically Inducted Three-Dimensional Hydrogel Fiber Alignment and its Application in Skeletal muscle Regeneration

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医用生物力学 2019年第A1期34卷 134-135页

作者： Nianyuan Shi Yuhui Li Tian Jian Lu Feng Xu The Key Laboratory of Biomedical Information Engineering of Ministry of Education Xi’an Jiaotong University School of Life Science and TechnologyXi’an710049China Bioinspired Engineering and Biomechanics center(BEBC) Xi’anJiaotong UniversityXi’an710049China

Skeletal muscle accounts for 40%~45%of the body weight and is composed of a large number of parallel arrangement of muscle fiber bundles through attaching to the skeleton by the *** robust skeletal muscles provide people the ability of daily activities such as walk,lift and so *** fibers are generated by multinucleated myotubes which form from the fusion of myoblasts with polarity development,and the synergistic effect between muscle fibers and spontaneous contraction provides support for the movement of the bodies and ***,because of common clinical genetic defect,trauma,tumor,primary myopathy there are so many people cannot exercise like normal *** it is an urgent task to treat these *** treatment methods are mainly through acupuncture,rehabilitation,drug treatment,*** these methods have long treatment times,poor efficacy,and high ***,the clinical researchers find that these diseases have similar pathological characteristics including structural damage,loss of skeletal muscle function,apoptosis and degradation of muscle fibers Therefore,there is academic and clinical value to study the repair and regeneration of skeletal ***,tissue engineering provides a new idea for repairing damaged muscle *** engineering uses biological materials as a carrier to regulate the structural properties of *** applying biological/chemical/physical stimuli to mimic the microenvironment of the living *** then construct a living tissue and transplant it into the body for wound *** the development of tissue engineering,we regulate the micro-structure of the cell matrix and applying mechanical stimulation to reconstruct a functional muscle microtissue in *** fabrication and mechanical loading strategy provide an easily adaptable platform to create functional muscle tissue *** the mature muscle microtissues provide a useful tool for the clinical application to treat musc

关键词： skeletal muscle tissue engineering mechanical stimulus

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Biologic and Clinical Efficacy of LentiGlobin for Sickle Cell Disease

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四川生理科学杂志 2021年第10期43卷 1802-1802页

作者： Julie Kanter From the University of Alabama Birmingham Birmingham (J.K.) UCSF Benioff Children’s Hospital Oakland CA (M.C.W.) Aflac cancer and Blood Disorders center Department of Pediatrics Children’s Healthcare of Atlanta Emory University Atlanta (L.K.) the Division of Hematology–Oncology Columbia Center for Translational Immunology Columbia University Medical Center New York (M.Y.M.) the Division of Pediatric Hematology Oncology and Cellular Therapy Cohen Children’s Medical Center New Hyde Park (B.A.) and Zucker School of Medicine at Hofstra–Northwell Hempstead (B.A.) — all in New York the Division of Hematology Children’s Hospital of Philadelphia and the Department of Pediatrics University of Pennsylvania Perelman School of Medicine — both in Philadelphia (J.L.K.) Hackensack University Medical center Hackensack NJ (S.R.-Z.) the University of North Carolina at Chapel Hill Chapel Hill (K.A.K.) Bluebird Bio Cambridge MA (F.J.P. M.B. A.M. X.Z. J.L. D.K. J.-A.R. M.A. S.G.) Northwestern University Feinberg School of Medicine and Ann and Robert H. Lurie Children’s Hospital — both in Chicago (A.A.T.) and the Cellular and Molecular Therapeutics Branch National Heart Lung and Blood Institute and National Institute of Diabetes and Digestive and Kidney Diseases (NHLBI–NIDDK) National Institutes of Health Bethesda MD (J.F.T.).Dr. Tisdale can be contacted at [email protected] or at the Cellular and Molecular Therapeutics Branch NHLBI–NIDDK National Institutes of Health Bethesda MD 20814.

Background:Sickle cell disease is characterized by the painful recurrence of vaso-occlusive *** therapy with the use of LentiGlobin for sickle cell disease(bb1111;lovotibeglogene autotemcel)consists of autologous transplantation of hematopoietic stem and progenitor cells transduced with the BB305 lentiviral vector encoding a modifiedβ-globin gene,which produces an antisickling hemoglobin,HbAT87Q.

关键词： Sick Clinical hematopoietic

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