Pilot study of atomoxetine in patients with Parkinson’s disease and dopa-unresponsive Freezing of Gait

作     者：Gonzalo J.Revuelta Aaron Embry Jordan J.Elm Chris Gregory Amy Delambo Steve Kautz Vanessa K.Hinson 

作者机构：Movement Disorders DivisionDepartment of NeurologyCollege of MedicineMedical University of South Carolina208B Rutledge AvenueMSC 108CharlestonSC 29425USA Department of Health Sciences and ResearchCenter for Rehabilitation Research in Neurological ConditionsCollege of Health ProfessionsMedical University of South CarolinaCharlestonSCUSA Department of Public Health SciencesCollege of MedicineMedical University of South CarolinaCharlestonSC 29425USA Ralph H.Johnson VA Medical CenterCharlestonSCUSA 

出 版 物：《Translational Neurodegeneration》 (转化神经变性病（英文）)

年 卷 期：2015年第4卷第1期

页      面：205-208页

核心收录：

学科分类：08[工学] 081101[工学-控制理论与控制工程] 0811[工学-控制科学与工程] 081102[工学-检测技术与自动化装置] 

基　　金：by the Barmore Fund for Parkinson’s Research the MUSC Department of Neurology and Neurosurgery,by the South Carolina Clinical&Translational Research(SCTR)Institute,with an academic home at the Medical University of South Carolina supported by NIH/NCATS Grant Number UL1TR000062 by NIH NINDS Grant Number 1K23NS091391-01A1 

主　　题：Parkinson’s disease Freezing of gait Noradrenaline Atomoxetine Dopa-response 

摘      要：Background:Freezing of gait(FoG)is a common and debilitating condition in Parkinson’s disease(PD)associated with executive dysfunction.A subtype of FoG does not respond to dopaminergic therapy and may be related to noradrenergic *** pilot study explores the effects of atomoxetine on gait in PD patients with dopaunresponsive FoG using a novel paradigm for objective gait ***:Ten patients with PD and dopa-unresponsive FoG were enrolled in this eight-week open label pilot *** included an exploratory gait analysis protocol that quantified spatiotemporal parameters during straight-away walking and turning,while performing a dual ***,and subjective assessments of gait,quality of life,and safety were also *** primary outcome was a validated subjective assessment for FoG(FOG-Q).Atomoxetine was well tolerated,however,no significant change was observed in the primary *** gait analysis protocol correlated well with clinical scales,but not with subjective *** patients were more likely to increase gait velocity(p=0.033),and improved in other clinical ***:Objective gait analysis protocols assessing gait while dual tasking are feasible and useful for this patient population,and may be superior correlates of FoG severity than subjective *** findings can inform future trials in this population.