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Pilot study of atomoxetine in patients with Parkinson’s disease and dopa-unresponsive Freezing of Gait

Translational Neurodegeneration 2015年第1期4卷 205-208页

作者： Gonzalo J.Revuelta Aaron Embry Jordan J.Elm Chris Gregory Amy Delambo Steve Kautz Vanessa K.Hinson Movement Disorders Division Department of NeurologyCollege of MedicineMedical University of South Carolina208B Rutledge AvenueMSC 108CharlestonSC 29425USA Department of Health Sciences and Research Center for Rehabilitation Research in Neurological ConditionsCollege of Health ProfessionsMedical University of South CarolinaCharlestonSCUSA Department of Public Health Sciences College of MedicineMedical University of South CarolinaCharlestonSC 29425USA Ralph H.Johnson VA Medical Center CharlestonSCUSA

Background:Freezing of gait(FoG)is a common and debilitating condition in Parkinson’s disease(PD)associated with executive dysfunction.A subtype of FoG does not respond to dopaminergic therapy and may be related to noradrenergic *** pilot study explores the effects of atomoxetine on gait in PD patients with dopaunresponsive FoG using a novel paradigm for objective gait ***:Ten patients with PD and dopa-unresponsive FoG were enrolled in this eight-week open label pilot *** included an exploratory gait analysis protocol that quantified spatiotemporal parameters during straight-away walking and turning,while performing a dual ***,and subjective assessments of gait,quality of life,and safety were also *** primary outcome was a validated subjective assessment for FoG(FOG-Q).Atomoxetine was well tolerated,however,no significant change was observed in the primary *** gait analysis protocol correlated well with clinical scales,but not with subjective *** patients were more likely to increase gait velocity(p=0.033),and improved in other clinical ***:Objective gait analysis protocols assessing gait while dual tasking are feasible and useful for this patient population,and may be superior correlates of FoG severity than subjective *** findings can inform future trials in this population.

关键词： Parkinson’s disease Freezing of gait Noradrenaline Atomoxetine dopa-response

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