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The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan Sun Lingyun Nie Jing Zhang Xue Fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

Functional modular organization unfolded by chimera-like dynamics in a large-scale brain network model

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Science China(Technological Sciences) 2022年第7期65卷 1435-1444页

作者： LIU ZiLu YU Ying WANG QingYun Department of dynamics and Control Beihang UniversityBeijing 100191China School of Engineering Medicine Beihang UniversityBeijing 100191China Beijing Institute of brain Disorders Capital Medical UniversityBeijing 100069China

The brain is organized as a complex network architecture, which can be mapped into structural(SC) and functional connectivity(FC) by advanced neuroimaging techniques. Achievements in brain network research have revealed that modularity is a universal trait in brain networks and may be vital for cognitive segregation and integration. Large-scale brain network modeling is a promising computational approach to combine neuroimaging data with generative rules for brain dynamics. Recently, it has been proposed that chimera states, a type of dynamics referring to the coexistence of coherent and incoherent participants, have traits in common with cognitive functions like segregated and integrated brain processing. Previous studies have reported the existence of chimera-like dynamics in large-scale brain network models, whereas they did not account for the relationship between chimeralike dynamics and corresponding functional modular organizations of the brain network. By specifying qualitatively different network dynamics in an anatomically-constrained brain network model, we compare the different modular organizations of FC unfolded by network dynamics. Our simulations reveal that chimera-like dynamics support a meaningful pattern of functional modular organization, which promotes a diversity of node roles with a distributed pattern of functional cartography. The distinct node roles in modular FC are also found to occur with a spatial preference in speciflc brain regions, and, to some extent, reflect the underlying structure constraints. Our results support the view that chimera-like dynamics is a functionally meaningful scenario that may play a fundamental role in the segregation and integration of brain functioning.

关键词： large-scale brain network modular network synchronization chimera state functional modularity

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The conditions for onset of beta oscillations in an extended subthalamic nucleus-globus pallidus network

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Science China(Technological Sciences) 2014年第10期57卷 2020-2027页

作者： HU Bing WANG QingYun Department of dynamics and Control Beihang University

The persistence of beta oscillations generated in the basal ganglia is typical pathological characteristic of Parkin-son's *** this paper,we construct a new network model,which is mainly composed of the subthalamic nu-cleus and the globus *** on theory analysis,we obtained the beta shock conditions in the proposed *** is shown that numerical simulations are in good agreement with analytical *** last,the effects of cortex and striatum inputs on the generation of oscillations are also *** hope that the obtained results may find applications to treatment of Parkinson’s disease and study of neural oscillations produced in other parts of the brain neural network.

关键词： Parkinson's disease beta oscillations stability delay

A review of computational modeling and deep brain stimulation:applications to Parkinson’s disease

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Applied Mathematics and Mechanics(English Edition) 2020年第12期41卷 1747-1768页

作者： Ying YU Xiaomin WANG Qishao WANG Qingyun WANG Department of dynamics and Control Beihang UniversityBeijing 100191China

Biophysical computational models are complementary to experiments and theories,providing powerful tools for the study of neurological *** focus of this review is the dynamic modeling and control strategies of Parkinson’s disease(PD).In previous studies,the development of parkinsonian network dynamics modeling has made great *** mainly focuses on the cortex-thalamus-basal ganglia(CTBG)circuit and its sub-circuits,which helps to explore the dynamic behavior of the parkinsonian network,such as *** brain stimulation(DBS)is an effective strategy for the treatment of *** present,many studies are based on the side effects of the ***,the translation from modeling results to clinical disease mitigation therapy still faces huge ***,we introduce the progress of DBS *** specific purpose is to develop novel DBS treatment methods,optimize the treatment effect of DBS for each patient,and focus on the study in closed-loop *** goal is to review the inspiration and insights gained by combining the system theory with these computational models to analyze neurodynamics and optimize DBS treatment.

关键词： computational model deep brain stimulation(DBS) Parkinson’s disease(PD) basal ganglia(BG)

Biphasic Cholinergic Modulation of Reverberatory Activity in Neuronal

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Neuroscience Bulletin 2023年第5期39卷 731-744页

作者： Xiao-Wei Li Yi Ren Dong-Qing Shi Lei Qi Fang Xu Yanyang Xiao Pak-Ming Lau Guo-Qiang Bi CAS Key Laboratory of brain Function and Disease School of Life SciencesDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230027China CAS Key Laboratory of brain Connectome and Manipulation Interdisciplinary Center for Brain Informationthe Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsShenzhen 518055China

Acetylcholine(ACh)is an important neuromod-ulator in various cognitive ***,it is unclear how ACh influences neural circuit dynamics by altering cellular ***,we investigated how ACh influ-ences reverberatory activity in cultured neuronal *** found that ACh suppressed the occurrence of evoked reverberation at low to moderate doses,but to a much lesser extent at high ***,high doses of ACh caused a longer duration of evoked reverberation,and a higher occur-rence of spontaneous *** whole-cell recording from single neurons,we found that ACh inhibited excita-tory postsynaptic currents(EPSCs)while elevating neu-ronal firing in a dose-dependent ***,all ACh-induced cellular and network changes were blocked by muscarinic,but not nicotinic receptor *** computational modeling,we found that simulated changes in EPSCs and the excitability of single cells mimicking the effects of ACh indeed modulated the evoked network reverberation similar to experimental ***,ACh modulates network dynamics in a biphasic fashion,probably by inhibiting excitatory synaptic transmission and facilitating neuronal excitability through muscarinic signaling pathways.

关键词： Acetylcholine Neuronal network Reverberation Synaptic current Excitability

Enabling discovery science in human connectomics

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Science Bulletin 2015年第1期60卷 139-140页

作者： Olaf Sporns Department of Psychological and brain Sciences and Indiana University network Science Institute Indiana UniversityBloomington IN 47405 USA

In recent years, the confluence of technological advances in human neuroimaging and quantitative tools for under- standing the structure and dynamics of complex systems have led to the emergence of new approaches toward understanding human brain function. These new approa- ches conceptualize the brain as a network organized across different spatial and temporal scales--a distributed com- plex system whose integrated function underlies human behavior and cognition. A core objective for this new conceptual approach is the construction of accurate and comprehensive network maps of human brain structural connectivity （the human connectome [1]） and its corre- sponding temporally fluctuating patterns of functionalconnectivity.

关键词：人类科学发现复杂系统网络地图结构连接空间尺度人的行为脑功能

Transcranial direct current stimulation inhibits epileptic activity propagation in a large-scale brain network model

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Science China(Technological Sciences) 2023年第12期66卷 3628-3638页

作者： YU Ying FAN YuBo HAN Fang LUAN GuoMing WANG QingYun School of Engineering Medicine Beihang UniversityBeijing 100191China Beihang University Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringKey Laboratory Biomechanics&MechanobiologyMinistry of EducationBeijing 100191China College of Information Science and Technology Donghua UniversityShanghai 201620China Beijing Key Laboratory of Epilepsy Sanbo Brain HospitalCapital Medical UniversityBeijing 100069China Department of dynamics and Control Beihang UniversityBeijing 100191China Beijing Institute of brain Disorders Capital Medical UniversityBeijing 100069China

Transcranial direct current stimulation(tDCS)is a noninvasive technique that uses constant,low-intensity direct current to regulate brain *** studies have shown that cathode-tDCS(c-tDCS)is effective in reducing seizure frequency in patients with *** to the heterogeneity and patient specificity of seizures,patient-specific epilepsy networks are increasingly important in exploring the regulatory role of *** this study,we first set the left hippocampus,parahippocampus,and amygdala as the epileptogenic zone(EZ),and the left inferior temporal cortex and ventral temporal cortex as the initial propagation zone(PZ)to establish a large-scale epilepsy network *** we set tDCS cathode locations according to the maximum average energy of the simulated EEG signals and systematically study c-tDCS inhibitory effects on the propagation of epileptic *** results show that c-tDCS is effective in suppressing the propagation of epileptic ***,to consider the patient specificity,we set specific EZ and PZ according to the clinical diagnosis of 6 patients and establish patient-specific epileptic *** find that c-tDCS can suppress the propagation of abnormal activity in most patient-specific epileptic ***,when the PZ is widely distributed in both hemispheres,the treatment effect of c-tDCS is not ***,we propose dual-cathode *** epilepsy models with a wide distribution of PZ,it can inhibit the propagation of epileptiform activity in other nodes except EZ and PZ without increasing the tDCS current *** results provide theoretical support for the treatment of epilepsy with tDCS.

关键词： epilepsy large-scale brain network modeling transcranial direct current stimulation neural mass model

network dynamics and its relationships to topology and coupling structure in excitable complex networks

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Chinese Physics B 2014年第10期23卷 626-632页

作者：张立升谷伟凤胡岗弭元元 State Key Laboratory of Cognitive Neuroscience and Learning International Digital Group (IDG)/McGovern Institute for Brain Research and Center for Collaboration and Innovation in Brain and Learning SciencesBeijing Normal University Department of Physics Beijing Normal University

All dynamic complex networks have two important aspects, pattern dynamics and network topology. Discovering different types of pattern dynamics and exploring how these dynamics depend or/network topologies are tasks of both great theoretical importance and broad practical significance. In this paper we study the oscillatory behaviors of excitable complex networks （ECNs） and find some interesting dynamic behaviors of ECNs in oscillatory probability, the multiplicity of oscillatory attractors, period distribution, and different types of oscillatory patterns （e.g., periodic, quasiperiodic, and chaotic）. In these aspects, we further explore strikingly sharp differences among network dynamics induced by different topologies （random or scale-free topologies） and different interaction structures （symmetric or asymmetric couplings）. The mechanisms behind these differences are explained physically.

关键词： excitable complex networks network topology symmetric and asymmetric couplings

Stochastic Alternating dynamics for Synchronous EAD-Like Beating Rhythms in Cultured Cardiac Myocytes

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Chinese Physics Letters 2009年第11期26卷 16-19页

作者：张宁张慧敏刘志强丁学利杨明浩古华光任维 brain and Behavior Institute College of Life Science Shaanxi Normal University Xi'an 710062

Dissolved cardiac myocytes can couple together and generate synchronous beatings in culture. We observed a synchronized early after-depolarization（EAD）-like rhythm in cultured cardiac myocytes and reproduced the experimental observation in a network mathematical model whose dynamics are close to a Hopf bifurcation. The mechanism for this EAD-like rhythm is attributed to noised-induced stochastic alternatings between the focus and the limit cycle. These results provide novel understandings for pathological heart rhythms like the early immature beatings.

关键词： Medical physics Biological physics