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Accuracy of multi-echo Dixon sequence in quantification of hepatic steatosis in Chinese children and adolescents

World Journal of Gastroenterology 2019年第12期25卷 1513-1523页

作者： Yu-Zhen Zhao Yun-Gen Gan Jian-Li Zhou Jia-Qi Liu Wei-Guo Cao Shu-Mei Cheng Da-Ming Bai Meng-Zhu Wang Fang-Qin Gao Shao-Ming Zhou Department of Gastroenterology Shenzhen Children's Hospital Department of Radiology Shenzhen Children's Hospital Department of Physical Examination Futian District Maternity and Child Healthcare Hospital Department of mr scientific marketing Siemens Healthineers Department of mr Clinical marketing Siemens Healthineers

BACKGROUND Nonalcoholic fatty liver disease(NAFLD) is currently the outstanding cause of chronic liver disease in children and adolescents, especially in overweight and obese groups. Liver biopsy is the reference standard to diagnose NAFLD but invasive, thus it is not the best choice in clinical diagnosis and *** resonance(mr) is widely used in clinical trials to noninvasively quantify liver fat content in adults and children in foreign countries. While currently, it is rarely used in Chinese children and adolescents. We postulated that quantifying hepatic steatosis by mr could be extended to children and adolescents in *** To investigate the accuracy of mr imaging(mrI) in quantifying liver fat with mr spectroscopy(mrS) as a reference. A secondary goal was to assess the prevalence of NAFLD in overweight and obese Chinese children and *** were 86 children and adolescents enrolled in this study, including 65 overweight and obese children and 21 healthy children. The participants underwent mrI and mrS. mrI and mrS were performed using multi-echo Dixon and HISTO sequences, respectively, to calculate hepatic proton density fat fraction(PDFF). Hepatic steatosis was diagnosed using mrS-PDFF > 5% as the threshold. Spearman's analysis was used to evaluate the correlation between mrI and mrS. The agreement between these two methods was assessed by BlandAltman *** The mrI-PDFF in the mrS region of interest and the entire liver was 9.9% ±10.3% with a range of 0.3%-39.9%, and 10.6% ± 9.4% with a range of 1.9%-38.9%,respectively. The mrS-PDFF was 9.1% ± 10.0%, with a range of 0.5%-37.8%. The incidence of hepatic steatosis detected by mrS-PDFF was 46.5%(40/86) of all participants, all of whom belonged to the overweight and obese ***'s analysis indicated an excellent correlation between multi-echo Dixon and mrS(r > 0.9, P < 0.01). Bland-Altman analysis also demonstrated a good agreement between these two ***

关键词： Nonalcoholic fatty liver disease Magnetic resonance imaging Magnetic resonance spectroscopy Children and adolescents Hepatic steatosis

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R2^(*) value derived from multi-echo Dixon technique can aid discrimination between benign and malignant focal liver lesions

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World Journal of Gastroenterology 2021年第12期27卷 1182-1193页

作者： Guang-Zi Shi Hong Chen Wei-Ke Zeng Ming Gao Meng-Zhu Wang Hui-Ting Zhang Jun Shen Department of Radiology Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120Guangdong ProvinceChina mr scientific marketing Siemens HealthineersGuangzhou 510120Guangdong ProvinceChina

BACKGROUND R2^(*)estimation reflects the paramagnetism of the tumor tissue,which may be used to differentiate between benign and malignant liver lesions when contrast agents are *** To investigate whether R2^(*)derived from multi-echo Dixon imaging can aid differentiating benign from malignant focal liver lesions(FLLs)and the impact of 2D region of interest(2D-ROI)and volume of interest(VOI)on the *** We retrospectively enrolled 73 patients with 108 benign or malignant *** patients underwent conventional abdominal magnetic resonance imaging and multi-echo Dixon *** radiologists independently measured the mean R2^(*)values of lesions using 2D-ROI and VOI *** Bland-Altman plot was used to determine the interobserver agreement between R2^(*)*** correlation coefficient(ICC)was used to determine the reliability between the two *** R2^(*)values were compared between benign and malignant FFLs using the nonparametric Mann-Whitney *** operating characteristic curve analysis was used to determine the diagnostic performance of R2^(*)in differentiation between benign and malignant *** compared the diagnostic performance of R2^(*)measured by 2D-ROI and VOI *** This study included 30 benign and 78 malignant *** interobserver reproducibility of R2^(*)measurements was excellent for the 2D-ROI(ICC=0.994)and VOI(ICC=0.998)***-Altman analysis also demonstrated excellent *** R2^(*)was significantly higher for malignant than benign FFLs as measured by 2D-ROI(P<0.001)and VOI(P<0.001).The area under the curve(AUC)of R2^(*)measured by 2D-ROI was 0.884 at a cut-off of 25.2/s,with a sensitivity of 84.6%and specificity of 80.0%for differentiating benign from malignant FFLs.R2^(*)measured by VOI yielded an AUC of 0.875 at a cut-off of 26.7/s in distinguishing benign from malignant FFLs,with a sensitivity of 85.9%and specificity of 76.7%.The AUCs of R2^(*)were

关键词： R2^(*) Multi-echo Dixon imaging Hypoxia Malignant lesion Benign lesion Focal liver lesion

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Liver fat accumulation measured by high-speed T2-corrected multiecho magnetic resonance spectroscopy can predict risk of cholelithiasis

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World Journal of Gastroenterology 2020年第33期26卷 4996-5007页

作者： Hong Chen Wei-Ke Zeng Guang-Zi Shi Ming Gao Meng-Zhu Wang Jun Shen Department of Radiology Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120Guangdong ProvinceChina Department of mr scientific marketing Siemens HealthineersGuangzhou 510120Guangdong ProvinceChina

BACKGROUND Liver fat accumulation is associated with increased cholesterol synthesis and hypersecretion of biliary cholesterol,which may be related to the development of *** To investigate whether liver fat accumulation measured by high-speed T2-corrected multi-echo magnetic resonance spectroscopy(mrS)is a risk factor for *** Forty patients with cholelithiasis and thirty-one healthy controls were retrospectively *** participants underwent high-speed T2-corrected multi-echo single-voxel mrS of the liver at a 3T mr *** proton density fat fraction(PDFF)and R2 value were *** parameters and waist circumference(WC)were ***’s correlation analysis was used to analyze the relationship between PDFF,R2,and WC *** logistic regression analysis was carried out to determine the significant predictors of the risk of *** operating characteristic curve(ROC)analysis was used to evaluate the discriminative performance of significant *** Patients with cholelithiasis had higher PDFF,R2,and WC values compared with healthy controls(5.8%±4.2%vs 3.3%±2.4%,P=0.001;50.4±24.8/s vs 38.3±8.8/s,P=0.034;85.3±9.0 cm vs 81.0±6.9 cm,P=0.030;respectively).Liver iron concentration extrapolated from R2 values was significantly higher in the cholelithiasis group(2.21±2.17 mg/g dry tissue vs 1.22±0.49 mg/g dry tissue,P=0.034)than in the healthy *** was positively correlated with WC(r=0.502,PmrS can predict the risk o

关键词： Magnetic resonance spectroscopy Cholelithiasis Liver fat accumulation Steatosis Iron

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Magnetic Properties of Perovskite Manganite La_ (0.3)Ca_ (0.7)Mn_ (0.96)W_ (0.04)O_3 in Charge Ordering Phase

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Journal of Rare Earths 2005年第S1期23卷 251-254页

作者：彭振生郭焕银严国清毛强 mr Materials Research Laboratory Suzhou College Suzhou 234000 China Structure Research Laboratory University of Science and Technology of China Hefei 230026 China mr Materials Research Laboratory Suzhou College Suzhou 234000 China

The sample La_ 0.3Ca_ 0.7Mn_ 0.96W_ 0.04O_3 was prepared by the solid-state method. Magnetic properties of La_ 0.3Ca_ 0.7Mn_ 0.96W_ 0.04O_3 was studied through the measurement of M-T curve, M-H curves and ESR curves of the sample. The results show that: charge ordering (CO) phase forms at 265 K; the system exhibits paramagnetism when T>265 K; it exhibits long-range anti-ferromagnetism (there is a little FM component in AFM background) and the coexistence of a little FM phase and AFM/CO phase forms when T<225 K; the system transforms from paramagnetism to antiferromagnetism in charge-ordering state with temperature decreasing from 265 to 225 K. The width of ESR spectrum line of the sample La_ 0.3Ca_ 0.7Mn_ 0.96W_ 0.04O_3 was measured, and the value of the line width of paramagnetic resonance ΔH_ PP increases with temperature decreasing, which indicates that ferromagnetic connection of the sample strengthens with temperature decreasing.

关键词： manganite La_ 0.3Ca_ 0.7Mn_ 0.96W_ 0.04O_3 charge ordering electron paramagnetic resonance magnetic properties

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儿童颅内单发炎性肉芽肿的mr诊断

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中华儿科杂志 2006年第2期44卷 141-142页

作者：李滨李吉金银华刘光锐吉林化学集团总医院mr科 132022

本文对我院1999-2004年经手术病理、临床证实的6例儿童颅内单发炎性肉芽肿病例进行回顾性分析、总结,旨在探讨儿童颅内单发炎性肉芽肿的mr诊断及鉴别诊断。[第一段]

关键词：炎性肉芽肿 mr诊断单发颅内儿童回顾性分析手术病理鉴别诊断

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腹主动脉、髂动脉及下肢动脉的mr数字减影血管造影

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中华放射学杂志 1999年第3期33卷 197-200页

作者：金延方尹南贺聪高顺禹岳云龙北京铁路总医院mr室

目的探讨增强ＭＲ血管造影的方法，评价快速梯度回波序列增强ＭＲ数字减影血管造影对腹主动脉、髂动脉及下肢动脉病变的诊断价值。方法３６例临床疑有腹主动脉、髂动脉或下肢动脉疾病的病人进行增强３Ｄ快速梯度回波扫描（重复时间１２... 详细信息

目的探讨增强ＭＲ血管造影的方法，评价快速梯度回波序列增强ＭＲ数字减影血管造影对腹主动脉、髂动脉及下肢动脉病变的诊断价值。方法３６例临床疑有腹主动脉、髂动脉或下肢动脉疾病的病人进行增强３Ｄ快速梯度回波扫描（重复时间１２或２０毫秒、回波时间４或５毫秒、反转角６０°）。对比剂用量０．２ｍｍｏｌ／ｋｇ。原始图像先进行减影处理，再进行最大信号强度投影（ＭＩＰ）重建。结果所有３６例患者（包括６例正常）均满意地显示了感兴趣区的血管。其中，腹主动脉夹层动脉瘤４例，肾动脉狭窄２例，人工血管移植术３例，腹主动脉瘤２例，髂动静脉瘘１例，髂动脉及下肢动脉狭窄１８例。结论三维磁共振数字减影血管造影是腹部及外周血管成像可靠的、充满活力的方法。

关键词：磁共振血管造影 mrA 动脉造影心血管疾病

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mr诊断中枢神经细胞瘤

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中国医学影像技术 2009年第9期25卷 1557-1559页

作者：赵天平程敬亮张勇焦作市人民医院mr室河南焦作454002 郑州大学第一附属医院mr室河南郑州450052

目的探讨中枢神经细胞瘤的mrI特点及其诊断价值。方法回顾性分析经手术病理证实的中枢神经细胞瘤17例,男10例,女7例,年龄21～41岁,平均29.6岁。结果全部肿瘤均位于侧脑室透明隔、邻近Monro孔;mrT1WI呈等、低信号,T2WI呈不均匀高信号。... 详细信息

目的探讨中枢神经细胞瘤的mrI特点及其诊断价值。方法回顾性分析经手术病理证实的中枢神经细胞瘤17例,男10例,女7例,年龄21～41岁,平均29.6岁。结果全部肿瘤均位于侧脑室透明隔、邻近Monro孔;mrT1WI呈等、低信号,T2WI呈不均匀高信号。矢状位和冠状位T1WI及增强扫描图像上,9例可见由胼胝体和侧脑室顶呈网状或丝条状垂向下的瘤组织,轴位7例见瘤组织牵拉侵犯单侧或双侧脑室侧壁形成索条状影。所有肿瘤均伴多发囊变,部分瘤体内可见出血及血管流空征象。肿瘤在增强扫描中多呈较明显不均匀强化。结论中枢神经细胞瘤mrI表现有一定的特异性,有助于诊断。

关键词：中枢神经系统肿瘤磁共振成像诊断显像

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mr成像对比增强在肝脏疾病中的应用

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中国医学影像技术 1996年第3期12卷 220-224页

作者：刘纳北京宣武医院mr室

ＭＲ成像对比增强在肝脏疾病中的应用刘纳译李坤成校１弥漫性肝脏疾病以肝硬化，肝铁沉积症和脂肪浸润常见，铜沉积症，肝糖原贮积病，结节病和血管病（如：布－加氏综合征）少见。弥漫性肝脏疾病通常由生化或组织学检查发现，而影像技... 详细信息

ＭＲ成像对比增强在肝脏疾病中的应用刘纳译李坤成校１弥漫性肝脏疾病以肝硬化，肝铁沉积症和脂肪浸润常见，铜沉积症，肝糖原贮积病，结节病和血管病（如：布－加氏综合征）少见。弥漫性肝脏疾病通常由生化或组织学检查发现，而影像技术居于次要地位。放射学家最常面对的...

关键词：肝疾病 Nmr 成像

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应用mr全身扩散加权成像寻找转移瘤原发灶的初步研究

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中华放射学杂志 2008年第12期42卷 1279-1282页

作者：顾太富肖新兰尹建华赵海南昌大学第二附属医院mr室 330006

目的探讨mr全身扩散加权成像（DWI）寻找转移瘤患者原发灶的可行性和灵敏度。方法前瞻性分析34例以转移瘤症状就诊，经CT、单光子发射计算机体层成像或mrI发现不明原发灶的转移瘤患者进行全身DWI扫描，分别测量可疑原发灶和转移瘤的表... 详细信息

目的探讨mr全身扩散加权成像（DWI）寻找转移瘤患者原发灶的可行性和灵敏度。方法前瞻性分析34例以转移瘤症状就诊，经CT、单光子发射计算机体层成像或mrI发现不明原发灶的转移瘤患者进行全身DWI扫描，分别测量可疑原发灶和转移瘤的表观扩散系数（ADC）值。对经活检或手术病理证实的肺癌患者，应用配对t检验比较原发灶和转移瘤的ADC值。探讨全身DWI对原发灶的检出率和灵敏度。结果通过对34例转移瘤患者全身DWI扫描，发现可疑原发灶24例，其中23例被证实为原发恶性肿瘤，1例可疑原发灶穿刺为良性病变；10例经全身DWI扫描未发现明确原发灶，其中2例经活检明确原发灶，8例经随访6—12个月仍未明确原发灶。确诊的14例肺癌原发灶和转移瘤的平均ADC值分别为（1．24±0．18）×10^-3和（1．16±0．27）×10^-3mm^2／s，差异无统计学意义（t=1．28，P〉0．05）。全身DWI对原发灶的检出率为67．6％（23／34），灵敏度为92．0％（23／25）。结论全身DWI对转移瘤患者寻找原发灶的灵敏度高，可以作为寻找原发灶的筛查方法。

关键词：磁共振成像弥散肿瘤未知原发灶肿瘤转移

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Etiology and functional status of liver cirrhosis by ^(31)P mr spectroscopy

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World Journal of Gastroenterology 2005年第44期11卷 6926-6931页

作者： Monika Dezortova Pavel Taimr Antonin Skoch Julius Spicak Milan Hajek mr Unit Institute for Clinical and Experimental Medicine Prague Czech Republic Department of Hepatogastroenterology Institute for Clinical and Experimental Medicine

AIM: To assess the functional status and etiology of liver cirrhosis by quantitative 31p magnetic resonance spectroscopy (mrS).METHODS: A total of 80 patients with liver cirrhosis of different etiology and functional status described by Child-Pugh score were examined and compared to 11 healthy volunteers. mr examination was performed on a 1.5 T imager using a 1H/31P surface coil by the 2D chemical shift imaging *** concentrations of phosphomonoesters (PME),phosphodiesters (PDE), inorganic phosphate (Pi) and adenosine triphosphate (ATP) were ***: mrS changes reflected the degree of liver dysfunction in all the patients as well as in individual etiological groups. The most important change was a decrease of PDE. It was possible to distinguish alcoholic,viral and cholestatic etiologies based on mr *** and viral etiology differed in PDE (alcoholic,viral, controls: 6.5±2.3, 6.5±3.1, 10.8±2.7 mmol/L,P＜0.001) and ATP (alcoholic, viral, controls: 2.9±0.8, 2.8±0.9, 3.7±1.0 mmol/L, P＜0.01) from the control *** viral etiology, patients with alcoholic etiology also differed in Pi (alcoholic, controls: 1.2±0.4, 1.6±0.6mmol/L, P＜0.05) from controls. No significant changes were found in patients with cholestatic disease and controls; nevertheless, this group differed from both alcoholic and viral groups (cholestatic, alcoholic, viral: 9.4±2.7, 6.5±2.3, 6.5±3.1 mmol/L, P＜0.005) in ***: 31p mrS can significantly help in noninvasive separation of different etiological groups leading to liver cirrhosis. In addition, mrS changes reflect functional liver injury.

关键词： Liver cirrhosis ^ 31p mr spectroscopy Absolute concentration Child-Pugh score Etiology

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