检索结果-南通市图书馆

Neural Regeneration Research 2012年第32期7卷 2554-2559页

作者： Prasanna Ghimire mr room Zhongnan Hospital of Wuhan University

1H magnetic resonance spectroscopy and diffusion weighted imaging features of the cerebellar vermis in 17 medulloblastoma patients were retrospectively analyzed, and 17 healthy volunteers were selected as controls. 1H magnetic resonance spectroscopy showed that in all 17 medulloblastoma patients, N-acetyl aspartate and creatine peaks were significantly decreased, the choline peak was significantly increased, and there was evidence of a myo-inositol peak. Further, 11 patients showed a low taurine peak at 3.4 ppm, five patients showed a lipid peak at 0.9-1.3 ppm, and three patients showed a negative lactic acid peak at 1.33 ppm. Compared with the control group, the ratios of N-acetyl aspartate/choline and N-acetyl aspartate/creatine were significantly decreased, and the ratio of choline/creatine was increased, in medulloblastoma patients. Diffusion weighted imaging displayed hyperintensity and decreased apparent diffusion coefficient in medulloblastoma patients. These findings indicate that 1H magnetic resonance spectroscopy and diffusion weighted imaging are useful for qualitative diagnosis of medulloblastoma.

关键词： medulloblastoma proton magnetic resonance spectroscopy diffusion weighted imaging apparent diffusion coefficient N-acetyl aspartate choline creatine taurine lactic acid myo-inositol

7.0T nuclear magnetic resonance evaluation of the amyloid beta(1–40) animal model of Alzheimer's disease: comparison of cytology verification

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2014年第4期9卷 430-435页

作者： Lei Zhang Shuai Dong Guixiang Zhao Yu Ma mr Neuroradiology room Beijing Tiantan Hospital Affiliated to Capital Medical University Department of Neurology Sixth People’s Hospital of Jinan Department of Rehabilitation Medicine Sixth People’s Hospital of Jinan Tsinghua University Yuquan Hospital

3.0T magnetic resonance spectroscopic imaging brain function in Alzheimer＇s disease. However, is a commonly used method in the research ot the role of 7.0T high-field magnetic resonance spectroscopic imaging in brain function of Alzheimer＇s disease remains unclear. In this study, 7.0T magnetic resonance spectroscopy showed that in the hippocampus of Alzheimer＇s disease rats, the N-acetylaspartate wave crest was reduced, and the creatine and choline wave crest was elevated. This finding was further supported by hematoxylin-eosin staining, which showed a loss of hippocampal neurons and more glial cells. Moreover, electron microscopy showed neuronal shrinkage and mitochondrial rupture, and scanning electron microscopy revealed small size hippocampal synaptic vesicles, incomplete synaptic structure, and reduced number. Overall, the results revealed that 7.0T high-field nuclear magnetic resonance spectroscopy detected the lesions and functional changes in hippocampal neurons of Alzheimer＇s disease rats in vivo, allowing the possibility for assessing the success rate and grading of the amyloid beta （1-40） animal model of Alzheimer＇s disease.

关键词： nerve regeneration Alzheimer's disease Aβ1-40 high-field functional magnetic resonance nuclear magnetic resonance spectroscopy neuropathology N-acetylaspartate creatine choline hippocampus NSFC grant neural regeneration

Circular RNA circFOXM1 triggers the tumorigenesis of non-small cell lung cancer through miR-132-3p/TMEM14A axis

在线全文

学校读者我要写书评

暂无评论

BIOCELL 2021年第4期45卷 901-910页

作者： WEIGAO ZHONG AIQIN CHEN XIAOHONG TANG YI LIU Department of Respiratory Sichuan Mianyang 404 HospitalMianyang621000China Department of Electrocardiogram room Wuxi Puren MedicalGroupWuxi214000China

Farlier studies indicated that circular RNAs(circRNAs)were found in various cancer clls,and circFOXM1 was reported to act as an oncogane in non-small cell lung cancer(NSCLC).However,the function of circFOXM1 in NSCLC remains *** epression lewels of genes were measured using quantative real-time polymerase chain reactions(qRT-PCR).Cell prolferation and apoptosis were determined by 3-(4,5 dimethylthiazol-2-yl)-25 dipbenyletrazolium bromide solution(MTT)and flow cytometry *** rdative protein expression was assed by westen blot Moreower,transwell assays were employed to examine ell migration and *** targeted relationship was confirmed by dual-luciferase reporter *** expression of circFOXMI was up-regulated in NSCIC tissues and cell *** depletion of circFOXM1 decreased the prolferation,migration,invasion,and induced cell apoptosis of NSCLC ***-132-3p(MiR-1323p)was idenified as a target of *** expression level of miR-132-3p was decrased in NSCLC tssues and cell lines and inversely corrdated with circFOXM1 ***,the efects of drdOXMl down regulation on NSCLC cell progression were abolished by mr-1323p *** protein 14A(TMEM14A)was verifed as a target gene of *** efects of circFOXM1 depletion on NSCLC cell proliferation,apoptosis,migration,and invasion were reversed by TMEMI4A *** study demonstrated that knodkdown of circFOXM1 suppressed NSCLC progression through rqgulating miR-132-3p/TMEMI4A axis,sugesting the drFOXM/miR-132-3p/TMEM14A axis may serve as the novd target for NSCLC diagnosis and therapy.

关键词： circFOXM1 miR-132-3p TMEM14A Non-small cell lung cancer Proliferation

胰腺实性假乳头状瘤与非功能性神经内分泌肿瘤的多层螺旋CT鉴别诊断

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

国际医学放射学杂志 2019年第3期42卷 279-284页

作者：赵莹佳殷小平闫旭新王谦刘洋周志强河北大学保定071000 河北大学附属医院CT/mr室保定市第一中心医院CT/mr室保定市第二医院CT/mr室

目的分析胰腺实性假乳头状瘤(SPTP)与非功能性胰腺神经内分泌肿瘤(NFPNET)的多层螺旋CT表现,探讨多层螺旋CT对两者的鉴别诊断价值。方法收集2013年5月—2018年8月术后经病理确诊的22例SPTP病人[男4例,女18例;年龄15～51岁,平均(31.5±10... 详细信息

目的分析胰腺实性假乳头状瘤(SPTP)与非功能性胰腺神经内分泌肿瘤(NFPNET)的多层螺旋CT表现,探讨多层螺旋CT对两者的鉴别诊断价值。方法收集2013年5月—2018年8月术后经病理确诊的22例SPTP病人[男4例,女18例;年龄15～51岁,平均(31.5±10.1)岁]及12例NFPNET病人[男4例,女8例;年龄49～79岁,平均(56.8±14.2)岁],术前均行CT腹部平扫和增强扫描。采用Fisher确切概率法对2组的病灶位置、密度、钙化、钙化位置、边界、强化峰值出现时相、环形强化、导管扩张及远处转移进行比较,采用独立样本t检验对2组的病灶长径、强化幅度进行比较。结果 NFPNET组发病年龄[(56.8±14.2)岁]高于SPTP组[(31.5±10.1)岁](t=-5.454,P=0.001)。2组的边界、有无钙化、强化峰值出现时相、强化幅度、有无远处转移间差异均有统计学意义(均P0.05)。结论多层螺旋CT检查对胰腺实性假乳头状瘤及非功能性神经内分泌肿瘤具有鉴别诊断价值。

关键词：乳头状瘤神经内分泌肿瘤体层摄影术,X线计算机诊断,鉴别

The molecular mechanisms that underlie neural network assembly

在线全文

学校读者我要写书评

暂无评论

Medical Review 2022年第3期2卷 244-250页

作者： Bing Ye Life Sciences Institute and Department of Cell and Developmental Biology University of Michigan210 Washtenaw AvenueRoom 5403Ann ArborMI 48109USA

Neural networks are groups of interconnected neurons,which collectively give rise to emergent neural activities and functions that cannot be explained by the activity of single *** neural networks are assembled is poorly *** all aspects of neuronal development are essential for the assembly of a functional neural network,we know little about high-level principles that govern neural network assembly beyond the basic steps of neuronal *** this review,I use vertebrate spinal motor columns,Drosophila larval motor circuit,and the lamination in the vertebrate inner retina to highlight the spatial codes,temporal codes,and cell adhesion codes for neural network ***,these examples only show preliminary connections between neural network development and their *** needs to be done to understand the molecular mechanisms that underlie the assembly of functional neural networks.

关键词： assembly development molecular mechanism neural network

膝关节半月板损伤的mrI分级分类及临床应用

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

安徽卫生职业技术学院学报 2020年第1期19卷 43-44页

作者：张新民曹结水望江县医院CT/mr室

目的:探讨磁共振成像在膝关节半月板损伤中分级、分型及临床价值。方法:搜集某院180例膝关节损伤患者的mrI检查资料,对mrI征象的特征进行分析,进行分级及分型。结果:正常(0级)15例,Ⅰ级22例,Ⅱ级55例,Ⅲ级88例。Ⅲ级撕裂中水平撕裂18例(... 详细信息

目的:探讨磁共振成像在膝关节半月板损伤中分级、分型及临床价值。方法:搜集某院180例膝关节损伤患者的mrI检查资料,对mrI征象的特征进行分析,进行分级及分型。结果:正常(0级)15例,Ⅰ级22例,Ⅱ级55例,Ⅲ级88例。Ⅲ级撕裂中水平撕裂18例(20.5%),垂直撕裂12例(13.6%),斜行撕裂30例(34.1%),复合型撕裂28例(31.8%)。结论:mrI作为一种无创性检查,对半月板损伤进行分级、分型,为临床医生治疗方案的制定、治疗效果的预测与评估提供极大价值,是临床医生目前首选的检查方法。

关键词：核磁共振成像半月板分类撕裂

十二指肠乳头旁憩室综合征影像学表现及分型的临床价值

在线全文

学校读者我要写书评

暂无评论

中国全科医学 2021年第S1期24卷 156-157页

作者：夏连仁甄光高星曹强熊建国河南省信阳市中心医院影像科CT/mr室 464000

目的分析十二指肠乳头旁憩室综合征的影像学表现、分型,探讨多层螺旋CT在该病诊断中的临床价值。方法选出本院2019年10月—2020年10月诊治的40例十二指肠乳头旁憩室综合征患者为研究对象,均对其行多层螺旋CT检查,分析其影像学表现以及... 详细信息

目的分析十二指肠乳头旁憩室综合征的影像学表现、分型,探讨多层螺旋CT在该病诊断中的临床价值。方法选出本院2019年10月—2020年10月诊治的40例十二指肠乳头旁憩室综合征患者为研究对象,均对其行多层螺旋CT检查,分析其影像学表现以及分型与分级的检查情况。结果共检出十二指肠乳头旁憩室47个,其中33例为单发憩室,7例为多发憩室。影像学表现主要为十二指肠内侧壁向腔外隆起的囊袋状病灶,薄层面可见病灶和十二指肠腔连通的窄小颈部,17例囊腔中含有气液平面;增强扫描17例憩室壁出现轻中度强化,憩室形态、大小不一。憩室分型中,中心型28例,周围型12例,合并胆管扩张38例,胆管结石16例,胆囊炎10例,胆囊结石9例。憩室分级中,I型19例,II型11例,III型6例,IV型4例。结论多层螺旋CT在十二指肠乳头旁憩室综合征诊断中的应用价值高,影像学表现具有一定的典型性;十二指肠乳头旁憩室综合征的分型与分级可指导临床治疗方案的制定,对提高该病的治疗效果具有显著意义。

关键词：十二指肠乳头旁憩室综合征多层螺旋CT 影像学表现分型诊断价值

双参数3D-ASL在单侧大脑中动脉慢性闭塞的侧支循环评估中的应用价值分析

在线全文

学校读者我要写书评

暂无评论

中华神经医学杂志 2018年第6期17卷 605-609页

作者：叶天涛陈锋张光辉李忠维王爱杰梁辉唐剑华张国伟烟台山医院CT/mr室烟台264001 烟台山医院神经内科烟台264001

目的探讨双参数3D动脉自旋标记灌注成像（3D-ASL）在单侧大脑中动脉（MCA）慢性闭塞患者的侧支循环评估中的应用价值。方法采用3．0Tmrj扫描仪，对烟台山医院神经内科自2015年5月至2017年11月收治的24例单侧MCA慢性闭塞患者行mrI常规序... 详细信息

目的探讨双参数3D动脉自旋标记灌注成像（3D-ASL）在单侧大脑中动脉（MCA）慢性闭塞患者的侧支循环评估中的应用价值。方法采用3．0Tmrj扫描仪，对烟台山医院神经内科自2015年5月至2017年11月收治的24例单侧MCA慢性闭塞患者行mrI常规序列、弥散加权成像（DWI）、三维时间飞跃法mrI血管成像（***）及***[标记后延迟时间（PLD）分别采用1．5s、2．5s]检查，测量MCA闭塞侧皮层区感兴趣区及对侧正常脑组织脑血流量（Ct3V）值，并采用统计学方法分析3D-ASL（PLD=I．5s1与3D-ASL（PLD=2．5s）测量的CBF值的差异。结果在24例单侧MCA慢性闭塞患者中，***（PLD=1．5s）均显示MCA闭塞侧供血区呈明显低灌注．而3D-ASL（PLD=2．5s、显示两侧大脑半球MCA供血区脑灌注基本一致，未见明显低灌注。3D-ASL（PLD2．5x-PLD1．5s）减影图像显示MCA闭塞侧皮层区存在片状高信号区。3D-ASL（PLD=2．5s）与3D-ASL（PLD=1.5s）测量的对侧正常脑组织的CBF值[（56．39±5．01）mL／（100g·min）vs．（55．87±6．89）mL／000g·min）]差异无统计学意义（胗0．05）；3D-ASL（PLD=1．5s）测量的MCA闭塞侧皮层区感兴趣区的CBF值[（23．34±4．53）mL／000g·min）]较对侧正常脑组织[（55．87±6．89）mL／000g·min）]明显降低，差异有统计学意义（P〈0．05）；3D-ASL（PLD=2．5s）测量的MCA闭塞侧皮层区感兴趣区的CBF值[（53．93±8．59）mE／（100g·min）]较3D-ASL（PLD=1．5s）[（23．34±4．53）mL／000g·min）]明显升高，差异有统计学意义（P〈0．05），但其与3D-ASL（PLD=2．5s）测量的对侧正常脑组织的CBF值比较差异无统计学意义（P〉0．05）。结论3D-ASL采用PLD=1.5s与PLD=2．5S成像能够无创、直观地评估单侧MCA慢性闭塞患者的侧支循环，其中3D-ASL（PLD=1.5s）能够反映出患者建立了一级侧支循环代偿，3D-ASL（PLD=2．5s）能够准确反映患者建立了二级侧支循环代偿。

关键词： 3D动脉自旋标记灌注成像大脑中动脉慢性闭塞侧支循环标记后延迟时间

mr弥散张量成像及弥散张量纤维束示踪成像在不同级别脑胶质瘤诊断中的应用

在线全文

学校读者我要写书评

暂无评论

影像科学与光化学 2021年第5期39卷 663-666页

作者：万正国贾雯孙源源吕晓清孟凯龙邯郸市第一医院CT、mr室河北邯郸056000 河北工程大学临床医学院河北邯郸056000

本文探讨不同级别脑胶质瘤诊断中应用mr弥散张量成像(DTI)及弥散张量纤维束示踪成像(DTT)的价值。选取脑胶质瘤患者84例,比较低级别和高级别脑胶质瘤DTI、DTT参数差异。实验结果显示:高级别瘤周白质纤维束破坏比例明显高于低级别(P<0.0... 详细信息

本文探讨不同级别脑胶质瘤诊断中应用mr弥散张量成像(DTI)及弥散张量纤维束示踪成像(DTT)的价值。选取脑胶质瘤患者84例,比较低级别和高级别脑胶质瘤DTI、DTT参数差异。实验结果显示:高级别瘤周白质纤维束破坏比例明显高于低级别(P<0.05);高级别病灶实质区部分各向异性(FA)值明显高于低级别脑胶质瘤(P<0.05),而表观扩散系数(ADC)值明显低于低级别(P<0.05);高级别瘤周水肿区纤维密度指数(FDi)值明显低于低级别(P<0.05);瘤周白质纤维束破坏,病灶实质区FA值和ADC值,瘤周水肿区FDi值鉴别诊断高级别脑胶质瘤的ROC曲线下面积分别为0.857、0.877、0.965和0.828(P<0.05)。研究证实:同级别脑胶质瘤中,DTI及DTT参数有所差异,在鉴别诊断中有一定应用价值。

关键词： mr弥散张量成像弥散张量纤维束示踪成像脑胶质瘤诊断价值

Arylazopyrazole-functionalized photoswitchable octanuclear Zn(Ⅱ)-silsesquioxane nanocage

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2021年第3期64卷 419-425页

作者： Kai Sheng Ya-Nan Liu Rakesh Kumar Gupta Mohamedally Kurmoo Di Sun School of Aeronautics Shandong Jiaotong UniversityJi'nan 250037China School of Chemistry and Chemical Engineering State Key Laboratory of Crystal MaterialsShandong UniversityJi'nan 250100China Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology School of Chemistry and Chemical Engineering厶iaocheng UniversityLiaocheng 252000China Institut de Chimie de Strasbourg Universite de StrasbourgCNRS-L/MR 71774 rue Blaise PascalStrasbourg Cedex 67008France

Photoswitchable organic materials have shown significant advancement for photonic applications,however,the polynuclear metal clusters conjugated with photoswitching properties are still ***,a novel octanuclear Zn(Ⅱ) nanocage{[Zn_(8)-(Me_(4)Si_(4)O_(8))_(2)(azopz)_(8)]·4CH_(2)Cl_(2)·MeOH·MeCN}(SD/Zn8)(Hazopz=3,5-dimethyl-4-(phenyldiazenyl)-1H-pyrazole),based on multidentate silsesquioxane and pyrazole modified by photoisomerizable azo group has been designed and synthesized to realize the reversible photoswitching behavior.X-ray crystallographic study reveals that the unique metal core consists of two annular Me_(4)Si_(4)O_(8)^(4-)sandwiching a ring of eight Zn atoms where the pyrazole end of azopz-bridges them *** azopz-ligands diverge above and below the plane defined by eight Zn ***,SD/Zn8 shows quick trans-to-cis transformation upon 365 nm light irradiation,which can be easily changed back by 450 nm light,but slow cis-to-trans reversibility at room temperature as confirmed by UV-V is and 1H Nmr *** process,which presumably regulates the spaces,acts like a pump and is completely *** such,it can be considered as a molecular pump energized by ***,the molecule is an energy reservoir where it absorbs the light energy and releases it slowly with time.

关键词： silsesquioxane metal-organic nanocage photochromism X-ray single-crystal structure