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Physiopathology of ischemic stroke and its modulation using memantine:evidence from preclinical stroke

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Neural Regeneration Research 2021年第3期16卷 433-439页

作者： Hilda martínez-Coria Isabel Arrieta-Cruz maría-Esther Cruz Héctor E.López-Valdés División de Investigación Facultad de MedicinaUniversidad Nacional Autónoma de México(UNAM)Ciudad de MéxicoMéxico Laboratorio Experimental de Enfermedades Neurodegenerativas Facultad de MedicinaUNAM/Instituto Nacional de Neurología y NeurocirugíaCiudad de MéxicoMéxico Departamento de Investigación Básica Instituto Nacional de GeriatríaCiudad de MéxicoMéxico Unidad de Investigación en Biología de la Reproducción Laboratorio de NeuroendocrinologíaFacultad de Estudios Superiores ZaragozaUNAMCiudad de MéxicoMéxico Unidad Periférica de Neurociencia Facultad de MedicinaUNAM/Instituto Nacional de Neurología y NeurocirugíaCiudad de MéxicoMéxico

Ischemic stroke is the most common type of cerebrovascular disease and is caused by an interruption of blood flow in the *** this disease,two different damage areas are identifying:the lesion core,in which cells quickly die;and the penumbra(surrounding the lesion core),in which cells are functionally weakened but may recover and restore their *** currently approved treatments for ischemic stroke are the recombinant tissue plasminogen activator and endovascular thrombectomy,but they have a short therapeutic window(4.5 and 6 hours after stroke onset,respectively)and a low percentage of stroke patients actually receive these *** is an approved drug for the treatment of Alzheimer's *** is a noncompetitive,low affinity and use-dependent antagonist of N-methyl-D-aspartate glutamate *** has several advantages over developing a new drug to treat focal ischemic stroke,but the most important is that it has sufficient safe probes in preclinical models and humans,and if the preclinical studies provide more evidence about pharmacological actions in tissue protection and repair,this could help to increase the number of clinical *** present review summarizes the physiopathology of isquemic stroke and the pharmacological actions in neuroprotection and neuroplasticity of memantine in the post stroke stage of preclinical stroke models,to illustrate their potential to improve functional recovery in human patients.

关键词： focal ischemic stroke memantine neuroplasticity neuroprotection stroke therapy

Organorhenium(Ⅶ) oxides

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Rare metals 2006年第z1期25卷 411-421页

作者： KüHN Fritz E. JAIN Kavita R. Department für Chemie der Technischen Universitt münchen Lichtenbergstrasse 4 D-85747 Garching bei München Germany

methyltrioxorhenium (mTO) and its derivatives were utilized as catalysts for a broad variety of organic reactions after the discovery of an easy synthetic access way to this class of compounds. Among the numerous characterization techniques, 17O-NmR spectroscopy and vibrational spectroscopy were exemplary discussed. The immobilization of mTO and its derivatives is of significant current interest as is the synthesis of chiral derivatives.

关键词： catalysis epoxidation immobilization olefination rhenium

Unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neuropathology and behavioral deficits in parkinsonian rats withα-synucleinopathy

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Neural Regeneration Research 2024年第9期19卷 2057-2067页

作者： Bismark Gatica-Garcia michael J.Bannon Irma Alicia martínez-Dávila Luis O.Soto-Rojas David Reyes-Corona Lourdes Escobedo minerva maldonado-Berny mE Gutierrez-Castillo Armando J.Espadas-Alvarez manuel A.Fernandez-Parrilla Juan U.mascotte-Cruz CP Rodríguez-Oviedo Irais E.Valenzuela-Arzeta Claudia Luna-Herrera Francisco E.Lopez-Salas Jaime Santoyo-Salazar Daniel martinez-Fong Departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Department of Pharmacology Wayne State University School of MedicineDetroitMIUSA Laboratorio de Patogénesis molecular Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Red de medicina para la Educación y Desarrollo y la Investigación Científica de Iztacala(Red mEDICI) Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Nanoparticle Therapy Institute AguascalientesMéxico Departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Escuela Nacional de medicina y Homeopatía Instituto Politécnico NacionalCiudad de MéxicoMéxico Departamento de Fisiología Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCiudad de MéxicoMéxico Departamento de Biología molecular y Biotecnología Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoMéxico Departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa de Nanociencias y Nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Parkinsonism by unilateral,intranigralβ-sitosterolβ-D-glucoside administration in rats is distinguished in that theα-synuclein insult begins unilaterally but spreads bilaterally and increases in severity over time,thus replicating several clinical features of Parkinson’s disease,a typicalα-*** Nurr1 repressesα-synuclein,we evaluated whether unilateral transfected of rNurr1-V5 transgene via neurotensin-polyplex to the substantia nigra on day 30 after unilateralβ-sitosterolβ-D-glucoside lesion could affect bilateral neuropathology and sensorimotor deficits on day 30 *** study found that rNurr1-V5 expression but not that of the green fluorescent protein(the negative control)reducedβ-sitosterolβ-D-glucoside-induced ***,a bilateral increase in tyrosine hydroxylase-positive cells and arborization occurred in the substantia nigra and increased tyrosine hydroxylase-positive ramifications in the *** addition,tyrosine hydroxylase-positive cells displayed less senescence markerβ-galactosidase and more neuron-cytoskeleton markerβIII-tubulin and brain-derived neurotrophic factor.A significant decrease in activated microglia(positive to ionized calcium-binding adaptor molecule 1)and neurotoxic astrocytes(positive to glial fibrillary acidic protein and complement component 3)and increased neurotrophic astrocytes(positive to glial fibrillary acidic protein and S100 calcium-binding protein A10)also occurred in the substantia *** effects followed the bilateral reduction inα-synuclein aggregates in the nigrostriatal system,improving sensorimotor *** results show that unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neurodegeneration(senescence and loss of neuron-cytoskeleton and tyrosine hydroxylase-positive cells),neuroinflammation(activated microglia,neurotoxic astrocytes),α-synuclein aggregation,and sensorimotor *** neurotrophic astrocytes and

关键词： A1 astrocytes A2 astrocytes gene therapy microglia motor deficits nanoparticles neurodegeneration neuroinflammation senescence α-synuclein aggregates

Benchmarking the ARPU and Productivity of Some Biggest Telecom Operators

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China Communications 2009年第1期6卷 104-108页

作者： Thorleif Herrstrm Gunnarsson & Herrstrm HB Sweden

This study is based on 15 of the biggest telecom operators globally. It focuses on two very simple measures, ARPU and Customers per Employee. The ARPU is a measure of the wealth of the specific context of the operation. While the Customers per Employee represents the productivity of the operator. Through a benchmark analysis, it shows that no one of the big operators has the ability to have both high ARPU and high productivity. The operators acting in high ARPU markets and with high ARPU market positioning seam to get "fat and lazy", while operators that have chosen markets with low GDP/capita and thus low expected ARPU are forced to be productive. The Chinese and Indian operators are characterized by "the big home market syndrome" with both low ARPU and low productivity. But the economy of scale fertilizes their profits. The African operators have very high productivities to accommodate themselves in very low-ARPU circumstances. Further, the research points out it is more possible for the operators in the "south-east" corner to enter the "north-west" corner through acquisition.

关键词： ARPU productivity benchmarking

Effect of rotation in generalized thermoelastic solid under the influence of gravity with an overlying infinite thermoelastic fluid

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Applied mathematics and mechanics(English Edition) 2009年第12期30卷 1505-1518页

作者： Praveen Ailawalia Naib Singh Narah Department of mathematics M.M. Engineering CollegeMaharishi Markandeshwar University Department of mathematics D.A.V. College

The present problem is concerned with the study of deformation of a rotating generalized thermoelastic solid with an overlying infinite thermoelastic fluid due to different forces acting along the interface under the influence of *** components of displacement,force stress,and temperature distribution are first obtained in Laplace and Fourier domains by applying integral transforms,and then obtained in the physical domain by applying a numerical inversion *** particular cases are also discussed in the context of the *** results are also presented graphically to show the effect of rotation and gravity in the medium.

关键词： rotation gravity generalized thermoelasticity thermoelastic fluid Laplaceand Fourier transforms temperature distribution

Polygeneration Study of Low-to-medium Enthalpy Geothermal Reservoirs in mexico

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Journal of Thermal Science 2021年第3期30卷 1077-1087页

作者： CHÁVEZ Oscar GODÍNEZ Francisco Tecnológico Nacional de méxico/I.T.Chihuahua.Av.Tecnológico 2909 C.P.31310ChihuahuaChihuahuaMéxico Instituto de Ingeniería Universidad Nacional Autónoma de MéxicoUNAMC.U.Ciudad de MéxicoC.P.04510México Polo Universitario de Tecnología Avanzada Universidad Nacional Autónoma de MéxicoVía de la Innovación No.410Autopista Monterrey-Aeropuertokm.10 PIITC.P.66629Apodaca Nuevo LeónMéxico

This study combines the thermodynamic analysis of a polygeneration system along with the numerical modelling of the thermal behavior of geothermal reservoirs in mexico to exploit their *** reservoir was modeled as a porous medium assuming a five-spot well configuration and local thermal *** heat conduction-convection along with the Laplace equations were solved to compute temperature distributions,the useful life and the optimum distance between injection-extraction *** predicted temperature and pressure of the geothermal fluid at the outlet of the reservoir were exploited in the polygeneration system consisting of:(1)a Rankine cycle,(2)an absorption refrigeration cycle,and(3)a heat *** developed approach allows calculating both the optimal distance between injection-extraction wells and the global(utilization)efficiency of six arrangements(each composed by a reservoir connected to a polygeneration system)by assuming that reservoirs have a lifespan of 30 *** also show that:(a)due to the low efficiency of the Rankine cycle,very little thermal energy is converted into electrical one;(b)not only the temperature and the size are important when evaluating the power production performance of reservoirs,but also the permeability plays a fundamental role;(c)the first law efficiency of the polygeneration system ranges from 41.9%to 43.7%;(d)the utilization efficiency of the six arrangements lies in the range between 25.8%and 31%.

关键词： polygeneration system geothermal reservoir local thermal equilibrium low-to-medium enthalpy

An online impedance adaptation controller for decoding skill intelligence

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Biomimetic Intelligence & Robotics 2023年第2期3卷 16-29页

作者： Xiaofeng Xiong Cheng Fang SDU Biorobotics the Mærsk Mc-Kinney MØller Institutethe University of Southern DenmarkOdense 5230Denmark SDU Robotics the Mærsk Mc-Kinney MØller Institutethe University of Southern DenmarkOdense 5230Denmark

Variable Impedance control allows robots and humans to safely and efficiently interact with unknown external *** tutorial introduces online impedance adaptation control(OIAC)for variable compliant joint motions in a range of control tasks:rapid(movement control(i.e.,whipping to hit),arm and finger impedance quantification,multifunctional exoskeleton control,and robot-inspired human arm control *** OIAC has been introduced as a feedback control,which can be integrated into a feedforward control,e.g.,learned by data-driven *** integration facilitates the understanding of human and robot arm control,closing a research loop between biomechanics and *** shows not only a research way from biomechanics to robotics,but also another reserved *** tutorial aims at presenting research examples and Python codes for advancing the understanding of variable impedance adaptation in human and robot motor *** contributes to the state-of-the-art by providing an online impedance adaptation controller for wearable robots(i.e.,exoskeletons)which can be used in robotic and biomechanical applications.

关键词： Variable impedance control Wearable robots motor control Deformable object manipulation

Effect of inductively coupled plasma surface treatment on silica gel and mesoporous mCm-41 particles

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Plasma Science and Technology 2018年第6期20卷 104-113页

作者： J A JUAREZ-mORENO U CHACON-ARGAEZ J BARRON-ZAmBRANO C CARRERA-FIGUEIRAS P QUINTANA-OWEN W TALAVERA-PECH Y PEREZ-PADILLA A AVILA-ORTEGA facultad de ingeniería química-uady periférico norte kilómetro 33.5col.chuburna de hidalgo inn C.P. 97203 Mérida Yucatan México centro de investigación y de estudios avanzados del ipn-unidad mérida km.6 antigua carretera a progreso apdo. Postal 73 Cordemex 97310 Méfida Yucatán México

Silica gel and mCm-41 synthesized mesoporous materials were treated with either oxygen（O_2）,hexamethyldisiloxane（HmDSO） and organic vapors like ethanol（Et OH）,and acrylonitrile（AN）inductive *** radiofrequency power for the modification was fixed to 120 W and30 min,assuring a high degree of organic ionization energy in the *** surface properties were studied by infrared spectroscopy（FTIR）,scanning electron microscopy,x-ray photoelectron spectroscopy and dynamic light scattering technique was used for characterizing size *** the silica and mCm-41 particles were modified by AN and HmDSO plasma gases,the surface morphology of the particles was changed,presenting another color,size or *** contrast,the treatments of oxygen and Et OH did not affect the surface morphology of both particles,but increased the oxygen content at the surface bigger than the AN and HmDSO plasma *** this study,we investigated the influence of different plasma treatments on changes in morphology and the chemical composition of the modified particles which render them a possible new adsorbent for utilization in sorptive extraction techniques for polar compounds.

关键词： silica mCm-41 nanoparticles plasma treatment

Geothermal structure of the eastern Black Sea basin and the eastern Pontides orogenic belt:Implications for subduction polarity of Tethys oceanic lithosphere

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Geoscience Frontiers 2013年第4期4卷 389-398页

作者： Nafiz maden Department of Geophysics Gmshane University

The numerical results of thermal modeling studies indicate that the lithosphere is cold and strong beneath the Black Sea basin. The thermal litbospheric thickness increases southward fiom the eastern Pontides orogenic belt （49.4 kin） to Black Sea basin （152.2 kin）. The moho temperature increases from 367 C in the trench to 978 C in the arc region. The heat flow values for the moho surface change between 16.4 mW m 2 in the Black Sea basin and 56.9 mW m 2 in the eastern Pontides orogenic belt. Along the southern Black Sea coast, the trench region has a relatively low geothermal potential with respect to the arc and back-arc region. The numerical studies support the existence of southward sub- duction beneath the Pontides during the late mesozoic-Cenozoic.

关键词： Eastern Black Sea basinEastern PontidesHeat flowLithospheric thicknessGeodynamic evolutionSubduction polarity