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Incense smoke(IS)inhalation exposure system:Physicochemical characterization,IS particle deposition and clearance in human airway using MPPD model

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Particuology 2024年第4期87卷 271-285页

作者： Vyas Kumar Hafsa Hashmi Anshita Nasreen Ghazi Ansari Jyotsna Singh Inhalation Toxicology Facility Regulatory Toxicology GroupCSR-Indian Institute of Toxicology ResearchLucknow22001UPIndi Academy of Scientific and Innovative Research(AcsSIR) Ghaziabad201002UPIndia Analytical Chemistry Regulatory Toxicology GroupCSIR-Indian Institute of Toxicology ResearchLucknow226001UPIndia

Incense smoke(IS)is source of indoor air pollution and key risk for diverse human *** in-formation is available regarding controlled IS rodent inhalation exposure system and IS particulate matter(PM)deposition in human *** aimed to demonstrate stable ISPM physicochemical parameters of 10 incense products inside the customized whole body inhalation exposure chamber(without animal)connected to smoke generation unit via aerosol mixing *** analyzed for size segregated PM emission,ISPM in vitro aerodynamics(MMAD and GSD determination),fine and ultrafine particle's SEM,SEM-EDX and PAH *** real life exposure scenario by utilizing MMAD,GSD and PM concentration after Tier 1 exposure assessment as key input parameters,ISPM dosimetry in infant(3 months)and adult(21 years male and female)human airways was calculated using multiple-path particle dosimetry(MPPD 3.04)*** median aerodynamic diameter(MMAD)and geo-metric standard deviation(GSD)ranged between 0.55 and 2.10μm and 1.22 to 1.77(polydisperse)***1.0 and PM0.1 showed multiple morphology and presence of heavy and trace *** like acenaphthylene,anthracene,fluorene,naphthalene and phenanthrene were detected(0.84-143.17μg/g).MPPD results showed higher ISPM deposition in pulmonary region and lowest in trachea bronchial *** deposition in tissue was higher in lower,peripheral lung as compared to upper and central lung *** body inhalation exposure system showed stable IS atmosphere(physi-cochemical parameters)indicating the device suitability in future inhalation *** ISPM deposition fraction and clearance data showed deep lung penetrating and retention behavior with higher risk in infant followed by female and then *** modeled particle deposition and clearance data may be useful in risk assessment analysis of IS.

关键词： Inhalation Incense smoke Multiple-path particle dosimetry(MPPD) Particle deposition Particulate matter(PM) Mass median aerodynamic diameter (MMAD) Human airway

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Genetic variability and trait association analysis in linseed(Linum usitatissimum L.)for yield and related traits

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Oil Crop Science 2024年第3期9卷 151-159页

作者： Sandeep Kumar Yadav Neha Singh Hemant Kumar Yadav CSIR-National Botanical Research Institute Rana Pratap MargLucknow226001UPIndia Academy of Scientific and Innovative Research(AcSIR) Ghaziabad201002India State Planning Commission LucknowUPIndia

Diversity information mining about a crop for different attributes is an essential step for effective breeding *** present investigation evaluates the quantum of genetic variability and determines the relationship among the important agro-economic traits based on two years of phenotypic data of 210 accessions of *** traits,capsule weight per plant,capsule per plant,husk weight per plant,and seed weight per plant exhibited comparatively higher genetic coefficient of variation(GCV)and phenotypic coefficient of variation(PCV).In contrast,oil content and seed per capsule exhibited a lower *** high magnitude of broad sense heritability was observed for all traits except seeds per capsule and husk weight per *** trait,capsules per plant,plant height,and days to 50%flowering showed high genetic advance coupled with high *** cluster analysis grouped 210 accessions into six distinct *** of 210,144(68.57%)accessions were grouped into three clusters(I,II,and III),in which cluster-III was the largest,containing 64 accessions followed by cluster II and *** highest inter-cluster distance was observed between clusters-I and V(127.85),while the lowest was between clusters-II and IV(27.09).The positive correlation of capsule weight per plant with the seed weight per plant and a negative correlation with the days to 50%flowering indicates that high yielding linseed varieties with early flowering/maturity could be developed through direct and indirect ***,seed yield and oil content could be enhanced together as indicated by ghe positive association among these two important *** this study,high yielding accessions with moderate to high oil content such as GP36,GP31,GP14,GP54,GP26,GP24,GP34,GP21,GP37 and GP27 and early flowering(less than 70 days)accessions such as GP2,GP26,GP27,CG33,CG44,CG42,CG132,and CG31 identified as potential genetic materials that could be exploited for developing early matu

关键词： Linseed Genetic variability Heritability Genetic advance PCA Dendrogram

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Flavonoid Myricetin as Potent Anticancer Agent: A Possibility towards Development of Potential Anticancer Nutraceuticals

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Chinese Journal of Integrative Medicine 2024年第1期30卷 75-84页

作者： Anchal Trivedi Adria Hasan Rumana Ahmad Sahabjada Siddiqui Aditi Srivastava Aparna Misra Snober S.Mir Department of Biochemistry Era's Lucknow Medical College&HospitalEra UniversityLucknow(226003)India Molecular Cell Biology Laboratory Integral Information and Research Centre-4(IIRC-4)Department of BioengineeringFaculty of EngineeringIntegral UniversityLucknow(226026)India Department of Biotechnology Era's Lucknow Medical College&HospitalEra UniversityLucknow(226003)India Department of Biosciences Faculty of ScienceIntegral UniversityLucknow(226026)India

Good nutrition plays a crucial role in maintaining a balanced lifestyle. The beneficial effects of nutrition have been found to counteract nutritional disturbances with the expanded use of nutraceuticals to treat and manage cardiovascular diseases, cancer, and other developmental defects over the last decade. Flavonoids are found abundantly in plant-derived foods such as fruits, vegetables, tea, cocoa, and wine. Fruits and vegetables contain phytochemicals like flavonoids, phenolics, alkaloids, saponins, and terpenoids. Flavonoids can act as anti-inflammatory, anti-allergic, anti-microbial(antibacterial, antifungal, and antiviral) antioxidant, anti-cancer, and anti-diarrheal agents. Flavonoids are also reported to upregulate apoptotic activity in several cancers such as hepatic, pancreatic, breast, esophageal, and colon. Myricetin is a flavonol which is naturally present in fruits and vegetables and has shown possible nutraceutical value. Myricetin has been portrayed as a potent nutraceutical that may protect against cancer. The focus of the present review is to present an updated account of studies demonstrating the anticancer potential of myricetin and the molecular mechanisms involved therein. A better understanding of the molecular mechanism(s) underlying its anticancer activity would eventually help in its development as a novel anticancer nutraceutical having minimal side effects.

关键词： myricetin flavonoids anticancer nutraceuticals Chinese medicine Ayurveda complementary and alternative medicine

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Role of renin-angiotensin system/angiotensin converting enzyme-2 mechanism and enhanced COVID-19 susceptibility in type 2 diabetes mellitus

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World Journal of Diabetes 2024年第4期15卷 606-622页

作者： Ashwin Kumar Shukla Komal Awasthi Kauser Usman Monisha Banerjee Molecular and Human Genetics Laboratory Department of ZoologyUniversity of LucknowLucknow 226007Uttar PradeshIndia Department of Medicine King Georges’Medical UniversityLucknow 226003Uttar PradeshIndia Institute of Advanced Molecular Genetics and Infectious Diseases(IAMGID)University of LucknowLucknow 226007Uttar PradeshIndia

Coronavirus disease 2019(COVID-19)is a disease that caused a global pandemic and is caused by infection of severe acute respiratory syndrome coronavirus 2 *** has affected over 768 million people worldwide,resulting in approx-imately 6900000 ***-risk groups,identified by the Centers for Disease Control and Prevention,include individuals with conditions like type 2 diabetes mellitus(T2DM),obesity,chronic lung disease,serious heart conditions,and chronic kidney *** indicates that those with T2DM face a hei-ghtened susceptibility to COVID-19 and increased mortality compared to non-diabetic *** the renin-angiotensin system(RAS),a vital regulator of blood pressure and pulmonary stability,reveals the significance of the angiotensin-converting enzyme(ACE)and ACE2 *** converts angiotensin-I to the vasoconstrictor angiotensin-II,while ACE2 counters this by converting angiotensin-II to angiotensin 1-7,a *** ACE2 exp-ression,common in diabetes,intensifies RAS activity,contributing to conditions like inflammation and *** ACE inhibitors and angiotensin receptor blockers can be therapeutically beneficial by increasing ACE2 levels,concerns arise regarding the potential elevation of ACE2 receptors on cell membranes,potentially facilitating COVID-19 *** review explored the role of the RAS/ACE2 mechanism in amplifying severe acute respiratory syndrome cor-onavirus 2 infection and associated complications in *** treatment strategies,including recombinant human ACE2 therapy,broad-spectrum antiviral drugs,and epigenetic signature detection,are discussed as promising avenues in the battle against this pandemic.

关键词： Angiotensin-converting enzyme 2 Angiotensin-converting enzyme inhibitors Angiotensin-II receptor blockers Complex diseases COVID-19 Type 2 diabetes

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Metabolic complications of psychotropic medications in psychiatric disorders:Emerging role of de novo lipogenesis and therapeutic consideration

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World Journal of Psychiatry 2024年第6期14卷 767-783页

作者： Mohammad M Khan Zaw Ali Khan Mohsin Ali Khan Laboratory of Translational Neurology and Molecular Psychiatry Department of BiotechnologyEra’s Lucknow Medical College and Hospitaland Faculty of ScienceEra UniversityLucknow 226003India Era’s lucknow Medical College and Hospital Era UniversityLucknow 226003India

Although significant advances have been made in understanding the pathophysiology of psychiatric disorders(PDs),therapeutic advances have not been very *** psychotropic medications can reduce classical symptoms in patients with PDs,their long-term use has been reported to induce or exaggerate various pre-existing metabolic abnormalities including diabetes,obesity and non-alcoholic fatty liver disease(NAFLD).The mechanism(s)underlying these metabolic abnormalities is not clear;however,lipid/fatty acid accumulation due to enhanced de novo lipogenesis(DNL)has been shown to reduce membrane fluidity,increase oxidative stress and inflammation leading to the development of the aforementioned metabolic ***,emerging evidence suggest that DNL dysregulation and fatty acid accumulation could be the major mechanisms associated with the development of obesity,diabetes and NAFLD after long-term treatment with psychotropic medications in patients with *** support of this,several adjunctive drugs comprising of anti-oxidants and antiinflammatory agents,that are used in treating PDs in combination with psychotropic medications,have been shown to reduce insulin resistance and development of *** conclusion,the above evidence suggests that DNL could be a potential pathological factor associated with various metabolic abnormalities,and a new avenue for translational research and therapeutic drug designing in PDs.

关键词： Psychotropic medications Metabolic complications De novo lipogenesis Obesity Diabetes Non-alcoholic fatty liver disease

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Microalgal bioinoculants for sustainable agriculture and their interactions with soil biotic and abiotic components:A review

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Pedosphere 2024年第2期34卷 297-314页

作者： Shisy JOSE Nirmal RENUKA Sachitra Kumar RATHA Sheena KUMARI Faizal BUX Institute for Water and Wastewater Technology Durban University of TechnologyP.O.Box 1334Durban 4000South Africa Algal Biotechnology Laboratory Department of BotanyCentral University of PunjabBathinda 151401India Phycology Laboratory Council of Scientific and Industrial Research-National Botanical Research InstituteLucknowUttar Pradesh 226001India

Modern agricultural practices have posed a detrimental impact on the environment due to their intensive use to meet the food demands of an ever-increasing *** this context,microalgal bioinoculants,specifically cyanobacteria and green microalgae,have emerged as sustainable options for agricultural practices to improve soil organic carbon,nutrient availability,microbial quality,and plant *** overview of current and future perspectives on the use of microalgal bioinoculants in agriculture practices is presented in this review,along with a discussion of their interactions with soil biotic and abiotic factors that affect soil fertility,plant health,and crop *** benefits of microalgal bioinoculants include releasing agronomically important metabolites(exopolymers and phytohormones)as well as solubilizing soil ***,they function as biocontrol agents against soil-borne pathogens and facilitate the establishment of rhizosphere communities of agricultural *** far,very few studies have explored the basic mechanisms by which microalgal bioinoculants interact with soil biotic and abiotic *** recent years,advanced molecular techniques have contributed to a better understanding of these interactions.

关键词： biocontrol agent biofertilizer cyanobacteria microalgae microbial community molecular technique plant growth soil fertility

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Trigonometric tension B-spline collocation approximations for time fractional Burgers’equation

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Journal of Ocean Engineering and Science 2024年第5期9卷 508-516页

作者： Brajesh Kumar Singh Mukesh Gupta School of Physical and Decision Sciences Department of MathematicsBabasaheb Bhimrao Ambedkar University Lucknow 226025(UP)INDIA

This manuscript’s aim is to form and examine the numerical simulation of Caputo-time fractional nonlinear Burgers’equation via collocation approach with trigonometric tension B-splines as base ***,L 1 discretization formula is utilized for the time fractional derivative and after linearizing the nonlinear term,the trigonometric tension B-spline interpolants are utilized to get a system of simultaneous linear equations that are solved via Gauss elimination ***,numerical approximation at the desired time level is *** is demonstrated via von-Neumann approach that proposed scheme produces stable *** results of six different test examples having their analytical solutions are compared with the results in the literature to validate the accuracy and efficiency of the scheme.

关键词： Fractional Burgers’equation Trigonometric tension B-spline Collocation scheme Gauss elimination method

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Transcranial direct current stimulation as early augmentation in adolescent obsessive compulsive disorder:A pilot proof-of-concept randomized control trial

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World Journal of Clinical Pediatrics 2024年第2期13卷 161-170页

作者： Aditya Agrawal Vivek Agarwal Sujita Kumar Kar Amit Arya Department of Psychiatry King George Medical UniversityUttar PradeshLucknow 226003India

BACKGROUND Transcranial direct current stimulation(tDCS)is proven to be safe in treating various neurological conditions in children and *** is also an effective method in the treatment of OCD in *** To assess the safety and efficacy of tDCS as an add-on therapy in drug-naive adolescents with *** We studied drug-naïve adolescents with OCD,using a Children’s Yale-Brown obsessive-compulsive scale(CY-BOCS)scale to assess their *** active and sham groups were given fluoxetine,and we applied cathode and anode over the supplementary motor area and deltoid for 20 min in 10 *** occurred at 2,6,and 12 wk using *** Eighteen adolescents completed the study(10-active,8-sham group).CY-BOCS scores from baseline to 12 wk reduced significantly in both groups but change at baseline to 2 wk was significant in the active group *** mean change at 2 wk was more in the active group(11.8±7.77 vs 5.25±2.22,P=0.056).Adverse effects between the groups were *** tDCS is safe and well tolerated for the treatment of OCD in ***,there is a need for further studies with a larger sample population to confirm the effectiveness of tDCS as early augmentation in OCD in this population.

关键词： Adolescents Early augmentation Obsessive compulsive disorder Safety Transcranial direct current stimulation

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Sodium glucose cotransporter 2 inhibitors in the management of heart failure:Veni,Vidi,and Vici

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World Journal of Cardiology 2024年第10期16卷 550-563页

作者： Monika Bhandari Akshyaya Pradhan Pravesh Vishwakarma Abhishek Singh Rishi Sethi Department of Cardiology King Georg’s Medical UniversityLucknow 226003Uttar PradeshIndia

Heart failure(HF)is a chronic disease associated with high morbidity and mortality ***-angiotensin-aldosterone system blockers(including angiotensin receptor/neprilysin inhibitors),beta-blockers,and mineralocorticoid receptor blockers remain the mainstay of pharmacotherapy for HF with reduced ejection fraction(HFrEF).However,despite the use of guideline-directed medical therapy,the mortality from HFrEF remains *** with preserved ejection fraction(HFpEF)comprises approximately half of the total incident HF cases;however,unlike HFrEF,there are no proven therapies for this *** glucose cotransporter-2 inhibitors(SGLT-2is)represent a new class of pharmacological agents approved for diabetes mellitus(DM)that inhibit SGLT-2 receptors in the kidney.A serendipitous finding from seminal trials of SGLT-2is in DM was the significant improvement in renal and cardiovascular(CV)*** importantly,the improvement in HF hospitalization(HHF)in the CV outcomes trials of SGLT-2is was *** mechanisms have been proposed for the pleiotropic effects of SGLT-2is beyond their glycemic ***,as patients with HF were not included in any of these trials,it can be considered as a primary ***,two landmark studies of SGLT-2is in patients with HFrEF,namely,an empagliflozin outcome trial in patients with chronic HF and a reduced ejection fraction(EMPEROR-Reduced)and dapagliflozin and prevention of adverse outcomes in HF(DAPA-HF),demonstrated significant improvement in HHF and CV mortality regardless of the presence of *** impressive results pitchforked these drugs as class I indications in patients with HFrEF across major ***,empagliflozin outcome trial in patients with chronic HF with preserved ejection fraction(EMPEROR-Preserved)and dapagliflozin evaluation to improve the lives of patients with preserved ejection fraction HF(DELIVER)trials successively confirmed that SGLT-2is also benefit patients w

关键词： Heart failure with preserved ejection fraction Gliflozins Diuresis Natriuresis N terminal-pro brain natriuretic peptide Heart failure hospitalization

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Emerging molecules,tools,technology,and future of surgical knife in gastroenterology

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 988-998页

作者： Ashok Kumar Anirudh Goyal Department of Surgical Gastroenterology Sanjay Gandhi Post Graduate Institute of Medical SciencesLucknow 226014Uttar PradeshIndia

The 21^(st) century has started with several innovations in the medical sciences,with wide applications in health care *** development has taken in the field of medicines(newer drugs/molecules),various tools and technology which has completely changed the patient management including abdominal *** for abdominal diseases has moved from maximally invasive to minimally invasive(laparoscopic and robotic)*** of the newer medicines have its impact on need for surgical *** article focuses on the development of these emerging molecules,tools,and technology and their impact on present surgical form and its future effects on the surgical intervention in gastroenterological diseases.

关键词： Newer molecules Tools and technology Gastroenterology Future of surgical knife

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