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Studies on the allostimulatory function of dendritic cells from HCV-HIV-1 co-infected patients

Cell Research 2004年第3期14卷 251-256页

作者： Justin STEBBING,Steve PATTERSON,Simon PORTSMOUTH,Claire THOMAS,Robert GLASSMAN,Adrian WILDFIRE,Frances GOTCH,Mark BOWER,Mark NELSON,Brian GAZZARD The Department of Immunology Division of Investigative Science Faculty of Medicine Imperial College of Science Technology and Medicine The Chelsea and Westminster Hospital 369 Fulham Road london sw10 9nh UK The Department of Immunology Division of Investigative Science Faculty of Medicine Imperial College of Science Technology and Medicine The Chelsea and Westminster Hospital 369 Fulham Road london sw10 9nh UK The Department of Immunology Division of Investigative Science Faculty of Medicine Imperial College of Science Technology and Medicine The Chelsea and Westminster Hospital 369 Fulham Road london sw10 9nh UK The Department of Immunology Division of Investigative Science Faculty of Medicine Imperial College of Science Technology and Medicine The Chelsea and Westminster Hospital 369 Fulham Road london sw10 9nh UK The Department of Immunology Division of Investigative Science Faculty of Medicine Imperial College of Science Technology and Medicine The Chelsea and Westminster Hospital 369 Fulham Road london sw10 9nh UK The Department of Immunology Division of Investigative Science Faculty of Medicine Imperial College of Science Technology and Medicine The Chelsea and Westminster Hospital 369 Fulham Road london sw10 9nh UK The Department of Immunology Division of Investigative Science Faculty of Medicine Imperial College of Science Technology and Medicine The Chelsea and Westminster Hospital 369 Fulham Road london sw10 9nh UK The Department of Immunology Division of Investigative Science Faculty of Medicine Imperial College of Science Technology and Medicine The Chelsea and Westminster Hospital 369 Fulham Road london sw10 9nh UK The Department of Immunology Division of Investigative Science Faculty of Medicine Imperial College of Science Technology and Medicine The Chelsea and Westminster Hospital 369 Fulham Road london sw10 9nh UK The Department of Immunology Division of Investigative Science Faculty of Medicine Imperial College of Science Technology and Medicine The Chelsea and Westminster Hospital 369 Fulham Ro

There is increasing recognition of the potential morbidity and mortality associated with HIV-1 and hepatitis C (HCV) co-infection. HIV appears to adversely affect HCV disease while the reciprocal effect of HCV on HIV remains controversial. We therefore studied the effect of co-infection on dendritic cell function versus HIV infection alone, as previous work has shown that HCV impairs dendritic cell (DC) function. HIV-1 positive individuals with HCV were matched for CD4 count, HIV-1 RNA viral load and therapy, to HIV-1 positive patients without HCV. Monocyte-derived DC were generated and mixed leukocyte reactions were performed. We assessed allostimulatory capacity with and without administration of exogenous Thl cytokines, using thymidine uptake and cell division analyses with the vital dye CFSE. We found that monocyte-derived DC from co-infected individuals showed no significant differences in allostimulatory capacity to ex vivo generated DC from HIV-1 infected individuals without HCV. Unlike the situat

关键词： hepatitis C HIV co-infection dendritic cells.

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New insights into the immunology and evolution of HIV

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Cell Research 2003年第1期13卷 1-7页

作者： JUSTINSTEBBING,STEVEPATTERSON,FRANCESGOTCH Department Department Department of Immunology Division of Investigative Science Faculty of Medicine Imperial College of Science Technology and Medicine The Chelsea and Westminster Hospital 369 Fulham Road london sw10 9nh United Kingdom of Immunology Division of Investigative Science Faculty of Medicine Imperial College of Science Technology and Medicine The Chelsea and Westminster Hospital 369 Fulham Road london sw10 9nh United Kingdom of Immunology Division of Investigative Science Faculty of Medicine Imperial College of Science Technology and Medicine The Chelsea and Westminster Hospital 369 Fulham Road london sw10 9nh United Kingdom

Fewer than one million HIV infected individuals are currently receiving anti-retroviral therapy. The limitations of such treatment have underscored the need to develop more effective strategies to control the spread and pathogenesis of HIV. Typically, naturally occurring protective immune responses provide the paradigm for such development. It is now clear however that HIV can utilise the millieu of an activated immune system to its own replicative advantage. Mobilisation of the immune response, intended to thwart the virus, may instead fuel its dissemination, 'immune escape' and spread. The immense genetic variation of HIV contributes to lack of immune control and the development of progressive disease in the majority of infected, untreated individuals. Further delineation of the intimate interactions between the HIV and the immune system will be critical and recent advances in this direction are discussed.

关键词： HIV immune response CTL evolution vaccine.

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Complex regional pain syndrome: a recent update

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Burns & Trauma 2017年第1期5卷 24-34页

作者： En Lin Goh swathikan Chidambaram Daqing Ma Anaesthetics Pain Medicine and Intensive CareDepartment of Surgery and CancerFaculty of MedicineImperial College LondonChelsea and Westminster Hospital369 Fulham RoadLondon SW10 9NHUK

Complex regional pain syndrome (CRPS) is a debilitating condition affecting the limbs that can be induced by surgery or trauma. This condition can complicate recovery and impair one’s functional and psychological well-being. The wide variety of terminology loosely used to describe CRPS in the past has led to misdiagnosis of this condition, resulting in poor evidence-base regarding the treatment modalities available and their impact. The aim of this review is to report on the recent progress in the understanding of the epidemiology, pathophysiology and treatment of CRPS and to discuss novel approaches in treating this condition.

关键词： CRPS Epidemiology Pathophysiology Treatment Future therapy

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Perioperative"remote"acute lung injury:recent update

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The Journal of Biomedical Research 2017年第3期31卷 197-212页

作者： Zhaosheng Jin Ka Chun Suen Daqing Ma Anaesthetics Pain Medicine and intensive CareDepartment of Surgery and CancerFaculty of MedicineImperial College LondonChelsea&Westminster HospitalLondon SW10 9NHUK

Perioperative acute lung injury（ALI） is a syndrome characterised by hypoxia and chest radiograph *** is a serious post-operative complication,associated with considerable mortality and *** addition to mechanical ventilation,remote organ insult could also trigger systemic responses which induce ***,there are limited treatment options available beyond conservative respiratory ***,increasing understanding of the pathophysiology of ALI and the biochemical pathways involved will aid the development of novel treatments and help to improve patient outcome as well as to reduce cost to the health *** this review we will discuss the epidemiology of peri-operative ALI;the cellular and molecular mechanisms involved on the pathological process;the clinical considerations in preventing and managing perioperative ALI and the potential future treatment options.

关键词： acute lung injury intraoperative care/adverse effects postoperative complications inflammation,anesthetics general fluid therapy

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Hepatic ischemia-reperfusion injury in liver transplant setting:mechanisms and protective strategies

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The Journal of Biomedical Research 2019年第4期33卷 221-234页

作者： Sanketh Rampes Daqing Ma Faculty of Life Sciences &Medicine King's College LondonLondon SE1 1UUK Anaesthetics Pain Medicine and Intensive CareDepartment of Surgery and CancerFaculty of MedicineImperial College LondonChelsea and Westminster HospitalLondon SW10 9NHUK.

Hepatic ischemia-reperfusion injury is a major cause of liver transplant failure,and is of increasing significance due to increased use of expanded criteria livers for *** review summarizes the mechanisms and protective strategies for hepatic ischemia-reperfusion injury in the context of liver *** therapies,the use of pre-and post-conditioning and machine perfusion are discussed as protective *** use of machine perfusion offers significant potential in the reconditioning of liver grafts and the prevention of hepatic ischemia-reperfusion injury,and is an exciting and active area of research,which needs more study clinically.

关键词： liver transplantation reperfusion injury mechanism therapeutics ischemic preconditioning

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全身麻醉药物对发育期大脑影响的争鸣

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中国药理学与毒理学杂志 2012年第3期26卷 363-367页

作者：钱敏李民郭向阳马大青北京大学第三医院麻醉科北京100191 Department of Anaesthetics Imperial College LondonLondon SW10 9NHUnited Kingdom

麻醉药物作用于N-甲基-D-天冬氨酸(NMDA)受体和(或)γ氨基丁酸(GABA)引起发育期动物大脑神经退行性变和成年后认知功能障碍,且神经元凋亡或功能受损具有年龄、接触时间和剂量的依赖性。然而麻醉药物诱导神经细胞凋亡的假说仍存在争议。... 详细信息

麻醉药物作用于N-甲基-D-天冬氨酸(NMDA)受体和(或)γ氨基丁酸(GABA)引起发育期动物大脑神经退行性变和成年后认知功能障碍,且神经元凋亡或功能受损具有年龄、接触时间和剂量的依赖性。然而麻醉药物诱导神经细胞凋亡的假说仍存在争议。麻醉药物引起的凋亡是病理性凋亡还是生理性凋亡及其与与神经认知功能障碍间的因果关系尚不清楚。动物实验中不同种属动物麻醉/镇痛所需要的药物剂量、发育易感期各不相同,因此动物实验结果不能直接应用于临床。临床上全麻药物对婴幼儿神经毒性的临床研究证据尚不充分,仍需进一步获取多中心、大样本人类研究数据,以证实麻醉药物与发育期大脑退行性变的因果关系,阐述其机制,指导临床医师的工作。本文综述了全身麻醉药物对发育期大脑影响的研究进展。

关键词：麻醉药物发育期大脑神经退行性变认知功能障碍

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超声介导经皮穿刺松解弹响指的环形滑车

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国际医学放射学杂志 2009年第6期 596-597页

作者： G.Rajeswaran J.C.Lee R.Eckersley E.Katsarma J.C.Healy 蒋新华 Department of Radiology Chelsea & Westminster Hospital369 Fulham RoadLondon SW10 9NHUK

本研究的目的是描述及评价采用超声介导经皮穿刺的新方法,利用改进的皮下注射针松解环形滑车。收集2006年10月至最近16个月以来在本研究中心手外科就诊的25例病例,共对35个手指行超声介导经皮穿刺松解术纳入标准如下:成年人,弹性痛4个... 详细信息

本研究的目的是描述及评价采用超声介导经皮穿刺的新方法,利用改进的皮下注射针松解环形滑车。收集2006年10月至最近16个月以来在本研究中心手外科就诊的25例病例,共对35个手指行超声介导经皮穿刺松解术纳入标准如下:成年人,弹性痛4个月以上,

关键词：超声介导滑车葫芦(工具) 经皮穿刺弹响指

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米索前列醇经口、直肠和阴道给药的药代动力学

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世界核心医学期刊文摘（妇产科学分册） 2005年第8期1卷 27-28页

作者： Khan R.-U. El-Refaey H. Sharma S. 侯巍 Dr.Chelsea and Westminster Hospital 369 Fulham Road London SW10 9NH United Kingdom

OBJECTIVE: To compare the pharmacokinetic profiles of orally, rectally, and vaginally administered misoprostol tablets in pregnant women. METHODS: Women between 7 and 14 completed weeks of gestation were recruited and randomly assigned to be given 400 μmisoprostol orally, rectally, or vaginally 3 hours before surgical termination of pregnancy. Blood samples were obtained at 0, 7.5, 15, 30, 45, 60, 60, 120, and 240 minutes and later analyzed for plasma concentrations of misoprostol free acid (the principle metabolite). RESULTS: Vaginal misoprostol was present in the circulation longer than oral misoprostol and had a greater area under curve at 240 minutes (P < .001). Rectal misoprostol had a similar pattern but a much lower area under curve at 240 minutes. Oral misoprostol had a significantly greater peak plasma concentration and a shorter duration to maximum concentration than either rectal or vaginal misoprostol (both P < .001). CONCLUSION: Oral misoprostol tablet is also absorbed by the rectal and vaginal routes. Misoprostol administered in early pregnancy has route-dependent pharmacokimetics and is absorbed best when administered vaginally.

关键词：阴道给药药代动力学经口终止妊娠浓度峰值血药浓度妊娠早期用药途径给药时间吸收效果

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Global transplantation:Lessons from organ transplantation organizations worldwide

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World Journal of Transplantation 2025年第1期15卷 44-56页

作者： Solonas Symeou Eleni Avramidou Vassilios Papalois Georgios Tsoulfas Medical School University of IoanninaIoannina 45110Greece Department of Transplantation Surgery Center for Research and Innovation in Solid Organ TransplantationSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece Imperial College Renal and Transplant Centre Imperial College Healthcare NHS TrustHammersmith HospitalLondon W120HSUnited Kingdom Department of Surgery and Cancer Imperial College LondonLondon SW72AZUnited Kingdom

Although national transplant organizations share common visions and goals,the creation of a unified global organization remains *** in ethnicity,culture,religion,and education shape local practices and infrastructure,making the establishment of a single global entity *** with these social disparities aside,logistical factors such as time and distance between organ procurement and transplantation sites pose significant *** technological advancements have extended organ preservation times,they have yet to support the demands of transcontinental transplantations *** review presents a comparative analysis of the structures,operational frameworks,policies,and legislation governing various transplant organizations around the *** differences pertain to the administration of these organizations,trends in organ donation,and organ allocation policies,which reflect the financial,cultural,and religious diversity across different *** a global transplant organization may be out of reach,agreeing on best practices for the benefit of patients is essential.

关键词： Organ transplantation National transplant organizations Organ donation Global transplantation Transplant systems

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慢性淋巴细胞白血病的皮肤表现

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世界核心医学期刊文摘（皮肤病学分册） 2005年第1期1卷 5-6页

作者： Agnew K.L. Ruchlemer R. Catovsky R. 张宪旗 Department of Dermatology Chelsea andWestminster Hospital 369 Fulham Road London SW10 9NH United Kingdom Dr.

Background: Chronic lymphocytic leukaemia (CLL) is a malignancy characterized by clonal expansion of B lymphocytes with distinct morphology and immunophenotype. The dermatological literature relating to CLL is sparse. A global descriptive survey of a large number of CLL patients has not previously been published. Objectives: To report the spectrum of dermatological conditions seen in a large series of CLL patients. Methods: Skin complications in patients with established CLL were identified retrospectively from clinical and photographic records, principally a database of over 750 consecutive cases. These events were classified, enumerated and compared. Results: Forty patients with 125 skin manifestations were identified and studied. Forty one manifestations had documented clinical or histological atypia. In 21 of these 41 complications there had been no prior immunosuppressive therapy. We observed that cutaneous malignancies frequently presented atypically both clinically and histologically. There were 18 patients with 56 instances of basal cell carcinoma (BCC) or squamous cell carcinoma (SCC), and clinical atypia was more common with SCC than with BCC. Other cutaneous findings included varicella zoster (n = 6), leukaemia cutis (n = 3), acute graft versus host disease (n = 5), cutaneous drug eruptions (n = 9), multiple warts (n = 3), herpes simplex (n = 3), cutaneous T cell lymphoma (n = 2), eosinophilic folliculitis (n = 2), malignant melanoma (n = 2) and Merkel cell tumour (n = 2). Conclusions: We have identified a range of dermatological conditions in CLL patients, with a tendency to atypical presentations. The atypia was independent of priorchemotherapy.

关键词：基底细胞癌恶性黑色素瘤克隆性增生异型性免疫特性照片资料淋巴瘤带状疱疹嗜酸性粒细胞单纯疱疹

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