Hepatic ischemia-reperfusion injury in liver transplant setting:mechanisms and protective strategies

作     者：Sanketh Rampes Daqing Ma 

作者机构：Faculty of Life Sciences &MedicineKing's College LondonLondon SE1 1UUK AnaestheticsPain Medicine and Intensive CareDepartment of Surgery and CancerFaculty of MedicineImperial College LondonChelsea and Westminster HospitalLondon SW10 9NHUK. 

出 版 物：《The Journal of Biomedical Research》 (生物医学研究杂志（英文版）)

年 卷 期：2019年第33卷第4期

页      面：221-234页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by British Journal of Anaesthesia Fellowship grant NIAA London UK 

主　　题：liver transplantation reperfusion injury mechanism therapeutics ischemic preconditioning 

摘      要：Hepatic ischemia-reperfusion injury is a major cause of liver transplant failure,and is of increasing significance due to increased use of expanded criteria livers for *** review summarizes the mechanisms and protective strategies for hepatic ischemia-reperfusion injury in the context of liver *** therapies,the use of pre-and post-conditioning and machine perfusion are discussed as protective *** use of machine perfusion offers significant potential in the reconditioning of liver grafts and the prevention of hepatic ischemia-reperfusion injury,and is an exciting and active area of research,which needs more study clinically.