检索结果-南通市图书馆

Risk factors for hepatocellular carcinoma associated with hepatitis C genotype 3 infection:A systematic review

在线全文

学校读者我要写书评

暂无评论

world Journal of Gastrointestinal Oncology 2024年第4期16卷 1596-1612页

作者： Hamzah Z Farooq Michael James Jane Abbott Patrick Oyibo Pip Divall Naheed Choudhry Graham R Foster Blizard Institute Queen Mary University of LondonLondon E12ATUnited Kingdom School of Health and Psychological Sciences University of LondonLondon EC1V 0HBUnited Kingdom University Hospitals of Leicester Library University Hospitals of Leicester NHS TrustLeicester LE39QPUnited Kingdom

BACKGROUND Hepatitis C virus(HCV)is a blood-borne virus which globally affects around 79 million people and is associated with high morbidity and *** infection leads to cirrhosis in a large proportion of patients and often causes hepatocellular carcinoma(HCC)in people with *** the 6 HCV genotypes(G1-G6),genotype-3 accounts for 17.9%of *** genotype-3 responds least well to directly-acting antivirals and patients with genotype-3 infection are at increased risk of HCC even if they do not have *** To systematically review and critically appraise all risk factors for HCC secondary to HCV-G3 in all ***,we studied possible risk factors for HCC due to HCV-G3 in the literature from 1946 to *** This systematic review aimed to synthesise existing and published studies of risk factors for HCC secondary to HCV genotype-3 and evaluate their strengths and *** searched web of Science,Medline,EMBASE,and CENTRAL for publications reporting risk factors for HCC due to HCV genotype-3 in all settings,*** Four thousand one hundred and forty-four records were identified from the four databases with 260 records removed as *** thousand eight hundred and eighty-four records were screened with 3514 *** hundred and seventy-one full-texts were assessed for eligibility with seven studies included for *** the seven studies,three studies were retrospective case-control trials,two retrospective cohort studies,one a prospective cohort study and one a cross-sectional study *** were based in hospital settings with four in Pakistan,two in South Korea and one in the United *** total number of participants were 9621 of which 167 developed HCC(1.7%).All seven studies found cirrhosis to be a risk factor for HCC secondary to HCV genotype-3 followed by higher age(five-studies),with two studies each showing male sex,high alpha feto-protein,directly-acting antivirals trea

关键词： Hepatocellular carcinoma Hepatitis C Genotype 3 Systematic review Blood-borne viruses Liver cancer

利用探针跳跃式扫描离子电导显微镜技术揭示结直肠癌单细胞层面对H_(2)O_(2)良性应激的动态响应

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science Bulletin 2024年第12期69卷 1909-1919页

作者：王东 Emily woodcock 杨羲 Hiromi Nishikawa Elena V.Sviderskaya Masanobu Oshima Christopher Edwards 张彦军 Yuri Korchev wPI Nano Life Science Institute(wPI-Nano LSI) Kanazawa UniversityKanazawa 920-1192Japan Department of Medicine Imperial College LondonLondon W120NNUnited Kingdom Cell Biology Research Centre Molecular and Clinical Sciences Research InstituteSt George’sUniversity of LondonLondon SW170REUnited Kingdom

Colorectal cancer(CRC),a widespread malignancy,is closely associated with tumor microenvironmental hydrogen peroxide(H_(2)O_(2))*** clinical trials targeting H_(2)O_(2)for cancer treatment have revealed its paradoxical role as a promoter of cancer *** the dynamics of cancer cell H_(2)O_(2)eustress at the single–cell level is *** this study,non–contact hopping probe mode scanning ion conductance microscopy(HPICM)with high-sensitive Pt–functionalized nanoelectrodes was employed to measure dynamic extracellular to intracellular H_(2)O_(2)gradients in individual colorectal cancer Caco–*** explored the relationship between cellular mechanical properties and H_(2)O_(2)*** to 0.1 or 1 mmol/L H_(2)O_(2)eustress increased the extracellular to intracellular H_(2)O_(2)gradient from 0.3 to 1.91 or 3.04,***,cellular F–actin–dependent stiffness increased at 0.1 mmol/L but decreased at 1 mmol/L H_(2)O_(2)*** H_(2)O_(2)–induced stiffness modulated AKT activation positively and glutathione peroxidase 2(GPX2)expression *** findings unveil the failure of some H_(2)O_(2)-targeted therapies due to their ineffectiveness in generating H_(2)O_(2),which instead acts eustress to promote cancer cell *** research also reveals the complex interplay between physical properties and biochemical signaling in cancer cells'antioxidant defense,illuminating the exploitation of H_(2)O_(2)eustress for survival at the single–cell *** GPX and/or catalase(CAT)enhances the cytotoxic activity of H_(2)O_(2)eustress against CRC cells,which holds significant promise for developing innovative therapies targeting cancer and other H_(2)O_(2)-related inflammatory diseases.

关键词： SPM Nanoprobe Nanobiology SECM ROS Stiffness

Managing type 2 diabetes:targeting a microbial enzyme as a novel treatment option

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第1期9卷 3-5页

作者： Anikó Keller-Pintér Tamás Korcsmáros Tibor Vellai Department of Biochemistry Albert Szent-Györgyi Medical SchoolUniversity of SzegedSzeged6720Hungary Department of Metabolism Digestion and ReproductionImperial College LondonLondonW120NNUK Quadram Institute Bioscience Norwich Research ParkNorwichNR47UQUK Department of Genetics Eötvös Loránd University(ELTE)Budapest1117Hungary Hungarian Research Network HUN-REN-ELTE Genetics Research Group Budapest1117Hungary

In a recent Science article,wang and colleagues showed that the dipeptidyl peptidase 4(DPP4)enzyme produced by the gut microbiota can interfere with the effect of host glucagon-like peptide-1(GLP-1)involved in stimulating insulin secretion,and the specific inhibitor of microbial DPP4(mDPP4),combined with clinical inhibitors of host DPP4 isoenzymes,further promotes blood glucose homeostasis.1 These results point out why certain patients respond inadequately to an antidiabetic medication.

关键词： homeostasis stimulating clinical

Microbially-mediated formation of Ca-Fe carbonates during dissimilatory ferrihydrite reduction:Implications for the origin of sedimentary ankerite

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Earth Sciences 2024年第1期67卷 208-221页

作者： Deng LIU Jinpeng CAO Shanshan YANG Yating YIN Pengcong wANG Dominic PAPINEAU Hongmei wANG Xuan QIU Genming LUO Zongmin ZHU Fengping wANG State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesWuhan 430074China School of Environmental Studies China University of GeosciencesWuhan 430074China london Centre for Nanotechnology University College LondonLondon WC1H 0AHUK Department of Earth Sciences University College LondonLondon WC1E 6BTUK Center for Planetary Sciences University College London and Birkbeck College LondonLondon WC1E 6BTUK State Key Laboratory of Microbial Metabolism State Key Laboratory of Ocean EngineeringShanghai Jiao Tong UniversityShanghai 200240China

The origin of sedimentary dolomite has become a long-standing problem in the Earth *** carbonate minerals like ankerite have the same crystal structure as dolomite,hence their genesis may provide clues to help solving the dolomite *** purpose of this study was to probe whether microbial activity can be involved in the formation of ***-carbonation experiments associated with microbial iron reduction were performed in batch systems with various concentrations of Ca^(2+)(0–20 mmol/L),with a marine iron-reducing bacterium Shewanella piezotolerans wP3 as the reaction mediator,and with lactate and ferrihydrite as the respective electron donor and *** biomineralization data showed that Ca-amendments expedited microbially-mediated ferrihydrite reduction by enhancing the adhesion between wP3 cells and ferrihydrite *** bioreduction,siderite occurred as the principal secondary mineral in the Ca-free ***,Ca-Fe carbonates were formed when Ca^(2+)ions were *** CaCO_(3) content of microbially-induced Ca-Fe carbonates was positively correlated with the initial Ca2+*** Ca-Fe carbonate phase produced in the 20 mmol/L Ca-amended biosystems had a chemical formula of Ca_(0.8)Fe_(1.2)(CO_(3))_(2),which is close to the theoretical composition of *** ankeritelike phase was nanometric in size and spherical,Ca-Fe disordered,and structurally *** simulated diagenesis experiments further demonstrated that the resulting ankerite-like phase could be converted into ordered ankerite under hydrothermal *** introduced the term“proto-ankerite”to define the Ca-Fe phases that possess near-ankerite stoichiometry but disordered cation *** the basis of the present study,we proposed herein that microbial activity is an important contributor to the genesis of sedimentary ankerite by providing the metastable Ca-Fe carbonate precursors.

关键词： Ankerite Proto-ankerite Microbial iron reduction Dolomite problem Mineral transformation

An Exploration of How Practitioners Make Meaning in a Chinese Medicine Consultation and Treatment

在线全文

学校读者我要写书评

暂无评论

Chinese Medicine and Culture 2024年第1期7卷 63-71页

作者： Felicity Clare Moir University of westminster London W1B 2HWthe United Kingdom

In Chinese medicine, practitioners assess patients’ complaints, analyze their underlying problems, identify causes and come to a diagnosis, which then directs treatment. what is not obvious and not recorded in a consultation is the clinical reasoning process that practitioners use. The research filmed three practitioners in the UK while they conducted a consultation and treatment on new patients. The practitioners and researchers viewed the films and used them as aide-memoirs while the reasoning process throughout was discussed. In order to determine the pattern, practitioners used the four examinations to gather information from the patient in an iterative process;their aesthetic reasoning was highly developed. Through triangulation they checked the information they received against a detailed understanding of the qi-dynamic. They used highly analytical strategies of forward(inductive) and backward(deductive) reasoning against the prototypes of the signs and symptoms that indicate a specific Zheng. This was achieved through an abductive process that linked description with explanation and causal factors with pathological mechanisms. The feedback loop with the patient continued through the consultation and into the treatment. A process of translation and interpretation was needed to turn the patient’s story into the practitioner’s story of qi-dynamics that then directed the treatment. Awareness of our clinical reasoning process will mitigate against biases, improve our diagnoses and treatment choices and support the training of students.

关键词： Chinese medicine Clinical reasoning Abduction Translation and interpretation

Contrast-enhanced 3D ultrasound in the radiofrequency ablation of liver tumors

在线全文

学校读者我要写书评

暂无评论

world Journal of Gastroenterology 2009年第3期15卷 289-299页

作者： Edward Leen Senthil Kumar Shahid A Khan Gavin Low Keh Oon Ong Paul Tait Mike Averkiou Imaging Science Department Imperial College LondonLondon W12 0NNUnited Kingdom Department of Hepatology and Gastroenterology Imperial College LondonLondon W12 0NNUnited Kingdom Department of Mechanical Engineering University of CyprusLondon W12 0NNUnited Kingdom

Liver metastases and hepatocellular carcinomas are two of the most common causes of cancer deaths in the *** ablation(RFA) is a well recognized,effective and minimally invasive means of treating malignant hepatic *** article describes the use of contrast-enhanced 3D ultrasound(CE-3DUS) in the staging,targeting and follow-up of patients with liver tumors undergoing *** particular,its value in the management of large hepatic lesions will be *** limitations of CE-3DUS and future developments in the technique will also be *** summary,CE-3DUS is useful in the RFA of liver tumors with improved detection and display of occult lesions and recurrence,in the assessment of lesional geometry and orientation for a more accurate planning and guidance of multiple RFA needle electrodes in large tumors and in the evaluation of residual or recurrent disease within the immediate and/or subsequent follow-up periods.

关键词：肝肿瘤射频消融三维超声检查肝细胞癌

Enhancing the clinical relevance of haemorrhage prediction models in trauma

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Military Medical Research 2024年第3期11卷 467-468页

作者： Sankalp Tandle Jared M.wohlgemut Max E.R.Marsden Erhan Pisirir Evangelia Kyrimi Rebecca S.Stoner william Marsh Zane B.Perkins Nigel R.M.Tai Centre for Trauma Sciences Blizard InstituteQueen Mary University of LondonLondon E12ATUK The Royal london Hospital Barts Health NHS TrustLondon E11FRUK Academic Department of Military Surgery and Trauma Research and Clinical InnovationThe Royal Centre for Defence MedicineBirmingham B152WBUK Department of Electronic Engineering and Computer Science Queen Mary University of LondonLondon E14NSUK

we read with interest the recent systematic reviewaArtificial intelligence and machine learning for hemorrhagic trauma careoby Peng et al.[1],which evaluated literature on machine learning(ML)in the management of trau... 详细信息

关键词： Trauma Injury Blood transfusion Massive transfusion Prediction Artificial intelligence Machine learning

Molecular engineering binuclear copper catalysts for selective CO_(2) reduction to C_(2) products

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第6期93卷 166-173,I0005页

作者： Qi Zhao Kai Lei Bao Yu Xia Rachel Crespo-Otero Devis Di Tommaso Department of Chemistry School of Physical and Chemical SciencesQueen Mary University of LondonLondonE14NSUK Key Laboratory of Material Chemistry for Energy Conversion and Storage(Ministry of Education) Hubei Key Laboratory of Material Chemistry and Service FailureState Key Laboratory of Materials Processing and Die&Mould TechnologySchool of Chemistry and Chemical EngineeringHuazhong University of Science and Technology(HUST)Wuhan 430074HubeiChina Department of Chemistry University College LondonLondonWC1H 0AJUK Digital Environment Research Institute Queen Mary University of LondonEmpire HouseLondon E11HHUK

Molecular copper catalysts serve as exemplary models for correlating the structure-reaction-mechanism relationship in the electrochemical CO_(2) reduction(eCO_(2)R),owing to their adaptable environments surrounding the copper metal *** investigation,employing density functional theory calculations,focuses on a novel family of binuclear Cu molecular *** modulation of their coordination configuration through the introduction of organic groups aims to assess their efficacy in converting CO_(2) to C_(2)*** findings highlight the crucial role of chemical valence state in shaping the characteristics of binuclear Cu catalysts,consequently influencing the eCO_(2)R behaviour,Notably,the Cu(Ⅱ)Cu(Ⅱ)macrocycle catalyst exhibits enhanced suppression of the hydrogen evolution reaction(HER),facilitating proton trans fer and the eCO_(2)R *** rthermore,we explo re the impact of diverse electro n-withdrawing and electron-donating groups coordinated to the macrocycle(R=-F,-H,and-OCH_3)on the electron distribution in the molecular *** placement of-OCH_3 groups in the macrocycles leads to a favourable oxidation state of the Cu centres and subsequent C-C coupling to form C_(2) *** research provides fundamental insights into the design and optimization of binuclear Cu molecular catalysts for the electrochemical conversion of CO_(2) to value-added C_(2) products.

关键词： Molecular catalyst design Selective CO_(2)reduction C_(2)products Density functional theory calculations

DCEL:classifier fusion model for Android malware detection

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Engineering and Electronics 2024年第1期35卷 163-177页

作者： XU Xiaolong JIANG Shuai ZHAO Jinbo wANG Xinheng Jiangsu Key Laboratory of Big Data Security&Intelligent Processing Nanjing University of Posts and TelecommunicationsNanjing 210023China School of Computer Science Nanjing University of Posts and TelecommunicationsNanjing 210023China School of Computing and Engineering University of West LondonLondon W55RFUK

The rapid growth of mobile applications,the popularity of the Android system and its openness have attracted many hackers and even criminals,who are creating lots of Android ***,the current methods of Android malware detection need a lot of time in the feature engineering ***,these models have the defects of low detection rate,high complexity,and poor practicability,*** analyze the Android malware samples,and the distribution of malware and benign software in application programming interface(API)calls,permissions,and other *** classify the software’s threat levels based on the correlation of ***,we propose deep neural networks and convolutional neural networks with ensemble learning(DCEL),a new classifier fusion model for Android malware ***,DCEL preprocesses the malware data to remove redundant data,and converts the one-dimensional data into a two-dimensional gray ***,the ensemble learning approach is used to combine the deep neural network with the convolutional neural network,and the final classification results are obtained by voting on the prediction of each single *** based on the Drebin and Malgenome datasets show that compared with current state-of-art models,the proposed DCEL has a higher detection rate,higher recall rate,and lower computational cost.

关键词： Android malware detection deep learning ensemble learning model fusion