Managing type 2 diabetes:targeting a microbial enzyme as a novel treatment option

作     者：Anikó Keller-Pintér Tamás Korcsmáros Tibor Vellai Anikó Keller-Pintér;Tamás Korcsmáros;Tibor Vellai

作者机构：Department of BiochemistryAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzeged6720Hungary Department of MetabolismDigestion and ReproductionImperial College LondonLondonW120NNUK Quadram Institute BioscienceNorwich Research ParkNorwichNR47UQUK Department of GeneticsEötvös Loránd University(ELTE)Budapest1117Hungary Hungarian Research Network HUN-REN-ELTE Genetics Research GroupBudapest1117Hungary 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2024年第9卷第1期

页      面：3-5页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the National Research,Development and Innovation Office of Hungary(grant number:NKFI FK134684) project TKP2021-EGA-28 was implemented with the support provided by the Ministry of Innovation and Technology of Hungary from the National Research,Development and Innovation Fund,financed under the TKP2021-EGA funding scheme The work of T.K.was supported by the UKRI BBSRC Institute Strategic Programme Food Microbiome and Health BB/X011054/1 and its constituent project BBS/E/F/000PR13631 T.K.was also supported by the NIHR Imperial Biomedical Research Centre Organoid Facility The views expressed are those of the authors and not necessarily those of the NIHR or the UK Department of Health and Social Care T.V.was supported by grant OTKA(Hungarian Scientific Research Fund,K132439) HUN-REN-ELTE Genetics Research Group(01062) 

主　　题：homeostasis stimulating clinical 

摘      要：In a recent Science article,Wang and colleagues showed that the dipeptidyl peptidase 4(DPP4)enzyme produced by the gut microbiota can interfere with the effect of host glucagon-like peptide-1(GLP-1)involved in stimulating insulin secretion,and the specific inhibitor of microbial DPP4(mDPP4),combined with clinical inhibitors of host DPP4 isoenzymes,further promotes blood glucose homeostasis.1 These results point out why certain patients respond inadequately to an antidiabetic medication.