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Study on the force chain characteristics with coal dust layer and the three-body contact stiffness

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Particuology 2024年第9期92卷 288-304页

作者： Xinwei Yang Dongxuan Wu Hongyue Chen Dong Wang School of Mechanical Engineering Liaoning Technical UniversityFuxin123000China Ordos Institute of liaoning Technical University Ordos017000China School of Mining Liaoning Technical UniversityFuxin123000China China National Coal Association Dynamic Research for High-end Complete Integrated Coal Mining Equipment and Big Data Analysis CentreFuxin123000China

To explore the influence of the meso-mechanical behaviors of the wet coal dust layers on the contact stiffness of mechanical bonding surfaces,a three-body contact model incorporating an interface with wet coal dust was constructed based on breakage *** model considered the mechanical surface morphology and contact characteristics of the wet coal *** force chain evolution laws of the wet coal dust layer were elucidated under the effects of gap filling and the cover layer,and the bearing characteristics of the three-body contact bonding surfaces were revealed by quantitative analyses of the number,length,collimation coefficient,and coordination number of the force chains within the wet coal dust ***,the three-body normal contact stiffness under various preload forces was computed and experimentally *** results demonstrate that the external load transfer path of the three-body contact bonding surfaces was from mechanical surface(macroscopic stress)to wet coal dust layer(mesoscopic force chains)and then to mechanical surface(peaks and valleys).The interactions among these three elements contributed to transforming the distributions of the macroscopic stresses and mesoscopic force chains to the locations at the peaks and valleys of the mechanical *** them,the proportion of short force chains in the wet coal dust layer increased from approximately 0.8%–91%,while the proportion of long force chains exhibited an opposite changing *** force chain collimation coefficient initially increased and subsequently stabilized,reaching a maximum value of 0.93.A large number of broken,small particles in the wet coal dust layer mainly served to fill the gaps among large *** maximum relative error between the experimental and simulated values on the three-body contact stiffness is 7.26%,indicating that the simulation results can be an approximate substitute for the experimental results with a certain degree of accuracy and practic

关键词： Wet coal dust Force chain Three-body contact stiffness Gap flling effect Cover layer effect

Dissolution kinetics and reaction mechanism of Al_(2)O_(3) in molten CaF_(2)-CaO-Al_(2)O_(3) slag

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Journal of Iron and Steel Research International 2024年第4期31卷 861-869页

作者： Yao-xin Du Yan-wu Dong Zhou-hua Jiang Ganna Stovpchenko Yu-shuo Li Jun Huang Xin-wei Wang Yu-xiao Liu School of Metallurgy Northeastern UniversityShenyang 110819LiaoningChina Key Laboratory of Ecological Metallurgy of Multimetallic Mineral Northeastern UniversityShenyang 110819LiaoningChina State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819LiaoningChina E.O.Paton Electric Welding Institute of the National Academy of Science of Ukraine Kiev 03115Ukraine

The dissolution behavior of Al_(2)O_(3) in molten CaF_(2)-CaO-Al_(2)O_(3) slag,a basic slag system of electroslag remelting process,was investigated by rotating cylinder method using corundum rods to simulate Al_(2)O_(3) inclusions in *** experimental results show that the dissolution rate of Al_(2)O_(3);rods in CaF_(2)-CaO-Al_(2)O_(3) slag increases with the increase in rotating speed and temperature,and the rate-controlling step is the mass transfer in the *** dissolution rate of Al_(2)O,in CaF_(2)-CaO-Al_(2)O_(3) slag increases with the increase in the ratio of CaO to Al_(2)O_(3),which is due to the increase in dissolution driving force and the decrease in slag *** apparent activation energy of the mass transfer of AlOs in slag C is calculated to be 222.86 kJ mol^(-1).During the dissolution of Al_(2)0,inclusions in the slag,it reacts with F in liquid slag at first,then reacts with CaO to form the intermediate compounds of xCaO-yAl_(2)O_(3) system,and finally dissolves in molten *** dissolution rate of Al_(2)O_(3) inclusions in CaF_(2)-CaO-Al_(2)O_(3) slag for electroslag remelting is positively correlated with the ratio of the dissolution driving force and slag viscosity,and the correlation coeficient is 2.487×10^(-11).

关键词： Inclusion Electroslag remelting Mass transfer:Dissolution rate-Dissolution driving force

Strip flatness prediction of cold rolling based on ensemble methods

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Journal of Iron and Steel Research International 2024年第1期31卷 237-251页

作者： Wu-quan Yang Zhi-ting Zhao Liang-yu Zhu Xun-yang Gao Li Wang School of Mechanical and Power Engineering Shenyang University of Chemical TechnologyShenyang110142LiaoningChina

Aiming at the problem of insufficient prediction accuracy of strip flatness at the outlet of cold tandem rolling,the prediction performance of strip flatness based on different ensemble methods was studied and a high-precision prediction ensemble model of strip flatness at the outlet was ***,based on linear regression(LR),K nearest neighbors(KNN),support vector regression,regression trees(RT),and backpropagation neural network(BPN),bagging,boosting,and stacking ensemble methods were used for ensemble ***,three existing ensemble models,i.e.,random forest,extreme random tree(ET)and extreme gradient boosting,were used to conduct experiments and compare the *** research shows that bagging,boosting,and stacking three ensemble methods have the most significant improvement in the prediction accuracy of the regression trees model,which is increased by 5.28%,6.51%,and 5.32%,*** the same time,the stacking ensemble method improves both the simple model and the complex model,and the improvement effect on the simple base model is the greatest,which is 4.69%higher than that of the base model *** all of the ensemble models,the stacking ensemble model of level-1(ET,AdaBoost-RT,LR,BPN)paired with level-2(LR)was discovered to be the best model(EALB-LR)and can be further studied for industrial applications.

关键词： Tandem cold rolling Flatness prediction Machine learning Ensemble method

IGF2BPs as novel m^(6)A readers:Diverse roles in regulating cancer cell biological functions,hypoxia adaptation,metabolism,and immunosuppressive tumor microenvironment

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Genes & Diseases 2024年第2期11卷 890-920页

作者： Meiqi Duan Haiyang Liu Shasha Xu Zhi Yang Fusheng Zhang Guang Wang Yutian Wang Shan Zhao Xiaofeng Jiang Department of General Surgery The Fourth Affiliated Hospital of China Medical UniversityShenyangLiaoning 110032China Department of Gastroendoscopy The Fourth Affiliated Hospital of China Medical UniversityShenyangLiaoning 110032China Department of Rheumatology and Immunology The First Affiliated Hospital of China Medical UniversityShenyangLiaoning 110002China

m^(6)A methylation is the most frequent modification of mRNA in eukaryotes and plays a crucial role in cancer progression by regulating biological ***-like growth factor 2 mRNA-binding proteins(IGF2BP)are newly identified m^(6)A‘readers’.They belong to a family of RNA-binding proteins,which bind to the m^(6)A sites on different RNA sequences and stabilize them to promote cancer *** this review,we summarize the mechanisms by which different upstream factors regulate IGF2BP in *** current literature analyzed here reveals that the IGF2BP family proteins promote cancer cell proliferation,survival,and chemoresistance,inhibit apoptosis,and are also associated with cancer glycolysis,angiogenesis,and the immune response in the tumor ***,with the discovery of their role as‘readers’of m^(6)A and the characteristic re-expression of IGF2BPs in cancers,it is important to elucidate their mechanism of action in the immunosuppressive tumor *** also describe in detail the regulatory and interaction network of the IGF2BP family in downstream target RNAs and discuss their potential clinical applications as diagnostic and prognostic markers,as well as recent advances in IGF2BP biology and associated therapeutic value.

关键词： Cancer IGF2BP Immunosuppressive TME m^(6)A Molecular mechanism Therapy

DNL-16:A new zeolitic layered silicate unraveled by three-dimensional electron diffraction

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Chinese Journal of Structural Chemistry 2024年第4期43卷 4-6页

作者： Chao Ma Peng Guo Zhongmin Liu School of Chemistry Dalian University of TechnologyDalianLiaoning116024China National Engineering Research center of Lower-Carbon Catalysis Technology Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalianLiaoning116023China University of Chinese Academy of Sciences Beijing100049China

Two-dimensional(2D)zeolitic layered silicates(ZLSs)are drawing increasing attention since they have large external surface areas,easy convenience for further pillaring or exfoliating for desirable properties,and even promising candidates for constructing novel three-dimensional(3D)zeolites[1,2].From the structural point of view,basic building units SiO4 in ZLSs are interconnected through sharing the bridging oxygen atoms.

关键词： layered silicate SiO4

An all-biomaterials-based aqueous binder based on adsorption redox-mediated synergism for advanced lithium–sulfur batteries

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eScience 2024年第3期4卷 116-126页

作者： Wanyuan Jiang Tianpeng Zhang Runyue Mao Zihui Song Siyang Liu Ce Song Xigao Jian Fangyuan Hu State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical EngineeringSchool of Chemical EngineeringTechnology Innovation Center of High Performance Resin Materials(Liaoning Province)Key Laboratory of Energy Materials and Devices(Liaoning Province)Dalian University of TechnologyDalian 116024China School of Materials Science and Engineering State Key Laboratory of Fine ChemicalsFrontiers Science Center for Smart Materials Oriented Chemical EngineeringTechnology Innovation Center of High Performance Resin Materials(Liaoning Province)Key Laboratory of Energy Materials and Devices(Liaoning Province)Dalian University of TechnologyDalian 116024China

The complex multistep electrochemical reactions of lithium polysulfides and the solid–liquid–solid phase transformation involved in the S8 to Li2S reactions lead to slow redox kinetics in lithium–sulfur batteries(Li–S batteries).However,some targeted researches have proposed strategies requiring the introduction of significant additional inactive components,which can seriously affect the energy *** polymer binders,proven to be effective in suppressing shuttle effects and constraining electrode volume expansion,also have promising potential in enhancing Li–S batteries redox ***,a novel aqueous polymer binder is prepared by convenient amidation reaction of fully biomaterials,utilizing its inherent rich amide groups for chemisorption and redox mediating ability of thiol groups to achieve adsorption redox-mediated synergism for efficient conversion of ***–S batteries based on N-Acetyl-L-Cysteine-Chitosan(NACCTS)binder exhibit high initial discharge specific capacity(1260.1mAhg−1 at 0.2C)and excellent cycling performance over 400 cycles(capacity decay rate of 0.018%per cycle).In addition,the batteries exhibit great areal capacity and stable capacity retention of 83.6%over 80 cycles even under high sulfur loading of 8.4mgcm−*** work offers a novel perspective on the redox-mediated functional design and provides an environmentally friendly biomaterials-based aqueous binder for practical Li–S battery.

关键词： Li–S batteries Aqueous binder Biomaterials Adsorption redox-mediated synergism Hydrogen bonding

Effect of Modification Treatment on Chloride Ions Permeability and Microstructure of Recycled Brick-mixed Aggregate Concrete

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Journal of Wuhan University of Technology(Materials Science) 2024年第3期39卷 728-737页

作者：何子明申爱琴 WANG Xiaobin WU Jinhua WANG Lusheng School of Civil and Architectural Engineering Liaoning University of TechnologyJinzhou 121001China School of Highway Chang’an UniversityXi’an 710064China Department of Road and Bridge Engineering Liaoning Provincial College of Communica-tionsShenyang 110122China

The modification methods of pozzolan slurry combined with sodium silicate and silicon-based additive were respectively adopted to treat recycled coarse brick-mixed aggregate(RCBA)in this *** compressive strength and chloride permeability resistance of recycled aggregate concrete(RAC)before and after modification treatment were tested,and the microstructure of RAC was analyzed by mercury intrusion porosimetry(MIP)and scanning electron microscopy(SEM).The results show that the physical properties of RCBA strengthened by modification treatment are improved,and the compressive strength and chloride permeability resistance of treated RAC are also significantly *** modification treatment optimizes the pore size distribution of RAC,which increases the number of gel pores and transition pores,and decreases the number of capillary pores and macro *** surface fractal dimension shows a significant correlation with chloride diffusion coefficient,indicating that the variation of chloride permeability of treated RAC is consistent with the microstructure evolution.

关键词： recycled aggregate concrete modification treatment compressive strength chloride permeability resistance microstructure

Overcoming neutrophil-induced immunosuppression in postoperative cancer therapy: Combined sialic acid-modified liposomes with scaffold-based vaccines

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Asian Journal of Pharmaceutical Sciences 2024年第2期19卷 153-169页

作者： Cong Li Lihong Wang Kexin Zhang Zeyu Wang Zhihang Li Zehao Li Lijiang Chen School of Pharmaceutical Science Liaoning UniversityShenyang 110036China

Immunotherapy is a promising approach for preventing postoperative tumor recurrence and metastasis. However, inflammatory neutrophils, recruited to the postoperative tumor site, have been shown to exacerbate tumor regeneration and limit the efficacy of cancer vaccines. Consequently, addressing postoperative immunosuppression caused by neutrophils is crucial for improving treatment outcomes. This study presents a combined chemoimmunotherapeutic strategy that employs a biocompatible macroporous scaffold-based cancer vaccine (S-CV) and a sialic acid (SA)-modified, doxorubicin (DOX)-loaded liposomal platform (DOX@SAL). The S-CV contains whole tumor lysates as antigens and imiquimod (R837, Toll-like receptor 7 activator)-loaded PLGA nanoparticles as immune adjuvants for cancer, which enhance dendritic cell activation and cytotoxic T cell proliferation upon localized implantation. When administered intravenously, DOX@SAL specifically targets and delivers drugs to activated neutrophils in vivo, mitigating neutrophil infiltration and suppressing postoperative inflammatory responses. In vivo and vitro experiments have demonstrated that S-CV plus DOX@SAL, a combined chemo-immunotherapeutic strategy, has a remarkable potential to inhibit postoperative local tumor recurrence and distant tumor progression, with minimal systemic toxicity, providing a new concept for postoperative treatment of tumors.

关键词： Postoperative tumor treatment Immunotherapy Scaffold-based cancer vaccine Inflammatory neutrophils Sialic acid-modied liposome

A complete assembly of the sorghum BTx623 reference genome

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Plant Communications 2024年第6期5卷 13-16页

作者： Yuan Deng Peng Zhou Fei Li Jing Wang Kun Xie Hongkai Liang Chunchao Wang Bin Liu Zhenxing Zhu Wenbin Zhou Baoqing Dun Xiaochun Lu Xianmin Diao Qiang He State Key Laboratory of Crop Gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China Crop Molecular Improvement Lab Liaoning Academy of Agricultural SciencesShenyangLiaoning 110161China Zhongyuan Research center Chinese Academy of Agricultural SciencesXinxiangHenan 453599China

Dear Editor,Sorghum(Sorghum bicolor),recognized as the world’s fifth most significant cereal crop,plays an essential role as a model for genomic comparison and functional genomics of C4 *** was domesticated in Ethiop... 详细信息

关键词： ). Sorghum environments